Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Факторы риска прогрессирования сосудистого ремоделирования сонных артерий у пациентов с артериальной гипертензией
Факторы риска прогрессирования сосудистого ремоделирования сонных артерий у пациентов с артериальной гипертензией
Павлова О.С., Коробко И.Ю., Нечесова Т.А. и др. Факторы риска прогрессирования сосудистого ремоделирования сонных артерий у пациентов с артериальной гипертензией. Системные гипертензии. 2018; 15 (3): 32–38. DOI: 10.26442/2075-082X_2018.3.32-38
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Цель исследования – определить клинико-генетические факторы риска развития и прогрессирования сосудистого ремоделирования сонных артерий по данным проспективного 5-летнего наблюдения пациентов с эссенциальной артериальной гипертензией (АГ).
Материал и методы. Повторное клинико-инструментальное обследование с оценкой сопутствующих факторов сердечно-сосудистого риска (ожирение, курение, употребление алкоголя, уровень физической активности, гипергликемия, гиперхолестеринемия, признаки депрессии) проведено у 78 пациентов с АГ. При ультразвуковом исследовании сонных артерий определялись толщина комплекса интима–медиа (КИМ) и наличие атеросклеротических бляшек. Для изучения полиморфизма генов ренин-ангиотензин-альдостероновой системы использовали метод полимеразной цепной реакции и полиморфизма длин рестрикционных фрагментов.
Результаты. Прогрессирование сосудистого ремоделирования по результатам повторного обследования сонных артерий через 5 лет наблюдалось у 26 пациентов (33,3%). Возраст (r=0,53; p=0,001), степень АГ (r=0,43; p=0,001), уровень офисного систолического артериального давления (r=0,295; p=0,009), наличие мутантного С аллеля полиморфизма A1166C гена рецепторов 1-го типа к ангиотензину II – AGTR1 (r=0,387; p=0,0001), содержание глюкозы в крови (r=0,30; p=0,011), окружность талии (r=0,258; p=0,023) были ассоциированы с увеличением КИМ общей сонной артерии (ОСА) у пациентов с АГ. При проведении множественного линейного регрессионного анализа определены независимые факторы, влияющие на толщину КИМ ОСА – возраст (b=0,62; p=0,01), мужской пол (b=0,321; p=0,01) и носительство мутантного С аллеля полиморфизма A1166C гена AGTR1 (b=0,312; p=0,01).
Выводы. Факторами риска прогрессирования сосудистого ремоделирования сонных артерий у пациентов с АГ являлись возраст, мужской пол и полиморфизм A1166C гена AGTR1.
Ключевые слова: эссенциальная артериальная гипертензия, сосудистое ремоделирование, сонные артерии, комплекс интима–медиа, генетический полиморфизм, ренин-ангиотензин-альдостероновая система, ген рецепторов 1-го типа к ангиотензину II.
Material and methods. The repeat clinical and instrumental examination with assessment of concomitant cardiovascular risk factors (obesity, smoking, alcohol consumption, physical activity level, hyperglycemia, hypercholesterolemia, signs of depression) was performed in 78 patients with AH. The ultrasound examination of carotid arteries included evaluation of intima–media complex thickness (IMT) and the presence of atherosclerotic plaques. The polymorphism of the genes of the renin-angiotensin-aldosterone system analyzed by polymerase chain reaction and polymorphism of restriction fragment lengths.
Results. Progression of vascular remodeling was observed in 26 patients (33.3%) according to the results of carotid arteries examination after 5 years. Age (r=0.53; p=0.001), degree of AH (r=0.43; p=0.0001), level of office systolic blood pressure (r=0.295; p=0.0090), presence of the mutant C allele polymorphism A1166C of the angiotensin II type 1 receptor gene – AGTR1 (r=0.387; p=0.0001), blood glucose (r=0.30; p=0.010), waist circumference (r=0.258; p=0.023) were associated with an increase IMT common carotid artery (CCA) in patients with AH. The multiple linear regression analysis identified independent factors influencing on the IMT CCA – age (b=0.62; p=0.01), males (b=0.321; p=0.01) and the mutant C allele carrier polymorphism A1166C of AGTR1 gene (b=0.312; p=0.01).
Conclusions. The progression of carotid vascular remodeling risk factors in patients with AH were age, male gender and polymorphism of A1166C gene AGTR1.
Key words: essential arterial hypertension, vascular remodeling, carotid arteries, intima–media complex, genetic polymorphism, renin-angiotensin-aldosterone system, angiotensin II type 1 receptor gene.
Материал и методы. Повторное клинико-инструментальное обследование с оценкой сопутствующих факторов сердечно-сосудистого риска (ожирение, курение, употребление алкоголя, уровень физической активности, гипергликемия, гиперхолестеринемия, признаки депрессии) проведено у 78 пациентов с АГ. При ультразвуковом исследовании сонных артерий определялись толщина комплекса интима–медиа (КИМ) и наличие атеросклеротических бляшек. Для изучения полиморфизма генов ренин-ангиотензин-альдостероновой системы использовали метод полимеразной цепной реакции и полиморфизма длин рестрикционных фрагментов.
Результаты. Прогрессирование сосудистого ремоделирования по результатам повторного обследования сонных артерий через 5 лет наблюдалось у 26 пациентов (33,3%). Возраст (r=0,53; p=0,001), степень АГ (r=0,43; p=0,001), уровень офисного систолического артериального давления (r=0,295; p=0,009), наличие мутантного С аллеля полиморфизма A1166C гена рецепторов 1-го типа к ангиотензину II – AGTR1 (r=0,387; p=0,0001), содержание глюкозы в крови (r=0,30; p=0,011), окружность талии (r=0,258; p=0,023) были ассоциированы с увеличением КИМ общей сонной артерии (ОСА) у пациентов с АГ. При проведении множественного линейного регрессионного анализа определены независимые факторы, влияющие на толщину КИМ ОСА – возраст (b=0,62; p=0,01), мужской пол (b=0,321; p=0,01) и носительство мутантного С аллеля полиморфизма A1166C гена AGTR1 (b=0,312; p=0,01).
Выводы. Факторами риска прогрессирования сосудистого ремоделирования сонных артерий у пациентов с АГ являлись возраст, мужской пол и полиморфизм A1166C гена AGTR1.
Ключевые слова: эссенциальная артериальная гипертензия, сосудистое ремоделирование, сонные артерии, комплекс интима–медиа, генетический полиморфизм, ренин-ангиотензин-альдостероновая система, ген рецепторов 1-го типа к ангиотензину II.
________________________________________________
Material and methods. The repeat clinical and instrumental examination with assessment of concomitant cardiovascular risk factors (obesity, smoking, alcohol consumption, physical activity level, hyperglycemia, hypercholesterolemia, signs of depression) was performed in 78 patients with AH. The ultrasound examination of carotid arteries included evaluation of intima–media complex thickness (IMT) and the presence of atherosclerotic plaques. The polymorphism of the genes of the renin-angiotensin-aldosterone system analyzed by polymerase chain reaction and polymorphism of restriction fragment lengths.
Results. Progression of vascular remodeling was observed in 26 patients (33.3%) according to the results of carotid arteries examination after 5 years. Age (r=0.53; p=0.001), degree of AH (r=0.43; p=0.0001), level of office systolic blood pressure (r=0.295; p=0.0090), presence of the mutant C allele polymorphism A1166C of the angiotensin II type 1 receptor gene – AGTR1 (r=0.387; p=0.0001), blood glucose (r=0.30; p=0.010), waist circumference (r=0.258; p=0.023) were associated with an increase IMT common carotid artery (CCA) in patients with AH. The multiple linear regression analysis identified independent factors influencing on the IMT CCA – age (b=0.62; p=0.01), males (b=0.321; p=0.01) and the mutant C allele carrier polymorphism A1166C of AGTR1 gene (b=0.312; p=0.01).
Conclusions. The progression of carotid vascular remodeling risk factors in patients with AH were age, male gender and polymorphism of A1166C gene AGTR1.
Key words: essential arterial hypertension, vascular remodeling, carotid arteries, intima–media complex, genetic polymorphism, renin-angiotensin-aldosterone system, angiotensin II type 1 receptor gene.
Полный текст
Список литературы
1. Распространенность факторов риска неинфекционных заболеваний в Республике Беларусь. STEPS 2016. Отчет по результатам Всемирной организации здравоохранения. Минск, 2017; c. 247. / Rasprostranennost faktorov riska neinfekcionnyh zabolevanij v Respublike Belarus. STEPS 2016. Otchet po rezultatam Vsemirnoj organizacii zdravoohraneniya. Minsk, 2017; c. 247. [in Russian]
2. Kearney PM, Whelton M, Reynolds K et al. Global burden of hypertension: analysis worldwide data. Lancet 2005; 365 (9455): 217–23.
3. O Donnell M, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
4. Шляхто Е.В. Ремоделирование сердечно-сосудистой системы при артериальной гипертензии. СПб.: Издательство Политехнического университета, 2009. / Shlyakhto E.V. Remodelirovanie serdechno-sosudistoi sistemy pri arterial'noi gipertenzii. SPb.: Izdatel'stvo Politekhnicheskogo universiteta, 2009. [in Russian]
5. Lacolley P, Challande P, Osborne-Pellegrin M, Regnault V. Genetics and pathophysiology of arterial stiffness. Cardiovasc Res 2009; 81: 637–48.
6. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34 (28): 2159–221.
7. Van den Oord SC, Sijbrands EJ, ten Kate GL et al. Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 2013; 228: 1–11.
8. Chambless LE, Heiss G, Folsom AR et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146 (6): 483–94.
9. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. J Intern Med 1991; 229: 225–31.
10. Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study. Stroke 1997; 28: 348–53.
11. O’Leary DH, Polak JF, Kronmal RA et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14–22.
12. Wang JG, Staessen JA, Li Y et al. Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials. Stroke 2006; 37: 1933–40.
13. Bots ML, Groenewegen KA, Anderson TJ et al. Common carotid intima‐media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE‐IMT collaboration. Hypertension 2014; 63: 1173–81.
14. Свищенко Е., Коваленко В. Гипертоническая болезнь. Вторичные гипертензии. Киев: Лыбидь, 2002. / Svishchenko E., Kovalenko V. Gipertonicheskaya bolezn'. Vtorichnye gipertenzii. Kiev: Lybid', 2002. [in Russian]
15. Ferreira JP, Girerd N, Bozec E et al. Intima-Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population-Based Cohort (STANISLAS Cohort Study). J Am Heart Assoc 2016; 16 (5): 1–15.
16. Карпов Р.С., Кошельская О.А., Винницкая И.В. Структурные изменения магистральных артерий при артериальной гипертонии, ассоциированной с сахарным диабетом: гендерные особенности и влияние контроля артериального давления. Бюллетень СО РАМН. 2012; 32 (1): 67–80. / Karpov R.S., Koshel'skaya O.A., Vinnitskaya I.V. Strukturnye izmeneniya magistral'nykh arterii pri arterial'noi gipertonii, assotsiirovannoi s sakharnym diabetom: gendernye osobennosti i vliyanie kontrolya arterial'nogo davleniya. Byulleten' SO RAMN. 2012; 32 (1): 67–80. [in Russian]
17. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 1994; 25 (1): 66–73.
18. Tatsukawa M, Sawayama Y, Maeda N et al. Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis 2004; 172 (2): 337–43.
19. Tsivgoulis G, Vemmos K, Papamichael C. Common Carotid Artery Intima-Media Thickness and the Risk of Stroke Recurrence. Stroke 2006; 37: 1913–6.
20. Fox CS, Polak JF, Chazaro I et al. Framingham Heart Study. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 2003; 34: 397–401.
21. Zannad F, Visvikis S, Gueguen R et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998; 103: 183–8.
22. Xiang AH, Azen SP, Buchanan TA et al. Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent. Arterioscler Thromb Vasc Biol 2002; 22: 843–8.
23. North KE, MacCluer JW, Devereux RB et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 2002; 22: 1698–703.
24. Juo SH, Lin HF, Rundek T et al. Stroke. Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study. Stroke 2004; 35 (10): 2243–7.
25. Goodfriend TL, Elliott ME, Catt KJ. Angiotensin receptors and their antagonists. N Engl J Med 1996; 334 (25): 1649–54.
26. Jeunemaitre X. Genetics of the human rennin angiotensin system. J Mol Med 2008; 86: 637–41.
27. Spiering W, Kroon AA, Fuss-Lejeune MM et al. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 2000; 36 (3): 411–6.
28. Li Y, Li X, Jia N et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations. J RAAS 2013; 14 (1): 82–90.
29. Rubattu S, Di Angelantonio E, Stanzione R et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens 2004; 22 (11): 2129–34.
30. Jin Y, Kuznetsova T, Thijs L, Staessen JA. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens 2012; 25 (4): 472–8.
31. Benetos A, Topouchian J, Ricard S et al. Hypertension. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995; 26 (1): 44–7.
32. Lajemi M, Labat C, Gautier S et al. Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. J Hypertens 2001; 19 (3): 407–13.
33. Кузнецова Т.Ю. Клинико-генетические факторы предрасположенности к артериальной гипертензии и поражению органов-мишеней. Автореф. ... д-ра мед. наук. М., 2009. / Kuznetsova T.Yu. Kliniko-geneticheskie faktory predraspolozhennosti k arterial'noi gipertenzii i porazheniyu organov-mishenei. Avtoref. ... d-ra med. nauk. M., 2009. [in Russian]
2. Kearney PM, Whelton M, Reynolds K et al. Global burden of hypertension: analysis worldwide data. Lancet 2005; 365 (9455): 217–23.
3. O Donnell M, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
4. Shlyakhto E.V. Remodelirovanie serdechno-sosudistoi sistemy pri arterial'noi gipertenzii. SPb.: Izdatel'stvo Politekhnicheskogo universiteta, 2009. [in Russian]
5. Lacolley P, Challande P, Osborne-Pellegrin M, Regnault V. Genetics and pathophysiology of arterial stiffness. Cardiovasc Res 2009; 81: 637–48.
6. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34 (28): 2159–221.
7. Van den Oord SC, Sijbrands EJ, ten Kate GL et al. Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 2013; 228: 1–11.
8. Chambless LE, Heiss G, Folsom AR et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146 (6): 483–94.
9. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. J Intern Med 1991; 229: 225–31.
10. Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study. Stroke 1997; 28: 348–53.
11. O’Leary DH, Polak JF, Kronmal RA et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14–22.
12. Wang JG, Staessen JA, Li Y et al. Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials. Stroke 2006; 37: 1933–40.
13. Bots ML, Groenewegen KA, Anderson TJ et al. Common carotid intima‐media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE‐IMT collaboration. Hypertension 2014; 63: 1173–81.
14. Svishchenko E., Kovalenko V. Gipertonicheskaya bolezn'. Vtorichnye gipertenzii. Kiev: Lybid', 2002. [in Russian]
15. Ferreira JP, Girerd N, Bozec E et al. Intima-Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population-Based Cohort (STANISLAS Cohort Study). J Am Heart Assoc 2016; 16 (5): 1–15.
16. Karpov R.S., Koshel'skaya O.A., Vinnitskaya I.V. Strukturnye izmeneniya magistral'nykh arterii pri arterial'noi gipertonii, assotsiirovannoi s sakharnym diabetom: gendernye osobennosti i vliyanie kontrolya arterial'nogo davleniya. Byulleten' SO RAMN. 2012; 32 (1): 67–80. [in Russian]
17. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 1994; 25 (1): 66–73.
18. Tatsukawa M, Sawayama Y, Maeda N et al. Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis 2004; 172 (2): 337–43.
19. Tsivgoulis G, Vemmos K, Papamichael C. Common Carotid Artery Intima-Media Thickness and the Risk of Stroke Recurrence. Stroke 2006; 37: 1913–6.
20. Fox CS, Polak JF, Chazaro I et al. Framingham Heart Study. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 2003; 34: 397–401.
21. Zannad F, Visvikis S, Gueguen R et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998; 103: 183–8.
22. Xiang AH, Azen SP, Buchanan TA et al. Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent. Arterioscler Thromb Vasc Biol 2002; 22: 843–8.
23. North KE, MacCluer JW, Devereux RB et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 2002; 22: 1698–703.
24. Juo SH, Lin HF, Rundek T et al. Stroke. Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study. Stroke 2004; 35 (10): 2243–7.
25. Goodfriend TL, Elliott ME, Catt KJ. Angiotensin receptors and their antagonists. N Engl J Med 1996; 334 (25): 1649–54.
26. Jeunemaitre X. Genetics of the human rennin angiotensin system. J Mol Med 2008; 86: 637–41.
27. Spiering W, Kroon AA, Fuss-Lejeune MM et al. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 2000; 36 (3): 411–6.
28. Li Y, Li X, Jia N et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations. J RAAS 2013; 14 (1): 82–90.
29. Rubattu S, Di Angelantonio E, Stanzione R et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens 2004; 22 (11): 2129–34.
30. Jin Y, Kuznetsova T, Thijs L, Staessen JA. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens 2012; 25 (4): 472–8.
31. Benetos A, Topouchian J, Ricard S et al. Hypertension. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995; 26 (1): 44–7.
32. Lajemi M, Labat C, Gautier S et al. Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. J Hypertens 2001; 19 (3): 407–13.
33. Kuznetsova T.Yu. Kliniko-geneticheskie faktory predraspolozhennosti k arterial'noi gipertenzii i porazheniyu organov-mishenei. Avtoref. ... d-ra med. nauk. M., 2009. [in Russian]
2. Kearney PM, Whelton M, Reynolds K et al. Global burden of hypertension: analysis worldwide data. Lancet 2005; 365 (9455): 217–23.
3. O Donnell M, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
4. Шляхто Е.В. Ремоделирование сердечно-сосудистой системы при артериальной гипертензии. СПб.: Издательство Политехнического университета, 2009. / Shlyakhto E.V. Remodelirovanie serdechno-sosudistoi sistemy pri arterial'noi gipertenzii. SPb.: Izdatel'stvo Politekhnicheskogo universiteta, 2009. [in Russian]
5. Lacolley P, Challande P, Osborne-Pellegrin M, Regnault V. Genetics and pathophysiology of arterial stiffness. Cardiovasc Res 2009; 81: 637–48.
6. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34 (28): 2159–221.
7. Van den Oord SC, Sijbrands EJ, ten Kate GL et al. Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 2013; 228: 1–11.
8. Chambless LE, Heiss G, Folsom AR et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146 (6): 483–94.
9. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. J Intern Med 1991; 229: 225–31.
10. Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study. Stroke 1997; 28: 348–53.
11. O’Leary DH, Polak JF, Kronmal RA et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14–22.
12. Wang JG, Staessen JA, Li Y et al. Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials. Stroke 2006; 37: 1933–40.
13. Bots ML, Groenewegen KA, Anderson TJ et al. Common carotid intima‐media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE‐IMT collaboration. Hypertension 2014; 63: 1173–81.
14. Свищенко Е., Коваленко В. Гипертоническая болезнь. Вторичные гипертензии. Киев: Лыбидь, 2002. / Svishchenko E., Kovalenko V. Gipertonicheskaya bolezn'. Vtorichnye gipertenzii. Kiev: Lybid', 2002. [in Russian]
15. Ferreira JP, Girerd N, Bozec E et al. Intima-Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population-Based Cohort (STANISLAS Cohort Study). J Am Heart Assoc 2016; 16 (5): 1–15.
16. Карпов Р.С., Кошельская О.А., Винницкая И.В. Структурные изменения магистральных артерий при артериальной гипертонии, ассоциированной с сахарным диабетом: гендерные особенности и влияние контроля артериального давления. Бюллетень СО РАМН. 2012; 32 (1): 67–80. / Karpov R.S., Koshel'skaya O.A., Vinnitskaya I.V. Strukturnye izmeneniya magistral'nykh arterii pri arterial'noi gipertonii, assotsiirovannoi s sakharnym diabetom: gendernye osobennosti i vliyanie kontrolya arterial'nogo davleniya. Byulleten' SO RAMN. 2012; 32 (1): 67–80. [in Russian]
17. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 1994; 25 (1): 66–73.
18. Tatsukawa M, Sawayama Y, Maeda N et al. Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis 2004; 172 (2): 337–43.
19. Tsivgoulis G, Vemmos K, Papamichael C. Common Carotid Artery Intima-Media Thickness and the Risk of Stroke Recurrence. Stroke 2006; 37: 1913–6.
20. Fox CS, Polak JF, Chazaro I et al. Framingham Heart Study. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 2003; 34: 397–401.
21. Zannad F, Visvikis S, Gueguen R et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998; 103: 183–8.
22. Xiang AH, Azen SP, Buchanan TA et al. Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent. Arterioscler Thromb Vasc Biol 2002; 22: 843–8.
23. North KE, MacCluer JW, Devereux RB et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 2002; 22: 1698–703.
24. Juo SH, Lin HF, Rundek T et al. Stroke. Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study. Stroke 2004; 35 (10): 2243–7.
25. Goodfriend TL, Elliott ME, Catt KJ. Angiotensin receptors and their antagonists. N Engl J Med 1996; 334 (25): 1649–54.
26. Jeunemaitre X. Genetics of the human rennin angiotensin system. J Mol Med 2008; 86: 637–41.
27. Spiering W, Kroon AA, Fuss-Lejeune MM et al. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 2000; 36 (3): 411–6.
28. Li Y, Li X, Jia N et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations. J RAAS 2013; 14 (1): 82–90.
29. Rubattu S, Di Angelantonio E, Stanzione R et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens 2004; 22 (11): 2129–34.
30. Jin Y, Kuznetsova T, Thijs L, Staessen JA. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens 2012; 25 (4): 472–8.
31. Benetos A, Topouchian J, Ricard S et al. Hypertension. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995; 26 (1): 44–7.
32. Lajemi M, Labat C, Gautier S et al. Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. J Hypertens 2001; 19 (3): 407–13.
33. Кузнецова Т.Ю. Клинико-генетические факторы предрасположенности к артериальной гипертензии и поражению органов-мишеней. Автореф. ... д-ра мед. наук. М., 2009. / Kuznetsova T.Yu. Kliniko-geneticheskie faktory predraspolozhennosti k arterial'noi gipertenzii i porazheniyu organov-mishenei. Avtoref. ... d-ra med. nauk. M., 2009. [in Russian]
________________________________________________
2. Kearney PM, Whelton M, Reynolds K et al. Global burden of hypertension: analysis worldwide data. Lancet 2005; 365 (9455): 217–23.
3. O Donnell M, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376 (9735): 112–23.
4. Shlyakhto E.V. Remodelirovanie serdechno-sosudistoi sistemy pri arterial'noi gipertenzii. SPb.: Izdatel'stvo Politekhnicheskogo universiteta, 2009. [in Russian]
5. Lacolley P, Challande P, Osborne-Pellegrin M, Regnault V. Genetics and pathophysiology of arterial stiffness. Cardiovasc Res 2009; 81: 637–48.
6. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34 (28): 2159–221.
7. Van den Oord SC, Sijbrands EJ, ten Kate GL et al. Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 2013; 228: 1–11.
8. Chambless LE, Heiss G, Folsom AR et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146 (6): 483–94.
9. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. J Intern Med 1991; 229: 225–31.
10. Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study. Stroke 1997; 28: 348–53.
11. O’Leary DH, Polak JF, Kronmal RA et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14–22.
12. Wang JG, Staessen JA, Li Y et al. Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials. Stroke 2006; 37: 1933–40.
13. Bots ML, Groenewegen KA, Anderson TJ et al. Common carotid intima‐media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE‐IMT collaboration. Hypertension 2014; 63: 1173–81.
14. Svishchenko E., Kovalenko V. Gipertonicheskaya bolezn'. Vtorichnye gipertenzii. Kiev: Lybid', 2002. [in Russian]
15. Ferreira JP, Girerd N, Bozec E et al. Intima-Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population-Based Cohort (STANISLAS Cohort Study). J Am Heart Assoc 2016; 16 (5): 1–15.
16. Karpov R.S., Koshel'skaya O.A., Vinnitskaya I.V. Strukturnye izmeneniya magistral'nykh arterii pri arterial'noi gipertonii, assotsiirovannoi s sakharnym diabetom: gendernye osobennosti i vliyanie kontrolya arterial'nogo davleniya. Byulleten' SO RAMN. 2012; 32 (1): 67–80. [in Russian]
17. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 1994; 25 (1): 66–73.
18. Tatsukawa M, Sawayama Y, Maeda N et al. Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis 2004; 172 (2): 337–43.
19. Tsivgoulis G, Vemmos K, Papamichael C. Common Carotid Artery Intima-Media Thickness and the Risk of Stroke Recurrence. Stroke 2006; 37: 1913–6.
20. Fox CS, Polak JF, Chazaro I et al. Framingham Heart Study. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 2003; 34: 397–401.
21. Zannad F, Visvikis S, Gueguen R et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998; 103: 183–8.
22. Xiang AH, Azen SP, Buchanan TA et al. Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent. Arterioscler Thromb Vasc Biol 2002; 22: 843–8.
23. North KE, MacCluer JW, Devereux RB et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 2002; 22: 1698–703.
24. Juo SH, Lin HF, Rundek T et al. Stroke. Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study. Stroke 2004; 35 (10): 2243–7.
25. Goodfriend TL, Elliott ME, Catt KJ. Angiotensin receptors and their antagonists. N Engl J Med 1996; 334 (25): 1649–54.
26. Jeunemaitre X. Genetics of the human rennin angiotensin system. J Mol Med 2008; 86: 637–41.
27. Spiering W, Kroon AA, Fuss-Lejeune MM et al. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 2000; 36 (3): 411–6.
28. Li Y, Li X, Jia N et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations. J RAAS 2013; 14 (1): 82–90.
29. Rubattu S, Di Angelantonio E, Stanzione R et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens 2004; 22 (11): 2129–34.
30. Jin Y, Kuznetsova T, Thijs L, Staessen JA. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens 2012; 25 (4): 472–8.
31. Benetos A, Topouchian J, Ricard S et al. Hypertension. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995; 26 (1): 44–7.
32. Lajemi M, Labat C, Gautier S et al. Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. J Hypertens 2001; 19 (3): 407–13.
33. Kuznetsova T.Yu. Kliniko-geneticheskie faktory predraspolozhennosti k arterial'noi gipertenzii i porazheniyu organov-mishenei. Avtoref. ... d-ra med. nauk. M., 2009. [in Russian]
Авторы
О.С.Павлова*1, И.Ю.Коробко1, Т.А.Нечесова1, М.М.Ливенцева1, Н.В.Затолока1, Е.В.Ковш1, С.Э.Огурцова2, А.Г.Мрочек1
1 Республиканский научно-практический центр «Кардиология». 220036, Республика Беларусь, Минск, ул. Розы Люксембург, д. 110б;
2 Институт биоорганической химии Национальной академии наук Беларуси. 220141, Республика Беларусь, Минск, ул. Aкадемика Купревича, д. 5/2
*olga.s_pavlova@yahoo.com
1 Republican Scientific and Practical Centre “Cardiology”. 220036, Republic of Belarus, Minsk, ul. Rosy Luxembourg, d. 110b;
2 Institute of Bioorganic Chemistry of the National Academy of Sciences of the Republic of Belarus. 220141, Republic of Belarus, Minsk, Akademika Kuprevicha str., 5/2
*olga.s_pavlova@yahoo.com
1 Республиканский научно-практический центр «Кардиология». 220036, Республика Беларусь, Минск, ул. Розы Люксембург, д. 110б;
2 Институт биоорганической химии Национальной академии наук Беларуси. 220141, Республика Беларусь, Минск, ул. Aкадемика Купревича, д. 5/2
*olga.s_pavlova@yahoo.com
________________________________________________
1 Republican Scientific and Practical Centre “Cardiology”. 220036, Republic of Belarus, Minsk, ul. Rosy Luxembourg, d. 110b;
2 Institute of Bioorganic Chemistry of the National Academy of Sciences of the Republic of Belarus. 220141, Republic of Belarus, Minsk, Akademika Kuprevicha str., 5/2
*olga.s_pavlova@yahoo.com
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.