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Эффективность зофеноприла при сердечно-сосудистых заболеваниях
Эффективность зофеноприла при сердечно-сосудистых заболеваниях
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Аннотация
Гиперактивность ренин-ангиотензин-альдостероновой системы играет важную роль в патогенезе любой сердечно-сосудистой патологии. Среди множества средств, влияющих на активность ренин-ангиотензин-альдостероновой системы, ингибиторы ангиотензинпревращающего фермента являются самыми изученными препаратами, обладающими широким спектром благоприятных эффектов. Наличие сульфгидрильной группы в молекуле ингибитора ангиотензинпревращающего фермента зофеноприла обусловливает ряд уникальных свойств данного препарата. Последние данные свидетельствуют о его эффективности при лечении сочетанной сердечно-сосудистой патологии. В статье представлены последние данные исследований, посвященных эффективности и безопасности зофеноприла.
Ключевые слова: ренин-ангиотензин-альдостероновая система, ингибиторы ангиотензинпревращающего фермента, зофеноприл.
Key words: the renin-angiotensin-aldosteronesystem, angiotensin-converting enzyme inhibitors, zofenopril.
Ключевые слова: ренин-ангиотензин-альдостероновая система, ингибиторы ангиотензинпревращающего фермента, зофеноприл.
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Key words: the renin-angiotensin-aldosteronesystem, angiotensin-converting enzyme inhibitors, zofenopril.
Полный текст
Список литературы
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11. Nilsson P. Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. Blood Press (Suppl.) 2007; 2: 25–30.
12. Malacco E, Castiglioni G, Corradi L et al. Dose-Response Relationship of Zofenopril in Essential Hypertension: A 24-Hour Blood Pressure-Monitoring Study. Clin Drag Invest 2002; 22 (1): 9–15.
13. Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure. Am J Cardiol 2013; 112 (1): 90–3.
14. Malacco E, Omboni S. Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome. Adv Ther 2007; 24 (5): 1006–15.
15. Agabiti-Rosei E, Manolis A, Zava D, Omboni S. Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients. Adv Ther 2014; 31 (2): 217–33.
2. Persson S. Update on the use of angiotensin converting enzyme inhibitors and calcium antagonists in postinfarction patients. J Hypertens (Suppl.) 1995; 13 (2): S57–63.
3. De Graeff PA, van Gilst WH. The effect of bradykinin on coronary flow and its potentiation by SH-containing ACE-inhibitors. Agents Actions (Suppl.) 1992; 38 (Pt 3): 110–8.
4. Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр) ВНОК. 2010.
5. Napoli C, Bruzzese G, Ignarro LJ et al. Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima–media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension. Am Heart J 2008; 156 (6): 1154.e1–8.
6. Borghi C, Ambrosioni E, Novo S et al. Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel-group, multicenter, European study (SMILE-4). Clin Cardiol 2012; 35 (7): 416–23
7. Borghi C, Ambrosioni E, Omboni S et al. Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study. J Hypertens 2013; 31 (6): 1256–64.
8. Borghi C, Ambrosioni E. Survival of Myocardial Infarction Long-term Evaluation Study Group. Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study. Am Heart J 2007; 153 (3): 445.e7–14.
9. Narkiewicz K. Comparison of home and office blood pressure in hypertensive patients treated with zofenopril or losartan. Blood Press (Suppl.) 2007; 2: 7–12.
10. Farsang C. Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients. Blood Press (Suppl.) 2007; 2: 19–24.
11. Nilsson P. Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. Blood Press (Suppl.) 2007; 2: 25–30.
12. Malacco E, Castiglioni G, Corradi L et al. Dose-Response Relationship of Zofenopril in Essential Hypertension: A 24-Hour Blood Pressure-Monitoring Study. Clin Drag Invest 2002; 22 (1): 9–15.
13. Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure. Am J Cardiol 2013; 112 (1): 90–3.
14. Malacco E, Omboni S. Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome. Adv Ther 2007; 24 (5): 1006–15.
15. Agabiti-Rosei E, Manolis A, Zava D, Omboni S. Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients. Adv Ther 2014; 31 (2): 217–33.
2. Persson S. Update on the use of angiotensin converting enzyme inhibitors and calcium antagonists in postinfarction patients. J Hypertens (Suppl.) 1995; 13 (2): S57–63.
3. De Graeff PA, van Gilst WH. The effect of bradykinin on coronary flow and its potentiation by SH-containing ACE-inhibitors. Agents Actions (Suppl.) 1992; 38 (Pt 3): 110–8.
4. Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр) ВНОК. 2010.
5. Napoli C, Bruzzese G, Ignarro LJ et al. Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima–media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension. Am Heart J 2008; 156 (6): 1154.e1–8.
6. Borghi C, Ambrosioni E, Novo S et al. Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel-group, multicenter, European study (SMILE-4). Clin Cardiol 2012; 35 (7): 416–23
7. Borghi C, Ambrosioni E, Omboni S et al. Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study. J Hypertens 2013; 31 (6): 1256–64.
8. Borghi C, Ambrosioni E. Survival of Myocardial Infarction Long-term Evaluation Study Group. Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study. Am Heart J 2007; 153 (3): 445.e7–14.
9. Narkiewicz K. Comparison of home and office blood pressure in hypertensive patients treated with zofenopril or losartan. Blood Press (Suppl.) 2007; 2: 7–12.
10. Farsang C. Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients. Blood Press (Suppl.) 2007; 2: 19–24.
11. Nilsson P. Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. Blood Press (Suppl.) 2007; 2: 25–30.
12. Malacco E, Castiglioni G, Corradi L et al. Dose-Response Relationship of Zofenopril in Essential Hypertension: A 24-Hour Blood Pressure-Monitoring Study. Clin Drag Invest 2002; 22 (1): 9–15.
13. Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure. Am J Cardiol 2013; 112 (1): 90–3.
14. Malacco E, Omboni S. Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome. Adv Ther 2007; 24 (5): 1006–15.
15. Agabiti-Rosei E, Manolis A, Zava D, Omboni S. Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients. Adv Ther 2014; 31 (2): 217–33.
________________________________________________
2. Persson S. Update on the use of angiotensin converting enzyme inhibitors and calcium antagonists in postinfarction patients. J Hypertens (Suppl.) 1995; 13 (2): S57–63.
3. De Graeff PA, van Gilst WH. The effect of bradykinin on coronary flow and its potentiation by SH-containing ACE-inhibitors. Agents Actions (Suppl.) 1992; 38 (Pt 3): 110–8.
4. Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр) ВНОК. 2010.
5. Napoli C, Bruzzese G, Ignarro LJ et al. Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima–media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension. Am Heart J 2008; 156 (6): 1154.e1–8.
6. Borghi C, Ambrosioni E, Novo S et al. Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel-group, multicenter, European study (SMILE-4). Clin Cardiol 2012; 35 (7): 416–23
7. Borghi C, Ambrosioni E, Omboni S et al. Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study. J Hypertens 2013; 31 (6): 1256–64.
8. Borghi C, Ambrosioni E. Survival of Myocardial Infarction Long-term Evaluation Study Group. Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study. Am Heart J 2007; 153 (3): 445.e7–14.
9. Narkiewicz K. Comparison of home and office blood pressure in hypertensive patients treated with zofenopril or losartan. Blood Press (Suppl.) 2007; 2: 7–12.
10. Farsang C. Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients. Blood Press (Suppl.) 2007; 2: 19–24.
11. Nilsson P. Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. Blood Press (Suppl.) 2007; 2: 25–30.
12. Malacco E, Castiglioni G, Corradi L et al. Dose-Response Relationship of Zofenopril in Essential Hypertension: A 24-Hour Blood Pressure-Monitoring Study. Clin Drag Invest 2002; 22 (1): 9–15.
13. Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure. Am J Cardiol 2013; 112 (1): 90–3.
14. Malacco E, Omboni S. Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome. Adv Ther 2007; 24 (5): 1006–15.
15. Agabiti-Rosei E, Manolis A, Zava D, Omboni S. Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients. Adv Ther 2014; 31 (2): 217–33.
Авторы
В.Г.Кукес1, Г.С.Аникин1,2
1 ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России
2 ФГБУ Поликлиника №3 Управления делами Президента Российской Федерации, Москва
1 ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России
2 ФГБУ Поликлиника №3 Управления делами Президента Российской Федерации, Москва
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