Современные тенденции и проблемы безопасности применения деконгестантов в детском возрасте.
Современные тенденции и проблемы безопасности применения деконгестантов в детском возрасте.
Карнеева О.В., Гаращенко Т.И., Карпова Е.П., Рязанцев С.В., Никифорова Г.Н., Геппе Н.А., Горелов А.В., Малахов А.Б., Кондюрина Е.Г., Бакрадзе М.Д., Колосова Н.Г. Современные тенденции и проблемы безопасности применения деконгестантов в детском возрасте. Резолюция совета экспертов. Педиатрия (Прил. к журн. Consilium Medicum). 2018; 1: 32–35. DOI: 10.26442/2413-8460_2018.1.32-35
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Аннотация
27 октября 2017 г. состоялось рабочее совещание экспертов «Современные тенденции и проблемы безопасности применения деконгестантов в детском возрасте» при участии ведущих специалистов МОО «Педиатрическое респираторное общество» и Национальной медицинской ассоциации оториноларингологов России, объединившее ведущих российских экспертов в области педиатрии, оториноларингологии, пульмонологии и инфекционных болезней. Предлагаем вашему вниманию согласованное мнение экспертов.
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Список литературы
1. Геппе Н.А., Дронов И.А., Баяндина Г.Н. Терапевтическая тактика при острых респираторных инфекциях у детей. Доктор. Ру. 2017; 4 (133). / Geppe N.A., Dronov I.A., Baiandina G.N. Terapevticheskaia taktika pri ostrykh respiratornykh infektsiiakh u detei. Doktor. Ru. 2017; 4 (133). [in Russian]
2. Комплексный подход к лечению и профилактике острых респираторных инфекций у детей. Практическое руководство для врачей. Под ред. Н.А.Геппе, А.Б.Малахова. М., 2012. / Kompleksnyi podkhod k lecheniiu i profilaktike ostrykh respiratornykh infektsii u detei. Prakticheskoe rukovodstvo dlia vrachei. Pod red. N.A.Geppe, A.B.Malakhova. M., 2012. [in Russian]
3. Рязанцев С.В., Карнеева О.В., Гаращенко Т.И. и др. Острый синусит. Клинические рекомендации. 2016. http://www.nmaoru.org/files/KR313%20Ostryj%20sinusit.pdf [in Russian]
4. Приказ Министерства здравоохранения Российской Федерации от 20 декабря 2012 г. №1201н «Об утверждении стандарта первичной медико-санитарной помощи при остром синусите». / Prikaz Ministerstva zdravookhraneniia Rossiiskoi Federatsii ot 20 dekabria 2012 g. №1201n “Ob utverzhdenii standarta pervichnoi mediko-sanitarnoi pomoshchi pri ostrom sinusite”. [in Russian]
5. Козлов В.С., Шиленкова В.В., Азатян А.С., Крамной А.И. Мукоцилиарный транспорт и двигательная активность цилиарного аппарата слизистой оболочки носа у больных хроническим полипозным риносинуситом. Вестн. оториноларингологии. 2008; 2: 10–3. / Kozlov V.S., Shilenkova V.V., Azatian A.S., Kramnoi A.I. Mukotsiliarnyi transport i dvigatel'naia aktivnost' tsiliarnogo apparata slizistoi obolochki nosa u bol'nykh khronicheskim polipoznym rinosinusitom. Vestn. otorinolaringologii. 2008; 2: 10–3. [in Russian]
6. Заплатников А.Л. Топические деконгестанты в педиатрической практике: безопасность и клиническая эффективность. Педиатрия. Журн. им. Г.Н.Сперанского. 2006; 6: 69–75. / Zaplatnikov A.L. Topicheskie dekongestanty v pediatricheskoi praktike: bezopasnost' i klinicheskaia effektivnost'. Pediatriia. Zhurn. im. G.N.Speranskogo. 2006; 6: 69–75. [in Russian]
7. Рачинский С.В., Таточенко В.К. Болезни органов дыхания у детей. М.: Медицина, 1987. / Rachinskii S.V., Tatochenko V.K. Bolezni organov dykhaniia u detei. M.: Meditsina, 1987. [in Russian]
8. Карпова Е.П., Тулупов Д.А. Сосудосуживающие препараты в педиатрической практике. Эффективная фармакотерапия. Педиатрия. 2012; 1: 18–24. / Karpova E.P., Tulupov D.A. Sosudosuzhivaiushchie preparaty v pediatricheskoi praktike. Effektivnaia farmakoterapiia. Pediatriia. 2012; 1: 18–24. [in Russian]
9. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8. https://doi.org/10.1055/s-2007-966891
10. Morris SE. New Visions. Issues in anatomy and physiology of swallowing: Impact on the assessment and treatment of children with dysphagia. 2016.
11. Taverner D, Latte GJ. WITHDRAWN: Nasal decongestants for the common cold. Cochrane Database Syst Rev 2009; 15 (2): CD001953. https://doi.org/10.1002/14651858.cd001953.pub4
12. Reinecke S, Tschaikin M. Investigation of the Effect of Oxymetazoline on the Duration of Rhinitis. Results of a placebo-controlled double-blind study in patients with acute rhinitis. MMW Fortschr Med 2005; 147 (Suppl. 3): 113–8.
13. Semmelmayer U. Testung von Nasivin 0,01%. (Clinical trial of Nasivin 0.01%). Merck KGaA, Darmstadt, 1972; EMD 6529.
14. Boek WM, Graamans K, Natzijl H et al. Nasal mucociliary transport: new evidence for key role of ciliary beat frequency. Laryngoscope 2002; 112 (3): 570–3. https://doi.org/10.1097/00005537-200203000-00029
15. Wenzel S, Sagowski C, Laux G. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83. https://doi.org/10.1016/j.ijporl.2004.02.011
16. The Airway Jedi. 2016. Intubating the Infant or Toddler. [cited: 24.05.0217] available from: https://airwayjedi.com/2016/04/18/intubating-the-infant-or-toddler/#more-1087
17. Chirico G et al. Nasal congestion in infants and children: A literature review on efficacy and safety of non-pharmacological treatments. Minerva Pediatr 2014. 66: 549–57.
18. Svenningsen N. En klinisk prövning av näsdroppar för spädbarn. (Clinical trials of nose drops for infants). Draco por Medico 1968; 9: 6–8. EMEMD 6529
19. Koelsch K et al. Anti-Rhinovirus-specific Activity of the Alpha-sympathomimetic Oxymetazoline. Arzneimittel Forschung (Drug Research) 2007; 57: 475–82.<br>
20. Martindale. The complete drug reference. Oxymetazoline Hydrochloride. Editor: Thomson Reuters (online database). 2010.
21. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro. Rhinology 1993; 31: 151–3.
22. Bergner A, Tschaikin M. Treating rhinitis in babies and toddlers. Translation Deutsche Apotheker Zeitung 2005;145:97-99 (English translation).
23. Wegener T, Grebe W. Efficacy, tolerability, and ease of application of nasal sprays with alpha-sympathomimetics. J Pharmakol Ther 2012; 3: 75–80.
24. European Position Paper on Rhinosinusitis and Nasal Polyps, 2012.
25. U.S. Food and Drug Administration, Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations, https://www.accessdata.fda.gov/scripts/Cder/ob/; orangebook@fda.hhs.gov
26. Beck-Speier I, Dayal N, Karg E еt al. Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites. J Pharmacol Exp Ther 2006; 316 (2): 843–51.
27. Cannon NL, Dalgleisch J, Frank H et al. Evaluation of oxymetazoline pediatric in the treatment of nasal congestion. J Matern Child Health 1976; 1: 32–33.11.
28. Ruggeberg F. Clinical trials of oxymetazoline hydrochloride nasal drops for babies (NasivinTM 0,01%). Z Allg Med 1974; 11: 535–7.
29. Schmidtke M. Besitzen oxymetazoline-haltige nasen-sprays eine antivirale wirkung gegenuber inflenraviren. J Chemother 2005; 14: 207–11.
30. Von Reinecke S, Tschaikin M. Untersuchung der Wirksamkeit von Oxymetazolin auf die Rhinitisdauer, MMWFortschritte der Medizin Orginalien 2005; 147: 113–8.
31. Hochban W et al. Nasal decongestion with imidazoline derivatives: acoustic rhinomanometry measurements. Eur J Сlin Pharmacol 1999; 55: 7–12.
32. Dorn M, Hofmann W, Knick E. Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis. HNO 2003; 10: 794–9.
33. Klemens C, Rasp G, Jund F et al. Mediators and cytokines in allergic and viraltriggered rhinitis. Allergy and asthma proceedings: the official journal of regional and state allergy societies. 2007; 28 (4): 434–41.
34. Ellegard EK. The etiology and management of pregnancy rhinitis. Am J Respir Med 2003; 2 (6): 469–75.
35. Sorri M, Hartikainen-Sorri AL, Karja J. Rhinitis during pregnancy. Rhinology 1980; 18 (2): 83–6.
36. Simola M, Malmberg H. Sensation of nasal airflow compared with nasal airway resistance in patients with rhinitis. Clin Otolaryngol 1997; 22 (3): 260–2.
37. Nathan RA, Eccles R, Howar th PH et al. Objective monitoring of nasal patency and nasal physiology in rhinitis. J Allergy Clin Immunol 2005; 15 (3 Suppl. 1): S442–9.<br>
nol 2005; 15 (3 Suppl. 1): S442–9.
38. Smart BA. The impact of allergic and nonallergic rhinitis on pediatric sinusitis. Curr Allergy Asthma Reports 2006; 6 (3): 221–7.
39. Лопатин А.С. Сосудосуживающие препараты: механизм действия, клиническое применение и побочные эффекты. Рос. ринология. 2007; 1: 43–9. / Lopatin A.S. Sosudosuzhivaiushchie preparaty: mekhanizm deistviia, klinicheskoe primenenie i pobochnye effekty. Ros. rinologiia. 2007; 1: 43–9. [in Russian]
40. Gwaltney JMJR et al. JAMA 1967; 202: 494–500.
41. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants in ciliary beat frequency in vitro. Rhinology. 1993 (31):
151–3.
2. Kompleksnyi podkhod k lecheniiu i profilaktike ostrykh respiratornykh infektsii u detei. Prakticheskoe rukovodstvo dlia vrachei. Pod red. N.A.Geppe, A.B.Malakhova. M., 2012. [in Russian]
3. Riazantsev S.V., Karneeva O.V., Garashchenko T.I. i dr. Ostryi sinusit. Klinicheskie rekomendatsii. 2016. http://www.nmaoru.org/files/KR313%20Ostryj%20sinusit.pdf [in Russian]
4. Prikaz Ministerstva zdravookhraneniia Rossiiskoi Federatsii ot 20 dekabria 2012 g. №1201n “Ob utverzhdenii standarta pervichnoi mediko-sanitarnoi pomoshchi pri ostrom sinusite”. [in Russian]
5. Kozlov V.S., Shilenkova V.V., Azatian A.S., Kramnoi A.I. Mukotsiliarnyi transport i dvigatel'naia aktivnost' tsiliarnogo apparata slizistoi obolochki nosa u bol'nykh khronicheskim polipoznym rinosinusitom. Vestn. otorinolaringologii. 2008; 2: 10–3. [in Russian]
6. Zaplatnikov A.L. Topicheskie dekongestanty v pediatricheskoi praktike: bezopasnost' i klinicheskaia effektivnost'. Pediatriia. Zhurn. im. G.N.Speranskogo. 2006; 6: 69–75. [in Russian]
7. Rachinskii S.V., Tatochenko V.K. Bolezni organov dykhaniia u detei. M.: Meditsina, 1987. [in Russian]
8.Karpova E.P., Tulupov D.A. Sosudosuzhivaiushchie preparaty v pediatricheskoi praktike. Effektivnaia farmakoterapiia. Pediatriia. 2012; 1: 18–24. [in Russian]
9. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8. https://doi.org/10.1055/s-2007-966891
10. Morris SE. New Visions. Issues in anatomy and physiology of swallowing: Impact on the assessment and treatment of children with dysphagia. 2016.
11. Taverner D, Latte GJ. WITHDRAWN: Nasal decongestants for the common cold. Cochrane Database Syst Rev 2009; 15 (2): CD001953. https://doi.org/10.1002/14651858.cd001953.pub4
12. Reinecke S, Tschaikin M. Investigation of the Effect of Oxymetazoline on the Duration of Rhinitis. Results of a placebo-controlled double-blind study in patients with acute rhinitis. MMW Fortschr Med 2005; 147 (Suppl. 3): 113–8.
13. Semmelmayer U. Testung von Nasivin 0,01%. (Clinical trial of Nasivin 0.01%). Merck KGaA, Darmstadt, 1972; EMD 6529.
14. Boek WM, Graamans K, Natzijl H et al. Nasal mucociliary transport: new evidence for key role of ciliary beat frequency. Laryngoscope 2002; 112 (3): 570–3. https://doi.org/10.1097/00005537-200203000-00029
15. Wenzel S, Sagowski C, Laux G. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83. https://doi.org/10.1016/j.ijporl.2004.02.011
16. The Airway Jedi. 2016. Intubating the Infant or Toddler. [cited: 24.05.0217] available from: https://airwayjedi.com/2016/04/18/intubating-the-infant-or-toddler/#more-1087
17. Chirico G et al. Nasal congestion in infants and children: A literature review on efficacy and safety of non-pharmacological treatments. Minerva Pediatr 2014. 66: 549–57.
18. Svenningsen N. En klinisk prövning av näsdroppar för spädbarn. (Clinical trials of nose drops for infants). Draco por Medico 1968; 9: 6–8. EMEMD 6529
19. Koelsch K et al. Anti-Rhinovirus-specific Activity of the Alpha-sympathomimetic Oxymetazoline. Arzneimittel Forschung (Drug Research) 2007; 57: 475–82.
20. Martindale. The complete drug reference. Oxymetazoline Hydrochloride. Editor: Thomson Reuters (online database). 2010.
21. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro. Rhinology 1993; 31: 151–3.
22. Bergner A, Tschaikin M. Treating rhinitis in babies and toddlers. Translation Deutsche Apotheker Zeitung 2005;145:97-99 (English translation).
23. Wegener T, Grebe W. Efficacy, tolerability, and ease of application of nasal sprays with alpha-sympathomimetics. J Pharmakol Ther 2012; 3: 75–80.
24. European Position Paper on Rhinosinusitis and Nasal Polyps, 2012.
25. U.S. Food and Drug Administration, Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations, https://www.accessdata.fda.gov/scripts/Cder/ob/, orangebook@fda.hhs.gov
26. Beck-Speier I, Dayal N, Karg E еt al. Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites. J Pharmacol Exp Ther 2006; 316 (2): 843–51.
27. Cannon NL, Dalgleisch J, Frank H et al. Evaluation of oxymetazoline pediatric in the treatment of nasal congestion. J Matern Child Health 1976; 1: 32–33.11.;
28. Ruggeberg F. Clinical trials of oxymetazoline hydrochloride nasal drops for babies (NasivinTM 0,01%). Z Allg Med 1974; 11: 535–7.
29. Schmidtke M. Besitzen oxymetazoline-haltige nasen-sprays eine antivirale wirkung gegenuber inflenraviren. J Chemother 2005; 14: 207–11.
30. Von Reinecke S, Tschaikin M. Untersuchung der Wirksamkeit von Oxymetazolin auf die Rhinitisdauer, MMWFortschritte der Medizin Orginalien 2005; 147: 113–8.
31. Hochban W et al. Nasal decongestion with imidazoline derivatives: acoustic rhinomanometry measurements. Eur J Сlin Pharmacol 1999; 55: 7–12.
32. Dorn M, Hofmann W, Knick E. Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis. HNO 2003; 10: 794–9.
33. Klemens C, Rasp G, Jund F et al. Mediators and cytokines in allergic and viraltriggered rhinitis. Allergy and asthma proceedings: the official journal of regional and state allergy societies. 2007; 28 (4): 434–41.
34. Ellegard EK. The etiology and management of pregnancy rhinitis. Am J Respir Med 2003; 2 (6): 469–75.
35. Sorri M, Hartikainen-Sorri AL, Karja J. Rhinitis during pregnancy. Rhinology 1980; 18 (2): 83–6.
36. Simola M, Malmberg H. Sensation of nasal airflow compared with nasal airway resistance in patients with rhinitis. Clin Otolaryngol 1997; 22 (3): 260–2.
37. Nathan RA, Eccles R, Howar th PH et al. Objective monitoring of nasal patency and nasal physiology in rhinitis. J Allergy Clin Immunol 2005; 15 (3 Suppl. 1): S442–9.
nol 2005; 15 (3 Suppl. 1): S442–9.
38. Smart BA. The impact of allergic and nonallergic rhinitis on pediatric sinusitis. Curr Allergy Asthma Reports 2006; 6 (3): 221–7.
39. Lopatin A.S. Sosudosuzhivaiushchie preparaty: mekhanizm deistviia, klinicheskoe primenenie i pobochnye effekty. Ros. rinologiia. 2007; 1: 43–9. [in Russian]
40. Gwaltney JMJR et al. JAMA 1967; 202: 494–500.
41. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants in ciliary beat frequency in vitro. Rhinology. 1993 (31):
151–3.
2. Комплексный подход к лечению и профилактике острых респираторных инфекций у детей. Практическое руководство для врачей. Под ред. Н.А.Геппе, А.Б.Малахова. М., 2012. / Kompleksnyi podkhod k lecheniiu i profilaktike ostrykh respiratornykh infektsii u detei. Prakticheskoe rukovodstvo dlia vrachei. Pod red. N.A.Geppe, A.B.Malakhova. M., 2012. [in Russian]
3. Рязанцев С.В., Карнеева О.В., Гаращенко Т.И. и др. Острый синусит. Клинические рекомендации. 2016. http://www.nmaoru.org/files/KR313%20Ostryj%20sinusit.pdf [in Russian]
4. Приказ Министерства здравоохранения Российской Федерации от 20 декабря 2012 г. №1201н «Об утверждении стандарта первичной медико-санитарной помощи при остром синусите». / Prikaz Ministerstva zdravookhraneniia Rossiiskoi Federatsii ot 20 dekabria 2012 g. №1201n “Ob utverzhdenii standarta pervichnoi mediko-sanitarnoi pomoshchi pri ostrom sinusite”. [in Russian]
5. Козлов В.С., Шиленкова В.В., Азатян А.С., Крамной А.И. Мукоцилиарный транспорт и двигательная активность цилиарного аппарата слизистой оболочки носа у больных хроническим полипозным риносинуситом. Вестн. оториноларингологии. 2008; 2: 10–3. / Kozlov V.S., Shilenkova V.V., Azatian A.S., Kramnoi A.I. Mukotsiliarnyi transport i dvigatel'naia aktivnost' tsiliarnogo apparata slizistoi obolochki nosa u bol'nykh khronicheskim polipoznym rinosinusitom. Vestn. otorinolaringologii. 2008; 2: 10–3. [in Russian]
6. Заплатников А.Л. Топические деконгестанты в педиатрической практике: безопасность и клиническая эффективность. Педиатрия. Журн. им. Г.Н.Сперанского. 2006; 6: 69–75. / Zaplatnikov A.L. Topicheskie dekongestanty v pediatricheskoi praktike: bezopasnost' i klinicheskaia effektivnost'. Pediatriia. Zhurn. im. G.N.Speranskogo. 2006; 6: 69–75. [in Russian]
7. Рачинский С.В., Таточенко В.К. Болезни органов дыхания у детей. М.: Медицина, 1987. / Rachinskii S.V., Tatochenko V.K. Bolezni organov dykhaniia u detei. M.: Meditsina, 1987. [in Russian]
8. Карпова Е.П., Тулупов Д.А. Сосудосуживающие препараты в педиатрической практике. Эффективная фармакотерапия. Педиатрия. 2012; 1: 18–24. / Karpova E.P., Tulupov D.A. Sosudosuzhivaiushchie preparaty v pediatricheskoi praktike. Effektivnaia farmakoterapiia. Pediatriia. 2012; 1: 18–24. [in Russian]
9. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8. https://doi.org/10.1055/s-2007-966891
10. Morris SE. New Visions. Issues in anatomy and physiology of swallowing: Impact on the assessment and treatment of children with dysphagia. 2016.
11. Taverner D, Latte GJ. WITHDRAWN: Nasal decongestants for the common cold. Cochrane Database Syst Rev 2009; 15 (2): CD001953. https://doi.org/10.1002/14651858.cd001953.pub4
12. Reinecke S, Tschaikin M. Investigation of the Effect of Oxymetazoline on the Duration of Rhinitis. Results of a placebo-controlled double-blind study in patients with acute rhinitis. MMW Fortschr Med 2005; 147 (Suppl. 3): 113–8.
13. Semmelmayer U. Testung von Nasivin 0,01%. (Clinical trial of Nasivin 0.01%). Merck KGaA, Darmstadt, 1972; EMD 6529.
14. Boek WM, Graamans K, Natzijl H et al. Nasal mucociliary transport: new evidence for key role of ciliary beat frequency. Laryngoscope 2002; 112 (3): 570–3. https://doi.org/10.1097/00005537-200203000-00029
15. Wenzel S, Sagowski C, Laux G. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 2004; 68 (7): 979–83. https://doi.org/10.1016/j.ijporl.2004.02.011
16. The Airway Jedi. 2016. Intubating the Infant or Toddler. [cited: 24.05.0217] available from: https://airwayjedi.com/2016/04/18/intubating-the-infant-or-toddler/#more-1087
17. Chirico G et al. Nasal congestion in infants and children: A literature review on efficacy and safety of non-pharmacological treatments. Minerva Pediatr 2014. 66: 549–57.
18. Svenningsen N. En klinisk prövning av näsdroppar för spädbarn. (Clinical trials of nose drops for infants). Draco por Medico 1968; 9: 6–8. EMEMD 6529
19. Koelsch K et al. Anti-Rhinovirus-specific Activity of the Alpha-sympathomimetic Oxymetazoline. Arzneimittel Forschung (Drug Research) 2007; 57: 475–82.<br>
20. Martindale. The complete drug reference. Oxymetazoline Hydrochloride. Editor: Thomson Reuters (online database). 2010.
21. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro. Rhinology 1993; 31: 151–3.
22. Bergner A, Tschaikin M. Treating rhinitis in babies and toddlers. Translation Deutsche Apotheker Zeitung 2005;145:97-99 (English translation).
23. Wegener T, Grebe W. Efficacy, tolerability, and ease of application of nasal sprays with alpha-sympathomimetics. J Pharmakol Ther 2012; 3: 75–80.
24. European Position Paper on Rhinosinusitis and Nasal Polyps, 2012.
25. U.S. Food and Drug Administration, Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations, https://www.accessdata.fda.gov/scripts/Cder/ob/; orangebook@fda.hhs.gov
26. Beck-Speier I, Dayal N, Karg E еt al. Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites. J Pharmacol Exp Ther 2006; 316 (2): 843–51.
27. Cannon NL, Dalgleisch J, Frank H et al. Evaluation of oxymetazoline pediatric in the treatment of nasal congestion. J Matern Child Health 1976; 1: 32–33.11.
28. Ruggeberg F. Clinical trials of oxymetazoline hydrochloride nasal drops for babies (NasivinTM 0,01%). Z Allg Med 1974; 11: 535–7.
29. Schmidtke M. Besitzen oxymetazoline-haltige nasen-sprays eine antivirale wirkung gegenuber inflenraviren. J Chemother 2005; 14: 207–11.
30. Von Reinecke S, Tschaikin M. Untersuchung der Wirksamkeit von Oxymetazolin auf die Rhinitisdauer, MMWFortschritte der Medizin Orginalien 2005; 147: 113–8.
31. Hochban W et al. Nasal decongestion with imidazoline derivatives: acoustic rhinomanometry measurements. Eur J Сlin Pharmacol 1999; 55: 7–12.
32. Dorn M, Hofmann W, Knick E. Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis. HNO 2003; 10: 794–9.
33. Klemens C, Rasp G, Jund F et al. Mediators and cytokines in allergic and viraltriggered rhinitis. Allergy and asthma proceedings: the official journal of regional and state allergy societies. 2007; 28 (4): 434–41.
34. Ellegard EK. The etiology and management of pregnancy rhinitis. Am J Respir Med 2003; 2 (6): 469–75.
35. Sorri M, Hartikainen-Sorri AL, Karja J. Rhinitis during pregnancy. Rhinology 1980; 18 (2): 83–6.
36. Simola M, Malmberg H. Sensation of nasal airflow compared with nasal airway resistance in patients with rhinitis. Clin Otolaryngol 1997; 22 (3): 260–2.
37. Nathan RA, Eccles R, Howar th PH et al. Objective monitoring of nasal patency and nasal physiology in rhinitis. J Allergy Clin Immunol 2005; 15 (3 Suppl. 1): S442–9.<br>
nol 2005; 15 (3 Suppl. 1): S442–9.
38. Smart BA. The impact of allergic and nonallergic rhinitis on pediatric sinusitis. Curr Allergy Asthma Reports 2006; 6 (3): 221–7.
39. Лопатин А.С. Сосудосуживающие препараты: механизм действия, клиническое применение и побочные эффекты. Рос. ринология. 2007; 1: 43–9. / Lopatin A.S. Sosudosuzhivaiushchie preparaty: mekhanizm deistviia, klinicheskoe primenenie i pobochnye effekty. Ros. rinologiia. 2007; 1: 43–9. [in Russian]
40. Gwaltney JMJR et al. JAMA 1967; 202: 494–500.
41. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants in ciliary beat frequency in vitro. Rhinology. 1993 (31):
151–3.
________________________________________________
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9. Mickenhagen A, Siefer O, Neugebauer P, Stennert E. The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells. Laryngorhinootologie 2008; 87 (1): 30–8. https://doi.org/10.1055/s-2007-966891
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12. Reinecke S, Tschaikin M. Investigation of the Effect of Oxymetazoline on the Duration of Rhinitis. Results of a placebo-controlled double-blind study in patients with acute rhinitis. MMW Fortschr Med 2005; 147 (Suppl. 3): 113–8.
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27. Cannon NL, Dalgleisch J, Frank H et al. Evaluation of oxymetazoline pediatric in the treatment of nasal congestion. J Matern Child Health 1976; 1: 32–33.11.;
28. Ruggeberg F. Clinical trials of oxymetazoline hydrochloride nasal drops for babies (NasivinTM 0,01%). Z Allg Med 1974; 11: 535–7.
29. Schmidtke M. Besitzen oxymetazoline-haltige nasen-sprays eine antivirale wirkung gegenuber inflenraviren. J Chemother 2005; 14: 207–11.
30. Von Reinecke S, Tschaikin M. Untersuchung der Wirksamkeit von Oxymetazolin auf die Rhinitisdauer, MMWFortschritte der Medizin Orginalien 2005; 147: 113–8.
31. Hochban W et al. Nasal decongestion with imidazoline derivatives: acoustic rhinomanometry measurements. Eur J Сlin Pharmacol 1999; 55: 7–12.
32. Dorn M, Hofmann W, Knick E. Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis. HNO 2003; 10: 794–9.
33. Klemens C, Rasp G, Jund F et al. Mediators and cytokines in allergic and viraltriggered rhinitis. Allergy and asthma proceedings: the official journal of regional and state allergy societies. 2007; 28 (4): 434–41.
34. Ellegard EK. The etiology and management of pregnancy rhinitis. Am J Respir Med 2003; 2 (6): 469–75.
35. Sorri M, Hartikainen-Sorri AL, Karja J. Rhinitis during pregnancy. Rhinology 1980; 18 (2): 83–6.
36. Simola M, Malmberg H. Sensation of nasal airflow compared with nasal airway resistance in patients with rhinitis. Clin Otolaryngol 1997; 22 (3): 260–2.
37. Nathan RA, Eccles R, Howar th PH et al. Objective monitoring of nasal patency and nasal physiology in rhinitis. J Allergy Clin Immunol 2005; 15 (3 Suppl. 1): S442–9.
nol 2005; 15 (3 Suppl. 1): S442–9.
38. Smart BA. The impact of allergic and nonallergic rhinitis on pediatric sinusitis. Curr Allergy Asthma Reports 2006; 6 (3): 221–7.
39. Lopatin A.S. Sosudosuzhivaiushchie preparaty: mekhanizm deistviia, klinicheskoe primenenie i pobochnye effekty. Ros. rinologiia. 2007; 1: 43–9. [in Russian]
40. Gwaltney JMJR et al. JAMA 1967; 202: 494–500.
41. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants in ciliary beat frequency in vitro. Rhinology. 1993 (31):
151–3.
Авторы
О.В.Карнеева1, Т.И.Гаращенко1, Е.П.Карпова2, С.В.Рязанцев3, Г.Н.Никифорова4, Н.А.Геппе*4, А.В.Горелов4,5,А.Б.Малахов4, Е.Г.Кондюрина6, М.Д.Бакрадзе7,8, Н.Г.Колосова4
1 ФГБУ «Научно-клинический центр оториноларингологии» ФМБА России. 123182, Россия, Москва, Волоколамское ш., д. 30, стр. 2;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»
Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1;
3 ФГБУ «Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи» Минздрава России. 190013, Россия, Санкт-Петербург, ул. Бронницкая, д. 9;
4 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова»
Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
5 ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора. 111123, Россия, Москва, ул. Новогиреевская, д. 3а;
6 ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России. 630091, Россия, Новосибирск, Красный пр-т, д. 52;
7 ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России.
119991, Россия, Москва, Ломоносовский пр-т, д. 2, стр. 1;
8 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*geppe@mail.ru
1 Research and Clinical Center of Otorhinolaryngology of FMBA of Russia. 123182, Russian Federation, Moscow, Volokolamskoe sh., d. 30, str. 2;
2 Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1;
3 Saint Petersburg Scientific Research Institute of Ear, Throat, Nose and Speech of the Ministry of Health of the Russian Federation. 190013, Russian Federation, Saint Petersburg, ul. Bronnitskaia, d. 9;
4 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
5 Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance. 111123, Russian Federation, Moscow, ul. Novogireevskaia, d. 3a;
6 Novosibirsk State Medical University. 630091, Russian Federation, Novosibirsk, ul. Krasnyi pr-t, d. 52;
7 National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation. 119991, Russia, Moscow, Lomonosovskii pr-t, d. 2, str. 1;
8 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*geppe@mail.ru
1 ФГБУ «Научно-клинический центр оториноларингологии» ФМБА России. 123182, Россия, Москва, Волоколамское ш., д. 30, стр. 2;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»
Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1;
3 ФГБУ «Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи» Минздрава России. 190013, Россия, Санкт-Петербург, ул. Бронницкая, д. 9;
4 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова»
Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
5 ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора. 111123, Россия, Москва, ул. Новогиреевская, д. 3а;
6 ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России. 630091, Россия, Новосибирск, Красный пр-т, д. 52;
7 ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России.
119991, Россия, Москва, Ломоносовский пр-т, д. 2, стр. 1;
8 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*geppe@mail.ru
________________________________________________
1 Research and Clinical Center of Otorhinolaryngology of FMBA of Russia. 123182, Russian Federation, Moscow, Volokolamskoe sh., d. 30, str. 2;
2 Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1;
3 Saint Petersburg Scientific Research Institute of Ear, Throat, Nose and Speech of the Ministry of Health of the Russian Federation. 190013, Russian Federation, Saint Petersburg, ul. Bronnitskaia, d. 9;
4 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
5 Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance. 111123, Russian Federation, Moscow, ul. Novogireevskaia, d. 3a;
6 Novosibirsk State Medical University. 630091, Russian Federation, Novosibirsk, ul. Krasnyi pr-t, d. 52;
7 National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation. 119991, Russia, Moscow, Lomonosovskii pr-t, d. 2, str. 1;
8 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*geppe@mail.ru
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