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О значении реализации программы «Недостаточность витамина D у детей и подростков Российской Федерации» для улучшения противоинфекционного иммунитета и долгосрочного прогноза состояния здоровья детей
О значении реализации программы «Недостаточность витамина D у детей и подростков Российской Федерации» для улучшения противоинфекционного иммунитета и долгосрочного прогноза состояния здоровья детей
Малявская С.И. О значении реализации программы «Недостаточность витамина D у детей и подростков Российской Федерации» для улучшения противоинфекционного иммунитета и долгосрочного прогноза состояния здоровья детей. Педиатрия. Consilium Medicum. 2021;4:362–368.
DOI: 10.26442/26586630.2021.4.201330
DOI: 10.26442/26586630.2021.4.201330
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Аннотация
В статье приведены данные литературы, свидетельствующие об иммуномодулирующих свойствах витамина D, и результаты исследований, в которых отмечено повышение риска и частоты возникновения разных респираторных инфекций при его дефиците у детей. Витамин D относится к классу секостероидов и, обладая плейотропным механизмом действия, играет важную роль в поддержании основных регулирующих функций в организме во все периоды онтогенеза. Как показывают многочисленные исследования, адекватная обеспеченность витамином D способствует снижению заболеваемости, в том числе инфекционной, и с его низким уровнем сопряжено много негативных моментов в отношении ряда заболеваний (онкологические, аллергические, аутоиммунные, кардиологические). Способность витамина D выступать протективным фактором, обеспечивающим иммуномодулирующий ответ и, напротив, при наличии дефицита выступать фактором риска развития и течения респираторной вирусной инфекции делает актуальным поиск взаимосвязей и причинно-следственных факторов. Использование препаратов витамина D необходимо для профилактики и лечения детей и взрослых при комплексном подходе к терапии инфекций, в том числе и SARS-CoV-2.
Ключевые слова: витамин D, 25-гидроксихолекальциферол, острая респираторная вирусная инфекция, COVID-19, иммунитет, недостаточность и дефицит витамина D, адаптация, инфекционные заболевания
Keywords: vitamin D, 25-hydroxycholecalciferol, acute respiratory viral infection, COVID-19, immunity, vitamin D insufficiency and deficiency, adaptation, infectious diseases
Ключевые слова: витамин D, 25-гидроксихолекальциферол, острая респираторная вирусная инфекция, COVID-19, иммунитет, недостаточность и дефицит витамина D, адаптация, инфекционные заболевания
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Keywords: vitamin D, 25-hydroxycholecalciferol, acute respiratory viral infection, COVID-19, immunity, vitamin D insufficiency and deficiency, adaptation, infectious diseases
Полный текст
Список литературы
1. Боровик Т.Э., Громова О.А., Захарова И.Н., и др. Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции. Национальная программа. 2-е изд. М., 2021 [Borovik TE, Gromova OA, Zaharova IN, et al. Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podhody k korrektsii. Natsional'naia programma. 2-e izd. Moscow, 2021 (in Russian)].
2. Дроздов В.Н. Дефицит витамина D как фактор полиморбидности. Экспериментальная и клиническая гастроэнтерология. 2015;118(6):82-8 [Drozdov VN. Vitamin D deficiency as a factor polymorbidity. Eksperimental’naia i klinicheskaia gastroenterologiia. 2015;118(6):82-8 (in Russian)].
3. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73. DOI:10.4065/81.3.353
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. DOI:10.1093/ajcn/84.1.18
5. Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012;7:155-72. DOI:10.1007/s11657-012-0093-0
6. Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. DOI:10.1016/j.autrev.2013.02.004
7. Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. DOI:10.1016/j.beem.2011.06.007
8. Малявская С.И., Кострова Г.Н., Лебедев А.В., и др. Уровни витамина D у представителей различных групп населения города Архангельска. Экология человека. 2018;1:60-4 [Malyavskaya SI, Kostrova GN, Lebedev АV, et al. 25(OH)D Levels in the population of Arkhangelsk city in different age groups. Ekologiya cheloveka. 2018;1:60-4 (in Russian)].
9. Кондратьева Е.И., Лошкова Е.В., Захарова И.Н., и др. Оценка обеспеченности витамином D детей Москвы и Московской области. Рос. вестн. перинатологии и педиатрии. 2021;66(1):78-84 [Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Ros. vestn. perinatologii i pediatrii. 2021;66(1):78-84 (in Russian)]. DOI:10.21508/1027-4065-2021-66-2-78-84
10. Суплотова Л.А., Авдеева В.А., Пигарова Е.А., и др. Дефицит витамина D в России: первые результаты регистрового неинтервенционного исследования частоты дефицита и недостаточности витамина D в различных географических регионах страны. Проблемы эндокринологии. 2021;67(2):84-92 [Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian)]. DOI:10.14341/probl12736
11. Торшин И.Ю., Лиманова О.А., Сардарян И.С., и др. Обеспеченность витамином D детей и подростков 7–14 лет и взаимосвязь дефицита витамина D с нарушениями здоровья: анализ крупномасштабной выборки пациентов посредством интеллектуального анализа данных. Педиатрия. 2015;94(2):175-84 [Torshin IYu, Limanova OA, Sardaryan IS, et al. Provision of vitamin D in children and adolescents aged 7 to 14 years and the relationship of deficiency of vitamin D with violations of children’s health: the analysis of a large-scale sample of patients by means of data mining. Pediatria. 2015;94(2):175-84 (in Russian)].
12. Palermo NE, Holick MF. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179-92. DOI:10.3233/PRM-140287
13. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000;374(2):334-8. DOI:10.1006/abbi.1999.1605
14. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154(Suppl.):S57-73.
15. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase. J Clin Endocr Metab. 2001;86(2):888-94. DOI:10.1210/jcem.86.2.7220
16. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26-34. DOI:10.1210/jc.2008-1454
17. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2017 [Gromova OA, Torshin IYu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2017 (in Russian)].
18. Захарова И.Н., Климов Л.Я., Касьянова А.Н., и др. Взаимосвязь инфекционной заболеваемости и недостаточности витамина D: современное состояние проблемы. Инфекционные болезни. 2018;16(3):69-78 [Zakharova IN, Klimov LYa, Kasyanova AN, et al. Interrelationships between the incidence of infectious diseases and vitamin D deficiency: the current state of the problem. Infektsionnye bolezni. 2018;16(3):69-78 (in Russian)]. DOI:10.20953/1729-9225-2018-3-69-78
19. Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. Front Immunol. 2017;7:697. DOI:10.3389/fimmu.2016.00697
20. Liu NQ, Kaplan AT, Lagishetty V, et al. Vitamin D and the regulation of placental inflammation. J Immunol. 2011;186(10):5968-74. DOI:10.4049/jimmunol.1003332
21. Пигарова Е.А., Плещева А.В., Дзеранова Л.К. Влияние витамина D на иммунную систему. Иммунология. 2015;36(1):62-6 [Pigarova EA, Pleshcheev AV, Dzeranova LK. Influence of vitamin D on the immune system. Immunologiya. 2015;36(1):62-6 (in Russian)].
22. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365-79. DOI:10.1016/j.ecl.2010.02.010
23. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169(4):384-90. DOI:10.1001/archinternmed.2008.560
24. Panda DК, Miao D, Tremblay МL, et al. Targeted ablation of the 25-hydroxyvitamin D alpha-hydroxylase enzyme: evidence for skeletal reproductive and immune dysfunction. Proc Natl Acad Sci USA. 2001;98(13):7498-503. DOI:10.1073/pnas.131029498
25. Захарова И.Н., Климов Л.Я., Касьянова А.Н., и др. Современные представления об иммунотропных эффектах витамина D. Вопросы практической педиатрии. 2019;14(1):7-17 [Zakharova IN, Klimov LYa, Kasyanova AN, et al. Modern conception about vitamin D immunotropic effects. Clinical Practice in Pediatrics. 2019;14(1):7-17 (in Russian)]. DOI:10.20953/1817-7646-2019-1-7-17
26. Захарова И.Н., Мальцев С.В., Заплатников А.Л., и др. Влияние витамина D на иммунный ответ организма. Педиатрия. Consilium Medicum. 2020;2:29-37 [Zakharova IN, Maltsev SV, Zaplatnikov AL, et al. Influence of vitamin D on the immune response of the organism. Pediatrics. Consilium Medicum. 2020;2:29-37 (in Russian)]. DOI:10.26442/26586630.2020.2.200238
27. Абатуров А.Е., Герасименко О.Н., Высочина И.Л., Завгородняя Н.Ю. Дефензины и дефензин-зависимые заболевания. Одесса: ВМВ, 2011 [Abaturov AE, Gerasimenko ON, Vysochina IL, Zavgorodnyaya NYu. Defenziny i defenzin-zavisimye zabolevaniya. Odessa: VMV, 2011 (in Russian)].
28. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50(3):194‑200. DOI:10.1016/j.jcv.2010.12.006
29. Hope-Simpson RE. The role of season in the epidemiology of influenza. J Hyg (Lond). 1981;86(1):35-47. DOI:10.1017/s0022172400068728
30. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106(9):1433-40. DOI:10.1017/S0007114511001991
31. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134(6):1129-40. DOI:10.1017/S0950268806007175
32. Каронова Т.Л., Вашукова М.А., Гусев Д.А., и др. Витамин D как фактор повышения иммунитета и снижения риска развития острых респираторных вирусных инфекций и COVID-19. Артериальная гипертензия. 2020;26(3):295-303 [Karonova TL, Vashukova MA, Gusev DA, et al. Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID‑19. Arterial Hypertension. 2020;26(3):295-303 (in Russian)]. DOI:10.18705/1607-419X-2020-26-3-295-303
33. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. DOI:10.1136/bmj.i6583
34. Karatekin G, Kaya A, Salihoğlu O, et al. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63(4):473-7. DOI:10.1038/sj.ejcn.1602960
35. Zhou J, Du J, Huang L, et al. Preventive effects of vitamin D on seasonal influenza a in infants: a multicenter, randomized, open, controlled clinical trial. Pediatr Infect Dis J. 2018;37(8):749-54. DOI:10.1097/INF.0000000000001890
36. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-60. DOI:10.3945/ajcn.2009.29094
37. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323(18):1775-6. DOI:10.1001/jama.2020.4683
38. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China summary of a report of 72,314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. DOI:10.1001/jama.2020.2648
39. Charoenngam N, Shirvani A, Holick MF. Vitamin D and its potential benefit for the covid-19 pandemic. Endocr Pract. 2021;27(5):484-93. DOI:10.1016/j.eprac.2021.03.006
40. Taha R, Abureesh S, Alghamdi S, et al. The relationship between vitamin D and infections including COVID-19: any hopes? Int J Gen Med. 2021;14:3849-70. DOI:10.2147/IJGM.S317421
41. Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. DOI:10.1001/jamanetworkopen.2020.19722
42. Mercola J, Grant WB, Wagner CL. Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. Nutrients. 2020;12(11):3361. DOI:10.3390/nu12113361
43. Benskin LL. A basic review of the preliminary evidence that covid-19 risk and severity is increased in vitamin D deficiency. Front Public Health. 2020;8:513. DOI:10.3389/fpubh.2020.00513
44. Vasheghani M, Jannati N, Baghaei P, et al. The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality. Sci Rep. 2021;11(1):17594. DOI:10.1038/s41598-021-97017-9
45. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI:10.1001/jama.2020.1585
46. Wimalawansa SJ. Global epidemic of coronaviruses – COVID-19: What can we do to minimize risks. Eur J Biomed Pharm Sci. 2020;7:432-8.
47. Бычинин М.В., Мандель И.А., Клыпа Т.В., и др. Распространенность гиповитаминоза D у пациентов c COVID-19 в отделении реанимации и интенсивной терапии. Клиническая практика. 2021;12(1):25-32 [Bychinin MV, Mandel' IA, Klypa TV, et al. Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit. Klinicheskaia praktika. 2021;12(1):25-32 (in Russian)]. DOI:10.17816/clinpract64976
48. D’Avolio A, Avataneo V, Manca A, et al. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. DOI:10.3390/nu12051359
49. Громова О.А., Торшин И.Ю., Малявская С.И., Лапочкина Н.П. О перспективах использования витамина D и других микронутриентов в профилактике и терапии COVID-19. РМЖ. 2020;28(9):32-8 [Gromova OA, Torshin IYu, Malyavskaia SI, Lapochkina NP. About the prospects of using vitamin D and other micronutrients in the prevention and therapy of COVID-19. RMZh. 2020;28(9):32-8 (in Russian)].
50. Громова О.А., Торшин И.Ю., Габдулина Г.Х. Пандемия COVID-19: защитная роль витамина D. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(2):132-45 [Gromova OA, Torshin IYu, Gabdulina GH. COVID-19 pandemic: protective role of vitamin D. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-45 (in Russian)]. DOI:10.17749/2070-4909/farmakoekonomika.2020.044
51. WHO Director-General’s opening remarks at the Special Session of the World Health Assembly. 29 November 2021. Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-s.... Accessed: 30.12.2021.
52. Давыдовский И.В. Общая патология человека. М.: Медицина, 1969 [Davydovskii IV. Obshchaia patologiia cheloveka. Moscow: Meditsina, 1969 (in Russian)].
53. Судаков К.В. Эволюция концепции стресса. Вестник Российской академии медицинских наук. 2008;11:59-66 [Sudakov KV. Evolution of the stress concept. Vestnik Rossiyskoi akademii meditsinskikh nauk. 2008;11:59-66 (in Russian)].
54. Valtueña J, González-Gross M, Huybrechts I, et al. Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):161-71. DOI:10.3177/jnsv.59.161
55. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60-84 [Pigarova EA, Rozhinskaya LYa, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy endokrinologii. 2016;62(4):60-84 (in Russian)].
56. COVID-19 rapid guideline: vitamin D. London: National Institute for Health and Care Excellence (NICE). 17 December 2020. NICE Guideline. 2020;187. Available at: https://www.ncbi.nlm.nih.gov/books/NBK566063/. Accessed: 30.12.2021.
57. Громова О.А., Торшин И.Ю., Пронин А.В. Особенности фармакологии водорастворимой формы витамина D на основе мицелл. Фарматека. 2015;1(294):28-35 [Gromova OA, Torshin IIu, Pronin AV. Osobennosti farmakologii vodorastvorimoi formy vitamina D na osnove mitsell. Farmateka. 2015;1(294):28-35 (in Russian)].
58. Heaney RP, Davies KM, Chen TC et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10. DOI:10.1093/ajcn/77.1.204
2. Drozdov VN. Vitamin D deficiency as a factor polymorbidity. Eksperimental’naia i klinicheskaia gastroenterologiia. 2015;118(6):82-8 (in Russian).
3. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73. DOI:10.4065/81.3.353
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. DOI:10.1093/ajcn/84.1.18
5. Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012;7:155-72. DOI:10.1007/s11657-012-0093-0
6. Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. DOI:10.1016/j.autrev.2013.02.004
7. Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. DOI:10.1016/j.beem.2011.06.007
8. Malyavskaya SI, Kostrova GN, Lebedev АV, et al. 25(OH)D Levels in the population of Arkhangelsk city in different age groups. Ekologiya cheloveka. 2018;1:60-4 (in Russian).
9. Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Ros. vestn. perinatologii i pediatrii. 2021;66(1):78-84 (in Russian). DOI:10.21508/1027-4065-2021-66-2-78-84
10. Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian). DOI:10.14341/probl12736
11. Torshin IYu, Limanova OA, Sardaryan IS, et al. Provision of vitamin D in children and adolescents aged 7 to 14 years and the relationship of deficiency of vitamin D with violations of children’s health: the analysis of a large-scale sample of patients by means of data mining. Pediatria. 2015;94(2):175-84 (in Russian).
12. Palermo NE, Holick MF. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179-92. DOI:10.3233/PRM-140287
13. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000;374(2):334-8. DOI:10.1006/abbi.1999.1605
14. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154(Suppl.):S57-73.
15. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase. J Clin Endocr Metab. 2001;86(2):888-94. DOI:10.1210/jcem.86.2.7220
16. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26-34. DOI:10.1210/jc.2008-1454
17. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2017 [Gromova OA, Torshin IYu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2017 (in Russian)].
18. Zakharova IN, Klimov LYa, Kasyanova AN, et al. Interrelationships between the incidence of infectious diseases and vitamin D deficiency: the current state of the problem. Infektsionnye bolezni. 2018;16(3):69-78 (in Russian). DOI:10.20953/1729-9225-2018-3-69-78
19. Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. Front Immunol. 2017;7:697. DOI:10.3389/fimmu.2016.00697
20. Liu NQ, Kaplan AT, Lagishetty V, et al. Vitamin D and the regulation of placental inflammation. J Immunol. 2011;186(10):5968-74. DOI:10.4049/jimmunol.1003332
21. Pigarova EA, Pleshcheev AV, Dzeranova LK. Influence of vitamin D on the immune system. Immunologiya. 2015;36(1):62-6 (in Russian).
22. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365-79. DOI:10.1016/j.ecl.2010.02.010
23. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169(4):384-90. DOI:10.1001/archinternmed.2008.560
24. Panda DК, Miao D, Tremblay МL, et al. Targeted ablation of the 25-hydroxyvitamin D alpha-hydroxylase enzyme: evidence for skeletal reproductive and immune dysfunction. Proc Natl Acad Sci USA. 2001;98(13):7498-503. DOI:10.1073/pnas.131029498
25. Zakharova IN, Klimov LYa, Kasyanova AN, et al. Modern conception about vitamin D immunotropic effects. Clinical Practice in Pediatrics. 2019;14(1):7-17 (in Russian). DOI:10.20953/1817-7646-2019-1-7-17
26. Zakharova IN, Maltsev SV, Zaplatnikov AL, et al. Influence of vitamin D on the immune response of the organism. Pediatrics. Consilium Medicum. 2020;2:29-37 (in Russian). DOI:10.26442/26586630.2020.2.200238
27. Abaturov AE, Gerasimenko ON, Vysochina IL, Zavgorodnyaya NYu. Defenziny i defenzin-zavisimye zabolevaniya. Odessa: VMV, 2011 (in Russian).
28. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50(3):194‑200. DOI:10.1016/j.jcv.2010.12.006
29. Hope-Simpson RE. The role of season in the epidemiology of influenza. J Hyg (Lond). 1981;86(1):35-47. DOI:10.1017/s0022172400068728
30. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106(9):1433-40. DOI:10.1017/S0007114511001991
31. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134(6):1129-40. DOI:10.1017/S0950268806007175
32. Karonova TL, Vashukova MA, Gusev DA, et al. Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID‑19. Arterial Hypertension. 2020;26(3):295-303 (in Russian). DOI:10.18705/1607-419X-2020-26-3-295-303
33. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. DOI:10.1136/bmj.i6583
34. Karatekin G, Kaya A, Salihoğlu O, et al. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63(4):473-7. DOI:10.1038/sj.ejcn.1602960
35. Zhou J, Du J, Huang L, et al. Preventive effects of vitamin D on seasonal influenza a in infants: a multicenter, randomized, open, controlled clinical trial. Pediatr Infect Dis J. 2018;37(8):749-54. DOI:10.1097/INF.0000000000001890
36. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-60. DOI:10.3945/ajcn.2009.29094
37. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323(18):1775-6. DOI:10.1001/jama.2020.4683
38. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China summary of a report of 72,314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. DOI:10.1001/jama.2020.2648
39. Charoenngam N, Shirvani A, Holick MF. Vitamin D and its potential benefit for the covid-19 pandemic. Endocr Pract. 2021;27(5):484-93. DOI:10.1016/j.eprac.2021.03.006
40. Taha R, Abureesh S, Alghamdi S, et al. The relationship between vitamin D and infections including COVID-19: any hopes? Int J Gen Med. 2021;14:3849-70. DOI:10.2147/IJGM.S317421
41. Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. DOI:10.1001/jamanetworkopen.2020.19722
42. Mercola J, Grant WB, Wagner CL. Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. Nutrients. 2020;12(11):3361. DOI:10.3390/nu12113361
43. Benskin LL. A basic review of the preliminary evidence that covid-19 risk and severity is increased in vitamin D deficiency. Front Public Health. 2020;8:513. DOI:10.3389/fpubh.2020.00513
44. Vasheghani M, Jannati N, Baghaei P, et al. The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality. Sci Rep. 2021;11(1):17594. DOI:10.1038/s41598-021-97017-9
45. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI:10.1001/jama.2020.1585
46. Wimalawansa SJ. Global epidemic of coronaviruses – COVID-19: What can we do to minimize risks. Eur J Biomed Pharm Sci. 2020;7:432-8.
47. Bychinin MV, Mandel' IA, Klypa TV, et al. Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit. Klinicheskaia praktika. 2021;12(1):25-32 (in Russian). DOI:10.17816/clinpract64976
48. D’Avolio A, Avataneo V, Manca A, et al. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. DOI:10.3390/nu12051359
49. Gromova OA, Torshin IYu, Malyavskaia SI, Lapochkina NP. About the prospects of using vitamin D and other micronutrients in the prevention and therapy of COVID-19. RMZh. 2020;28(9):32-8 (in Russian).
50. Gromova OA, Torshin IYu, Gabdulina GH. COVID-19 pandemic: protective role of vitamin D. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-45 (in Russian). DOI:10.17749/2070-4909/farmakoekonomika.2020.044
51. WHO Director-General’s opening remarks at the Special Session of the World Health Assembly. 29 November 2021. Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-s.... Accessed: 30.12.2021.
52. Davydovskii IV. Obshchaia patologiia cheloveka. Moscow: Meditsina, 1969 (in Russian).
53. Sudakov KV. Evolution of the stress concept. Vestnik Rossiyskoi akademii meditsinskikh nauk. 2008;11:59-66 (in Russian).
54. Valtueña J, González-Gross M, Huybrechts I, et al. Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):161-71. DOI:10.3177/jnsv.59.161
55. Pigarova EA, Rozhinskaya LYa, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy endokrinologii. 2016;62(4):60-84 (in Russian).
56. COVID-19 rapid guideline: vitamin D. London: National Institute for Health and Care Excellence (NICE). 17 December 2020. NICE Guideline. 2020;187. Available at: https://www.ncbi.nlm.nih.gov/books/NBK566063/. Accessed: 30.12.2021.
57. Gromova OA, Torshin IIu, Pronin AV. Osobennosti farmakologii vodorastvorimoi formy vitamina D na osnove mitsell. Farmateka. 2015;1(294):28-35 (in Russian).
58. Heaney RP, Davies KM, Chen TC et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10. DOI:10.1093/ajcn/77.1.204
2. Дроздов В.Н. Дефицит витамина D как фактор полиморбидности. Экспериментальная и клиническая гастроэнтерология. 2015;118(6):82-8 [Drozdov VN. Vitamin D deficiency as a factor polymorbidity. Eksperimental’naia i klinicheskaia gastroenterologiia. 2015;118(6):82-8 (in Russian)].
3. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73. DOI:10.4065/81.3.353
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. DOI:10.1093/ajcn/84.1.18
5. Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012;7:155-72. DOI:10.1007/s11657-012-0093-0
6. Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. DOI:10.1016/j.autrev.2013.02.004
7. Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. DOI:10.1016/j.beem.2011.06.007
8. Малявская С.И., Кострова Г.Н., Лебедев А.В., и др. Уровни витамина D у представителей различных групп населения города Архангельска. Экология человека. 2018;1:60-4 [Malyavskaya SI, Kostrova GN, Lebedev АV, et al. 25(OH)D Levels in the population of Arkhangelsk city in different age groups. Ekologiya cheloveka. 2018;1:60-4 (in Russian)].
9. Кондратьева Е.И., Лошкова Е.В., Захарова И.Н., и др. Оценка обеспеченности витамином D детей Москвы и Московской области. Рос. вестн. перинатологии и педиатрии. 2021;66(1):78-84 [Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Ros. vestn. perinatologii i pediatrii. 2021;66(1):78-84 (in Russian)]. DOI:10.21508/1027-4065-2021-66-2-78-84
10. Суплотова Л.А., Авдеева В.А., Пигарова Е.А., и др. Дефицит витамина D в России: первые результаты регистрового неинтервенционного исследования частоты дефицита и недостаточности витамина D в различных географических регионах страны. Проблемы эндокринологии. 2021;67(2):84-92 [Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian)]. DOI:10.14341/probl12736
11. Торшин И.Ю., Лиманова О.А., Сардарян И.С., и др. Обеспеченность витамином D детей и подростков 7–14 лет и взаимосвязь дефицита витамина D с нарушениями здоровья: анализ крупномасштабной выборки пациентов посредством интеллектуального анализа данных. Педиатрия. 2015;94(2):175-84 [Torshin IYu, Limanova OA, Sardaryan IS, et al. Provision of vitamin D in children and adolescents aged 7 to 14 years and the relationship of deficiency of vitamin D with violations of children’s health: the analysis of a large-scale sample of patients by means of data mining. Pediatria. 2015;94(2):175-84 (in Russian)].
12. Palermo NE, Holick MF. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179-92. DOI:10.3233/PRM-140287
13. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000;374(2):334-8. DOI:10.1006/abbi.1999.1605
14. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154(Suppl.):S57-73.
15. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase. J Clin Endocr Metab. 2001;86(2):888-94. DOI:10.1210/jcem.86.2.7220
16. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26-34. DOI:10.1210/jc.2008-1454
17. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2017 [Gromova OA, Torshin IYu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2017 (in Russian)].
18. Захарова И.Н., Климов Л.Я., Касьянова А.Н., и др. Взаимосвязь инфекционной заболеваемости и недостаточности витамина D: современное состояние проблемы. Инфекционные болезни. 2018;16(3):69-78 [Zakharova IN, Klimov LYa, Kasyanova AN, et al. Interrelationships between the incidence of infectious diseases and vitamin D deficiency: the current state of the problem. Infektsionnye bolezni. 2018;16(3):69-78 (in Russian)]. DOI:10.20953/1729-9225-2018-3-69-78
19. Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. Front Immunol. 2017;7:697. DOI:10.3389/fimmu.2016.00697
20. Liu NQ, Kaplan AT, Lagishetty V, et al. Vitamin D and the regulation of placental inflammation. J Immunol. 2011;186(10):5968-74. DOI:10.4049/jimmunol.1003332
21. Пигарова Е.А., Плещева А.В., Дзеранова Л.К. Влияние витамина D на иммунную систему. Иммунология. 2015;36(1):62-6 [Pigarova EA, Pleshcheev AV, Dzeranova LK. Influence of vitamin D on the immune system. Immunologiya. 2015;36(1):62-6 (in Russian)].
22. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365-79. DOI:10.1016/j.ecl.2010.02.010
23. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169(4):384-90. DOI:10.1001/archinternmed.2008.560
24. Panda DК, Miao D, Tremblay МL, et al. Targeted ablation of the 25-hydroxyvitamin D alpha-hydroxylase enzyme: evidence for skeletal reproductive and immune dysfunction. Proc Natl Acad Sci USA. 2001;98(13):7498-503. DOI:10.1073/pnas.131029498
25. Захарова И.Н., Климов Л.Я., Касьянова А.Н., и др. Современные представления об иммунотропных эффектах витамина D. Вопросы практической педиатрии. 2019;14(1):7-17 [Zakharova IN, Klimov LYa, Kasyanova AN, et al. Modern conception about vitamin D immunotropic effects. Clinical Practice in Pediatrics. 2019;14(1):7-17 (in Russian)]. DOI:10.20953/1817-7646-2019-1-7-17
26. Захарова И.Н., Мальцев С.В., Заплатников А.Л., и др. Влияние витамина D на иммунный ответ организма. Педиатрия. Consilium Medicum. 2020;2:29-37 [Zakharova IN, Maltsev SV, Zaplatnikov AL, et al. Influence of vitamin D on the immune response of the organism. Pediatrics. Consilium Medicum. 2020;2:29-37 (in Russian)]. DOI:10.26442/26586630.2020.2.200238
27. Абатуров А.Е., Герасименко О.Н., Высочина И.Л., Завгородняя Н.Ю. Дефензины и дефензин-зависимые заболевания. Одесса: ВМВ, 2011 [Abaturov AE, Gerasimenko ON, Vysochina IL, Zavgorodnyaya NYu. Defenziny i defenzin-zavisimye zabolevaniya. Odessa: VMV, 2011 (in Russian)].
28. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50(3):194‑200. DOI:10.1016/j.jcv.2010.12.006
29. Hope-Simpson RE. The role of season in the epidemiology of influenza. J Hyg (Lond). 1981;86(1):35-47. DOI:10.1017/s0022172400068728
30. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106(9):1433-40. DOI:10.1017/S0007114511001991
31. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134(6):1129-40. DOI:10.1017/S0950268806007175
32. Каронова Т.Л., Вашукова М.А., Гусев Д.А., и др. Витамин D как фактор повышения иммунитета и снижения риска развития острых респираторных вирусных инфекций и COVID-19. Артериальная гипертензия. 2020;26(3):295-303 [Karonova TL, Vashukova MA, Gusev DA, et al. Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID‑19. Arterial Hypertension. 2020;26(3):295-303 (in Russian)]. DOI:10.18705/1607-419X-2020-26-3-295-303
33. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. DOI:10.1136/bmj.i6583
34. Karatekin G, Kaya A, Salihoğlu O, et al. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63(4):473-7. DOI:10.1038/sj.ejcn.1602960
35. Zhou J, Du J, Huang L, et al. Preventive effects of vitamin D on seasonal influenza a in infants: a multicenter, randomized, open, controlled clinical trial. Pediatr Infect Dis J. 2018;37(8):749-54. DOI:10.1097/INF.0000000000001890
36. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-60. DOI:10.3945/ajcn.2009.29094
37. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323(18):1775-6. DOI:10.1001/jama.2020.4683
38. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China summary of a report of 72,314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. DOI:10.1001/jama.2020.2648
39. Charoenngam N, Shirvani A, Holick MF. Vitamin D and its potential benefit for the covid-19 pandemic. Endocr Pract. 2021;27(5):484-93. DOI:10.1016/j.eprac.2021.03.006
40. Taha R, Abureesh S, Alghamdi S, et al. The relationship between vitamin D and infections including COVID-19: any hopes? Int J Gen Med. 2021;14:3849-70. DOI:10.2147/IJGM.S317421
41. Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. DOI:10.1001/jamanetworkopen.2020.19722
42. Mercola J, Grant WB, Wagner CL. Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. Nutrients. 2020;12(11):3361. DOI:10.3390/nu12113361
43. Benskin LL. A basic review of the preliminary evidence that covid-19 risk and severity is increased in vitamin D deficiency. Front Public Health. 2020;8:513. DOI:10.3389/fpubh.2020.00513
44. Vasheghani M, Jannati N, Baghaei P, et al. The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality. Sci Rep. 2021;11(1):17594. DOI:10.1038/s41598-021-97017-9
45. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI:10.1001/jama.2020.1585
46. Wimalawansa SJ. Global epidemic of coronaviruses – COVID-19: What can we do to minimize risks. Eur J Biomed Pharm Sci. 2020;7:432-8.
47. Бычинин М.В., Мандель И.А., Клыпа Т.В., и др. Распространенность гиповитаминоза D у пациентов c COVID-19 в отделении реанимации и интенсивной терапии. Клиническая практика. 2021;12(1):25-32 [Bychinin MV, Mandel' IA, Klypa TV, et al. Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit. Klinicheskaia praktika. 2021;12(1):25-32 (in Russian)]. DOI:10.17816/clinpract64976
48. D’Avolio A, Avataneo V, Manca A, et al. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. DOI:10.3390/nu12051359
49. Громова О.А., Торшин И.Ю., Малявская С.И., Лапочкина Н.П. О перспективах использования витамина D и других микронутриентов в профилактике и терапии COVID-19. РМЖ. 2020;28(9):32-8 [Gromova OA, Torshin IYu, Malyavskaia SI, Lapochkina NP. About the prospects of using vitamin D and other micronutrients in the prevention and therapy of COVID-19. RMZh. 2020;28(9):32-8 (in Russian)].
50. Громова О.А., Торшин И.Ю., Габдулина Г.Х. Пандемия COVID-19: защитная роль витамина D. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(2):132-45 [Gromova OA, Torshin IYu, Gabdulina GH. COVID-19 pandemic: protective role of vitamin D. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-45 (in Russian)]. DOI:10.17749/2070-4909/farmakoekonomika.2020.044
51. WHO Director-General’s opening remarks at the Special Session of the World Health Assembly. 29 November 2021. Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-s.... Accessed: 30.12.2021.
52. Давыдовский И.В. Общая патология человека. М.: Медицина, 1969 [Davydovskii IV. Obshchaia patologiia cheloveka. Moscow: Meditsina, 1969 (in Russian)].
53. Судаков К.В. Эволюция концепции стресса. Вестник Российской академии медицинских наук. 2008;11:59-66 [Sudakov KV. Evolution of the stress concept. Vestnik Rossiyskoi akademii meditsinskikh nauk. 2008;11:59-66 (in Russian)].
54. Valtueña J, González-Gross M, Huybrechts I, et al. Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):161-71. DOI:10.3177/jnsv.59.161
55. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60-84 [Pigarova EA, Rozhinskaya LYa, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy endokrinologii. 2016;62(4):60-84 (in Russian)].
56. COVID-19 rapid guideline: vitamin D. London: National Institute for Health and Care Excellence (NICE). 17 December 2020. NICE Guideline. 2020;187. Available at: https://www.ncbi.nlm.nih.gov/books/NBK566063/. Accessed: 30.12.2021.
57. Громова О.А., Торшин И.Ю., Пронин А.В. Особенности фармакологии водорастворимой формы витамина D на основе мицелл. Фарматека. 2015;1(294):28-35 [Gromova OA, Torshin IIu, Pronin AV. Osobennosti farmakologii vodorastvorimoi formy vitamina D na osnove mitsell. Farmateka. 2015;1(294):28-35 (in Russian)].
58. Heaney RP, Davies KM, Chen TC et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10. DOI:10.1093/ajcn/77.1.204
________________________________________________
2. Drozdov VN. Vitamin D deficiency as a factor polymorbidity. Eksperimental’naia i klinicheskaia gastroenterologiia. 2015;118(6):82-8 (in Russian).
3. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-73. DOI:10.4065/81.3.353
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28. DOI:10.1093/ajcn/84.1.18
5. Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012;7:155-72. DOI:10.1007/s11657-012-0093-0
6. Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. DOI:10.1016/j.autrev.2013.02.004
7. Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. DOI:10.1016/j.beem.2011.06.007
8. Malyavskaya SI, Kostrova GN, Lebedev АV, et al. 25(OH)D Levels in the population of Arkhangelsk city in different age groups. Ekologiya cheloveka. 2018;1:60-4 (in Russian).
9. Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Ros. vestn. perinatologii i pediatrii. 2021;66(1):78-84 (in Russian). DOI:10.21508/1027-4065-2021-66-2-78-84
10. Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian). DOI:10.14341/probl12736
11. Torshin IYu, Limanova OA, Sardaryan IS, et al. Provision of vitamin D in children and adolescents aged 7 to 14 years and the relationship of deficiency of vitamin D with violations of children’s health: the analysis of a large-scale sample of patients by means of data mining. Pediatria. 2015;94(2):175-84 (in Russian).
12. Palermo NE, Holick MF. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179-92. DOI:10.3233/PRM-140287
13. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000;374(2):334-8. DOI:10.1006/abbi.1999.1605
14. Haussler MR, Haussler CA, Jurutka PW, et al. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154(Suppl.):S57-73.
15. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase. J Clin Endocr Metab. 2001;86(2):888-94. DOI:10.1210/jcem.86.2.7220
16. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26-34. DOI:10.1210/jc.2008-1454
17. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2017 [Gromova OA, Torshin IYu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2017 (in Russian)].
18. Zakharova IN, Klimov LYa, Kasyanova AN, et al. Interrelationships between the incidence of infectious diseases and vitamin D deficiency: the current state of the problem. Infektsionnye bolezni. 2018;16(3):69-78 (in Russian). DOI:10.20953/1729-9225-2018-3-69-78
19. Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. Front Immunol. 2017;7:697. DOI:10.3389/fimmu.2016.00697
20. Liu NQ, Kaplan AT, Lagishetty V, et al. Vitamin D and the regulation of placental inflammation. J Immunol. 2011;186(10):5968-74. DOI:10.4049/jimmunol.1003332
21. Pigarova EA, Pleshcheev AV, Dzeranova LK. Influence of vitamin D on the immune system. Immunologiya. 2015;36(1):62-6 (in Russian).
22. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365-79. DOI:10.1016/j.ecl.2010.02.010
23. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169(4):384-90. DOI:10.1001/archinternmed.2008.560
24. Panda DК, Miao D, Tremblay МL, et al. Targeted ablation of the 25-hydroxyvitamin D alpha-hydroxylase enzyme: evidence for skeletal reproductive and immune dysfunction. Proc Natl Acad Sci USA. 2001;98(13):7498-503. DOI:10.1073/pnas.131029498
25. Zakharova IN, Klimov LYa, Kasyanova AN, et al. Modern conception about vitamin D immunotropic effects. Clinical Practice in Pediatrics. 2019;14(1):7-17 (in Russian). DOI:10.20953/1817-7646-2019-1-7-17
26. Zakharova IN, Maltsev SV, Zaplatnikov AL, et al. Influence of vitamin D on the immune response of the organism. Pediatrics. Consilium Medicum. 2020;2:29-37 (in Russian). DOI:10.26442/26586630.2020.2.200238
27. Abaturov AE, Gerasimenko ON, Vysochina IL, Zavgorodnyaya NYu. Defenziny i defenzin-zavisimye zabolevaniya. Odessa: VMV, 2011 (in Russian).
28. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50(3):194‑200. DOI:10.1016/j.jcv.2010.12.006
29. Hope-Simpson RE. The role of season in the epidemiology of influenza. J Hyg (Lond). 1981;86(1):35-47. DOI:10.1017/s0022172400068728
30. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106(9):1433-40. DOI:10.1017/S0007114511001991
31. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134(6):1129-40. DOI:10.1017/S0950268806007175
32. Karonova TL, Vashukova MA, Gusev DA, et al. Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID‑19. Arterial Hypertension. 2020;26(3):295-303 (in Russian). DOI:10.18705/1607-419X-2020-26-3-295-303
33. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. DOI:10.1136/bmj.i6583
34. Karatekin G, Kaya A, Salihoğlu O, et al. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63(4):473-7. DOI:10.1038/sj.ejcn.1602960
35. Zhou J, Du J, Huang L, et al. Preventive effects of vitamin D on seasonal influenza a in infants: a multicenter, randomized, open, controlled clinical trial. Pediatr Infect Dis J. 2018;37(8):749-54. DOI:10.1097/INF.0000000000001890
36. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-60. DOI:10.3945/ajcn.2009.29094
37. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323(18):1775-6. DOI:10.1001/jama.2020.4683
38. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China summary of a report of 72,314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. DOI:10.1001/jama.2020.2648
39. Charoenngam N, Shirvani A, Holick MF. Vitamin D and its potential benefit for the covid-19 pandemic. Endocr Pract. 2021;27(5):484-93. DOI:10.1016/j.eprac.2021.03.006
40. Taha R, Abureesh S, Alghamdi S, et al. The relationship between vitamin D and infections including COVID-19: any hopes? Int J Gen Med. 2021;14:3849-70. DOI:10.2147/IJGM.S317421
41. Meltzer DO, Best TJ, Zhang H, et al. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. DOI:10.1001/jamanetworkopen.2020.19722
42. Mercola J, Grant WB, Wagner CL. Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. Nutrients. 2020;12(11):3361. DOI:10.3390/nu12113361
43. Benskin LL. A basic review of the preliminary evidence that covid-19 risk and severity is increased in vitamin D deficiency. Front Public Health. 2020;8:513. DOI:10.3389/fpubh.2020.00513
44. Vasheghani M, Jannati N, Baghaei P, et al. The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality. Sci Rep. 2021;11(1):17594. DOI:10.1038/s41598-021-97017-9
45. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI:10.1001/jama.2020.1585
46. Wimalawansa SJ. Global epidemic of coronaviruses – COVID-19: What can we do to minimize risks. Eur J Biomed Pharm Sci. 2020;7:432-8.
47. Bychinin MV, Mandel' IA, Klypa TV, et al. Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit. Klinicheskaia praktika. 2021;12(1):25-32 (in Russian). DOI:10.17816/clinpract64976
48. D’Avolio A, Avataneo V, Manca A, et al. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. DOI:10.3390/nu12051359
49. Gromova OA, Torshin IYu, Malyavskaia SI, Lapochkina NP. About the prospects of using vitamin D and other micronutrients in the prevention and therapy of COVID-19. RMZh. 2020;28(9):32-8 (in Russian).
50. Gromova OA, Torshin IYu, Gabdulina GH. COVID-19 pandemic: protective role of vitamin D. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-45 (in Russian). DOI:10.17749/2070-4909/farmakoekonomika.2020.044
51. WHO Director-General’s opening remarks at the Special Session of the World Health Assembly. 29 November 2021. Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-s.... Accessed: 30.12.2021.
52. Davydovskii IV. Obshchaia patologiia cheloveka. Moscow: Meditsina, 1969 (in Russian).
53. Sudakov KV. Evolution of the stress concept. Vestnik Rossiyskoi akademii meditsinskikh nauk. 2008;11:59-66 (in Russian).
54. Valtueña J, González-Gross M, Huybrechts I, et al. Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):161-71. DOI:10.3177/jnsv.59.161
55. Pigarova EA, Rozhinskaya LYa, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy endokrinologii. 2016;62(4):60-84 (in Russian).
56. COVID-19 rapid guideline: vitamin D. London: National Institute for Health and Care Excellence (NICE). 17 December 2020. NICE Guideline. 2020;187. Available at: https://www.ncbi.nlm.nih.gov/books/NBK566063/. Accessed: 30.12.2021.
57. Gromova OA, Torshin IIu, Pronin AV. Osobennosti farmakologii vodorastvorimoi formy vitamina D na osnove mitsell. Farmateka. 2015;1(294):28-35 (in Russian).
58. Heaney RP, Davies KM, Chen TC et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10. DOI:10.1093/ajcn/77.1.204
Авторы
С.И. Малявская*
ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России, Архангельск, Россия
*malyavskaya@yandex.ru
Northern State Medical University, Arkhangelsk, Russia
*malyavskaya@yandex.ru
ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России, Архангельск, Россия
*malyavskaya@yandex.ru
________________________________________________
Northern State Medical University, Arkhangelsk, Russia
*malyavskaya@yandex.ru
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