Розувастатин является одним из часто назначаемых препаратов для первичной и вторичной профилактики инфаркта миокарда и инсульта. В статье рассмотрены основные исследования, подтверждающие эффективность розувастатина у пациентов с различным сердечно-сосудистым риском.
Rosuvastatin is one of the most frequently prescribed drugs for primary and secondary prevention of myocardial infarction and stroke. The present article deals with the main studies confirming the effectiveness of rosuvastatin in patients with different cardiovascular risks.
Key words: rosuvastatin, prevention of cardiovascular complications, hypercholesterolemia, atherosclerosis.
1. Agneta Å et al. Low-Risk Diet and Lifestyle Habits in the Primary Prevention of Myocardial Infarction in Men. J Am Coll Cardiol 2014; 64 (13): 1299–306.
2. Chiuve SE et al. Primary prevention of stroke by healthy lifestyle. Circulation 2008; 118 (9): 947–54.
3. Boekholdt SM, Hovingh GK, Mora S et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events. J Am Coll Cardiol 2014; 64 (5): 485–94.
4. Jones PH et al. Effects of rosuvastatin versus atorvastatin, simvastatin, and pravastatin on non-high-density lipoprotein cholesterol, apolipoproteins, and lipid ratios in patients with hypercholesterolemia: additional results from the STELLAR trial. Clin Ther 2004; 26 (9): 1388–99.
5. Ridker P, Danielson E, Fonseca FAH et al for the JUPITER study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359: 2195–207.
6. Грацианский Н.А. Сверхнизкий уровень холестерина липопротеинов низкой плотности в первичной профилактике у людей с повышенным С-реактивным белком. Результаты испытания JUPITER. Кардиология. 2009; 1: 73–5. / Gratsianskii N.A. Sverkhnizkii uroven' kholesterina lipoproteinov nizkoi plotnosti v pervichnoi profilaktike u liudei s povyshennym S-reaktivnym belkom. Rezul'taty ispytaniia JUPITER. Kardiologiia. 2009; 1: 73–5. [in Russian]
7. Crouse JR 3rd, Raichlen JS, Riley WA et al; METEOR Study Group. Effect of rosuvastatin on progression of carotid intima–media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA 2007; 297 (12): 1344–53.
8. Nissen SE, Nicolls SJ, Sapahi I et al. ASTEROID Investigators. Effect of very high intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006; 296 (13): 1556–65.
9. Rollefstad S, Ikdahl E, Hisdal J et al. Rosuvastatin induced carotid plaque regression in patients with inflammatory joint diseases: the RORA-AS study. Arthritis Rheumatol 2015; 67: 1718–28.
10. Ikdahl E, Hisdal J, Rollefstad S et al. Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study. Arthritis Res Ther 2015; 17: 279.
11. Kjekshus J, Apetre E, Barrias W et al for the CORONA Group. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007; 357: 1–14.
12. Karlson BW et al. A VOYAGER Meta-Analysis of the Impact of Statin Therapy on Low-Density Lipoprotein Cholesterol and Triglyceride Levels in Patients With Hypertriglyceridemia. Am J Cardiol 2016; 117 (9): 1444–8.
13. Тарловская Е.И., Нечаева Г.И., Мальчикова С.В., Семенкин А.А. Прогнозирование влияния оригинального и генерического розувастатина на прямые медицинские затраты при вторичной профилактике у пациентов с хроническими формами ишемической болезни сердца. Кардиоваск. терапия и профилактика. 2015; 14 (4): 29–37. / Tarlovskaia E.I., Nechaeva G.I., Mal'chikova S.V., Semenkin A.A. Prognozirovanie vliianiia original'nogo i genericheskogo rozuvastatina na priamye meditsinskie zatraty pri vtorichnoi profilaktike u patsientov s khronicheskimi formami ishemicheskoi bolezni serdtsa. Kardiovask. terapiia i profilaktika. 2015; 14 (4): 29–37. [in Russian]
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1. Agneta Å et al. Low-Risk Diet and Lifestyle Habits in the Primary Prevention of Myocardial Infarction in Men. J Am Coll Cardiol 2014; 64 (13): 1299–306.
2. Chiuve SE et al. Primary prevention of stroke by healthy lifestyle. Circulation 2008; 118 (9): 947–54.
3. Boekholdt SM, Hovingh GK, Mora S et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events. J Am Coll Cardiol 2014; 64 (5): 485–94.
4. Jones PH et al. Effects of rosuvastatin versus atorvastatin, simvastatin, and pravastatin on non-high-density lipoprotein cholesterol, apolipoproteins, and lipid ratios in patients with hypercholesterolemia: additional results from the STELLAR trial. Clin Ther 2004; 26 (9): 1388–99.
5. Ridker P, Danielson E, Fonseca FAH et al for the JUPITER study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359: 2195–207.
6. Gratsianskii N.A. Sverkhnizkii uroven' kholesterina lipoproteinov nizkoi plotnosti v pervichnoi profilaktike u liudei s povyshennym S-reaktivnym belkom. Rezul'taty ispytaniia JUPITER. Kardiologiia. 2009; 1: 73–5. [in Russian]
7. Crouse JR 3rd, Raichlen JS, Riley WA et al; METEOR Study Group. Effect of rosuvastatin on progression of carotid intima–media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA 2007; 297 (12): 1344–53.
8. Nissen SE, Nicolls SJ, Sapahi I et al. ASTEROID Investigators. Effect of very high intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006; 296 (13): 1556–65.
9. Rollefstad S, Ikdahl E, Hisdal J et al. Rosuvastatin induced carotid plaque regression in patients with inflammatory joint diseases: the RORA-AS study. Arthritis Rheumatol 2015; 67: 1718–28.
10. Ikdahl E, Hisdal J, Rollefstad S et al. Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study. Arthritis Res Ther 2015; 17: 279.
11. Kjekshus J, Apetre E, Barrias W et al for the CORONA Group. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007; 357: 1–14.
12. Karlson BW et al. A VOYAGER Meta-Analysis of the Impact of Statin Therapy on Low-Density Lipoprotein Cholesterol and Triglyceride Levels in Patients With Hypertriglyceridemia. Am J Cardiol 2016; 117 (9): 1444–8.
13. Tarlovskaia E.I., Nechaeva G.I., Mal'chikova S.V., Semenkin A.A. Prognozirovanie vliianiia original'nogo i genericheskogo rozuvastatina na priamye meditsinskie zatraty pri vtorichnoi profilaktike u patsientov s khronicheskimi formami ishemicheskoi bolezni serdtsa. Kardiovask. terapiia i profilaktika. 2015; 14 (4): 29–37. [in Russian]
Авторы
Г.С.Аникин*1,2, И.К.Сторожук2, Я.Ю.Филязова2
1 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119992, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
2 ФГБУ «Поликлиника №3 Управления делами Президента РФ». 129090, Россия, Москва, Грохольский пер., д. 31
*medi321@mail.ru
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G.S.Anikin*1,2, I.K.Storozhuk2, Ya.Yu.Filyazova2
1 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119992, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
2 Out-Patient Сlinic №3 of Administration of the President of Russian Federation. 129090, Russian Federation, Moscow, Grokhol'skii per., d. 31
*medi321@mail.ru