Маркеры раннего поражения головного мозга как органа-мишени артериальной гипертензии: поиск продолжается. Возможности диффузионно-тензорной магнитно-резонансной томографии головного мозга

1. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertension 2013; 31: 1281–357.
2. Диагностика и лечение артериальной гипертонии: клинические рекомендации. Кардиол. вестн. 2015; 1: 3–30. / Diagnostika i lechenie arterial'noi gipertonii: klinicheskie rekomendatsii. Kardiol. vestn. 2015; 1: 3–30. [in Russian]
3. Бойцов С.А., Баланова Ю.А., Шальнова С.А. и др. Артериальная гипертония среди лиц 25–64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваск. терапия и профилактика. 2014; 13 (4): 4–14. / Boitsov S.A., Balanova Iu.A., Shal'nova S.A. i dr. Arterial'naia gipertoniia sredi lits 25–64 let: rasprostranennost', osvedomlennost', lechenie i kontrol'. Po materialam issledovaniia ESSE. Kardiovask. terapiia i profilaktika. 2014; 13 (4): 4–14. [in Russian]
4. O’Donnell MJ, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
5. Brown DW, Giles WH, Greenlund KJ. Blood pressure parameters and risk of fatal stroke, NHANES II mortality study. Am J Hypertens 2007; 20: 338–41.
6. Bushnell C, McCullough LD, Awad IA et al. American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council for High Blood Pressure Research. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45 (5): 1545–88.
7. Skoog I, Lernfelt B, Landahl S et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347: 1141–5.
8. Kilander L, Nyman H, Boberg M et al. Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men. Hypertension 1998; 31: 780–6.
9. Muela HCS, Costa-Hong VA, Yassuda MS et al. Hypertension severity is associated with impaired cognitive performance. J Am Heart Assoc 2017; 6 (1): e004579.
10. Perrotta M, Lembo G, Carnevale D. Hypertension and dementia: epidemiological and experimental evidence revealing adetrimental relationship. Int J Mol Sci 2016; 17: 347–58.
11. Iadecola C, Yaffe K, Biller J et al. Impact of hypertension on cognitive function. A scientific statement from the American Heart Association. Hypertension 2016; 68 (6): e67–e94.
12. De Leeuw FE, de Groot JC, Oudkerk M et al. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 2002; 125: 765–72.
13. Longstreth WT, Manolio TA, Arnold A et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996; 27: 1274–82.
14. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurology 2007; 6: 611–9.
15. Wong TY, Klein R, Sharrett AR et al. Cerebral white matter lesions, retinopathy and incident clinical stroke. JAMA 2002; 288: 67–74.
16. Buyck JF, Dufouil C, Mazoyer B et al. Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: the 3-City Dijon Study. Stroke 2009; 40: 2327–31.
17. Kearney-Schwartz A, Rossignol P, Bracard S et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009; 40: 1229–36.
18. Le Bihan D, van Zijl P. From the diffusion coefficient to the diffusion tensor. NMR Biomed 2002; 15: 431–4.
19. Horsfield MA, Larsson HB, Jones DK, Gass A. Diffusion magnetic resonance imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry 1998; 64 (Suppl. 1): S80–4.
20. Lövblad KO, Baird AE, Schlaug G et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997; 42: 164–70.
21. Eriksson SH, Rugg-Gunn FJ, Symms MR et al. Diffusion tensor imaging in patients with epilepsy and malformations of cortical development. Brain 2001; 124: 617–26.
22. Potgieser AR, Wagemakers M, van Hulzen AL et al. The role of diffusion tensor imaging in brain tumor surgery: a review of the literature. Clin Neurol Neurosurg 2014; 124: 51–8.
23. Rose SE, Chen E, Chalk JB et al. Loss of connectivity in Alzheimer’s disease: an evaluation of white matter tract integrity with color-coded MR diffusion tensor imaging. Neurol Neurosurg Psychiatry 2000; 69: 528–30.
24. Lenfeldt N, Hansson W, Larsson A et al. Diffusion tensor imaging and correlations to Parkinson rating scales. J Neurol 2013; 260 (11): 2823–30.
25. Левашкина И.М., Серебрякова С.В., Ефимцев А.Ю. Диффузионно-тензорная МРТ – современный метод оценки микроструктурных изменений вещества головного мозга (обзор литературы). Вестник СПбГУ. 2016; 4: 39–54. / Levashkina I.M., Serebriakova S.V., Efimtsev A.Iu. Diffuzionno-tenzornaia MRT – sovremennyi metod otsenki mikrostrukturnykh izmenenii veshchestva golovnogo mozga (obzor literatury). Vestnik SPbGU. 2016; 4: 39–54. [in Russian]
26. Le Bihan D, Breton E, Lallemand D et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986; 161 (2): 401–7.
27. Launer LJ, Lewis CE, Schreiner PJ et al. Vascular factors and multiple measures of early brain health: CARDIA brain MRI study. PLoS One 2015; 10 (3): e0122138.
28. Lawrence AJ, Patel B, Morris RJ et al. Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study. PLoS One 2013; 8 (4): e61014.
29. Gons RA, de Laat KF, van Norden AGW. Hypertension and cerebral diffusion tensor imaging in small vessel disease. Stroke 2010; 41: 2801–6.
30. Heye AK, Thrippleton MJ, Chappell FM et al. Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease. J Cereb Blood Flow Metab 2016; 36 (1): 264–74.
31. Power MC, Tingle JV, Reid RI et al. Midlife and late-life vascular risk factors and white matter microstructural integrity: the atherosclerosis risk in communities neurocognitive study. JAHA 2017; 6: e005608.
32. Rosano C, Abebe KZ, Aizenstein HJ et al. Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens 2015; 28 (3): 326–34.
33. Salat DH, Williams VJ, Leritz EC et al. Interindividual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. Neuroimage 2012; 59 (1): 181–92.
34. Maillard P, Seshadri S, Beiser A et al. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol 2012; 11 (12): 1039–47.
35. Friedman GD, Cutter GR, Donahue RP et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 1988; 41 (11): 1105–16.
36. Burgmans S, van Boxtel MPJ, Gronenschild EH et al. Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension. Neuroimage 2010; 49 (3): 2083.
37. Kennedya KM, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res 2009; 1297: 41–56.
38. Kochunov P, Thompson PM, Lancaster JL et al. Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage 2007; 35: 478–87.
39. Stadlbauer A, Salomonowitz E, Strunk G et al. Age-related degradation in the central nervous system: assessment with diffusion-tensor imaging and quantitative fiber tracking. Radiology 2008; 247: 179–88.
40. Jones D, Lythgoe D, Horsfield M et al. Characterization of white matter damage in ischaemicleukoaraiosis with diffusion tensor MRI. Stroke 1999; 30: 393–7.
41. Chabriat H, Pappata S, Poupon C et al. Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke 1999; 30: 2637–43.
42. Nitkunan A, Charlton RA, McIntyre DJ et al. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease. Magn Reson Med 2008; 59 (3): 528–34.
43. Benjamin P, Zeestraten E, Lambert Ch et al. Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials. Journal of Cerebral Blood Flow & Metabolism 2016; 36(1): 228–240. DOI: 10.1038/jcbfm.2015.113

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1. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertension 2013; 31: 1281–357.
2. Diagnostika i lechenie arterial'noi gipertonii: klinicheskie rekomendatsii. Kardiol. vestn. 2015; 1: 3–30. [in Russian]
3. Boitsov S.A., Balanova Iu.A., Shal'nova S.A. i dr. Arterial'naia gipertoniia sredi lits 25–64 let: rasprostranennost', osvedomlennost', lechenie i kontrol'. Po materialam issledovaniia ESSE. Kardiovask. terapiia i profilaktika. 2014; 13 (4): 4–14. [in Russian]
4. O’Donnell MJ, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
5. Brown DW, Giles WH, Greenlund KJ. Blood pressure parameters and risk of fatal stroke, NHANES II mortality study. Am J Hypertens 2007; 20: 338–41.
6. Bushnell C, McCullough LD, Awad IA et al. American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council for High Blood Pressure Research. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45 (5): 1545–88.
7. Skoog I, Lernfelt B, Landahl S et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347: 1141–5.
8. Kilander L, Nyman H, Boberg M et al. Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men. Hypertension 1998; 31: 780–6.
9. Muela HCS, Costa-Hong VA, Yassuda MS et al. Hypertension severity is associated with impaired cognitive performance. J Am Heart Assoc 2017; 6 (1): e004579.
10. Perrotta M, Lembo G, Carnevale D. Hypertension and dementia: epidemiological and experimental evidence revealing adetrimental relationship. Int J Mol Sci 2016; 17: 347–58.
11. Iadecola C, Yaffe K, Biller J et al. Impact of hypertension on cognitive function. A scientific statement from the American Heart Association. Hypertension 2016; 68 (6): e67–e94.
12. De Leeuw FE, de Groot JC, Oudkerk M et al. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 2002; 125: 765–72.
13. Longstreth WT, Manolio TA, Arnold A et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996; 27: 1274–82.
14. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurology 2007; 6: 611–9.
15. Wong TY, Klein R, Sharrett AR et al. Cerebral white matter lesions, retinopathy and incident clinical stroke. JAMA 2002; 288: 67–74.
16. Buyck JF, Dufouil C, Mazoyer B et al. Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: the 3-City Dijon Study. Stroke 2009; 40: 2327–31.
17. Kearney-Schwartz A, Rossignol P, Bracard S et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009; 40: 1229–36.
18. Le Bihan D, van Zijl P. From the diffusion coefficient to the diffusion tensor. NMR Biomed 2002; 15: 431–4.
19. Horsfield MA, Larsson HB, Jones DK, Gass A. Diffusion magnetic resonance imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry 1998; 64 (Suppl. 1): S80–4.
20. Lövblad KO, Baird AE, Schlaug G et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997; 42: 164–70.
21. Eriksson SH, Rugg-Gunn FJ, Symms MR et al. Diffusion tensor imaging in patients with epilepsy and malformations of cortical development. Brain 2001; 124: 617–26.
22. Potgieser AR, Wagemakers M, van Hulzen AL et al. The role of diffusion tensor imaging in brain tumor surgery: a review of the literature. Clin Neurol Neurosurg 2014; 124: 51–8.
23. Rose SE, Chen E, Chalk JB et al. Loss of connectivity in Alzheimer’s disease: an evaluation of white matter tract integrity with color-coded MR diffusion tensor imaging. Neurol Neurosurg Psychiatry 2000; 69: 528–30.
24. Lenfeldt N, Hansson W, Larsson A et al. Diffusion tensor imaging and correlations to Parkinson rating scales. J Neurol 2013; 260 (11): 2823–30.
25. Levashkina I.M., Serebriakova S.V., Efimtsev A.Iu. Diffuzionno-tenzornaia MRT – sovremennyi metod otsenki mikrostrukturnykh izmenenii veshchestva golovnogo mozga (obzor literatury). Vestnik SPbGU. 2016; 4: 39–54. [in Russian]
26. Le Bihan D, Breton E, Lallemand D et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986; 161 (2): 401–7.
27. Launer LJ, Lewis CE, Schreiner PJ et al. Vascular factors and multiple measures of early brain health: CARDIA brain MRI study. PLoS One 2015; 10 (3): e0122138.
28. Lawrence AJ, Patel B, Morris RJ et al. Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study. PLoS One 2013; 8 (4): e61014.
29. Gons RA, de Laat KF, van Norden AGW. Hypertension and cerebral diffusion tensor imaging in small vessel disease. Stroke 2010; 41: 2801–6.
30. Heye AK, Thrippleton MJ, Chappell FM et al. Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease. J Cereb Blood Flow Metab 2016; 36 (1): 264–74.
31. Power MC, Tingle JV, Reid RI et al. Midlife and late-life vascular risk factors and white matter microstructural integrity: the atherosclerosis risk in communities neurocognitive study. JAHA 2017; 6: e005608.
32. Rosano C, Abebe KZ, Aizenstein HJ et al. Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens 2015; 28 (3): 326–34.
33. Salat DH, Williams VJ, Leritz EC et al. Interindividual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. Neuroimage 2012; 59 (1): 181–92.
34. Maillard P, Seshadri S, Beiser A et al. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol 2012; 11 (12): 1039–47.
35. Friedman GD, Cutter GR, Donahue RP et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 1988; 41 (11): 1105–16.
36. Burgmans S, van Boxtel MPJ, Gronenschild EH et al. Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension. Neuroimage 2010; 49 (3): 2083.
37. Kennedya KM, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res 2009; 1297: 41–56.
38. Kochunov P, Thompson PM, Lancaster JL et al. Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage 2007; 35: 478–87.
39. Stadlbauer A, Salomonowitz E, Strunk G et al. Age-related degradation in the central nervous system: assessment with diffusion-tensor imaging and quantitative fiber tracking. Radiology 2008; 247: 179–88.
40. Jones D, Lythgoe D, Horsfield M et al. Characterization of white matter damage in ischaemicleukoaraiosis with diffusion tensor MRI. Stroke 1999; 30: 393–7.
41. Chabriat H, Pappata S, Poupon C et al. Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke 1999; 30: 2637–43.
42. Nitkunan A, Charlton RA, McIntyre DJ et al. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease. Magn Reson Med 2008; 59 (3): 528–34.
43. Benjamin P, Zeestraten E, Lambert Ch et al. Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials. Journal of Cerebral Blood Flow & Metabolism 2016; 36(1): 228–240. DOI: 10.1038/jcbfm.2015.113

В.А.Парфенов*1, Т.М.Остроумова1, О.Д.Остроумова1,2, Е.М.Перепелова1, В.А.Перепелов1

1 ФГАОУ ВО «Первый Московский государственный медицинский университет» им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
*Vladimirparfenov@mail.ru

________________________________________________

V.A.Parfenov*1, T.M.Ostroumova1, O.D.Ostroumova1,2, E.M.Perepelova1, V.A.Perepelov1

1 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
2 A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*Vladimirparfenov@mail.ru