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Осторожно – микропластик: влияние на организм человека и окружающую среду
Пупыкина В.В., Захарова И.Н. Осторожно – микропластик: влияние на организм человека и окружающую среду. Педиатрия. Consilium Medicum. 2024;3:230–236. DOI: 10.26442/26586630.2024.3.202959
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
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Pupykina VV, Zakharova IN. Problematic issues of the impact of microplastics on the human body and the environment: A review. Pediatrics. Consilium Medicum. 2024;3:230–236. DOI: 10.26442/26586630.2024.3.202959
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Аннотация
В настоящее время повсеместное распространение пластика стало серьезной проблемой не только для окружающей среды, но и для здоровья человека. Микропластик, являясь искусственным полимером, созданным человеком, отличается высокой устойчивостью к внешним воздействиям. Его разложение в почве требует значительного времени. В современном мире пластик стал неотъемлемой частью нашей повседневной жизни. Из микропластика, в частности, сделаны пакетики для хранения грудного молока, детские полипропиленовые бутылочки. В статье приведены сведения о влиянии данного вещества на организм человека. Микропластик обнаружен в крови, сердце, легких, плаценте, меконии младенца, грудном молоке. Выдвинуты гипотезы, объясняющие вероятные механизмы, с помощью которых микропластик проникает в ткани человека. В научной литературе обсуждается возможная связь пластификаторов с расстройством аутистического спектра, синдромом дефицита внимания и гиперактивности у детей. Описана возможная связь микропластика и послеродовой депрессии. Есть работы, доказывающие взаимосвязь между микропластиком и воспалительными заболеваниями кишечника. Принятие решения об ограничении использования пластиковых продуктов в быту является важным шагом, который может сыграть ключевую роль в уменьшении загрязнения окружающей среды и защите здоровья будущих поколений.
Ключевые слова: окружающая среда, дети, микропластик, влияние на организм человека, плацента, грудное молоко, аутизм, воспалительные заболевания кишечника
Ключевые слова: окружающая среда, дети, микропластик, влияние на организм человека, плацента, грудное молоко, аутизм, воспалительные заболевания кишечника
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Currently, the widespread use of plastic has become a serious problem for the environment and human health. Microplastics, being an artificial polymer created by man, are highly resistant to external influences and their decomposition requires a significant amount of time. The article provides information on the distribution of microplastics and their impact on the environment and the human body, issues of detecting microplastics in the blood, heart, lungs, placenta and meconium, in breast milk, hypothetical mechanisms by which microplastics penetrate into human tissues and the metabolism of plasticizers in children with autism spectrum disorder and attention deficit hyperactivity disorder. In the modern world, plastic has become an integral part of our daily lives, the presence of microplastics in plastic bags for storing breast milk, in baby formula and polypropylene bottles has been demonstrated, the relationship between microplastics and postpartum depression, the relationship between fecal microplastics and the status of inflammatory bowel diseases has been described. Making the decision to limit the use of plastic products in your home is an important step that can play a key role in reducing environmental pollution and protecting the health of future generations.
Keywords: environment, children, microplastics, impact on the human body, placenta, breast milk, autism, inflammatory bowel diseases
Полный текст
Список литературы
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26. Jacobson MH, Hamra GB, Monk C, et al. Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. JAMA Psychiatry. 2024;81(1):67-76. DOI:10.1001/jamapsychiatry.2023.3542
27. Yan Z, Liu Y, Zhang T, et al. Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environ Sci Technol. 2022;56(1):414-21. DOI:10.1021/acs.est.1c03924
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2. Омельченко Е.В., Киселева А.П. Микропластик в нашей жизни. Научные основы создания и реализации современных технологий здоровьесбережения. Материалы VI межрегиональной научно-практической конференции. Волгоград: Сфера, 2019;317-21 [Omelchenko EV, Kiseleva AP. Mikroplastik v nashei zhizni. Nauchnyie osnovy sozdaniia i realizatsii sovremennykh tekhnologii zdoroviesberezheniia. Materialy VI mezhregional'noi nauchno-prakticheskoi konferentsii. Volgograd: Sfera, 2019;317-21 (in Russian)].
3. Ермачкова П.А., Кравченко А.Н., Залата О.А., Шибанов С.Э. Негативное влияние микропластика: системы-мишени организма человека. Мотивационные аспекты физической активности. Материалы V Всероссийской междисциплинарной конференции. Великий Новгород. 2021;23-8 [Ermachkova PA, Kravchenko AN, Zalata OA, Shibanov SE. Negativnoie vliianiie mikroplastika: sistemy-misheni organizma cheloveka. Motivatsionnyie aspekty fizicheskoi aktivnosti. Materialy V Vserossiiskoi mezhdistsiplinarnoi konferentsii. Velikii Novgorod. 2021;23-8 (in Russian)].
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6. Difference Between Biomagnification and Bioaccumulation. 2023. Available at: https://www.geeksforgeeks.org/difference-between-biomagnification-and-bioaccumulation/ Accessed: 15.03.2024.
7. Peeken I, Primpke S, Beyer B, et al. Arctic sea ice is an important temporal sink and means of transport for microplastic. Nat Commun. 2018;9(1):1505.
DOI:10.1038/s41467-018-03825-5
8. Napper IE, Bede FR, Clifford H, et al. Reaching new heights in plastic pollution–preliminary findings of microplastics on Mount Everest. One Earth.
2020;3(5):621-30. DOI:10.1016/j.oneear.2020.10.020
9. Cox KD, Covernton GA, Davies HL, et al. Human Consumption of Microplastics. Environ Sci Technol. 2019;53(12):7068-74. DOI:10.1021/acs.est.9b01517
10. Plastic the hidden beautyngredient. 2022. Available at: https://www.beatthemicrobead.org/wp-content/uploads/2022/06/Plastic-TheHiddenBeautyIngredients.pdf. Accessed: 15.03.2024.
11. Stegmann P, Daioglou V, Londo M, et al. Plastic futures and their CO2 emissions. Nature. 2022;612(7939):272-6. DOI:10.1038/s41586-022-05422-5
12. Tisler S, Christensen JH. Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water. J Hazard Mater. 2022;429:128331. DOI:10.1016/j.jhazmat.2022.128331
13. Leslie HA, van Velzen MJM, Brandsma SH, et al. Discovery and quantification of plastic particle pollution in human blood. Environ Int. 2022;163:107199. DOI:10.1016/j.envint.2022.107199
14. Yang Y, Xie E, Du Z, et al. Detection of Various Microplastics in Patients Undergoing Cardiac Surgery. Environ Sci Technol. 2023;57(30):10911-8. DOI:10.1021/acs.est.2c07179
15. Jenner LC, Rotchell JM, Bennett RT, et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy. Sci Total Environ. 2022;831:154907. DOI:10.1016/j.scitotenv.2022.154907
16. Amato-Lourenço LF, Carvalho-Oliveira R, Júnior GR, et al. Presence of airborne microplastics in human lung tissue. J Hazard Mater. 2021;416:126124. DOI:10.1016/j.jhazmat.2021.126124
17. EcoReps Lunch & Learn Workshop: Health Impacts of Particulate Contaminants and Microplastics. Available at: https://louisville.edu/sustainability/events/ecoreps-lunch-learn-workshop-health-impacts-of-particul.... Accessed: 15.03.2024.
18. Sripada K, Wierzbicka A, Abass K, et al. A Children’s Health Perspective on Nano- and Microplastics. Environ Health Perspect. 2022;130(1):15001. DOI:10.1289/EHP9086
19. Ragusa A, Svelato A, Santacroce C, et al. Plasticenta: First evidence of microplastics in human placenta. Environ Int. 2021;146:106274. DOI:10.1016/j.envint.2020.106274
20. Braun T, Ehrlich L, Henrich W, et al. Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics. 2021;13(7):921. DOI:10.3390/pharmaceutics13070921
21. Ragusa A, Notarstefano V, Svelato A, et al. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers (Basel). 2022;14(13):2700. DOI:10.3390/polym14132700
22. Liu L, Zhang X, Jia P, et al. Release of microplastics from breastmilk storage bags and assessment of intake by infants: A preliminary study. Environ Pollut. 2023;323:121197. DOI:10.1016/j.envpol.2023.121197
23. Zhang Q, Liu L, Jiang Y, et al. Microplastics in infant milk powder. Environ Pollut. 2023;323:121225. DOI:10.1016/j.envpol.2023.121225
24. Li D, Shi Y, Yang L, et al. Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation. Nat Food.
2020;1(11):746-54. DOI:10.1038/s43016-020-00171-y
25. Stein TP, Schluter MD, Steer RA, Ming X. Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders. PLoS One. 2023;18(9):e0289841. DOI:10.1371/journal.pone.0289841
26. Jacobson MH, Hamra GB, Monk C, et al. Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. JAMA Psychiatry. 2024;81(1):67-76. DOI:10.1001/jamapsychiatry.2023.3542
27. Yan Z, Liu Y, Zhang T, et al. Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environ Sci Technol. 2022;56(1):414-21. DOI:10.1021/acs.est.1c03924
28. Seo MY, Moon S, Kim SH, Park MJ. Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017. Endocrinol Metab (Seoul). 2022;37(2):249-60. DOI:10.3803/EnM.2021.1235
29. Zhang J, Wang L, Trasande L, et al. Occurrence of Polyethylene Terephthalate and Polycarbonate Microplastics in Infant and Adult Feces. Environment Sci Technol Lett. 2021;8(11):989-94. DOI:10.1021/acs.estlett.1c00559
________________________________________________
1. Senathirajah K, Attwood S, Bhagwat G, et al. Estimation of the mass of microplastics ingested – A pivotal first step towards human health risk assessment. J Hazard Mater. 2021;404(Pt. B):124004. DOI:10.1016/j.jhazmat.2020.124004
2. Omelchenko EV, Kiseleva AP. Mikroplastik v nashei zhizni. Nauchnyie osnovy sozdaniia i realizatsii sovremennykh tekhnologii zdoroviesberezheniia. Materialy VI mezhregional'noi nauchno-prakticheskoi konferentsii. Volgograd: Sfera, 2019;317-21 (in Russian).
3. Ermachkova PA, Kravchenko AN, Zalata OA, Shibanov SE. Negativnoie vliianiie mikroplastika: sistemy-misheni organizma cheloveka. Motivatsionnyie aspekty fizicheskoi aktivnosti. Materialy V Vserossiiskoi mezhdistsiplinarnoi konferentsii. Velikii Novgorod. 2021;23-8 (in Russian).
4. Our Oceans: A Plastic Soup. 2011. Available at: https://news.climate.columbia.edu/2011/01/26/our-oceans-a-plastic-soup/ Accessed: 15.03.2024.
5. Gruber ES, Stadlbauer V, Pichler V, et al. To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity. Expo Health. 2023;15(1):33-51. DOI:10.1007/s12403-022-00470-8
6. Difference Between Biomagnification and Bioaccumulation. 2023. Available at: https://www.geeksforgeeks.org/difference-between-biomagnification-and-bioaccumulation/ Accessed: 15.03.2024.
7. Peeken I, Primpke S, Beyer B, et al. Arctic sea ice is an important temporal sink and means of transport for microplastic. Nat Commun. 2018;9(1):1505.
DOI:10.1038/s41467-018-03825-5
8. Napper IE, Bede FR, Clifford H, et al. Reaching new heights in plastic pollution–preliminary findings of microplastics on Mount Everest. One Earth.
2020;3(5):621-30. DOI:10.1016/j.oneear.2020.10.020
9. Cox KD, Covernton GA, Davies HL, et al. Human Consumption of Microplastics. Environ Sci Technol. 2019;53(12):7068-74. DOI:10.1021/acs.est.9b01517
10. Plastic the hidden beautyngredient. 2022. Available at: https://www.beatthemicrobead.org/wp-content/uploads/2022/06/Plastic-TheHiddenBeautyIngredients.pdf. Accessed: 15.03.2024.
11. Stegmann P, Daioglou V, Londo M, et al. Plastic futures and their CO2 emissions. Nature. 2022;612(7939):272-6. DOI:10.1038/s41586-022-05422-5
12. Tisler S, Christensen JH. Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water. J Hazard Mater. 2022;429:128331. DOI:10.1016/j.jhazmat.2022.128331
13. Leslie HA, van Velzen MJM, Brandsma SH, et al. Discovery and quantification of plastic particle pollution in human blood. Environ Int. 2022;163:107199. DOI:10.1016/j.envint.2022.107199
14. Yang Y, Xie E, Du Z, et al. Detection of Various Microplastics in Patients Undergoing Cardiac Surgery. Environ Sci Technol. 2023;57(30):10911-8. DOI:10.1021/acs.est.2c07179
15. Jenner LC, Rotchell JM, Bennett RT, et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy. Sci Total Environ. 2022;831:154907. DOI:10.1016/j.scitotenv.2022.154907
16. Amato-Lourenço LF, Carvalho-Oliveira R, Júnior GR, et al. Presence of airborne microplastics in human lung tissue. J Hazard Mater. 2021;416:126124. DOI:10.1016/j.jhazmat.2021.126124
17. EcoReps Lunch & Learn Workshop: Health Impacts of Particulate Contaminants and Microplastics. Available at: https://louisville.edu/sustainability/events/ecoreps-lunch-learn-workshop-health-impacts-of-particul.... Accessed: 15.03.2024.
18. Sripada K, Wierzbicka A, Abass K, et al. A Children’s Health Perspective on Nano- and Microplastics. Environ Health Perspect. 2022;130(1):15001. DOI:10.1289/EHP9086
19. Ragusa A, Svelato A, Santacroce C, et al. Plasticenta: First evidence of microplastics in human placenta. Environ Int. 2021;146:106274. DOI:10.1016/j.envint.2020.106274
20. Braun T, Ehrlich L, Henrich W, et al. Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics. 2021;13(7):921. DOI:10.3390/pharmaceutics13070921
21. Ragusa A, Notarstefano V, Svelato A, et al. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers (Basel). 2022;14(13):2700. DOI:10.3390/polym14132700
22. Liu L, Zhang X, Jia P, et al. Release of microplastics from breastmilk storage bags and assessment of intake by infants: A preliminary study. Environ Pollut. 2023;323:121197. DOI:10.1016/j.envpol.2023.121197
23. Zhang Q, Liu L, Jiang Y, et al. Microplastics in infant milk powder. Environ Pollut. 2023;323:121225. DOI:10.1016/j.envpol.2023.121225
24. Li D, Shi Y, Yang L, et al. Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation. Nat Food.
2020;1(11):746-54. DOI:10.1038/s43016-020-00171-y
25. Stein TP, Schluter MD, Steer RA, Ming X. Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders. PLoS One. 2023;18(9):e0289841. DOI:10.1371/journal.pone.0289841
26. Jacobson MH, Hamra GB, Monk C, et al. Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. JAMA Psychiatry. 2024;81(1):67-76. DOI:10.1001/jamapsychiatry.2023.3542
27. Yan Z, Liu Y, Zhang T, et al. Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environ Sci Technol. 2022;56(1):414-21. DOI:10.1021/acs.est.1c03924
28. Seo MY, Moon S, Kim SH, Park MJ. Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017. Endocrinol Metab (Seoul). 2022;37(2):249-60. DOI:10.3803/EnM.2021.1235
29. Zhang J, Wang L, Trasande L, et al. Occurrence of Polyethylene Terephthalate and Polycarbonate Microplastics in Infant and Adult Feces. Environment Sci Technol Lett. 2021;8(11):989-94. DOI:10.1021/acs.estlett.1c00559
Авторы
В.В. Пупыкина*, И.Н. Захарова
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*vika-pupykina@mail.ru
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*vika-pupykina@mail.ru
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Viktoria V. Pupykina*, Irina N. Zakharova
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*vika-pupykina@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.