Вторые злокачественные опухоли у лиц, перенесших онкологическое заболевание в детстве
Вторые злокачественные опухоли у лиц, перенесших онкологическое заболевание в детстве
Павлова Т.Ю., Валиев Т.Т. Вторые злокачественные опухоли у лиц, перенесших онкологическое заболевание в детстве. Педиатрия. Consilium Medicum. 2020; 2: 12–16. DOI: 10.26442/26586630.2020.2.200234
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Аннотация
Развитие второго злокачественного новообразования (ЗНО) является одним из наиболее серьезных отдаленных осложнений у детей, перенесших лечение по поводу первой злокачественной опухоли. Проводимое химиолучевое лечение является канцерогенным фактором развития второго ЗНО. Органы и ткани детского организма с учетом степени зрелости, микроокружения, возраста и факторов образа жизни по-разному восприимчивы к канцерогенному воздействию химиопрепаратов и лучевой терапии. С учетом увеличения числа больных, излеченных от первого ЗНО, совершенствование терапии направлено на уменьшение риска развития вторых ЗНО по мере роста и развития детского организма. Определение факторов риска вторых ЗНО и разработка мер, направленных на снижение частоты развития вторых опухолей у лиц, излеченных от первого онкологического заболевания, являются важной задачей современной онкопедиатрии. В настоящей работе представлены наиболее часто встречающиеся опухоли детского возраста, после терапии которых происходит развитие вторых ЗНО. Освещены факторы риска и сроки развития вторых опухолей. Отдельное внимание уделено рекомендациям по наблюдению лиц, излеченных от ЗНО в детском возрасте.
Ключевые слова: острый лейкоз, ретинобластома, лимфома, химиотерапия, лучевая терапия, вторые опухоли, лечение, дети.
Key words: acute leukemia, retinoblastoma, lymphoma, chemotherapy, radiation therapy, second tumors, treatment, children.
Ключевые слова: острый лейкоз, ретинобластома, лимфома, химиотерапия, лучевая терапия, вторые опухоли, лечение, дети.
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Key words: acute leukemia, retinoblastoma, lymphoma, chemotherapy, radiation therapy, second tumors, treatment, children.
Список литературы
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26. Hawkins MM, Wilson LM, Burton HS et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 1996; 88 (5): 270–8.
27. Wong FL, Boice JD Jr, Abramson DH et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 1997; 278 (15): 1262–7.
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38. Travis LB, Hill DA, Dores GM et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease [published correction appears in JAMA 2003; 290 (10): 1318]. JAMA 2003; 290 (4): 465–75.
39. Van Leeuwen FE, Klokman WJ, Stovall M et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst 2003; 95 (13): 971–80.
40. Guibout C, Adjadj E, Rubino C et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol 2005; 23 (1): 197–204.
41. Travis LB, Hill D, Dores GM et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 2005; 97 (19): 1428–37.
42. Sklar C, Whitton J, Mertens A et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000; 85 (9): 3227–32.
43. Van Leeuwen FE, Klokman WJ, Veer MB et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.
J Clin Oncol 2000; 18 (3): 487–97.
44. Sigurdson AJ, Ronckers CM, Mertens AC et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 2005; 365 (9476): 2014–23.
45. Acharya S, Sarafoglou K, LaQuaglia M et al. Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 2003; 97 (10): 2397–403.
46. Black P, Straaten A, Gutjahr P. Secondary thyroid carcinoma after treatment for childhood cancer. Med Pediatr Oncol 1998; 31 (2): 91–5.
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53. Jenkinson HC, Hawkins MM, Stiller CA et al. Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain. Br J Cancer 2004; 91 (11): 1905–10.
54. Mertens AC, Yasui Y, Neglia JP et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 2001; 19 (13): 3163–72.
55. Tucker MA, D'Angio GJ, Boice JD Jr et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987; 317 (10): 588–93.
56. Kleinerman RA, Tucker MA, Abramson DH et al. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 2007; 99 (1): 24‐31.
57. Broniscer A, Ke W, Fuller CE et al. Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience. Cancer 2004; 100 (10): 2246–52.
58. Jenkin D, Greenberg M, Hoffman H et al. Brain tumors in children: long-term survival after radiation treatment. Int J Radiat Oncol Biol Phys 1995; 31 (3): 445–51.
2. Meadows AT, Friedman DL, Neglia JP et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009; 27 (14): 2356–62.
3. Möller TR, Garwicz S, Barlow L et al. Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. J Clin Oncol 2001; 19 (13): 3173–81.
4. Skvortsova Iu.V., Balashov V.N., Shelikhova L.N. et al. Vtorichnye solidnye opukholi u detei posle allogennoi transplantatsii gemopoeticheskikh stvolovykh kletok (klinicheskie sluchai i obzor literatury). Onkogematologiia. 2017; 12 (2): 39–53 (in Russian).
5. Travis LB, Rabkin CS, Brown LM et al. Cancer survivorship-genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst 2006; 98 (1): 15–25.
6. Neglia JP, Friedman DL, Yasui Y et al. Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001; 93 (8): 618–29.
7. Curtis R, Freedman D, Ron E et al. New Malignancies Among Cancer Survivors: SEER Cancer Registriesю National Cancer Institute; Bethesda, MD: 2006; p. 1973–2000.
8. Hijiya N, Hudson MM, Lensing S et al. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 2007; 297 (11): 1207–15.
9. Neglia JP, Meadows AT, Robison LL et al. Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 1991; 325 (19): 1330–6.
10. Löning L, Zimmermann M, Reiter A et al. Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. Blood 2000; 95 (9): 2770–5.
11. Bhatia S, Sather HN, Pabustan OB et al. Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 2002; 99 (12): 4257–64.
12. Neglia JP, Robison LL, Stovall M et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 2006; 98 (21): 1528–37.
13. Walter AW, Hancock ML, Pui CH et al. Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J Clin Oncol 1998; 16 (12): 3761–7.
14. Nobuko Hijiya, Ness KK, Ribeiro RC. Acute Leukemia as a Secondary Malignancy in Children and Adolescents: Current Findings and Issues. Cancer 2009; 115 (1): 23–35. DOI: 10.1002/cncr.23988
15. Swerdlow SH, Campo E, Harris NL et al. WHO classification of tumours of hematopoietic and lymphoid tissues. Lyon, 2017.
16. Smith SM, Le Beau MM, Huo D et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 2003; 102 (1): 43–52.
17. Relling MV, Rubnitz JE, Rivera GK et al. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 1999; 354 (9172): 34–9.
18. Pui CH, Relling MV, Rivera GK et al. Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia 1995; 9 (12): 1990–6.
19. Van Leeuwen FE, Chorus AM, van den Belt-Dusebout AW et al. Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage. J Clin Oncol 1994; 12 (5): 1063–73.
20. Le Deley MC, Vassal G, Taïbi A et al. High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults. Pediatr Blood Cancer 2005; 45 (1): 25–31.
21. Haddy N, Le Deley MC, Samand A et al. Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood. Eur J Cancer 2006; 42 (16): 2757–64.
22. Cavenee WK, Murphree AL, Shull MM et al. Prediction of familial predisposition to retinoblastoma. N Engl J Med 1986; 314 (19): 1201–7.
23. Kleinerman RA, Tucker MA, Tarone RE et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol 2005; 23 (10): 2272–9.
24. Fletcher O, Easton D, Anderson K et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 2004; 96 (5): 357–63.
25. Marees T, Moll AC, Imhof SM et al. Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst 2008; 100 (24): 1771–9.
26. Hawkins MM, Wilson LM, Burton HS et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 1996; 88 (5): 270–8.
27. Wong FL, Boice JD Jr, Abramson DH et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 1997; 278 (15): 1262–7.
28. Kivelä T. Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol 1999; 17 (6): 1829–837.
29. Constine LS, Tarbell N, Hudson MM et al. Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose. Int J Radiat Oncol Biol Phys 2008; 72 (1): 24–33.
30. Bhatia S, Yasui Y, Robison LL et al. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group. J Clin Oncol 2003; 21 (23): 4386–94.
31. Sankila R, Garwicz S, Olsen JH et al. Risk of subsequent malignant neoplasms among 1,641 Hodgkin's disease patients diagnosed in childhood and adolescence: a population-based cohort study in the five Nordic countries. Association of the Nordic Cancer Registries and the Nordic Society of Pediatric Hematology and Oncology. J Clin Oncol 1996; 14 (5): 1442–6.
32. Ng AK, Bernardo MV, Weller E et al. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 2002; 100 (6): 1989–96.
33. Swerdlow AJ, Barber JA, Hudson GV et al. Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000; 18 (3): 498–509.
34. Green DM, Hyland A, Barcos MP et al. Second malignant neoplasms after treatment for Hodgkin's disease in childhood or adolescence. J Clin Oncol 2000; 18 (7): 1492–9.
35. Kenney LB, Yasui Y, Inskip PD et al. Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Intern Med 2004; 141 (8): 590–7.
36. Curtis RE, Metayer C, Rizzo JD et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood 2005; 105 (10): 3802–11.
37. Mauch P, Ng A, Aleman B et al. Report from the Rockefellar Foundation Sponsored International Workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy. Eur J Haematol Suppl 2005; 66: 68–76.
38. Travis LB, Hill DA, Dores GM et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease [published correction appears in JAMA 2003; 290 (10): 1318]. JAMA 2003; 290 (4): 465–75.
39. Van Leeuwen FE, Klokman WJ, Stovall M et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst 2003; 95 (13): 971–80.
40. Guibout C, Adjadj E, Rubino C et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol 2005; 23 (1): 197–204.
41. Travis LB, Hill D, Dores GM et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 2005; 97 (19): 1428–37.
42. Sklar C, Whitton J, Mertens A et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000; 85 (9): 3227–32.
43. Van Leeuwen FE, Klokman WJ, Veer MB et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.
J Clin Oncol 2000; 18 (3): 487–97.
44. Sigurdson AJ, Ronckers CM, Mertens AC et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 2005; 365 (9476): 2014–23.
45. Acharya S, Sarafoglou K, LaQuaglia M et al. Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 2003; 97 (10): 2397–403.
46. Black P, Straaten A, Gutjahr P. Secondary thyroid carcinoma after treatment for childhood cancer. Med Pediatr Oncol 1998; 31 (2): 91–5.
47. Tucker MA, Jones PH, Boice JD Jr et al. Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group. Cancer Res 1991; 51 (11): 2885–8.
48. Schneider AB, Ron E, Lubin J et al. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J Clin Endocrinol Metab 1993; 77 (2): 362–9.
49. Bassal M, Mertens AC, Taylor L et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
J Clin Oncol 2006; 24 (3): 476–83.
50. Walker DA, Perilongo G, Punt JAG et al. Brain and spinal tumors of childhood. Arnold, 2004; р. 314–330.
51. Matsko D.E., Korshunov A.G. Atlas of tumors of the central nervous system. Saint Petersburg, 1998; p. 76-80 (in Russian).
52. Galloway TJ, Indelicato DJ, Amdur RJ et al. Favorable outcomes of pediatric patients treated with radiotherapy to the central nervous system who develop radiation-induced meningiomas. Int J Radiat Oncol Biol Phys 2011; 79 (1): 117–20.
53. Jenkinson HC, Hawkins MM, Stiller CA et al. Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain. Br J Cancer 2004; 91 (11): 1905–10.
54. Mertens AC, Yasui Y, Neglia JP et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 2001; 19 (13): 3163–72.
55. Tucker MA, D'Angio GJ, Boice JD Jr et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987; 317 (10): 588–93.
56. Kleinerman RA, Tucker MA, Abramson DH et al. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 2007; 99 (1): 24‐31.
57. Broniscer A, Ke W, Fuller CE et al. Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience. Cancer 2004; 100 (10): 2246–52.
58. Jenkin D, Greenberg M, Hoffman H et al. Brain tumors in children: long-term survival after radiation treatment. Int J Radiat Oncol Biol Phys 1995; 31 (3): 445–51.
2. Meadows AT, Friedman DL, Neglia JP et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009; 27 (14): 2356–62.
3. Möller TR, Garwicz S, Barlow L et al. Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. J Clin Oncol 2001; 19 (13): 3173–81.
4. Скворцова Ю.В., Балашов В.Н., Шелихова Л.Н. и др. Вторичные солидные опухоли у детей после аллогенной трансплантации гемопоэтических стволовых клеток (клинические случаи и обзор литературы). Онкогематология. 2017; 12 (2): 39–53.
[Skvortsova Iu.V., Balashov V.N., Shelikhova L.N. et al. Vtorichnye solidnye opukholi u detei posle allogennoi transplantatsii gemopoeticheskikh stvolovykh kletok (klinicheskie sluchai i obzor literatury). Onkogematologiia. 2017; 12 (2): 39–53 (in Russian).]
5. Travis LB, Rabkin CS, Brown LM et al. Cancer survivorship-genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst 2006; 98 (1): 15–25.
6. Neglia JP, Friedman DL, Yasui Y et al. Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001; 93 (8): 618–29.
7. Curtis R, Freedman D, Ron E et al. New Malignancies Among Cancer Survivors: SEER Cancer Registriesю National Cancer Institute; Bethesda, MD: 2006; p. 1973–2000.
8. Hijiya N, Hudson MM, Lensing S et al. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 2007; 297 (11): 1207–15.
9. Neglia JP, Meadows AT, Robison LL et al. Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 1991; 325 (19): 1330–6.
10. Löning L, Zimmermann M, Reiter A et al. Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. Blood 2000; 95 (9): 2770–5.
11. Bhatia S, Sather HN, Pabustan OB et al. Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 2002; 99 (12): 4257–64.
12. Neglia JP, Robison LL, Stovall M et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 2006; 98 (21): 1528–37.
13. Walter AW, Hancock ML, Pui CH et al. Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J Clin Oncol 1998; 16 (12): 3761–7.
14. Nobuko Hijiya, Ness KK, Ribeiro RC. Acute Leukemia as a Secondary Malignancy in Children and Adolescents: Current Findings and Issues. Cancer 2009; 115 (1): 23–35. DOI: 10.1002/cncr.23988
15. Swerdlow SH, Campo E, Harris NL et al. WHO classification of tumours of hematopoietic and lymphoid tissues. Lyon, 2017.
16. Smith SM, Le Beau MM, Huo D et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 2003; 102 (1): 43–52.
17. Relling MV, Rubnitz JE, Rivera GK et al. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 1999; 354 (9172): 34–9.
18. Pui CH, Relling MV, Rivera GK et al. Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia 1995; 9 (12): 1990–6.
19. Van Leeuwen FE, Chorus AM, van den Belt-Dusebout AW et al. Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage. J Clin Oncol 1994; 12 (5): 1063–73.
20. Le Deley MC, Vassal G, Taïbi A et al. High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults. Pediatr Blood Cancer 2005; 45 (1): 25–31.
21. Haddy N, Le Deley MC, Samand A et al. Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood. Eur J Cancer 2006; 42 (16): 2757–64.
22. Cavenee WK, Murphree AL, Shull MM et al. Prediction of familial predisposition to retinoblastoma. N Engl J Med 1986; 314 (19): 1201–7.
23. Kleinerman RA, Tucker MA, Tarone RE et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol 2005; 23 (10): 2272–9.
24. Fletcher O, Easton D, Anderson K et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 2004; 96 (5): 357–63.
25. Marees T, Moll AC, Imhof SM et al. Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst 2008; 100 (24): 1771–9.
26. Hawkins MM, Wilson LM, Burton HS et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 1996; 88 (5): 270–8.
27. Wong FL, Boice JD Jr, Abramson DH et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 1997; 278 (15): 1262–7.
28. Kivelä T. Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol 1999; 17 (6): 1829–837.
29. Constine LS, Tarbell N, Hudson MM et al. Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose. Int J Radiat Oncol Biol Phys 2008; 72 (1): 24–33.
30. Bhatia S, Yasui Y, Robison LL et al. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group. J Clin Oncol 2003; 21 (23): 4386–94.
31. Sankila R, Garwicz S, Olsen JH et al. Risk of subsequent malignant neoplasms among 1,641 Hodgkin's disease patients diagnosed in childhood and adolescence: a population-based cohort study in the five Nordic countries. Association of the Nordic Cancer Registries and the Nordic Society of Pediatric Hematology and Oncology. J Clin Oncol 1996; 14 (5): 1442–6.
32. Ng AK, Bernardo MV, Weller E et al. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 2002; 100 (6): 1989–96.
33. Swerdlow AJ, Barber JA, Hudson GV et al. Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000; 18 (3): 498–509.
34. Green DM, Hyland A, Barcos MP et al. Second malignant neoplasms after treatment for Hodgkin's disease in childhood or adolescence. J Clin Oncol 2000; 18 (7): 1492–9.
35. Kenney LB, Yasui Y, Inskip PD et al. Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Intern Med 2004; 141 (8): 590–7.
36. Curtis RE, Metayer C, Rizzo JD et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood 2005; 105 (10): 3802–11.
37. Mauch P, Ng A, Aleman B et al. Report from the Rockefellar Foundation Sponsored International Workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy. Eur J Haematol Suppl 2005; 66: 68–76.
38. Travis LB, Hill DA, Dores GM et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease [published correction appears in JAMA 2003; 290 (10): 1318]. JAMA 2003; 290 (4): 465–75.
39. Van Leeuwen FE, Klokman WJ, Stovall M et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst 2003; 95 (13): 971–80.
40. Guibout C, Adjadj E, Rubino C et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol 2005; 23 (1): 197–204.
41. Travis LB, Hill D, Dores GM et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 2005; 97 (19): 1428–37.
42. Sklar C, Whitton J, Mertens A et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000; 85 (9): 3227–32.
43. Van Leeuwen FE, Klokman WJ, Veer MB et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.
J Clin Oncol 2000; 18 (3): 487–97.
44. Sigurdson AJ, Ronckers CM, Mertens AC et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 2005; 365 (9476): 2014–23.
45. Acharya S, Sarafoglou K, LaQuaglia M et al. Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 2003; 97 (10): 2397–403.
46. Black P, Straaten A, Gutjahr P. Secondary thyroid carcinoma after treatment for childhood cancer. Med Pediatr Oncol 1998; 31 (2): 91–5.
47. Tucker MA, Jones PH, Boice JD Jr et al. Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group. Cancer Res 1991; 51 (11): 2885–8.
48. Schneider AB, Ron E, Lubin J et al. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J Clin Endocrinol Metab 1993; 77 (2): 362–9.
49. Bassal M, Mertens AC, Taylor L et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
J Clin Oncol 2006; 24 (3): 476–83.
50. Walker DA, Perilongo G, Punt JAG et al. Brain and spinal tumors of childhood. Arnold, 2004; р. 314–330.
51. Мацко Д.Е., Коршунов А.Г. Атлас опухолей центральной нервной системы. СПб. 1998; с. 76–80.
[Matsko D.E., Korshunov A.G. Atlas of tumors of the central nervous system. Saint Petersburg, 1998; p. 76-80 (in Russian).]
52. Galloway TJ, Indelicato DJ, Amdur RJ et al. Favorable outcomes of pediatric patients treated with radiotherapy to the central nervous system who develop radiation-induced meningiomas. Int J Radiat Oncol Biol Phys 2011; 79 (1): 117–20.
53. Jenkinson HC, Hawkins MM, Stiller CA et al. Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain. Br J Cancer 2004; 91 (11): 1905–10.
54. Mertens AC, Yasui Y, Neglia JP et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 2001; 19 (13): 3163–72.
55. Tucker MA, D'Angio GJ, Boice JD Jr et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987; 317 (10): 588–93.
56. Kleinerman RA, Tucker MA, Abramson DH et al. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 2007; 99 (1): 24‐31.
57. Broniscer A, Ke W, Fuller CE et al. Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience. Cancer 2004; 100 (10): 2246–52.
58. Jenkin D, Greenberg M, Hoffman H et al. Brain tumors in children: long-term survival after radiation treatment. Int J Radiat Oncol Biol Phys 1995; 31 (3): 445–51.
________________________________________________
2. Meadows AT, Friedman DL, Neglia JP et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009; 27 (14): 2356–62.
3. Möller TR, Garwicz S, Barlow L et al. Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. J Clin Oncol 2001; 19 (13): 3173–81.
4. Skvortsova Iu.V., Balashov V.N., Shelikhova L.N. et al. Vtorichnye solidnye opukholi u detei posle allogennoi transplantatsii gemopoeticheskikh stvolovykh kletok (klinicheskie sluchai i obzor literatury). Onkogematologiia. 2017; 12 (2): 39–53 (in Russian).
5. Travis LB, Rabkin CS, Brown LM et al. Cancer survivorship-genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst 2006; 98 (1): 15–25.
6. Neglia JP, Friedman DL, Yasui Y et al. Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001; 93 (8): 618–29.
7. Curtis R, Freedman D, Ron E et al. New Malignancies Among Cancer Survivors: SEER Cancer Registriesю National Cancer Institute; Bethesda, MD: 2006; p. 1973–2000.
8. Hijiya N, Hudson MM, Lensing S et al. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 2007; 297 (11): 1207–15.
9. Neglia JP, Meadows AT, Robison LL et al. Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 1991; 325 (19): 1330–6.
10. Löning L, Zimmermann M, Reiter A et al. Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. Blood 2000; 95 (9): 2770–5.
11. Bhatia S, Sather HN, Pabustan OB et al. Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 2002; 99 (12): 4257–64.
12. Neglia JP, Robison LL, Stovall M et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 2006; 98 (21): 1528–37.
13. Walter AW, Hancock ML, Pui CH et al. Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J Clin Oncol 1998; 16 (12): 3761–7.
14. Nobuko Hijiya, Ness KK, Ribeiro RC. Acute Leukemia as a Secondary Malignancy in Children and Adolescents: Current Findings and Issues. Cancer 2009; 115 (1): 23–35. DOI: 10.1002/cncr.23988
15. Swerdlow SH, Campo E, Harris NL et al. WHO classification of tumours of hematopoietic and lymphoid tissues. Lyon, 2017.
16. Smith SM, Le Beau MM, Huo D et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 2003; 102 (1): 43–52.
17. Relling MV, Rubnitz JE, Rivera GK et al. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 1999; 354 (9172): 34–9.
18. Pui CH, Relling MV, Rivera GK et al. Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia 1995; 9 (12): 1990–6.
19. Van Leeuwen FE, Chorus AM, van den Belt-Dusebout AW et al. Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage. J Clin Oncol 1994; 12 (5): 1063–73.
20. Le Deley MC, Vassal G, Taïbi A et al. High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults. Pediatr Blood Cancer 2005; 45 (1): 25–31.
21. Haddy N, Le Deley MC, Samand A et al. Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood. Eur J Cancer 2006; 42 (16): 2757–64.
22. Cavenee WK, Murphree AL, Shull MM et al. Prediction of familial predisposition to retinoblastoma. N Engl J Med 1986; 314 (19): 1201–7.
23. Kleinerman RA, Tucker MA, Tarone RE et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol 2005; 23 (10): 2272–9.
24. Fletcher O, Easton D, Anderson K et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 2004; 96 (5): 357–63.
25. Marees T, Moll AC, Imhof SM et al. Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst 2008; 100 (24): 1771–9.
26. Hawkins MM, Wilson LM, Burton HS et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 1996; 88 (5): 270–8.
27. Wong FL, Boice JD Jr, Abramson DH et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA 1997; 278 (15): 1262–7.
28. Kivelä T. Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol 1999; 17 (6): 1829–837.
29. Constine LS, Tarbell N, Hudson MM et al. Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose. Int J Radiat Oncol Biol Phys 2008; 72 (1): 24–33.
30. Bhatia S, Yasui Y, Robison LL et al. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group. J Clin Oncol 2003; 21 (23): 4386–94.
31. Sankila R, Garwicz S, Olsen JH et al. Risk of subsequent malignant neoplasms among 1,641 Hodgkin's disease patients diagnosed in childhood and adolescence: a population-based cohort study in the five Nordic countries. Association of the Nordic Cancer Registries and the Nordic Society of Pediatric Hematology and Oncology. J Clin Oncol 1996; 14 (5): 1442–6.
32. Ng AK, Bernardo MV, Weller E et al. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 2002; 100 (6): 1989–96.
33. Swerdlow AJ, Barber JA, Hudson GV et al. Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000; 18 (3): 498–509.
34. Green DM, Hyland A, Barcos MP et al. Second malignant neoplasms after treatment for Hodgkin's disease in childhood or adolescence. J Clin Oncol 2000; 18 (7): 1492–9.
35. Kenney LB, Yasui Y, Inskip PD et al. Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Intern Med 2004; 141 (8): 590–7.
36. Curtis RE, Metayer C, Rizzo JD et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood 2005; 105 (10): 3802–11.
37. Mauch P, Ng A, Aleman B et al. Report from the Rockefellar Foundation Sponsored International Workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy. Eur J Haematol Suppl 2005; 66: 68–76.
38. Travis LB, Hill DA, Dores GM et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease [published correction appears in JAMA 2003; 290 (10): 1318]. JAMA 2003; 290 (4): 465–75.
39. Van Leeuwen FE, Klokman WJ, Stovall M et al. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease. J Natl Cancer Inst 2003; 95 (13): 971–80.
40. Guibout C, Adjadj E, Rubino C et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol 2005; 23 (1): 197–204.
41. Travis LB, Hill D, Dores GM et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 2005; 97 (19): 1428–37.
42. Sklar C, Whitton J, Mertens A et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000; 85 (9): 3227–32.
43. Van Leeuwen FE, Klokman WJ, Veer MB et al. Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.
J Clin Oncol 2000; 18 (3): 487–97.
44. Sigurdson AJ, Ronckers CM, Mertens AC et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 2005; 365 (9476): 2014–23.
45. Acharya S, Sarafoglou K, LaQuaglia M et al. Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 2003; 97 (10): 2397–403.
46. Black P, Straaten A, Gutjahr P. Secondary thyroid carcinoma after treatment for childhood cancer. Med Pediatr Oncol 1998; 31 (2): 91–5.
47. Tucker MA, Jones PH, Boice JD Jr et al. Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group. Cancer Res 1991; 51 (11): 2885–8.
48. Schneider AB, Ron E, Lubin J et al. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J Clin Endocrinol Metab 1993; 77 (2): 362–9.
49. Bassal M, Mertens AC, Taylor L et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
J Clin Oncol 2006; 24 (3): 476–83.
50. Walker DA, Perilongo G, Punt JAG et al. Brain and spinal tumors of childhood. Arnold, 2004; р. 314–330.
51. Matsko D.E., Korshunov A.G. Atlas of tumors of the central nervous system. Saint Petersburg, 1998; p. 76-80 (in Russian).
52. Galloway TJ, Indelicato DJ, Amdur RJ et al. Favorable outcomes of pediatric patients treated with radiotherapy to the central nervous system who develop radiation-induced meningiomas. Int J Radiat Oncol Biol Phys 2011; 79 (1): 117–20.
53. Jenkinson HC, Hawkins MM, Stiller CA et al. Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain. Br J Cancer 2004; 91 (11): 1905–10.
54. Mertens AC, Yasui Y, Neglia JP et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 2001; 19 (13): 3163–72.
55. Tucker MA, D'Angio GJ, Boice JD Jr et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987; 317 (10): 588–93.
56. Kleinerman RA, Tucker MA, Abramson DH et al. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 2007; 99 (1): 24‐31.
57. Broniscer A, Ke W, Fuller CE et al. Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience. Cancer 2004; 100 (10): 2246–52.
58. Jenkin D, Greenberg M, Hoffman H et al. Brain tumors in children: long-term survival after radiation treatment. Int J Radiat Oncol Biol Phys 1995; 31 (3): 445–51.
Авторы
Т.Ю. Павлова, Т.Т. Валиев*
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
*timurvaliev@mail.ru
Blokhin National Medical Research Center of Oncology, Moscow, Russia
*timurvaliev@mail.ru
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
*timurvaliev@mail.ru
________________________________________________
Blokhin National Medical Research Center of Oncology, Moscow, Russia
*timurvaliev@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.