Актуальность использования нефропротективных стратегий обусловлена возрастающей распространенностью хронической болезни почек у больных артериальной гипертонией и сахарным диабетом, возможностью замедления прогрессирования нефропатии при ее своевременном выявлении. Механизм действия прямого ингибитора ренина алискирена позволяет предположить высокий нефропротективный потенциал препарата. В обзоре представлены результаты экспериментальных и клинических исследований нефропротективных свойств алискирена в отношении различных патогенетических вариантов нефропатии: протеинурического (замедление гломерулосклероза) и непротеинурического (уменьшение прогрессирования тубулоинтерстициального фиброза).
The urgency of applying nephroprotective strategies is determined by the increasing prevalence of chronic renal disease in patients with arterial hypertension and diabetes mellitus and by the fact that the progression of nephropathy may be delayed in its timely detection. The mechanism of action of the direct renin inhibitor aliskiren may suggest that the drug has a high nephroprotective potential. The review presents the experimental and clinical findings of the nephroprotective properties of aliskiren against different pathogenetic types of nephropathy: proteinuric (delay in the onset of glomerulosclerosis) and nonproteinuric (reduction in the progression of tubulointerstitial fibrosis).
Keywords: nephroprotection, arterial hypertension, diabetes mellitus, direct renin inhibitor aliskiren
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