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Влияние оперативного лечения варикоцеле у подростков на состояние гематотестикулярного барьера
Влияние оперативного лечения варикоцеле у подростков на состояние гематотестикулярного барьера
Яцык С.П., Тарзян А.О., Семикина Е.Л. и др. Влияние оперативного лечения варикоцеле у подростков на состояние гематотестикулярного барьера. Педиатрия (Прил. к журн. Consilium Medicum). 2017; 2: 66–68.
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Аннотация
В исследовании представлены сведения о влиянии оперативного лечения варикоцеле у мальчиков от 11 до 17 лет на состояние гематотестикулярного барьера (ГТБ). Определялись критерии нарушения ГТБ до и после оперативной коррекции данной патологии. На основании исследований, проведенных после оперативного лечения варикоцеле, нами установлена положительная динамика в показателях состоятельности ГТБ (отсутствие повышения концентрации белка клаудин-11 и антиспермальных антител, увеличение уровня ингибина В).
Ключевые слова: варикоцеле, ингибин В, клаудин-11, гематотестикулярный барьер, антиспермальные антитела, мужское бесплодие.
Key words: varicocele, inhibin B, claudin 11, blood-testis barrier, antisperm antibodies, male infertility.
Ключевые слова: варикоцеле, ингибин В, клаудин-11, гематотестикулярный барьер, антиспермальные антитела, мужское бесплодие.
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Key words: varicocele, inhibin B, claudin 11, blood-testis barrier, antisperm antibodies, male infertility.
Полный текст
Список литературы
1. Каневская Т.А., Яцык С.П., Безлепкина О.Б. Гормональный статус и маркеры аутоиммунного нарушения сперматогенеза у подростков, перенесших хирургическое лечение по поводу варикоцеле. Педиатр. фармакология. 2010; 7 (4). / Kanevskaia T.A., Iatsyk S.P., Bezlepkina O.B. Gormonal'nyi status i markery autoimmunnogo narusheniia spermatogeneza u podrostkov, perenesshikh khirurgicheskoe lechenie po povodu varikotsele. Pediatr. farmakologiia. 2010; 7 (4). [in Russian]
2. Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64: 16–64.
3. Dohle GR et al. European Association of Urology. Guidelines on Male Infertility. European Association of Urology, 2010.
4. Fink C et al. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 2009; 131 (6): 755–64.
5. Nah WH et al. Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 2011; 95 (1): 385–8.
6. Haverfield JT et al. Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls. Fertil Steril 2013; 100 (3): 658–66.
7. Manzoor SM et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012; 24 (3-4): 113–6.
8. Chen Q et al. Laparoscopic Varicocelectomy with Single Incision in Children. Urol J 2015; 12 (6): 2400–3.
9. Akbay E et al.The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000; 86 (4): 490–3.
10. ASRM PAGES. Report on varicocele and infertility: a comitee opinion. Fertil Steril 2014; 102 (6): 1556–60.
2. Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64: 16–64.
3. Dohle GR et al. European Association of Urology. Guidelines on Male Infertility. European Association of Urology, 2010.
4. Fink C et al. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 2009; 131 (6): 755–64.
5. Nah WH et al. Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 2011; 95 (1): 385–8.
6. Haverfield JT et al. Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls. Fertil Steril 2013; 100 (3): 658–66.
7. Manzoor SM et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012; 24 (3-4): 113–6.
8. Chen Q et al. Laparoscopic Varicocelectomy with Single Incision in Children. Urol J 2015; 12 (6): 2400–3.
9. Akbay E et al.The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000; 86 (4): 490–3.
10. ASRM PAGES. Report on varicocele and infertility: a comitee opinion. Fertil Steril 2014; 102 (6): 1556–60.
2. Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64: 16–64.
3. Dohle GR et al. European Association of Urology. Guidelines on Male Infertility. European Association of Urology, 2010.
4. Fink C et al. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 2009; 131 (6): 755–64.
5. Nah WH et al. Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 2011; 95 (1): 385–8.
6. Haverfield JT et al. Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls. Fertil Steril 2013; 100 (3): 658–66.
7. Manzoor SM et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012; 24 (3-4): 113–6.
8. Chen Q et al. Laparoscopic Varicocelectomy with Single Incision in Children. Urol J 2015; 12 (6): 2400–3.
9. Akbay E et al.The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000; 86 (4): 490–3.
10. ASRM PAGES. Report on varicocele and infertility: a comitee opinion. Fertil Steril 2014; 102 (6): 1556–60.
________________________________________________
2. Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64: 16–64.
3. Dohle GR et al. European Association of Urology. Guidelines on Male Infertility. European Association of Urology, 2010.
4. Fink C et al. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 2009; 131 (6): 755–64.
5. Nah WH et al. Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 2011; 95 (1): 385–8.
6. Haverfield JT et al. Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls. Fertil Steril 2013; 100 (3): 658–66.
7. Manzoor SM et al. Serum inhibin B as a diagnostic marker of male infertility. J Ayub Med Coll Abbottabad 2012; 24 (3-4): 113–6.
8. Chen Q et al. Laparoscopic Varicocelectomy with Single Incision in Children. Urol J 2015; 12 (6): 2400–3.
9. Akbay E et al.The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000; 86 (4): 490–3.
10. ASRM PAGES. Report on varicocele and infertility: a comitee opinion. Fertil Steril 2014; 102 (6): 1556–60.
Авторы
С.П.Яцык, А.О.Тарзян*, Е.Л.Семикина, Э.К.Жамынчиев, А.А.Русаков, К.С.Абрамов, И.В.Зубкова
ФГАУ «Национальный научно-практический центр здоровья детей» Минздрава России. 119991, Россия, Москва, Ломоносовский пр-т, д. 2, стр. 1
*tarzianmd@mail.ru
National Scientific and Practical Center of Children's Health of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, Lomonosovskii pr-t, d. 2, str. 1
*tarzianmd@mail.ru
ФГАУ «Национальный научно-практический центр здоровья детей» Минздрава России. 119991, Россия, Москва, Ломоносовский пр-т, д. 2, стр. 1
*tarzianmd@mail.ru
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National Scientific and Practical Center of Children's Health of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, Lomonosovskii pr-t, d. 2, str. 1
*tarzianmd@mail.ru
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