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Аппендэктомия и воспалительные заболевания кишечника – существует ли связь?
Аппендэктомия и воспалительные заболевания кишечника – существует ли связь?
Коровин С.А., Оробинский С.Б., Оробинская Я.В.,Соколов Ю.Ю.,Захарова И.Н. Аппендэктомия и воспалительные заболевания кишечника – существует ли связь? Педиатрия. Consilium Medicum. 2024;2:198–203. DOI: 10.26442/26586630.2024.2.202931
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
DOI: 10.26442/26586630.2024.2.202931
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
DOI: 10.26442/26586630.2024.2.202931
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Аппендикс исторически считался рудиментарным органом с неизвестной функцией. В настоящее время его роли в человеческом организме отведено особое место. Доказано, что он является «копилкой» для комменсальных микроорганизмов и выполняет роль иммунологического органа. Влияние аппендэктомии на развитие язвенного колита и болезни Крона является предметом дискуссий на протяжении более 30 лет. Сообщается, что удаление червеобразного отростка в раннем возрасте уменьшает риск развития язвенного колита, но приводит к прогрессирующему течению болезни Крона. Эти наблюдения привели к постулату о том, что между аппендэктомией и воспалительными заболеваниями кишечника может существовать взаимосвязь, которую можно объяснить иммуномодулирующим эффектом оперативного вмешательства. До сих пор нет окончательных доказательств защитной или повреждающей роли червеобразного отростка при воспалительных заболеваниях кишечника, что является перспективой для будущих исследований.
Ключевые слова: аппендикс, аппендицит, аппендэктомия, воспалительные заболевания кишечника, микробиом кишечника, микробиота аппендикса
Keywords: appendix, appendicitis, appendectomy, inflammatory bowel disease, gut microbiome, appendix microbiota
Ключевые слова: аппендикс, аппендицит, аппендэктомия, воспалительные заболевания кишечника, микробиом кишечника, микробиота аппендикса
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Keywords: appendix, appendicitis, appendectomy, inflammatory bowel disease, gut microbiome, appendix microbiota
Полный текст
Список литературы
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2. Schumpelick V, Dreuw B, Ophoff K, Prescher A. Appendix and cecum. Embryology, anatomy, and surgical applications. Surg Clin North Am. 2000;80(1):295-318.
DOI:10.1016/s0039-6109(05)70407-2
3. Mohammadi S, Hedjazi A, Sajjadian M, et al. Morphological variations of the vermiform appendix in Iranian cadavers: a study fr om developing countries. Folia Morphol (Warsz). 2017;76(4):695-701. DOI:10.5603/FM.a2017.0032
4. Bhangu A, Søreide K, Di Saverio S, et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet.
2015;386(10000):1278-87. DOI:10.1016/S0140-6736(15)00275-5. Erratum in: Lancet. 2017;390(10104):1736. DOI:10.1016/S0140-6736(17)31502-7
5. Gonzalez DO, Deans KJ, Minneci PC. Role of non-operative management in pediatric appendicitis. Semin Pediatr Surg. 2016;25(4):204-7. DOI:10.1053/j.sempedsurg.2016.05.002
6. Shi F, Liu G, Lin Y, et al. Altered gut microbiome composition by appendectomy contributes to colorectal cancer. Oncogene. 2023;42(7):530-40. DOI:10.1038/s41388-022-02569-3
7. Kooij IA, Sahami S, Meijer SL, et al. The immunology of the vermiform appendix: a review of the literature. Clin Exp Immunol. 2016;186(1):1-9. DOI:10.1111/cei.12821
8. Kiasat A, Ekström LD, Marsk R, et al. Childhood appendicitis and future risk of inflammatory bowel disease – A nationwide cohort study in Sweden 1973-2017. Colorectal Dis. 2022;24(8):975-83. DOI:10.1111/codi.16128
9. Fava F, Danese S. Intestinal microbiota in inflammatory bowel disease: friend of foe? World J Gastroenterol. 2011;17(5):557-66. DOI:10.3748/wjg.v17.i5.557
10. Ansaloni L, Catena F, Pinna AD. What is the function of the human vermiform appendix? Evolution-based surgery: a new perspective in the Darwinian year 2009. Eur Surg Res. Europaische Chirurgische Forschung Recherches Chirurgicales Europeennes. 2009;43:67-71. DOI:10.1159/000219236
11. Darwin C. The descent of man, and selection in relation to sex. London, England UK: John Murray. 1871;1:423.
12. Rhee KJ, Sethupathi P, Driks A, et al. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol.
2004;172:1118-24. DOI:10.4049/jimmunol.172.2.1118
13. Hanson NB, Lanning DK. Microbial induction of B and T cell areas in rabbit appendix. Dev Comp Immunol. 2008;32:980-91. DOI:10.1016/j.dci.2008.01.013
14. Vitetta L, Chen J, Clarke S. The vermiform appendix: an immunological organ sustaining a microbiome inoculum. Clin Sci (Lond). 2019;133(1):1-8. DOI:10.1042/CS20180956
15. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8:523-32. DOI:10.1038/nri2343
16. Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, et al. Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology. 2004;113:371-7. DOI:10.1111/j.1365-2567.2004.01961.x
17. Costerton JW, Lewandowski Z, Caldwell DE, et al. Microbial biofilms. Annu Rev Microbiol. 1995;49:711-45. DOI:10.1146/annurev.mi.49.100195.003431
18. Guinane CM, Tadrous A, Fouhy F, et al. Microbial composition of human appendices from patients following appendectomy. mBio. 2013;4(1):e00366-12. DOI:10.1128/mBio.00366-12
19. Rogers MB, Brower-Sinning R, Firek B, et al. Acute Appendicitis in Children is Associated With a Local Expansion of Fusobacteria. Clin Infect Dis. 2016;63(1):71-8. DOI:10.1093/cid/ciw208
20. Vanhatalo S, Munukka E, Sippola S, et al. Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial. BMJ Open. 2019;9(9):e031137. DOI:10.1136/bmjopen-2019-031137
21. Clanton J, Subichin M, Drolshagen K, et al. Fulminant Clostridium difficile infection: An association with prior appendectomy? World J Gastrointest Surg. 2013;5(8):233-8. DOI:10.4240/wjgs.v5.i8.233
22. Smith HF, Fisher RE, Everett ML, et al. Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix. J Evol Biol. 2009;22(10):1984-99.
DOI:10.1111/j.1420-9101.2009.01809.x
23. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007;245(6):886-92. DOI:10.1097/01.sla.0000256391.05233.aa
24. Ferris M, Quan S, Kaplan BS, et al. The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. Ann Surg. 2017;266(2):237-41. DOI:10.1097/SLA.0000000000002188
25. Andreu-Ballester JC, Pérez-Griera J, Ballester F, et al. Secretory immunoglobulin A (sIgA) deficiency in serum of patients with GALTectomy (appendectomy and tonsillectomy). Clin Immunol. 2007;123(3):289-97. DOI:10.1016/j.clim.2007.02.004
26. Masahata K, Umemoto E, Kayama H, et al. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014;5:3704. DOI:10.1038/ncomms4704
27. Cai S, Fan Y, Zhang B, et al. Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities. Front Microbiol. 2021;12:724980. DOI:10.3389/fmicb.2021.724980
28. Koutroubakis IE, Vlachonikolis IG, Kouroumalis EA. Role of appendicitis and appendectomy in the pathogenesis of ulcerative colitis: a critical review. Inflamm Bowel Dis. 2002;8(4):277-86. DOI:10.1097/00054725-200207000-00007
29. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med. 2001;344(11):808-14. DOI:10.1056/NEJM200103153441104
30. Gecse K, Róka R, Séra T, et al. Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion. 2012;85(1):40-6. DOI:10.1159/000333083
31. Yokode M, Shiokawa M, Kawakami H, et al. Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis. Br J Cancer. 2024;130(9):1552-60. DOI:10.1038/s41416-024-02647-1
32. Barbara G, Barbaro MR, Fuschi D, et al. Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier. Front Nutr. 2021;8:718356. DOI:10.3389/fnut.2021.718356. Erratum in: Front Nutr. 2021;8:790387. DOI:10.3389/fnut.2021.790387
33. Lynch WD, Hsu R. Ulcerative Colitis. 2023 Jun 5. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
34. Gilat T, Hacohen D, Lilos P, Langman MJ. Childhood factors in ulcerative colitis and Crohn’s disease. An international cooperative study. Scand J Gastroenterol. 1987;22(8):1009-24. DOI:10.3109/00365528708991950
35. Kiasat A, Ekström LD, Marsk R, et al. Childhood appendicitis and future risk of inflammatory bowel disease – A nationwide cohort study in Sweden 1973-2017. Colorectal Dis. 2022;24(8):975-83. DOI:10.1111/codi.16128
36. Stellingwerf ME, Sahami S, Winter DC, et al. Prospective cohort study of appendicectomy for treatment of therapy-refractory ulcerative colitis. Br J Surg.
2019;106(12):1697-704. DOI:10.1002/bjs.11259
37. Myrelid P, Landerholm K, Nordenvall C, et al. Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study. Am J Gastroenterol. 2017;112(8):1311-9. DOI:10.1038/ajg.2017.183
38. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK. Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J Exp Med. 1996;184(2):707-15. DOI:10.1084/jem.184.2.707
39. Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J Gastroenterol Hepatol. 2002;17(8):849-53. DOI:10.1046/j.1440-1746.2002.02834.x
40. Motta JP, Allain T, Green-Harrison LE, et al. Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018;24(7):1493-502. DOI:10.1093/ibd/izy116
41. Jo Y, Matsumoto T, Yada S, et al. Histological and immunological features of appendix in patients with ulcerative colitis. Dig Dis Sci. 2003;48(1):99-108. DOI:10.1023/a:1021742616794
42. Zakharova IN, Osmanov IM, Korovin SA, et al. Appendix: “an appendage to a twelve-meter gut or a storehouse for microbiota”? Medical Council. 2024;(1):293-301 (in Russian). DOI:10.21518/ms2024-004
43. Arjomand Fard N, Armstrong H, Perry T, Wine E. Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies? Inflamm Bowel Dis. 2023;29(1):151-60. DOI:10.1093/ibd/izac106
44. Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005;129(2):550-64. DOI:10.1016/j.gastro.2005.05.002
45. Cheluvappa R, Luo AS, Grimm MC. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol. 2014;175(2):316-22. DOI:10.1111/cei.12237
46. Cheluvappa R, Eri R, Luo AS, Grimm MC. Endothelin and vascular remodelling in colitis pathogenesis – appendicitis and appendectomy lim it colitis by suppressing endothelin pathways. Int J Colorectal Dis. 2014;29(11):1321-8. DOI:10.1007/s00384-014-1974-z
47. Harnoy Y, Bouhnik Y, Gault N, et al. Effect of appendicectomy on colonic inflammation and neoplasia in experimental ulcerative colitis. Br J Surg. 2016;103(11):1530-8. DOI:10.1002/bjs.10209
48. Yue M, Shen Z, Yu CH, et al. Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis. World J Gastroenterol. 2011;17(19):2437-45. DOI:10.3748/wjg.v17.i19.2437
49. Morelli MS, Zucker SD. A role for the appendix in inflammatory bowel disease? Cut it out. Gastroenterology. 2003;125(4):1270-2.
50. Park SH, Loftus EV Jr, Yang SK. Appendiceal skip inflammation and ulcerative colitis. Dig Dis Sci. 2014;59(9):2050-7. DOI:10.1007/s10620-014-3129-z
51. Reijntjes MA, Heuthorst L, Gecse K, et al. Clinical relevance of endoscopic periappendiceal red patch in ulcerative colitis patients. Therap Adv Gastroenterol. 2022;15:17562848221098849. DOI:10.1177/17562848221098849
52. Liu X, Goldblum JR, Zhao Z, et al. Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: in comparison with sporadic microsatellite-stable and Lynch syndrome-related colorectal adenocarcinoma. Am J Surg Pathol. 2012;36(8):1228-33. DOI:10.1097/PAS.0b013e318253645a
53. MCVAY JR Jr. The appendix in relation to neoplastic disease. Cancer. 1964;17:929-37. DOI:10.1002/1097-0142(196407)17:7<929::aid-cncr2820170713>3.0.co;2-o
54. Zhang Y, Khil J, Feng X, et al. Risk of colorectal cancer and adenoma after an appendectomy: results from three large prospective cohort studies and meta-analysis. Cancer Causes Control. 2024. DOI:10.1007/s10552-024-01901-4
55. Hale LP, Greer PK. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One. 2012;7(7):e41797. DOI:10.1371/journal.pone.0041797
56. Wu SC, Chen WT, Muo CH, et al. Association between appendectomy and subsequent colorectal cancer development: an Asian population study. PLoS One. 2015;10(2):e0118411. DOI:10.1371/journal.pone.0118411
57. Collard MK, Tourneur-Marsille J, Uzzan M, et al. The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer. Cell Mol Gastroenterol Hepatol. 2023;15(3):665-87. DOI:10.1016/j.jcmgh.2022.10.016
58. Chung WS, Chung S, Hsu CY, Lin CL. Risk of Inflammatory Bowel Disease Following Appendectomy in Adulthood. Front Med (Lausanne). 2021;8:661752. DOI:10.3389/fmed.2021.661752
59. Fantodji C, Jantchou P, Parent ME, Rousseau MC. Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy – a cohort study. BMJ Open Gastroenterol. 2022;9(1):e000925. DOI:10.1136/bmjgast-2022-000925
60. Zhang L, Hu C, Zhang Z, et al. Association between prior appendectomy and the risk and course of Crohn’s disease: A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2023;47(3):102090. DOI:10.1016/j.clinre.2023.102090
61. van der Does de Willebois EML, Sari C, Mookhoek A, et al. The Clinical Relevance of an Inflamed Appendix in Crohn’s Disease. J Crohns Colitis. 2024;18(6):812-7.
DOI:10.1093/ecco-jcc/jjad202
62. Malvar G, Peric M, Gonzalez RS. Interval appendicitis shows histological differences from acute appendicitis and may mimic Crohn disease and other forms of granulomatous appendicitis. Histopathology. 2022;80(6):965-73. DOI:10.1111/his.14621
63. Mostyka M, Fulmer CG, Hissong EM, Yantiss RK. Crohn Disease Infrequently Affects the Appendix and Rarely Causes Granulomatous Appendicitis. Am J Surg Pathol. 2021;45(12):1703-6. DOI:10.1097/PAS.0000000000001734
64. Kaplan GG, Jackson T, Sands BE, et al. The risk of developing Crohn’s disease after an appendectomy: a meta-analysis. Am J Gastroenterol.
2008;103(11):2925-31. DOI:10.1111/j.1572-0241.2008.02118.x
2. Schumpelick V, Dreuw B, Ophoff K, Prescher A. Appendix and cecum. Embryology, anatomy, and surgical applications. Surg Clin North Am. 2000;80(1):295-318.
DOI:10.1016/s0039-6109(05)70407-2
3. Mohammadi S, Hedjazi A, Sajjadian M, et al. Morphological variations of the vermiform appendix in Iranian cadavers: a study fr om developing countries. Folia Morphol (Warsz). 2017;76(4):695-701. DOI:10.5603/FM.a2017.0032
4. Bhangu A, Søreide K, Di Saverio S, et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet.
2015;386(10000):1278-87. DOI:10.1016/S0140-6736(15)00275-5. Erratum in: Lancet. 2017;390(10104):1736. DOI:10.1016/S0140-6736(17)31502-7
5. Gonzalez DO, Deans KJ, Minneci PC. Role of non-operative management in pediatric appendicitis. Semin Pediatr Surg. 2016;25(4):204-7. DOI:10.1053/j.sempedsurg.2016.05.002
6. Shi F, Liu G, Lin Y, et al. Altered gut microbiome composition by appendectomy contributes to colorectal cancer. Oncogene. 2023;42(7):530-40. DOI:10.1038/s41388-022-02569-3
7. Kooij IA, Sahami S, Meijer SL, et al. The immunology of the vermiform appendix: a review of the literature. Clin Exp Immunol. 2016;186(1):1-9. DOI:10.1111/cei.12821
8. Kiasat A, Ekström LD, Marsk R, et al. Childhood appendicitis and future risk of inflammatory bowel disease – A nationwide cohort study in Sweden 1973-2017. Colorectal Dis. 2022;24(8):975-83. DOI:10.1111/codi.16128
9. Fava F, Danese S. Intestinal microbiota in inflammatory bowel disease: friend of foe? World J Gastroenterol. 2011;17(5):557-66. DOI:10.3748/wjg.v17.i5.557
10. Ansaloni L, Catena F, Pinna AD. What is the function of the human vermiform appendix? Evolution-based surgery: a new perspective in the Darwinian year 2009. Eur Surg Res. Europaische Chirurgische Forschung Recherches Chirurgicales Europeennes. 2009;43:67-71. DOI:10.1159/000219236
11. Darwin C. The descent of man, and selection in relation to sex. London, England UK: John Murray. 1871;1:423.
12. Rhee KJ, Sethupathi P, Driks A, et al. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol.
2004;172:1118-24. DOI:10.4049/jimmunol.172.2.1118
13. Hanson NB, Lanning DK. Microbial induction of B and T cell areas in rabbit appendix. Dev Comp Immunol. 2008;32:980-91. DOI:10.1016/j.dci.2008.01.013
14. Vitetta L, Chen J, Clarke S. The vermiform appendix: an immunological organ sustaining a microbiome inoculum. Clin Sci (Lond). 2019;133(1):1-8. DOI:10.1042/CS20180956
15. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8:523-32. DOI:10.1038/nri2343
16. Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, et al. Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology. 2004;113:371-7. DOI:10.1111/j.1365-2567.2004.01961.x
17. Costerton JW, Lewandowski Z, Caldwell DE, et al. Microbial biofilms. Annu Rev Microbiol. 1995;49:711-45. DOI:10.1146/annurev.mi.49.100195.003431
18. Guinane CM, Tadrous A, Fouhy F, et al. Microbial composition of human appendices from patients following appendectomy. mBio. 2013;4(1):e00366-12. DOI:10.1128/mBio.00366-12
19. Rogers MB, Brower-Sinning R, Firek B, et al. Acute Appendicitis in Children is Associated With a Local Expansion of Fusobacteria. Clin Infect Dis. 2016;63(1):71-8. DOI:10.1093/cid/ciw208
20. Vanhatalo S, Munukka E, Sippola S, et al. Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial. BMJ Open. 2019;9(9):e031137. DOI:10.1136/bmjopen-2019-031137
21. Clanton J, Subichin M, Drolshagen K, et al. Fulminant Clostridium difficile infection: An association with prior appendectomy? World J Gastrointest Surg. 2013;5(8):233-8. DOI:10.4240/wjgs.v5.i8.233
22. Smith HF, Fisher RE, Everett ML, et al. Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix. J Evol Biol. 2009;22(10):1984-99.
DOI:10.1111/j.1420-9101.2009.01809.x
23. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007;245(6):886-92. DOI:10.1097/01.sla.0000256391.05233.aa
24. Ferris M, Quan S, Kaplan BS, et al. The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. Ann Surg. 2017;266(2):237-41. DOI:10.1097/SLA.0000000000002188
25. Andreu-Ballester JC, Pérez-Griera J, Ballester F, et al. Secretory immunoglobulin A (sIgA) deficiency in serum of patients with GALTectomy (appendectomy and tonsillectomy). Clin Immunol. 2007;123(3):289-97. DOI:10.1016/j.clim.2007.02.004
26. Masahata K, Umemoto E, Kayama H, et al. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014;5:3704. DOI:10.1038/ncomms4704
27. Cai S, Fan Y, Zhang B, et al. Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities. Front Microbiol. 2021;12:724980. DOI:10.3389/fmicb.2021.724980
28. Koutroubakis IE, Vlachonikolis IG, Kouroumalis EA. Role of appendicitis and appendectomy in the pathogenesis of ulcerative colitis: a critical review. Inflamm Bowel Dis. 2002;8(4):277-86. DOI:10.1097/00054725-200207000-00007
29. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med. 2001;344(11):808-14. DOI:10.1056/NEJM200103153441104
30. Gecse K, Róka R, Séra T, et al. Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion. 2012;85(1):40-6. DOI:10.1159/000333083
31. Yokode M, Shiokawa M, Kawakami H, et al. Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis. Br J Cancer. 2024;130(9):1552-60. DOI:10.1038/s41416-024-02647-1
32. Barbara G, Barbaro MR, Fuschi D, et al. Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier. Front Nutr. 2021;8:718356. DOI:10.3389/fnut.2021.718356. Erratum in: Front Nutr. 2021;8:790387. DOI:10.3389/fnut.2021.790387
33. Lynch WD, Hsu R. Ulcerative Colitis. 2023 Jun 5. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
34. Gilat T, Hacohen D, Lilos P, Langman MJ. Childhood factors in ulcerative colitis and Crohn’s disease. An international cooperative study. Scand J Gastroenterol. 1987;22(8):1009-24. DOI:10.3109/00365528708991950
35. Kiasat A, Ekström LD, Marsk R, et al. Childhood appendicitis and future risk of inflammatory bowel disease – A nationwide cohort study in Sweden 1973-2017. Colorectal Dis. 2022;24(8):975-83. DOI:10.1111/codi.16128
36. Stellingwerf ME, Sahami S, Winter DC, et al. Prospective cohort study of appendicectomy for treatment of therapy-refractory ulcerative colitis. Br J Surg.
2019;106(12):1697-704. DOI:10.1002/bjs.11259
37. Myrelid P, Landerholm K, Nordenvall C, et al. Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study. Am J Gastroenterol. 2017;112(8):1311-9. DOI:10.1038/ajg.2017.183
38. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK. Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J Exp Med. 1996;184(2):707-15. DOI:10.1084/jem.184.2.707
39. Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J Gastroenterol Hepatol. 2002;17(8):849-53. DOI:10.1046/j.1440-1746.2002.02834.x
40. Motta JP, Allain T, Green-Harrison LE, et al. Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018;24(7):1493-502. DOI:10.1093/ibd/izy116
41. Jo Y, Matsumoto T, Yada S, et al. Histological and immunological features of appendix in patients with ulcerative colitis. Dig Dis Sci. 2003;48(1):99-108. DOI:10.1023/a:1021742616794
42. Захарова И.Н., Османов И.М., Коровин С.А., и др. Аппендикс – «приложение к двенадцати метрам кишечника или кладовая микробиоты»? Медицинский Совет.
2024;(1):293-301 [Zakharova IN, Osmanov IM, Korovin SA, et al. Appendix: “an appendage to a twelve-meter gut or a storehouse for microbiota”? Medical Council. 2024;(1):293-301 (in Russian)]. DOI:10.21518/ms2024-004
43. Arjomand Fard N, Armstrong H, Perry T, Wine E. Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies? Inflamm Bowel Dis. 2023;29(1):151-60. DOI:10.1093/ibd/izac106
44. Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005;129(2):550-64. DOI:10.1016/j.gastro.2005.05.002
45. Cheluvappa R, Luo AS, Grimm MC. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol. 2014;175(2):316-22. DOI:10.1111/cei.12237
46. Cheluvappa R, Eri R, Luo AS, Grimm MC. Endothelin and vascular remodelling in colitis pathogenesis – appendicitis and appendectomy lim it colitis by suppressing endothelin pathways. Int J Colorectal Dis. 2014;29(11):1321-8. DOI:10.1007/s00384-014-1974-z
47. Harnoy Y, Bouhnik Y, Gault N, et al. Effect of appendicectomy on colonic inflammation and neoplasia in experimental ulcerative colitis. Br J Surg. 2016;103(11):1530-8. DOI:10.1002/bjs.10209
48. Yue M, Shen Z, Yu CH, et al. Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis. World J Gastroenterol. 2011;17(19):2437-45. DOI:10.3748/wjg.v17.i19.2437
49. Morelli MS, Zucker SD. A role for the appendix in inflammatory bowel disease? Cut it out. Gastroenterology. 2003;125(4):1270-2.
50. Park SH, Loftus EV Jr, Yang SK. Appendiceal skip inflammation and ulcerative colitis. Dig Dis Sci. 2014;59(9):2050-7. DOI:10.1007/s10620-014-3129-z
51. Reijntjes MA, Heuthorst L, Gecse K, et al. Clinical relevance of endoscopic periappendiceal red patch in ulcerative colitis patients. Therap Adv Gastroenterol. 2022;15:17562848221098849. DOI:10.1177/17562848221098849
52. Liu X, Goldblum JR, Zhao Z, et al. Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: in comparison with sporadic microsatellite-stable and Lynch syndrome-related colorectal adenocarcinoma. Am J Surg Pathol. 2012;36(8):1228-33. DOI:10.1097/PAS.0b013e318253645a
53. MCVAY JR Jr. The appendix in relation to neoplastic disease. Cancer. 1964;17:929-37. DOI:10.1002/1097-0142(196407)17:7<929::aid-cncr2820170713>3.0.co;2-o
54. Zhang Y, Khil J, Feng X, et al. Risk of colorectal cancer and adenoma after an appendectomy: results from three large prospective cohort studies and meta-analysis. Cancer Causes Control. 2024. DOI:10.1007/s10552-024-01901-4
55. Hale LP, Greer PK. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One. 2012;7(7):e41797. DOI:10.1371/journal.pone.0041797
56. Wu SC, Chen WT, Muo CH, et al. Association between appendectomy and subsequent colorectal cancer development: an Asian population study. PLoS One. 2015;10(2):e0118411. DOI:10.1371/journal.pone.0118411
57. Collard MK, Tourneur-Marsille J, Uzzan M, et al. The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer. Cell Mol Gastroenterol Hepatol. 2023;15(3):665-87. DOI:10.1016/j.jcmgh.2022.10.016
58. Chung WS, Chung S, Hsu CY, Lin CL. Risk of Inflammatory Bowel Disease Following Appendectomy in Adulthood. Front Med (Lausanne). 2021;8:661752. DOI:10.3389/fmed.2021.661752
59. Fantodji C, Jantchou P, Parent ME, Rousseau MC. Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy – a cohort study. BMJ Open Gastroenterol. 2022;9(1):e000925. DOI:10.1136/bmjgast-2022-000925
60. Zhang L, Hu C, Zhang Z, et al. Association between prior appendectomy and the risk and course of Crohn’s disease: A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2023;47(3):102090. DOI:10.1016/j.clinre.2023.102090
61. van der Does de Willebois EML, Sari C, Mookhoek A, et al. The Clinical Relevance of an Inflamed Appendix in Crohn’s Disease. J Crohns Colitis. 2024;18(6):812-7.
DOI:10.1093/ecco-jcc/jjad202
62. Malvar G, Peric M, Gonzalez RS. Interval appendicitis shows histological differences from acute appendicitis and may mimic Crohn disease and other forms of granulomatous appendicitis. Histopathology. 2022;80(6):965-73. DOI:10.1111/his.14621
63. Mostyka M, Fulmer CG, Hissong EM, Yantiss RK. Crohn Disease Infrequently Affects the Appendix and Rarely Causes Granulomatous Appendicitis. Am J Surg Pathol. 2021;45(12):1703-6. DOI:10.1097/PAS.0000000000001734
64. Kaplan GG, Jackson T, Sands BE, et al. The risk of developing Crohn’s disease after an appendectomy: a meta-analysis. Am J Gastroenterol.
2008;103(11):2925-31. DOI:10.1111/j.1572-0241.2008.02118.x
________________________________________________
2. Schumpelick V, Dreuw B, Ophoff K, Prescher A. Appendix and cecum. Embryology, anatomy, and surgical applications. Surg Clin North Am. 2000;80(1):295-318.
DOI:10.1016/s0039-6109(05)70407-2
3. Mohammadi S, Hedjazi A, Sajjadian M, et al. Morphological variations of the vermiform appendix in Iranian cadavers: a study fr om developing countries. Folia Morphol (Warsz). 2017;76(4):695-701. DOI:10.5603/FM.a2017.0032
4. Bhangu A, Søreide K, Di Saverio S, et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet.
2015;386(10000):1278-87. DOI:10.1016/S0140-6736(15)00275-5. Erratum in: Lancet. 2017;390(10104):1736. DOI:10.1016/S0140-6736(17)31502-7
5. Gonzalez DO, Deans KJ, Minneci PC. Role of non-operative management in pediatric appendicitis. Semin Pediatr Surg. 2016;25(4):204-7. DOI:10.1053/j.sempedsurg.2016.05.002
6. Shi F, Liu G, Lin Y, et al. Altered gut microbiome composition by appendectomy contributes to colorectal cancer. Oncogene. 2023;42(7):530-40. DOI:10.1038/s41388-022-02569-3
7. Kooij IA, Sahami S, Meijer SL, et al. The immunology of the vermiform appendix: a review of the literature. Clin Exp Immunol. 2016;186(1):1-9. DOI:10.1111/cei.12821
8. Kiasat A, Ekström LD, Marsk R, et al. Childhood appendicitis and future risk of inflammatory bowel disease – A nationwide cohort study in Sweden 1973-2017. Colorectal Dis. 2022;24(8):975-83. DOI:10.1111/codi.16128
9. Fava F, Danese S. Intestinal microbiota in inflammatory bowel disease: friend of foe? World J Gastroenterol. 2011;17(5):557-66. DOI:10.3748/wjg.v17.i5.557
10. Ansaloni L, Catena F, Pinna AD. What is the function of the human vermiform appendix? Evolution-based surgery: a new perspective in the Darwinian year 2009. Eur Surg Res. Europaische Chirurgische Forschung Recherches Chirurgicales Europeennes. 2009;43:67-71. DOI:10.1159/000219236
11. Darwin C. The descent of man, and selection in relation to sex. London, England UK: John Murray. 1871;1:423.
12. Rhee KJ, Sethupathi P, Driks A, et al. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol.
2004;172:1118-24. DOI:10.4049/jimmunol.172.2.1118
13. Hanson NB, Lanning DK. Microbial induction of B and T cell areas in rabbit appendix. Dev Comp Immunol. 2008;32:980-91. DOI:10.1016/j.dci.2008.01.013
14. Vitetta L, Chen J, Clarke S. The vermiform appendix: an immunological organ sustaining a microbiome inoculum. Clin Sci (Lond). 2019;133(1):1-8. DOI:10.1042/CS20180956
15. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8:523-32. DOI:10.1038/nri2343
16. Ishimoto Y, Tomiyama-Miyaji C, Watanabe H, et al. Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice. Immunology. 2004;113:371-7. DOI:10.1111/j.1365-2567.2004.01961.x
17. Costerton JW, Lewandowski Z, Caldwell DE, et al. Microbial biofilms. Annu Rev Microbiol. 1995;49:711-45. DOI:10.1146/annurev.mi.49.100195.003431
18. Guinane CM, Tadrous A, Fouhy F, et al. Microbial composition of human appendices from patients following appendectomy. mBio. 2013;4(1):e00366-12. DOI:10.1128/mBio.00366-12
19. Rogers MB, Brower-Sinning R, Firek B, et al. Acute Appendicitis in Children is Associated With a Local Expansion of Fusobacteria. Clin Infect Dis. 2016;63(1):71-8. DOI:10.1093/cid/ciw208
20. Vanhatalo S, Munukka E, Sippola S, et al. Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial. BMJ Open. 2019;9(9):e031137. DOI:10.1136/bmjopen-2019-031137
21. Clanton J, Subichin M, Drolshagen K, et al. Fulminant Clostridium difficile infection: An association with prior appendectomy? World J Gastrointest Surg. 2013;5(8):233-8. DOI:10.4240/wjgs.v5.i8.233
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Авторы
С.А. Коровин*1,2, С.Б. Оробинский2, Я.В. Оробинская1,3, Ю.Ю. Соколов1,4, И.Н. Захарова1
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы, Москва, Россия;
3ГБУЗ МО «Химкинская больница», Химки, Россия;
4ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента РФ, Москва
*korovinsa@mail.ru
1Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2Bashlyaeva Children's City Clinical Hospital, Moscow, Russia;
3Khimki Hospital, Khimki, Russia
4Central Clinical Hospital with a Polyclinic, Moscow, Russia
*korovinsa@mail.ru
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы, Москва, Россия;
3ГБУЗ МО «Химкинская больница», Химки, Россия;
4ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента РФ, Москва
*korovinsa@mail.ru
________________________________________________
1Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2Bashlyaeva Children's City Clinical Hospital, Moscow, Russia;
3Khimki Hospital, Khimki, Russia
4Central Clinical Hospital with a Polyclinic, Moscow, Russia
*korovinsa@mail.ru
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