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Детская эндокринология сегодня и завтра: взгляд педиатра и эндокринолога. Сахарный диабет у детей
Детская эндокринология сегодня и завтра: взгляд педиатра и эндокринолога. Сахарный диабет у детей
Никитина И.Л., Петрова Т.А., Костарева А.А. Детская эндокринология сегодня и завтра: взгляд педиатра и эндокринолога. Сахарный диабет у детей. Consilium Medicum. Педиатрия (Прил.). 2016; 2: 24–32.
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Аннотация
Диабетология является одним из наиболее динамично развивающихся разделов эндокринологии. Настоящая публикация посвящена мини-
обзору основных направлений совершенствования медицинской помощи детям и подросткам с диабетом. Вместе с тем в статье представлены ключевые понятия в отношении данной патологии, необходимые для умения врачей-педиатров диагностировать сахарный диабет, контролировать метаболические показатели и иметь представление о современных достижениях детской диабетологии. Приведены собственные клинические наблюдения детей с неиммунными (моногенными) вариантами сахарного диабета.
Ключевые слова: сахарный диабет, дети, подростки, инсулинотерапия, новые технологии.
Key words: diabetes, children, adolescents, insulinotherapy, new technologies.
обзору основных направлений совершенствования медицинской помощи детям и подросткам с диабетом. Вместе с тем в статье представлены ключевые понятия в отношении данной патологии, необходимые для умения врачей-педиатров диагностировать сахарный диабет, контролировать метаболические показатели и иметь представление о современных достижениях детской диабетологии. Приведены собственные клинические наблюдения детей с неиммунными (моногенными) вариантами сахарного диабета.
Ключевые слова: сахарный диабет, дети, подростки, инсулинотерапия, новые технологии.
________________________________________________
Key words: diabetes, children, adolescents, insulinotherapy, new technologies.
Полный текст
Список литературы
1. Никитина И.Л. Детская эндокринология – научные достижения и перспективы развития. Артериальная гипертензия. 2015; 21 (1): 16–26. / Nikitina I.L. Detskaia endokrinologiia – nauchnye dostizheniia i perspektivy razvitiia. Arterial'naia gipertenziia. 2015; 21 (1): 16–26. [in Russian]
2. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 3–12.
3. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009;10 (12): 33–42.
4. Couper JJ, Donaghue KC. Phases of Diabetes in children and adolescents. Pediatric Diabetes 2009; 10 (12): 13–6.
5. Дедов И.И., Кураева Т.Л., Петеркова В.А. Сахарный диабет у детей и подростков. М.: ГЭОТАР-Медиа, 2008. / Dedov I.I., Kuraeva T.L., Peterkova V.A. Sakharnyi diabet u detei i podrostkov. M.: GEOTAR-Media, 2008. [in Russian]
6. Дедов И.И., Петеркова В.А., Кураева Т.Л. Российский консенсус по терапии сахарного диабета у детей и подростков. Сахарный диабет. Спецвыпуск. 2010; с. 1–8. / Dedov I.I., Peterkova V.A., Kuraeva T.L. Rossiiskii konsensus po terapii sakharnogo diabeta u detei i podrostkov. Sakharnyi diabet. Spetsvypusk. 2010; s. 1–8. [in Russian]
7. Никитина И.Л. Неаутоиммунный сахарный диабет у детей. Лечащий врач. 2010; 6: 22–7. / Nikitina I.L. Neautoimmunnyi sakharnyi diabet u detei. Lechashchii vrach. 2010; 6: 22–7. [in Russian]
8. Berchold LA, Storling ZM, Ortis F et al. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and b-cell apoptosis. Proc Natl Acad Sci 2011; 108: Е681–688.
9. Bergholdt R, Brorsson CA, Palleja A et al. Idenification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression. Diabetes 2012; 61: 954–62.
10. Rakyan VK, Beyan H, Down TA et al. Idenification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011; 7 (9): е1002300. doi: 10.1371/journal.pgen.1002300
11. Lindskog C, Korsgren O, Ponten F et al. Novel pancreatic b-cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. J Proteomics 2012; 5: 2611–20.
12. Koulmanda M, Bhasin M, Fan Z et al. Alpha-1-antitripsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci USA 2012; 109: 15443–8.
13. Sjoberg L, Pitkaniemi J, Haapala L et al. Fertility in people with childhood-onset type 1 diabetes. Diabetilogia 2013; 56: 78–81.
14. Sorensen IM, Joner G, Jenum PA et al. Maternal serum levels of 25-hydroxyvitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012; 61: 175–8.
15. Markle JG, Frank DN, Mortin-Toth S et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339: 1084–8.
16. Loredana M Marcovecchio, Chiarelli F. Type 1 diabetes: clinical and experimental. Yearbook of Pediatric Endocrinology. Ed. K.Ong, Z.Hochberg. 2013; p. 127–45.
17. Hovorka R, Elleri D, Thabit H et al. Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2014; 37: 1204–11.
18. Hirschfeld G, von Glischinski M, Blankenburg M, Zernikow B. Screening for peripheral neuropathies in children with diabetes:a systematic review. Pediatrics 2014; 133 (5): e1324–30. doi: 10.1542/peds.2013-3645.
19. Yi P, Park JS, Melton DA. Betatropin: a hormone that controls pancreatic b-cells proliferation. Cell 2013; 153: 747–58.
20. Каронова Т.Л., Гринева Е.Н., Михеева Е.П. и др. Уровень витамина D и его взаимосвязь с количеством жировой ткани и содержанием адипоцитокинов в жировой ткани у женщин репродуктивного возраста. Проблемы эндокринологии. 2012; 58 (6): 19–23. / Karonova T.L., Grineva E.N., Mikheeva E.P. i dr. Uroven' vitamina D i ego vzaimosviaz' s kolichestvom zhirovoi tkani i soderzhaniem adipotsitokinov v zhirovoi tkani u zhenshchin reproduktivnogo vozrasta. Problemy endokrinologii. 2012; 58 (6): 19–23. [in Russian]
21. Никитина И.Л. Старт пубертата – известное и новое. Артериальная гипертензия. 2013; 19 (3): 227–36. / Nikitina I.L. Start pubertata – izvestnoe i novoe. Arterial'naia gipertenziia. 2013; 19 (3): 227–36. [in Russian]
22. Copeland KC, Silverstein J, Moore KR et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131 (2): 364–82.
23. Sylvetsky AC, Nandagopal R, Nguyen TT et al. Buddy Study: Partners for better health in adolescents with type 2 diabetes. World J Diabetes 2015; 6 (18): 1355–62.
24. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 33–42.
2. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 3–12.
3. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009;10 (12): 33–42.
4. Couper JJ, Donaghue KC. Phases of Diabetes in children and adolescents. Pediatric Diabetes 2009; 10 (12): 13–6.
5. Dedov I.I., Kuraeva T.L., Peterkova V.A. Sakharnyi diabet u detei i podrostkov. M.: GEOTAR-Media, 2008. [in Russian]
6. Dedov I.I., Peterkova V.A., Kuraeva T.L. Rossiiskii konsensus po terapii sakharnogo diabeta u detei i podrostkov. Sakharnyi diabet. Spetsvypusk. 2010; s. 1–8. [in Russian]
7. Nikitina I.L. Neautoimmunnyi sakharnyi diabet u detei. Lechashchii vrach. 2010; 6: 22–7. [in Russian]
8. Berchold LA, Storling ZM, Ortis F et al. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and b-cell apoptosis. Proc Natl Acad Sci 2011; 108: Е681–688.
9. Bergholdt R, Brorsson CA, Palleja A et al. Idenification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression. Diabetes 2012; 61: 954–62.
10. Rakyan VK, Beyan H, Down TA et al. Idenification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011; 7 (9): е1002300. doi: 10.1371/journal.pgen.1002300
11. Lindskog C, Korsgren O, Ponten F et al. Novel pancreatic b-cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. J Proteomics 2012; 5: 2611–20.
12. Koulmanda M, Bhasin M, Fan Z et al. Alpha-1-antitripsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci USA 2012; 109: 15443–8.
13. Sjoberg L, Pitkaniemi J, Haapala L et al. Fertility in people with childhood-onset type 1 diabetes. Diabetilogia 2013; 56: 78–81.
14. Sorensen IM, Joner G, Jenum PA et al. Maternal serum levels of 25-hydroxyvitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012; 61: 175–8.
15. Markle JG, Frank DN, Mortin-Toth S et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339: 1084–8.
16. Loredana M Marcovecchio, Chiarelli F. Type 1 diabetes: clinical and experimental. Yearbook of Pediatric Endocrinology. Ed. K.Ong, Z.Hochberg. 2013; p. 127–45.
17. Hovorka R, Elleri D, Thabit H et al. Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2014; 37: 1204–11.
18. Hirschfeld G, von Glischinski M, Blankenburg M, Zernikow B. Screening for peripheral neuropathies in children with diabetes:a systematic review. Pediatrics 2014; 133 (5): e1324–30. doi: 10.1542/peds.2013-3645.
19. Yi P, Park JS, Melton DA. Betatropin: a hormone that controls pancreatic b-cells proliferation. Cell 2013; 153: 747–58.
20. Karonova T.L., Grineva E.N., Mikheeva E.P. i dr. Uroven' vitamina D i ego vzaimosviaz' s kolichestvom zhirovoi tkani i soderzhaniem adipotsitokinov v zhirovoi tkani u zhenshchin reproduktivnogo vozrasta. Problemy endokrinologii. 2012; 58 (6): 19–23. [in Russian]
21. Nikitina I.L. Start pubertata – izvestnoe i novoe. Arterial'naia gipertenziia. 2013; 19 (3): 227–36. [in Russian]
22. Copeland KC, Silverstein J, Moore KR et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131 (2): 364–82.
23. Sylvetsky AC, Nandagopal R, Nguyen TT et al. Buddy Study: Partners for better health in adolescents with type 2 diabetes. World J Diabetes 2015; 6 (18): 1355–62.
24. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 33–42.
2. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 3–12.
3. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009;10 (12): 33–42.
4. Couper JJ, Donaghue KC. Phases of Diabetes in children and adolescents. Pediatric Diabetes 2009; 10 (12): 13–6.
5. Дедов И.И., Кураева Т.Л., Петеркова В.А. Сахарный диабет у детей и подростков. М.: ГЭОТАР-Медиа, 2008. / Dedov I.I., Kuraeva T.L., Peterkova V.A. Sakharnyi diabet u detei i podrostkov. M.: GEOTAR-Media, 2008. [in Russian]
6. Дедов И.И., Петеркова В.А., Кураева Т.Л. Российский консенсус по терапии сахарного диабета у детей и подростков. Сахарный диабет. Спецвыпуск. 2010; с. 1–8. / Dedov I.I., Peterkova V.A., Kuraeva T.L. Rossiiskii konsensus po terapii sakharnogo diabeta u detei i podrostkov. Sakharnyi diabet. Spetsvypusk. 2010; s. 1–8. [in Russian]
7. Никитина И.Л. Неаутоиммунный сахарный диабет у детей. Лечащий врач. 2010; 6: 22–7. / Nikitina I.L. Neautoimmunnyi sakharnyi diabet u detei. Lechashchii vrach. 2010; 6: 22–7. [in Russian]
8. Berchold LA, Storling ZM, Ortis F et al. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and b-cell apoptosis. Proc Natl Acad Sci 2011; 108: Е681–688.
9. Bergholdt R, Brorsson CA, Palleja A et al. Idenification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression. Diabetes 2012; 61: 954–62.
10. Rakyan VK, Beyan H, Down TA et al. Idenification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011; 7 (9): е1002300. doi: 10.1371/journal.pgen.1002300
11. Lindskog C, Korsgren O, Ponten F et al. Novel pancreatic b-cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. J Proteomics 2012; 5: 2611–20.
12. Koulmanda M, Bhasin M, Fan Z et al. Alpha-1-antitripsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci USA 2012; 109: 15443–8.
13. Sjoberg L, Pitkaniemi J, Haapala L et al. Fertility in people with childhood-onset type 1 diabetes. Diabetilogia 2013; 56: 78–81.
14. Sorensen IM, Joner G, Jenum PA et al. Maternal serum levels of 25-hydroxyvitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012; 61: 175–8.
15. Markle JG, Frank DN, Mortin-Toth S et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339: 1084–8.
16. Loredana M Marcovecchio, Chiarelli F. Type 1 diabetes: clinical and experimental. Yearbook of Pediatric Endocrinology. Ed. K.Ong, Z.Hochberg. 2013; p. 127–45.
17. Hovorka R, Elleri D, Thabit H et al. Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2014; 37: 1204–11.
18. Hirschfeld G, von Glischinski M, Blankenburg M, Zernikow B. Screening for peripheral neuropathies in children with diabetes:a systematic review. Pediatrics 2014; 133 (5): e1324–30. doi: 10.1542/peds.2013-3645.
19. Yi P, Park JS, Melton DA. Betatropin: a hormone that controls pancreatic b-cells proliferation. Cell 2013; 153: 747–58.
20. Каронова Т.Л., Гринева Е.Н., Михеева Е.П. и др. Уровень витамина D и его взаимосвязь с количеством жировой ткани и содержанием адипоцитокинов в жировой ткани у женщин репродуктивного возраста. Проблемы эндокринологии. 2012; 58 (6): 19–23. / Karonova T.L., Grineva E.N., Mikheeva E.P. i dr. Uroven' vitamina D i ego vzaimosviaz' s kolichestvom zhirovoi tkani i soderzhaniem adipotsitokinov v zhirovoi tkani u zhenshchin reproduktivnogo vozrasta. Problemy endokrinologii. 2012; 58 (6): 19–23. [in Russian]
21. Никитина И.Л. Старт пубертата – известное и новое. Артериальная гипертензия. 2013; 19 (3): 227–36. / Nikitina I.L. Start pubertata – izvestnoe i novoe. Arterial'naia gipertenziia. 2013; 19 (3): 227–36. [in Russian]
22. Copeland KC, Silverstein J, Moore KR et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131 (2): 364–82.
23. Sylvetsky AC, Nandagopal R, Nguyen TT et al. Buddy Study: Partners for better health in adolescents with type 2 diabetes. World J Diabetes 2015; 6 (18): 1355–62.
24. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 33–42.
________________________________________________
2. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 3–12.
3. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009;10 (12): 33–42.
4. Couper JJ, Donaghue KC. Phases of Diabetes in children and adolescents. Pediatric Diabetes 2009; 10 (12): 13–6.
5. Dedov I.I., Kuraeva T.L., Peterkova V.A. Sakharnyi diabet u detei i podrostkov. M.: GEOTAR-Media, 2008. [in Russian]
6. Dedov I.I., Peterkova V.A., Kuraeva T.L. Rossiiskii konsensus po terapii sakharnogo diabeta u detei i podrostkov. Sakharnyi diabet. Spetsvypusk. 2010; s. 1–8. [in Russian]
7. Nikitina I.L. Neautoimmunnyi sakharnyi diabet u detei. Lechashchii vrach. 2010; 6: 22–7. [in Russian]
8. Berchold LA, Storling ZM, Ortis F et al. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and b-cell apoptosis. Proc Natl Acad Sci 2011; 108: Е681–688.
9. Bergholdt R, Brorsson CA, Palleja A et al. Idenification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression. Diabetes 2012; 61: 954–62.
10. Rakyan VK, Beyan H, Down TA et al. Idenification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011; 7 (9): е1002300. doi: 10.1371/journal.pgen.1002300
11. Lindskog C, Korsgren O, Ponten F et al. Novel pancreatic b-cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. J Proteomics 2012; 5: 2611–20.
12. Koulmanda M, Bhasin M, Fan Z et al. Alpha-1-antitripsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci USA 2012; 109: 15443–8.
13. Sjoberg L, Pitkaniemi J, Haapala L et al. Fertility in people with childhood-onset type 1 diabetes. Diabetilogia 2013; 56: 78–81.
14. Sorensen IM, Joner G, Jenum PA et al. Maternal serum levels of 25-hydroxyvitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012; 61: 175–8.
15. Markle JG, Frank DN, Mortin-Toth S et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339: 1084–8.
16. Loredana M Marcovecchio, Chiarelli F. Type 1 diabetes: clinical and experimental. Yearbook of Pediatric Endocrinology. Ed. K.Ong, Z.Hochberg. 2013; p. 127–45.
17. Hovorka R, Elleri D, Thabit H et al. Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2014; 37: 1204–11.
18. Hirschfeld G, von Glischinski M, Blankenburg M, Zernikow B. Screening for peripheral neuropathies in children with diabetes:a systematic review. Pediatrics 2014; 133 (5): e1324–30. doi: 10.1542/peds.2013-3645.
19. Yi P, Park JS, Melton DA. Betatropin: a hormone that controls pancreatic b-cells proliferation. Cell 2013; 153: 747–58.
20. Karonova T.L., Grineva E.N., Mikheeva E.P. i dr. Uroven' vitamina D i ego vzaimosviaz' s kolichestvom zhirovoi tkani i soderzhaniem adipotsitokinov v zhirovoi tkani u zhenshchin reproduktivnogo vozrasta. Problemy endokrinologii. 2012; 58 (6): 19–23. [in Russian]
21. Nikitina I.L. Start pubertata – izvestnoe i novoe. Arterial'naia gipertenziia. 2013; 19 (3): 227–36. [in Russian]
22. Copeland KC, Silverstein J, Moore KR et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131 (2): 364–82.
23. Sylvetsky AC, Nandagopal R, Nguyen TT et al. Buddy Study: Partners for better health in adolescents with type 2 diabetes. World J Diabetes 2015; 6 (18): 1355–62.
24. Hattersley AT, Shield J, Njolstad P et al. The diagnosis and management of monogenic diabetes in children and adolescents. ISPAD Clinical Practice Consensus Guidelines Compendium. Pediatric Diabetes 2009; 10 (12): 33–42.
Авторы
И.Л.Никитина*, Т.А.Петрова, А.А.Костарева
ФГБУ Северо-Западный федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России. 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2
*nikitina0901@gmail.com
V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation. 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2
*nikitina0901@gmail.com
ФГБУ Северо-Западный федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России. 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2
*nikitina0901@gmail.com
________________________________________________
V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation. 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2
*nikitina0901@gmail.com
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