Целиакия до настоящего времени остается не до конца изученным заболеванием. Хотя к настоящему времени многое известно о причинах его развития, определены его четкие критерии, остаются дискуссионными методы защиты детей из группы риска от развития заболевания и ряд других моментов. Рекомендации по диагностике и ведению целиакии постоянно обновляются. В статье приводятся последние взгляды на диагностику этого заболевания. Также напоминается о необходимости пожизненного соблюдения безглютеновой диеты.
Ключевые слова: целиакия, дети, глютен.
________________________________________________
Celiac disease is still not fully understood as a disease. Although much is known about the causes of the disease, there are clear criteria for the disease, the methods of protecting children at risk from development of the disease and a number of other issues remain controversial. Recommendations for diagnosis and management of celiac disease are constantly updated. The article gives the latest views on the diagnosis of this disease. Also recalled the need for a lifelong compliance gluten-free diet.
1. Dicke WK, Weijers HA, Van De Kamer JH. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr 1953; 42 (1): 34–42.
2. Husby S, Koletzko S, Korponay-Szabo IR et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54 (1): 136–60.
3. Ivarsson A, Persson LA, Nystrom L et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000; 89 (2): 165–71.
4. Vriezinga SL, Auricchio R, Bravi E et al. Randomized Feeding Intervention in Infants at High Risk for Celiac Disease. New Engl J Med 2014; 371 (14): 1304–15.
5. Lionetti E, Castellaneta S, Francavilla R et al. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014; 371 (14): 1295–303.
6. Szajewska H, Shamir R, Chmielewska A et al. Systematic review with meta-analysis: early infant feeding and coeliac disease – update 2015. Alimentary Pharmacology & Therapeutics 2015; 41 (11): 1038–54.
7. Szajewska H, Shamir R, Mearin L et al. Gluten Introduction and the Risk of Coeliac Disease: A Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2016; 62 (3): 507–13.
8. Plot L, Amital H. Infectious associations of Celiac disease. Autoimmun Rev 2009; 8 (4): 316–9.
9. Myleus A, Hernell O, Gothefors L et al. Early infections are associated with increa- sed risk for celiac disease: an incident case-referent study. BMC Pediatr 2012; 12: 194.
10. Bouziat R, Hinterleitner R, Brown JJ et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 2017; 356 (6333): 44–50.
11. Abadie V, Sollid LM, Barreiro LB, Jabri B. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 2011; 29: 493–525.
12. Verdu EF, Caminero A. How infection can incite sensitivity to food. Science 2017; 356 (6333): 29–30.
13. Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970; 59: 461–3.
14. Lerner A, Jeremias P, Matthias T. Gut-thyroid axis and celiac disease. Endocr Con- 2017; 6 (4): R52–R58.
________________________________________________
1. Dicke WK, Weijers HA, Van De Kamer JH. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr 1953; 42 (1): 34–42.
2. Husby S, Koletzko S, Korponay-Szabo IR et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54 (1): 136–60.
3. Ivarsson A, Persson LA, Nystrom L et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000; 89 (2): 165–71.
4. Vriezinga SL, Auricchio R, Bravi E et al. Randomized Feeding Intervention in Infants at High Risk for Celiac Disease. New Engl J Med 2014; 371 (14): 1304–15.
5. Lionetti E, Castellaneta S, Francavilla R et al. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014; 371 (14): 1295–303.
6. Szajewska H, Shamir R, Chmielewska A et al. Systematic review with meta-analysis: early infant feeding and coeliac disease – update 2015. Alimentary Pharmacology & Therapeutics 2015; 41 (11): 1038–54.
7. Szajewska H, Shamir R, Mearin L et al. Gluten Introduction and the Risk of Coeliac Disease: A Position Paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2016; 62 (3): 507–13.
8. Plot L, Amital H. Infectious associations of Celiac disease. Autoimmun Rev 2009; 8 (4): 316–9.
9. Myleus A, Hernell O, Gothefors L et al. Early infections are associated with increa- sed risk for celiac disease: an incident case-referent study. BMC Pediatr 2012; 12: 194.
10. Bouziat R, Hinterleitner R, Brown JJ et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 2017; 356 (6333): 44–50.
11. Abadie V, Sollid LM, Barreiro LB, Jabri B. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 2011; 29: 493–525.
12. Verdu EF, Caminero A. How infection can incite sensitivity to food. Science 2017; 356 (6333): 29–30.
13. Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970; 59: 461–3.
14. Lerner A, Jeremias P, Matthias T. Gut-thyroid axis and celiac disease. Endocr Con- 2017; 6 (4): R52–R58.
Авторы
Хорхе Амил Диас
Отделение детской гастроэнтерологии и педиатрии Госпиталя S.Joao г. Порто, Португалия
________________________________________________
Jorge Amil Dias
Centro Hospitalar de São João, Serviço de Pediatria, Unidade de Gastroenterologia Pediátrica, Porto, Portugal