В статье представлен клинический случай лечения пациента с артериальной гипертонией, ишемической болезнью сердца, нефропатией и пароксизмальной мерцательной аритмией, что обусловливало у него высокий риск развития сердечно-сосудистых осложнений. Приведены данные больших рандомизированных клинических исследований об эффективности лечения телмисартаном (40 и 80 мг) в виде монотерапии и в комбинации с гидрохлоротиазидом, наглядно демонстрирующие наряду с хорошей антигипертензивной эффективностью наличие нефро- и кардиопротективных свойств, а также способность существенно снижать риск развития сердечно-сосудистых осложнений и смерти от них. Высокая эффективность телмисартана как в этих исследованиях, так и в приведенном клиническом примере сочеталась с великолепной переносимостью лечения, сопоставимой с плацебо.
Case report of treatment of a patient with arterial hypertension, ischemic heart disease, nephropathy and atrial fibrillation which led to high risk of cardiovascular complications progression is presented. Data of large clinical randomized studies of efficacy of monotherapy of telmisartan and combined therapy with hydrochlorothiazide (40 and 80 mg) are presented. Good antihypertensive efficacy, nephro- and cardioprotective effects are demonstrated as well as ability to significantly reduce risk of cardiovascular morbidity and mortality. High efficacy of telmisartan in studies and in this case is associated with excellent tolerance of treatment compared to placebo.
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Авторы
Л.Г.Ратова, И.Е.Чазова
ФГУ Российский кардиологический научно-производственный комплекс, Москва
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L.G.Ratova, I.E.Chazova
FSI Russian cardiology scientific and production complex, Moscow