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К вопросу о лечении острых заболеваний верхних дыхательных путей
К вопросу о лечении острых заболеваний верхних дыхательных путей
Рябова М.А., Галкина О.В., Пестакова Л.В., Пособило Е.Е. К вопросу о лечении острых заболеваний верхних дыхательных путей. Consilium Medicum. Педиатрия (Прил.). 2016; 3: 51–54.
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Аннотация
В статье обсуждаются методы стартового лечения острых респираторных инфекций. На фоне терапии препаратом ОМ-85 с первых дней заболевания отмечены достоверно значимое нарастание продукции секреторного иммуноглобулина А, более быстрое уменьшение выраженности симптомов заболевания, сокращение длительности заболевания, снижение медикаментозной нагрузки и предотвращение развития осложнений.
Ключевые слова: острая респираторная инфекция, секреторный иммуноглобулин А, ОМ-85.
Key words: acute respiratory infection, secretory immunoglobulin A, ОМ-85.
Ключевые слова: острая респираторная инфекция, секреторный иммуноглобулин А, ОМ-85.
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Key words: acute respiratory infection, secretory immunoglobulin A, ОМ-85.
Полный текст
Список литературы
1. Малкоч А.В., Анастасевич Л.А., Боткина А.С. Острые респираторные заболевания и возможности иммуномодулирующей терапии. Лечащий врач. 2008; 8: 58–62. / Malkoch A.V., Anastasevich L.A., Botkina A.S. Ostrye respiratornye zabolevaniia i vozmozhnosti immunomoduliruiushchei terapii. Lechashchii vrach. 2008; 8: 58–62. [in Russian]
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3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–8.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129: 72–4.
5. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001; p. 5.
6. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
7. Del‐Rio‐Navarro BE, Espinosa‐Rosales FJ, Flenady V et al. Cochrane Review: Immunostimulants for preventing respiratory tract infection in children. Evidence‐Based Child Health: A Cochrane Rev J 2012; 7 (2): 629–717.
8. Баранов А.А., Лобзин Ю.В. Федеральные клинические рекомендации по оказанию медицинской помощи детям с острой респираторной вирусной инфекцией. 2015; 8. / Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei. 2015; 8. [in Russian]
9. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online). 2001; Issue 3.
10. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–16.
11. Землякова Э.И., Шакирова Э.М., Сафина Л.З. Экспертный анализ лечения острых респираторных инфекций участковыми педиатрами Практ. медицина. 2007; 12: 62. / Zemliakova E.I., Shakirova E.M., Safina L.Z. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami Prakt. meditsina. 2007; 12: 62. [in Russian]
12. Татотченко В.К. Острые респираторные заболевания у детей – антибиотики или иммуностимуляция. Вопр. соврем. педиатрии. 2004; 3 (2): 35–42. / Tatotchenko V.K. Ostrye respiratornye zabolevaniia u detei – antibiotiki ili immunostimuliatsiia. Vopr. sovrem. pediatrii. 2004; 3 (2): 35–42. [in Russian]
13. Андриянова И.В., Каширцева И.А., Казакова О.Э., Вахрушев С.Г. Исследование микробиоты носоглотки детей с хроническим аденоидитом по данным масс-спектрометрии по микробным маркерам. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. / Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym mass-spektrometrii po mikrobnym markeram. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. [in Russian]
14. Исаков В.А., Исаков Д.В., Беляева Т.В., Водейко Л.П. Перспективы терапии респираторных инфекций. Практ. пульмонология. 2015; 1: 14–21. / Isakov V.A., Isakov D.V., Beliaeva T.V., Vodeiko L.P. Perspektivy terapii respiratornykh infektsii. Prakt. pul'monologiia. 2015; 1: 14–21. [in Russian]
15. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review Eur J Pediatr 2007; 166: 365–76.
16. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4.
17. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom (OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5.
18. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61: 8–15.
19. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants – mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
20. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
21. Крюков А.И., Лучшева Ю.В., Баландин А.В. и др. Рациональная антибиотикотерапия при ангине и хроническом тонзиллите. Consilium Medicum. 2005; 7 (4): 297–300. / Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
22. Гаращенко Т.И., Богомильский М.Р., Маркова Т.П. Бактериальные иммунокорректоры в профилактике заболеваний верхних дыхательных путей и уха у часто болеющих детей. Consilium Medicum. Педиатрия (Прил.). 2002; 3: 7–14. / Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatrics (Suppl.). 2002; 3: 7–14. [in Russian]
23. Tacchi L , Musharrafieh R, Larragoite E et al. Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nat Commun 2014; 22 (5): 5205.
24. Nishio O, Sakae K, Ishihara Y et al. Adenovirus infection and specific secretory IgA responses in the intestine of infants. Microbiol Immunol 1992; 36: 623–31.
25. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
26. Płusa T, Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections. Pol Merkur Lekarski 1998; 5 (30): 368–71.
2. Lobzin Iu.V. Rukovodstvo po infektsionnym bolezniam. SPb.: Foliant, 2000; s. 932. [in Russian]
3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–8.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129: 72–4.
5. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001; p. 5.
6. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
7. Del‐Rio‐Navarro BE, Espinosa‐Rosales FJ, Flenady V et al. Cochrane Review: Immunostimulants for preventing respiratory tract infection in children. Evidence‐Based Child Health: A Cochrane Rev J 2012; 7 (2): 629–717.
8. Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei. 2015; 8. [in Russian]
9. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online). 2001; Issue 3.
10. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–16.
11. Zemliakova E.I., Shakirova E.M., Safina L.Z. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami Prakt. meditsina. 2007; 12: 62. [in Russian]
12. Tatotchenko V.K. Ostrye respiratornye zabolevaniia u detei – antibiotiki ili immunostimuliatsiia. Vopr. sovrem. pediatrii. 2004; 3 (2): 35–42. [in Russian]
13. Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym mass-spektrometrii po mikrobnym markeram. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. [in Russian]
14. Isakov V.A., Isakov D.V., Beliaeva T.V., Vodeiko L.P. Perspektivy terapii respiratornykh infektsii. Prakt. pul'monologiia. 2015; 1: 14–21. [in Russian]
15. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review Eur J Pediatr 2007; 166: 365–76.
16. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4.
17. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom (OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5.
18. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61: 8–15.
19. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants – mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
20. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
21. Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
22. Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatrics (Suppl.). 2002; 3: 7–14. [in Russian]
23. Tacchi L , Musharrafieh R, Larragoite E et al. Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nat Commun 2014; 22 (5): 5205.
24. Nishio O, Sakae K, Ishihara Y et al. Adenovirus infection and specific secretory IgA responses in the intestine of infants. Microbiol Immunol 1992; 36: 623–31.
25. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
26. Płusa T, Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections. Pol Merkur Lekarski 1998; 5 (30): 368–71.
2. Лобзин Ю.В. Руководство по инфекционным болезням. СПб.: Фолиант, 2000; с. 932. / Lobzin Iu.V. Rukovodstvo po infektsionnym bolezniam. SPb.: Foliant, 2000; s. 932. [in Russian]
3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–8.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129: 72–4.
5. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001; p. 5.
6. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
7. Del‐Rio‐Navarro BE, Espinosa‐Rosales FJ, Flenady V et al. Cochrane Review: Immunostimulants for preventing respiratory tract infection in children. Evidence‐Based Child Health: A Cochrane Rev J 2012; 7 (2): 629–717.
8. Баранов А.А., Лобзин Ю.В. Федеральные клинические рекомендации по оказанию медицинской помощи детям с острой респираторной вирусной инфекцией. 2015; 8. / Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei. 2015; 8. [in Russian]
9. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online). 2001; Issue 3.
10. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–16.
11. Землякова Э.И., Шакирова Э.М., Сафина Л.З. Экспертный анализ лечения острых респираторных инфекций участковыми педиатрами Практ. медицина. 2007; 12: 62. / Zemliakova E.I., Shakirova E.M., Safina L.Z. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami Prakt. meditsina. 2007; 12: 62. [in Russian]
12. Татотченко В.К. Острые респираторные заболевания у детей – антибиотики или иммуностимуляция. Вопр. соврем. педиатрии. 2004; 3 (2): 35–42. / Tatotchenko V.K. Ostrye respiratornye zabolevaniia u detei – antibiotiki ili immunostimuliatsiia. Vopr. sovrem. pediatrii. 2004; 3 (2): 35–42. [in Russian]
13. Андриянова И.В., Каширцева И.А., Казакова О.Э., Вахрушев С.Г. Исследование микробиоты носоглотки детей с хроническим аденоидитом по данным масс-спектрометрии по микробным маркерам. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. / Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym mass-spektrometrii po mikrobnym markeram. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. [in Russian]
14. Исаков В.А., Исаков Д.В., Беляева Т.В., Водейко Л.П. Перспективы терапии респираторных инфекций. Практ. пульмонология. 2015; 1: 14–21. / Isakov V.A., Isakov D.V., Beliaeva T.V., Vodeiko L.P. Perspektivy terapii respiratornykh infektsii. Prakt. pul'monologiia. 2015; 1: 14–21. [in Russian]
15. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review Eur J Pediatr 2007; 166: 365–76.
16. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4.
17. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom (OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5.
18. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61: 8–15.
19. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants – mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
20. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
21. Крюков А.И., Лучшева Ю.В., Баландин А.В. и др. Рациональная антибиотикотерапия при ангине и хроническом тонзиллите. Consilium Medicum. 2005; 7 (4): 297–300. / Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
22. Гаращенко Т.И., Богомильский М.Р., Маркова Т.П. Бактериальные иммунокорректоры в профилактике заболеваний верхних дыхательных путей и уха у часто болеющих детей. Consilium Medicum. Педиатрия (Прил.). 2002; 3: 7–14. / Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatrics (Suppl.). 2002; 3: 7–14. [in Russian]
23. Tacchi L , Musharrafieh R, Larragoite E et al. Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nat Commun 2014; 22 (5): 5205.
24. Nishio O, Sakae K, Ishihara Y et al. Adenovirus infection and specific secretory IgA responses in the intestine of infants. Microbiol Immunol 1992; 36: 623–31.
25. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
26. Płusa T, Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections. Pol Merkur Lekarski 1998; 5 (30): 368–71.
________________________________________________
2. Lobzin Iu.V. Rukovodstvo po infektsionnym bolezniam. SPb.: Foliant, 2000; s. 932. [in Russian]
3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–8.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129: 72–4.
5. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001; p. 5.
6. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
7. Del‐Rio‐Navarro BE, Espinosa‐Rosales FJ, Flenady V et al. Cochrane Review: Immunostimulants for preventing respiratory tract infection in children. Evidence‐Based Child Health: A Cochrane Rev J 2012; 7 (2): 629–717.
8. Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei. 2015; 8. [in Russian]
9. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online). 2001; Issue 3.
10. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–16.
11. Zemliakova E.I., Shakirova E.M., Safina L.Z. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami Prakt. meditsina. 2007; 12: 62. [in Russian]
12. Tatotchenko V.K. Ostrye respiratornye zabolevaniia u detei – antibiotiki ili immunostimuliatsiia. Vopr. sovrem. pediatrii. 2004; 3 (2): 35–42. [in Russian]
13. Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym mass-spektrometrii po mikrobnym markeram. Folia Otorhinolaryngologiae. 2015; 21 (2): 15–6. [in Russian]
14. Isakov V.A., Isakov D.V., Beliaeva T.V., Vodeiko L.P. Perspektivy terapii respiratornykh infektsii. Prakt. pul'monologiia. 2015; 1: 14–21. [in Russian]
15. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review Eur J Pediatr 2007; 166: 365–76.
16. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4.
17. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom (OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5.
18. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61: 8–15.
19. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants – mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
20. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
21. Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
22. Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatrics (Suppl.). 2002; 3: 7–14. [in Russian]
23. Tacchi L , Musharrafieh R, Larragoite E et al. Nasal immunity is an ancient arm of the mucosal immune system of vertebrates. Nat Commun 2014; 22 (5): 5205.
24. Nishio O, Sakae K, Ishihara Y et al. Adenovirus infection and specific secretory IgA responses in the intestine of infants. Microbiol Immunol 1992; 36: 623–31.
25. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
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Авторы
М.А.Рябова*, О.В.Галкина, Л.В.Пестакова, Е.Е.Пособило
ФГБОУ ВО Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8
*marinaryabova@mail.ru
I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8
*marinaryabova@mail.ru
ФГБОУ ВО Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8
*marinaryabova@mail.ru
________________________________________________
I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8
*marinaryabova@mail.ru
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