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Безопасность новой синбиотической молочной смеси для детей первых 6 мес жизни
Безопасность новой синбиотической молочной смеси для детей первых 6 мес жизни
Ванденплас И., Аналитис А., С.Циувара и соавт. Безопасность новой синбиотической молочной смеси для детей первых 6 мес жизни. Consilium Medicum. Педиатрия (Прил.). 2016; 4: 41–47.
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Аннотация
Грудное молоко является «золотым стандартом» вскармливания ребенка 1-го года жизни, однако исключительно грудное вскармливание возможно не во всех случаях. В такой ситуации детская молочная смесь является продуктом выбора для питания младенцев.
Методы. Безопасность новой синбиотической молочной смеси, обогащенной Bifidobacterium lactis и фруктоолигосахаридами, была исследована у 280 младенцев, получавших продукт на протяжении 3 мес.
Результаты. Средний возраст детей на момент включения в исследование составил 0,89 мес. Динамика массы тела в период наблюдения соответствовала стандартам Всемирной организации здравоохранения, принятым для младенцев, находящихся на грудном вскармливании. Частота возникновения запоров, срыгиваний, беспокойства и колик была ниже при сравнении с представленными в литературе эпидемиологическими данными для детей аналогичного возраста.
Заключение. Новая синбиотическая молочная смесь хорошо переносилась младенцами и продемонстрировала свою безопасность. Частота функциональных нарушений желудочно-кишечного тракта на фоне вскармливания смесью была ниже при сравнении с имеющимися в литературе данными.
Ключевые слова: функциональные нарушения желудочно-кишечного тракта, рост, молочная смесь, пребиотик, пробиотик, синбиотик.
Methods. The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, was tested in 280 infants during 3 months.
Results. The median age at inclusion was 0.89 months. Weight evolution was in accordance with the WHO growth charts for exclusive breastfed infants. The evolution of all antropometric parameters was within normal range. The incidence of constipation, regurgitation, infantile crying and colic was lower than the reported incidence in literature for a similar age.
Conclusion. The new synbiotic infant formula was safe and well tolerated. Functional gastro-intestinal manifestations were lower than reported in literature.
Key words: functional disorder, growth, infant formula, prebiotic, probiotic, synbiotic.
Методы. Безопасность новой синбиотической молочной смеси, обогащенной Bifidobacterium lactis и фруктоолигосахаридами, была исследована у 280 младенцев, получавших продукт на протяжении 3 мес.
Результаты. Средний возраст детей на момент включения в исследование составил 0,89 мес. Динамика массы тела в период наблюдения соответствовала стандартам Всемирной организации здравоохранения, принятым для младенцев, находящихся на грудном вскармливании. Частота возникновения запоров, срыгиваний, беспокойства и колик была ниже при сравнении с представленными в литературе эпидемиологическими данными для детей аналогичного возраста.
Заключение. Новая синбиотическая молочная смесь хорошо переносилась младенцами и продемонстрировала свою безопасность. Частота функциональных нарушений желудочно-кишечного тракта на фоне вскармливания смесью была ниже при сравнении с имеющимися в литературе данными.
Ключевые слова: функциональные нарушения желудочно-кишечного тракта, рост, молочная смесь, пребиотик, пробиотик, синбиотик.
________________________________________________
Methods. The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, was tested in 280 infants during 3 months.
Results. The median age at inclusion was 0.89 months. Weight evolution was in accordance with the WHO growth charts for exclusive breastfed infants. The evolution of all antropometric parameters was within normal range. The incidence of constipation, regurgitation, infantile crying and colic was lower than the reported incidence in literature for a similar age.
Conclusion. The new synbiotic infant formula was safe and well tolerated. Functional gastro-intestinal manifestations were lower than reported in literature.
Key words: functional disorder, growth, infant formula, prebiotic, probiotic, synbiotic.
Полный текст
Список литературы
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2. Garcia C, Duan RD, Brévaut-Malaty V et al. Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 2013; 59: 108–31.
3. Jost T, Lacroix C, Braegger C, Chassard C. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutr Rev 2015; 73: 426–37.
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6. Bäckhed F, Roswall J, Peng Y et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 690–703.
7. Reisinger KW, de Vaan L, Kramer BW et al. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr 2014; 59: 720–4.
8. Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015; 113: 1339–44.
9. Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr 2013; 13: 185.
10. Steenhout PG, Rochat F, Hager C. The effect of Bifido lactis on the growth of infants: a pooled analysis of randomized controlled trials. Ann Nutr Metab 2009; 55: 334–40.
11. Braegger C, Chmielewska A, Decsi T et al; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011; 52: 238–50.
12. Huet F, Abrahamse-Berkeveld M, Tims S et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016; 63: e43–53.
13. Weaver LT, Ewing G, Taylor LC. The bowel habit of milk-fed infants. J Pediatr Gastroenterol Nutr 1988; 7: 568–71.
14. Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto- and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013; 57: 180–7.
15. Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014; 5: 681–7.
16. Holscher HD, Czerkies LA, Cekola P et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 2012; 36 (1 Suppl): 106S–17S.
17. Indrio F, Di Mauro A, Riezzo G et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 2014; 168: 228–33.
18. Vandenplas Y, Abkari A, Bellaiche M et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61: 531–7.
19. Savino F, Maccario S, Castagno E et al. Advances in the management of digestive problems during the first months of life. Acta Paediatr (Suppl.) 2005; 94: 120–4.
20. Ben XM, Li J, Feng ZT et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008; 14: 6564–8.
21. Veereman-Wauters G, Staelens S, Van de Broek H et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 2011; 52: 763–71.
22. Scholtens PA, Alliet P, Raes M et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. J Nutr 2008; 138: 1141–7.
23. Iacono G, Merolla R, D'Amico D et al; Paediatric Study Group on Gastrointestinal Symptoms in Infancy. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005; 37: 432–8.
24. Giovannini M, Verduci E, Gregori D et al; PLAGOS Trial Study Group. Prebiotic effect of an infant formula supplemented with galacto-oligosaccharides: randomized multicenter trial. J Am Coll Nutr 2014; 33: 385–93.
25. Savino F, Palumeri E, Castagno E, Cresi F et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006; 60: 1304–10.
26. Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010; 11: 351–61.
2. Garcia C, Duan RD, Brévaut-Malaty V et al. Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 2013; 59: 108–31.
3. Jost T, Lacroix C, Braegger C, Chassard C. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutr Rev 2015; 73: 426–37.
4. Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol 2014; 25: 428–3.
5. Kapiki A, Costalos C, Oikonomidou C et al. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 2007; 83: 335–9.
6. Bäckhed F, Roswall J, Peng Y et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 690–703.
7. Reisinger KW, de Vaan L, Kramer BW et al. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr 2014; 59: 720–4.
8. Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015; 113: 1339–44.
9. Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr 2013; 13: 185.
10. Steenhout PG, Rochat F, Hager C. The effect of Bifido lactis on the growth of infants: a pooled analysis of randomized controlled trials. Ann Nutr Metab 2009; 55: 334–40.
11. Braegger C, Chmielewska A, Decsi T et al; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011; 52: 238–50.
12. Huet F, Abrahamse-Berkeveld M, Tims S et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016; 63: e43–53.
13. Weaver LT, Ewing G, Taylor LC. The bowel habit of milk-fed infants. J Pediatr Gastroenterol Nutr 1988; 7: 568–71.
14. Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto- and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013; 57: 180–7.
15. Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014; 5: 681–7.
16. Holscher HD, Czerkies LA, Cekola P et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 2012; 36 (1 Suppl): 106S–17S.
17. Indrio F, Di Mauro A, Riezzo G et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 2014; 168: 228–33.
18. Vandenplas Y, Abkari A, Bellaiche M et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61: 531–7.
19. Savino F, Maccario S, Castagno E et al. Advances in the management of digestive problems during the first months of life. Acta Paediatr (Suppl.) 2005; 94: 120–4.
20. Ben XM, Li J, Feng ZT et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008; 14: 6564–8.
21. Veereman-Wauters G, Staelens S, Van de Broek H et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 2011; 52: 763–71.
22. Scholtens PA, Alliet P, Raes M et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. J Nutr 2008; 138: 1141–7.
23. Iacono G, Merolla R, D'Amico D et al; Paediatric Study Group on Gastrointestinal Symptoms in Infancy. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005; 37: 432–8.
24. Giovannini M, Verduci E, Gregori D et al; PLAGOS Trial Study Group. Prebiotic effect of an infant formula supplemented with galacto-oligosaccharides: randomized multicenter trial. J Am Coll Nutr 2014; 33: 385–93.
25. Savino F, Palumeri E, Castagno E, Cresi F et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006; 60: 1304–10.
26. Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010; 11: 351–61.
2. Garcia C, Duan RD, Brévaut-Malaty V et al. Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 2013; 59: 108–31.
3. Jost T, Lacroix C, Braegger C, Chassard C. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutr Rev 2015; 73: 426–37.
4. Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol 2014; 25: 428–3.
5. Kapiki A, Costalos C, Oikonomidou C et al. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 2007; 83: 335–9.
6. Bäckhed F, Roswall J, Peng Y et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 690–703.
7. Reisinger KW, de Vaan L, Kramer BW et al. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr 2014; 59: 720–4.
8. Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015; 113: 1339–44.
9. Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr 2013; 13: 185.
10. Steenhout PG, Rochat F, Hager C. The effect of Bifido lactis on the growth of infants: a pooled analysis of randomized controlled trials. Ann Nutr Metab 2009; 55: 334–40.
11. Braegger C, Chmielewska A, Decsi T et al; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011; 52: 238–50.
12. Huet F, Abrahamse-Berkeveld M, Tims S et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016; 63: e43–53.
13. Weaver LT, Ewing G, Taylor LC. The bowel habit of milk-fed infants. J Pediatr Gastroenterol Nutr 1988; 7: 568–71.
14. Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto- and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013; 57: 180–7.
15. Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014; 5: 681–7.
16. Holscher HD, Czerkies LA, Cekola P et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 2012; 36 (1 Suppl): 106S–17S.
17. Indrio F, Di Mauro A, Riezzo G et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 2014; 168: 228–33.
18. Vandenplas Y, Abkari A, Bellaiche M et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61: 531–7.
19. Savino F, Maccario S, Castagno E et al. Advances in the management of digestive problems during the first months of life. Acta Paediatr (Suppl.) 2005; 94: 120–4.
20. Ben XM, Li J, Feng ZT et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008; 14: 6564–8.
21. Veereman-Wauters G, Staelens S, Van de Broek H et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 2011; 52: 763–71.
22. Scholtens PA, Alliet P, Raes M et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. J Nutr 2008; 138: 1141–7.
23. Iacono G, Merolla R, D'Amico D et al; Paediatric Study Group on Gastrointestinal Symptoms in Infancy. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005; 37: 432–8.
24. Giovannini M, Verduci E, Gregori D et al; PLAGOS Trial Study Group. Prebiotic effect of an infant formula supplemented with galacto-oligosaccharides: randomized multicenter trial. J Am Coll Nutr 2014; 33: 385–93.
25. Savino F, Palumeri E, Castagno E, Cresi F et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006; 60: 1304–10.
26. Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010; 11: 351–61.
________________________________________________
2. Garcia C, Duan RD, Brévaut-Malaty V et al. Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 2013; 59: 108–31.
3. Jost T, Lacroix C, Braegger C, Chassard C. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutr Rev 2015; 73: 426–37.
4. Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol 2014; 25: 428–3.
5. Kapiki A, Costalos C, Oikonomidou C et al. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 2007; 83: 335–9.
6. Bäckhed F, Roswall J, Peng Y et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 690–703.
7. Reisinger KW, de Vaan L, Kramer BW et al. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr 2014; 59: 720–4.
8. Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015; 113: 1339–44.
9. Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr 2013; 13: 185.
10. Steenhout PG, Rochat F, Hager C. The effect of Bifido lactis on the growth of infants: a pooled analysis of randomized controlled trials. Ann Nutr Metab 2009; 55: 334–40.
11. Braegger C, Chmielewska A, Decsi T et al; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011; 52: 238–50.
12. Huet F, Abrahamse-Berkeveld M, Tims S et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016; 63: e43–53.
13. Weaver LT, Ewing G, Taylor LC. The bowel habit of milk-fed infants. J Pediatr Gastroenterol Nutr 1988; 7: 568–71.
14. Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto- and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013; 57: 180–7.
15. Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014; 5: 681–7.
16. Holscher HD, Czerkies LA, Cekola P et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 2012; 36 (1 Suppl): 106S–17S.
17. Indrio F, Di Mauro A, Riezzo G et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 2014; 168: 228–33.
18. Vandenplas Y, Abkari A, Bellaiche M et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61: 531–7.
19. Savino F, Maccario S, Castagno E et al. Advances in the management of digestive problems during the first months of life. Acta Paediatr (Suppl.) 2005; 94: 120–4.
20. Ben XM, Li J, Feng ZT et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008; 14: 6564–8.
21. Veereman-Wauters G, Staelens S, Van de Broek H et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 2011; 52: 763–71.
22. Scholtens PA, Alliet P, Raes M et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. J Nutr 2008; 138: 1141–7.
23. Iacono G, Merolla R, D'Amico D et al; Paediatric Study Group on Gastrointestinal Symptoms in Infancy. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005; 37: 432–8.
24. Giovannini M, Verduci E, Gregori D et al; PLAGOS Trial Study Group. Prebiotic effect of an infant formula supplemented with galacto-oligosaccharides: randomized multicenter trial. J Am Coll Nutr 2014; 33: 385–93.
25. Savino F, Palumeri E, Castagno E, Cresi F et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006; 60: 1304–10.
26. Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010; 11: 351–61.
Авторы
И.Ванденплас*1, А.Аналитис2, С.Циувара3, А.Кунтцуглу3, А.Драку3, С.Цувалас3, А.Мавруди3, И.Зиниас3
1 Университетская клиника Брюсселя, Свободный университет Брюсселя, Брюссель, Бельгия;
2 Афинский национальный университет, Греция;
3 Больница Гиппократион, Фессалоники, Греция
*Yvan.Vandenplas@uzbrussel.be
1 Departement of Paediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium;
2 National and Kapodistrian University of Athens, Greece;
3 Hippocration Hospital, Thessaloniki, Greece
*Yvan.Vandenplas@uzbrussel.be
1 Университетская клиника Брюсселя, Свободный университет Брюсселя, Брюссель, Бельгия;
2 Афинский национальный университет, Греция;
3 Больница Гиппократион, Фессалоники, Греция
*Yvan.Vandenplas@uzbrussel.be
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1 Departement of Paediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium;
2 National and Kapodistrian University of Athens, Greece;
3 Hippocration Hospital, Thessaloniki, Greece
*Yvan.Vandenplas@uzbrussel.be
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