Висцеральный лейшманиоз у детей (собственные результаты и анализ литературы)
________________________________________________
Volkova G.I., Smirnova M.I., Delyagin W.M. Visceral leishmaniasis in children (own results and literature analysis). Pediatrics. Consilium Medicum. 2020; 3: 80–83.
DOI: 10.26442/26586630.2020.3.200344
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Ключевые слова: дети, лейшманиоз, диагностика, лечение, профилактика.
________________________________________________
Leishmaniasis is a tropical parasitic infection with a preferred lesion in children. Leishmaniasis, perceived as an infection in hot and humid regions, is not always taken into account in the differential diagnostic search in febrile children with splenomegaly, the degree of which prevails over hepatic anemia. The geographical factor is not taken into account. In our observations, the period from the first symptoms to the diagnosis ranged from 0.5 to 17 months. The diagnosis is confirmed by the results of bone marrow puncture, immunological tests. Treatment is based on the use of antimony drugs. Often, adverse reactions are recorded in the form of an increase in hepatic enzymes, bilirubinemia, anemia. Prevention is the avoiding of mosquito bites.
Key words: children, leishmaniasis, diagnosis, treatment, prevention.
2. Заславский Д.В., Андриенко Е.М., Александрова И.Ю. и др. Верификация лейшманиоза кожи. Вестник дерматологии и венерологии. 2014; 5: 91–5.
[Zaslavskii D.V., Andrienko E.M., Aleksandrova I.Iu. et al. Verification of cutaneous leishmaniasis. Vestnik dermatologii i venerologii. 2014; 5: 91–5 (in Russian).]
3. Hotez P, Lo N. Neglected tropical diseases: public health control programs and mass drug administration. In: Ryan E, Hill D, Solomin T et al. (Eds.) Hunter’s Tropical Medicine and Emerging Infectious Diseases. 2020. 10th Ed.; 209–13.
4. Garcia L. Leishmaniasis. In: Cherry J, Harrison G, Kaplan Sh et al. (Eds.) Feigin and cherry’s textbook of pediatric infectious diseases. 8th Ed. 2019; 2178–86.e2.
5. Leishmaniasis. 2014. http://www.who.int/topics/leishmaniasis/en/
6. Murray H, Berman J, Davies C et al. Advances in leishmaniasis. Lancet 2005; 366 (9496): 1561–77.
7. Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Centers for Diseases Control and Prevention. https://www.cdc.gov/parasites/leishmaniasis/epi.html
8. Gradoni L. Leishmaniasis. In: Kellerman R, Rakel D (Eds.). Conn’s Current Therapy. 2020; 577–80.
9. De Menezes J, Koushik A, Das S et al. Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins. Cell Microbiol 2017; 19 (3). DOI: 10.1111/cmi.12668
10. Ready P. Biology of phlebotomine sand flies as vectors of disease agents. An Rev Entomol 2013; 58: 227–50.
11. Pace D. Leishmaniasis. J Infect. 2014; 69; Suppl. 1: 10–8. DOI: 10.1016/j.jinf.2014.07.016
12. Hewitt S, Reyburn H, Ashford R, Rowland M. Anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: vertical distribution of cases in apartament blocks. Transact Royal Society Tropical Med Hyg 1998; 92 (3): 273–4.
13. World Health Organization (WHO). First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases. Geneva, 2010.
14. Kevric I, Cappel M, Keeling J. New World and Old World Leishmania Infections. A Practical Review. Dermatol Clin 2015; 33 (3): 579–93.
15. Banuls A, Hide M, Pruqnolle F. Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans. Adv Parasitol 2007; 64: 1–109.
16. Chappuis F, Sundar S, Hailu A et al. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 2007; 5 (11): 873–82.
17. Sakthianandeswaren A, Foote S, Handman E. The role of host genetics in leishmaniasis. Trends Parasitol 2009; 25 (8): 383–91.
18. Zhang W, Matlashewski G. Characterization of the A2-A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection. Mol Microbiol 2001; 39 (4): 935–48.
19. Okwor I, Uzonna J. Social and Economic Burden of Human Leishmaniasis. Am J Trop Med Hyg 2016; 94 (3): 489–93.
________________________________________________
1. Aronson N, Copeland N, Magill A. Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis. In: Benner J, Dolin R, Blaser M (Eds.) Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 9th Ed. 2020; 3321–40.e4.
2. Zaslavskii D.V., Andrienko E.M., Aleksandrova I.Iu. et al. Verification of cutaneous leishmaniasis. Vestnik dermatologii i venerologii. 2014; 5: 91–5 (in Russian).
3. Hotez P, Lo N. Neglected tropical diseases: public health control programs and mass drug administration. In: Ryan E, Hill D, Solomin T et al. (Eds.) Hunter’s Tropical Medicine and Emerging Infectious Diseases. 2020. 10th Ed.; 209–13.
4. Garcia L. Leishmaniasis. In: Cherry J, Harrison G, Kaplan Sh et al. (Eds.) Feigin and cherry’s textbook of pediatric infectious diseases. 8th Ed. 2019; 2178–86.e2.
5. Leishmaniasis. 2014. http://www.who.int/topics/leishmaniasis/en/
6. Murray H, Berman J, Davies C et al. Advances in leishmaniasis. Lancet 2005; 366 (9496): 1561–77.
7. Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Centers for Diseases Control and Prevention. https://www.cdc.gov/parasites/leishmaniasis/epi.html
8. Gradoni L. Leishmaniasis. In: Kellerman R, Rakel D (Eds.). Conn’s Current Therapy. 2020; 577–80.
9. De Menezes J, Koushik A, Das S et al. Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins. Cell Microbiol 2017; 19 (3). DOI: 10.1111/cmi.12668
10. Ready P. Biology of phlebotomine sand flies as vectors of disease agents. An Rev Entomol 2013; 58: 227–50.
11. Pace D. Leishmaniasis. J Infect. 2014; 69; Suppl. 1: 10–8. DOI: 10.1016/j.jinf.2014.07.016
12. Hewitt S, Reyburn H, Ashford R, Rowland M. Anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: vertical distribution of cases in apartament blocks. Transact Royal Society Tropical Med Hyg 1998; 92 (3): 273–4.
13. World Health Organization (WHO). First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases. Geneva, 2010.
14. Kevric I, Cappel M, Keeling J. New World and Old World Leishmania Infections. A Practical Review. Dermatol Clin 2015; 33 (3): 579–93.
15. Banuls A, Hide M, Pruqnolle F. Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans. Adv Parasitol 2007; 64: 1–109.
16. Chappuis F, Sundar S, Hailu A et al. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 2007; 5 (11): 873–82.
17. Sakthianandeswaren A, Foote S, Handman E. The role of host genetics in leishmaniasis. Trends Parasitol 2009; 25 (8): 383–91.
18. Zhang W, Matlashewski G. Characterization of the A2-A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection. Mol Microbiol 2001; 39 (4): 935–48.
19. Okwor I, Uzonna J. Social and Economic Burden of Human Leishmaniasis. Am J Trop Med Hyg 2016; 94 (3): 489–93.
1 ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва, Россия;
2 Российская детская клиническая больница ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
*delyagin-doktor@yandex.ru
________________________________________________
Galina I. Volkova1,2, Mariia I. Smirnova1, Wassili M. Delyagin*1
1 Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia;
2 Russian Children's Clinical Hospital, Pirogov Russian National Research Medical University, Moscow, Russia
*delyagin-doktor@yandex.ru