Гипертрофия левого желудочка (ГЛЖ) – один из компонентов сердечно-сосудистого континуума, определяющих прогноз пациента с артериальной гипертензией (АГ). Патогенез ГЛЖ имеет мультифакторный характер. Важная роль в развитии гипертрофии кардиомиоцитов, интракардиального фиброза, дилатации полости левого желудочка (ЛЖ) принадлежит ренин-ангиотензин-альдостероновой системе (РААС). Фармакологическая блокада РААС составляет основу терапии, ориентированной на достижение регресса ГЛЖ. Применение телмисартана считается высокообоснованным подходом к лечению пациента с АГ, имеющего ГЛЖ.
Ключевые слова: артериальная гипертензия, гипертрофия левого желудочка, ренин-ангиотензин-альдостероновая система, телмисартан.
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Left ventricular hypertrophy (LVH) is one of the cardio-vascular continuum components, determining the prognosis of patient with essential hypertension (EH). Pathogenesis of LVH has a multifactor character. Important role in development of cardiomyocites hypertrophy, Intracardiac fibrosis, left ventricle cavity dilation belongs to renin-angiotensin-aldosteron system (RAAS). Pharmacologic blockade of RAAS composes the basis of therapy, directed to LVH regress. Application of Telmisartan is considered high-reasonable approach to treatment of EH-patient with LVH.
Key words: essential hypertension, left ventricular hypertrophy, renin-angiotensin-aldosteron system, Telmisartan.
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1 ФГКВОУ ВПО Военная медицинская академия им. С.М.Кирова Минобороны РФ, Санкт-Петербург;
2 ГБУЗ «Госпиталь ветеранов войн», Москва;
3 Санкт-Петербургский филиал ФГБМУ «Медицинский центр при Спецстрое России»
*avbarsukov@yandex.ru