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Хроническое миокардиальное повреждение при идиопатической легочной артериальной гипертензии. Клиническое наблюдение
Хроническое миокардиальное повреждение при идиопатической легочной артериальной гипертензии. Клиническое наблюдение
Быков А.Н., Архипов М.В., Климушева Н.Ф. и др. Хроническое миокардиальное повреждение при идиопатической легочной артериальной гипертензии. Клиническое наблюдение. Системные гипертензии. 2018; 15 (4): 83–90. DOI: 10.26442/2075082X.2018.4.180105
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Аннотация
Хроническое миокардиальное повреждение, определяемое постоянно повышенным уровнем сердечного тропонина (cTn), может наблюдаться у пациентов с легочной гипертензией (ЛГ), что указывает на тяжесть заболевания и связано с неблагоприятным прогнозом. Увеличение cTn среди пациентов с ЛГ регистрировалось и ранее 2018 г., но лишь с принятием Четвертого пересмотра определения инфаркта миокарда (2018 г.) пришло понимание этого феномена. Одной из причин хронического миокардиального повреждения у пациентов с ЛГ является компрессия коронарных артерий. Синдром сдавления ствола левой коронарной артерии (ЛКА) является редкой, вероятно, недооцененной причиной стенокардитической боли в груди и желудочковой недостаточности у пациентов с тяжелой формой легочной артериальной гипертензии (ЛАГ). Компрессия ствола ЛКА расширенным стволом легочной артерии была ассоциирована со стенокардией, однако правильные подходы к диагностике и лечению остаются до настоящего момента малоизученными. Приводится клинический случай пациентки с идиопатической ЛАГ и компрессией ствола ЛКА расширенной легочной артерией. Диагноз стеноза ЛКА был подтвержден мультиспиральной компьютерной томографией и коронарной ангиографией. Биомаркеры, такие как cTn и мозговой натрийуретический пептид, были определены как критерии оптимального лечения. Чрескожное коронарное вмешательство в сочетании с ЛАГ-специфической терапией – возможный, безопасный и эффективный вариант лечения пациентов с наружной компрессией ствола ЛКА расширенной легочной артерии.
Ключевые слова: хроническое миокардиальное повреждение, мозговой натрийуретический пептид, сердечный тропонин, легочная артериальная гипертензия, сдавление ствола левой коронарной артерии, ствол легочной артерии, чрескожное коронарное вмешательство, ЛАГ-специфическая терапия.
Key words: chronic myocardial injury, brain natriuretic peptide, cardiac troponin, pulmonary arterial hypertension, compression of the left main coronary artery, pulmonary artery trunk, percutaneous coronary intervention, pulmonary arterial hypertension-specific therapy.
Ключевые слова: хроническое миокардиальное повреждение, мозговой натрийуретический пептид, сердечный тропонин, легочная артериальная гипертензия, сдавление ствола левой коронарной артерии, ствол легочной артерии, чрескожное коронарное вмешательство, ЛАГ-специфическая терапия.
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Key words: chronic myocardial injury, brain natriuretic peptide, cardiac troponin, pulmonary arterial hypertension, compression of the left main coronary artery, pulmonary artery trunk, percutaneous coronary intervention, pulmonary arterial hypertension-specific therapy.
Полный текст
Список литературы
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47. Weil BR, Suzuki G, Young RF et al. Troponin release and reversible left ventricular dysfunction following transient pressure overload: Stressinduced myocardial stunning. J Am Cardiol Coll 2018; 71: 2906–16.
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52. Akbal OY, Kaymaz C, Tanboga IH et al. Extrinsic compression of left main coronary artery by aneurysmal pulmonary artery in severe pulmonary hypertension: its correlates, clinical impact, and management strategies Eur Heart J Cardiovasc Imaging 2018; 19: 1302–8. DOI: 10.1093/ehjci/jex303
2. Galie N, Humbert M, Vachiery JL et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Respir J 2015; 46 (4): 903–75.
3. Martyniuk T.V. Legochnaia gipertenziia: diagnostika i lechenie. M., 2018; s. 148. [in Russian]
4. Galiè N, Saia F et al. Left Main Coronary Artery Compression in Patients With Pulmonary Arterial Hypertension and Angina. JACC 2017; 69 (2): 808–17.
5. Rich S, Dantzker D, Ayres S et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216–23.
6. De Jesus Perez VA, Haddad F et al. Angina associated with left main coronary artery compression in pulmonary hypertension. J Heart Lung Transplant 2009; 28: 527–30.
7. Mesquita S, Castro C et al. Likelihood of left main coronary artery compression based on pulmonary trunk diameter in patients with pulmonary hypertension. Am J Med 2004; 116: 369–74.
8. Vaseghi M, Lee J et al. Acute myocardial infarction secondary to left main coronary artery compression by pulmonary artery aneurysm in pulmonary arterial hypertension. J Invasive Cardiol 2007; 19 (12): 375–77.
9. Kajita L, Martinez E, Ambrose J et al. Extrinsic compression of the left main coronary artery by a dilated pulmonary artery: clinical, angiographic, and hemodynamic determinants. Catheter Cardiovasc Interv 2001; 52: 49–54.
10. Corday E, Gold H, Kaplan L. Coronary artery compression: an explanation for the cause of coronary insufficiency in pulmonary hypertension. Trans Am Coll Cardiol 1957; 7: 93–103.
11. Paç FA, Cağdaş DN, Ulaş M et al. Left main coronary artery and aortic root compression associated with atrial septal defect and pulmonary hypertension. Int J Cardiol 2007; 118: e41–e43.
12. Andjelkovic K, Kalimanovska-Ostric D et al. Two rare conditions in an Eisenmenger patient: Left main coronary artery compression and Ortner’s syndrome due to pulmonary artery dilatation. Heart Lung 2013; 42: 382–6.
13. Sivakumar K, Rajan M, Francis G et al. Extrinsic compression of the left coronary ostium by the pulmonary trunk: management in a case of Eisenmenger syndrome. Tex Heart Inst J 2010; 37 (1): 95–8.
14. Rich S, Dantzker DR, Ayres SM et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987; 107: 216–23.
15. Seabra LF, Ribeiro HB et al. Left Main Ostial Compression in a Patient with Pulmonary Hypertension: Dynamic Findings by IVUS. Am J Case Rep 2015; 16: 899–903.
16. Ogiso M, Serizawa N et al. Percutaneous Coronary Intervention for Left Main Compression Syndrome due to Severe Idiopathic Pulmonary Arterial Hypertension: One Year Follow-up Using Intravascular Imaging. Intern Med 2015; 54: 801–4.
17. Salhab KF, Al Kindi AH et al. Percutaneous coronary intervention of the left main coronary artery in a patient with extrinsic compression caused by massive pulmonary artery enlargement. J Thorac Cardiovasc Surg 2012; 144: 1517–8.
18. Vaseghi M, Lee M et al. Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm. Catheter Cardiovasc Interv 2010; 76: 352–6.
19. Lee M, Oyama J et al. Left Main Coronary Artery Compression from Pulmonary Artery Enlargement Due to Pulmonary Hypertension: A Contemporary Review and Argument for Percutaneous Revascularization. Catheter Cardiovasc Interv 2010; 76: 543–50.
20. Caldera A, Cruz-Gonzalez I et al. Endovascular Therapy for Left Main Compression Syndrome, Case Report and Literature Review. CHEST 2009; 135: 1648–50.
21. Godfrey A, Cajigas H et al. A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain. CHEST 2014; 145 (3): 642–5.
22. Albadri K, Jensen J et al. Left main coronary artery compression in pulmonary arterial hypertension. Pulm Circ 2015; 5 (4): 734–6. DOI: 10.1086/683690
23. Yoon-Jung Choi, Ung Kim et al. A Case of Extrinsic Compression of the Left Main Coronary Artery Secondary to Pulmonary Artery Dilatation. J Korean Med Sci 2013; 28: 1543–8.
24. Kawut S, Silvestry FE et al. Extrinsic Compression of the Left Main Coronary Artery by the Pulmonary Artery in Patients With Long-Standing Pulmonary Hypertension. Am J Cardiol 1999; 83.
25. Mitsudo K, Fujino T, Matsunaga K et al. Coronary angiographic findings in the patients with atrial septal defect and pulmonary hypertension-compression of left main coronary artery by pulmoanry trunk. Kokyu To Junkan 1989; 37(6): 649-655. Article in Japanese.
26. Lindsey JB, Brilakis ES, Banerjee S. Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention. Cardiovasc Revasc Med 2008; 9 (1): 47–51.
27. Tespili M, Saino A, Personeni D et al. Life-threatening left main stenosis induced by compression from a dilated pulmonary artery J Cardiovasc Med (Hagerstown) 2009; 10 (2): 183–7.
28. Fujiwara K, Naito Y et al. Left main coronary trunk compression by dilated main pulmonary artery in atrial septal defect. Report of three cases. J Thorac Cardiovasc Surg 1992; 104 (2): 449–52.
29. Pina Y, Exaire J et al. Left main coronary artery extrinsic compression syndrome: a combined intravascular ultrasound and pressure wire. J Invasive Cardiol 2006; 18: 102–4.
30. Badagliacca R, Poscia R et al. Pulmonary arterial dilatation in pulmonary hypertension: prevalence and prognostic relevance. Cardiology 2012; 121 (2): 76–82.
31. Humbert M, Sitbon O, Chaouat A et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023–30. DOI: 10.1164/rccm.200510-1668OC
32. Peacock AJ, Murphy NF, McMurray J et al. An epidemiological study of pulmonary arterial hypertension. Eur Respir J 2007; 30: 104–9. DOI: 10.1183/09031936.00092306
33. Ghofrani HA, Voswinckel R, Gall H et al. Riociguat for pulmonary hypertension. Future Cardiol 2010; 6: 155–66.
34. Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 2011; 123: 2263–73.
35. Shmal'ts A.A., Gorbachevskii S.V. Riotsiguat i sildenafil v lechenii legochnoi gipertenzii: skhodstva i razlichiia. Pul'monologiia. 2016; 26 (1): 85–91. [in Russian]
36. Guha M. First-in-class guanylate cyclase stimulator approved for PAH. Nat. Biotechnol 2013; 31: 1064.
37. Hemnes AR, Champion HC. Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. Exp Rev Cardiovasc Ther 2006; 4: 293–300.
38. Ghofrani HA, Hoeper MM, Halank M et al. Riociguat for chronic Thromboembolic pulmonary hypertension and pulmonary arterial hypertension: A phase II study. Eur Respir J 2010; 36: 792–9.
39. Мершин К.В., Мартынюк Т.В. Место медикаментозной терапии в лечении хронической тромбоэмболической легочной гипертензии. Евразийский кардиол. журн. 2014; 1: 113–8. [in Russian]
40. Thygesen K, Alpert JS, Jaffe A et al. The ESC/ACC/AHA/WHF Expert Consensus Document. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2018. DOI: 10.1093/eurheartj/ehy462
41. Thygesen K, Mair J, Katus H et al. The Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010; 31: 2197–204.
42. Thygesen K, Mair J, Giannitsis E et al. Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 2012; 33: 2252–7.
43. Mair J, Lindahl B, Hammarsten O et al. European Society of Cardiology (ESC) Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association (ACCA). How is cardiac troponin released from injured myocardium? Eur Heart J Acute Cardiovasc Care. DOI: 10.1177/2048872617748553. Published ahead of print 1 December 2017.
44. Vestergaard KR, Jespersen CB, Arnadottir A et al. Prevalence and significance of troponin elevations in patients without acute coronary disease. Int J Cardiol 2016; 222: 819–25.
45. Schmid J, Liesinger L, Birner-Gruenberger R et al. Elevated cardiac troponin T in skeletal myopathies. J Am Cardiol Coll 2018; 71: 1540–9.
46. Apple FS, Jaffe AS, Collinson P et al. On behalf of the International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem 2015; 48: 201–3.
47. Weil BR, Suzuki G, Young RF et al. Troponin release and reversible left ventricular dysfunction following transient pressure overload: Stressinduced myocardial stunning. J Am Cardiol Coll 2018; 71: 2906–16.
48. Turer AT, Addo TA, Martin JL et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: Insights from a coronary sinus sampling study. J Am Coll Cardiol 2011; 57: 2398–405.
49. Siriwardena M, Campbell V et al. Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clin Chem 2012; 58: 1492–4.
50. White HD. Pathobiology of troponin elevations: Do elevations occur with myocardial ischemia as well as necrosis? J Am Coll Cardiol 2011; 57: 2406–8.
51. Cherepanova N.A., Dupliakov D.V., Kuz'min V.P. i dr. Opyt ambulatornoi raboty tsentra legochnoi gipertenzii v Samarskoi oblasti. Kompleksnye problemy serdechno-sosudistykh zabolevanii. 2018; 7 (1): 108–13. DOI: 10.17802/2306-1278-2018-7-1-108-113 [in Russian]
52. Akbal OY, Kaymaz C, Tanboga IH et al. Extrinsic compression of left main coronary artery by aneurysmal pulmonary artery in severe pulmonary hypertension: its correlates, clinical impact, and management strategies Eur Heart J Cardiovasc Imaging 2018; 19: 1302–8. DOI: 10.1093/ehjci/jex303
2. Galie N, Humbert M, Vachiery JL et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Respir J 2015; 46 (4): 903–75.
3. Мартынюк Т.В. Легочная гипертензия: диагностика и лечение. М., 2018; с. 148. / Martyniuk T.V. Legochnaia gipertenziia: diagnostika i lechenie. M., 2018; s. 148. [in Russian]
4. Galiè N, Saia F et al. Left Main Coronary Artery Compression in Patients With Pulmonary Arterial Hypertension and Angina. JACC 2017; 69 (2): 808–17.
5. Rich S, Dantzker D, Ayres S et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216–23.
6. De Jesus Perez VA, Haddad F et al. Angina associated with left main coronary artery compression in pulmonary hypertension. J Heart Lung Transplant 2009; 28: 527–30.
7. Mesquita S, Castro C et al. Likelihood of left main coronary artery compression based on pulmonary trunk diameter in patients with pulmonary hypertension. Am J Med 2004; 116: 369–74.
8. Vaseghi M, Lee J et al. Acute myocardial infarction secondary to left main coronary artery compression by pulmonary artery aneurysm in pulmonary arterial hypertension. J Invasive Cardiol 2007; 19 (12): 375–77.
9. Kajita L, Martinez E, Ambrose J et al. Extrinsic compression of the left main coronary artery by a dilated pulmonary artery: clinical, angiographic, and hemodynamic determinants. Catheter Cardiovasc Interv 2001; 52: 49–54.
10. Corday E, Gold H, Kaplan L. Coronary artery compression: an explanation for the cause of coronary insufficiency in pulmonary hypertension. Trans Am Coll Cardiol 1957; 7: 93–103.
11. Paç FA, Cağdaş DN, Ulaş M et al. Left main coronary artery and aortic root compression associated with atrial septal defect and pulmonary hypertension. Int J Cardiol 2007; 118: e41–e43.
12. Andjelkovic K, Kalimanovska-Ostric D et al. Two rare conditions in an Eisenmenger patient: Left main coronary artery compression and Ortner’s syndrome due to pulmonary artery dilatation. Heart Lung 2013; 42: 382–6.
13. Sivakumar K, Rajan M, Francis G et al. Extrinsic compression of the left coronary ostium by the pulmonary trunk: management in a case of Eisenmenger syndrome. Tex Heart Inst J 2010; 37 (1): 95–8.
14. Rich S, Dantzker DR, Ayres SM et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987; 107: 216–23.
15. Seabra LF, Ribeiro HB et al. Left Main Ostial Compression in a Patient with Pulmonary Hypertension: Dynamic Findings by IVUS. Am J Case Rep 2015; 16: 899–903.
16. Ogiso M, Serizawa N et al. Percutaneous Coronary Intervention for Left Main Compression Syndrome due to Severe Idiopathic Pulmonary Arterial Hypertension: One Year Follow-up Using Intravascular Imaging. Intern Med 2015; 54: 801–4.
17. Salhab KF, Al Kindi AH et al. Percutaneous coronary intervention of the left main coronary artery in a patient with extrinsic compression caused by massive pulmonary artery enlargement. J Thorac Cardiovasc Surg 2012; 144: 1517–8.
18. Vaseghi M, Lee M et al. Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm. Catheter Cardiovasc Interv 2010; 76: 352–6.
19. Lee M, Oyama J et al. Left Main Coronary Artery Compression from Pulmonary Artery Enlargement Due to Pulmonary Hypertension: A Contemporary Review and Argument for Percutaneous Revascularization. Catheter Cardiovasc Interv 2010; 76: 543–50.
20. Caldera A, Cruz-Gonzalez I et al. Endovascular Therapy for Left Main Compression Syndrome, Case Report and Literature Review. CHEST 2009; 135: 1648–50.
21. Godfrey A, Cajigas H et al. A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain. CHEST 2014; 145 (3): 642–5.
22. Albadri K, Jensen J et al. Left main coronary artery compression in pulmonary arterial hypertension. Pulm Circ 2015; 5 (4): 734–6. DOI: 10.1086/683690
23. Yoon-Jung Choi, Ung Kim et al. A Case of Extrinsic Compression of the Left Main Coronary Artery Secondary to Pulmonary Artery Dilatation. J Korean Med Sci 2013; 28: 1543–8.
24. Kawut S, Silvestry FE et al. Extrinsic Compression of the Left Main Coronary Artery by the Pulmonary Artery in Patients With Long-Standing Pulmonary Hypertension. Am J Cardiol 1999; 83.
25. Mitsudo K, Fujino T, Matsunaga K et al. Coronary angiographic findings in the patients with atrial septal defect and pulmonary hypertension-compression of left main coronary artery by pulmoanry trunk. Kokyu To Junkan 1989; 37(6): 649-655. Article in Japanese.
26. Lindsey JB, Brilakis ES, Banerjee S. Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention. Cardiovasc Revasc Med 2008; 9 (1): 47–51.
27. Tespili M, Saino A, Personeni D et al. Life-threatening left main stenosis induced by compression from a dilated pulmonary artery J Cardiovasc Med (Hagerstown) 2009; 10 (2): 183–7.
28. Fujiwara K, Naito Y et al. Left main coronary trunk compression by dilated main pulmonary artery in atrial septal defect. Report of three cases. J Thorac Cardiovasc Surg 1992; 104 (2): 449–52.
29. Pina Y, Exaire J et al. Left main coronary artery extrinsic compression syndrome: a combined intravascular ultrasound and pressure wire. J Invasive Cardiol 2006; 18: 102–4.
30. Badagliacca R, Poscia R et al. Pulmonary arterial dilatation in pulmonary hypertension: prevalence and prognostic relevance. Cardiology 2012; 121 (2): 76–82.
31. Humbert M, Sitbon O, Chaouat A et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023–30. DOI: 10.1164/rccm.200510-1668OC
32. Peacock AJ, Murphy NF, McMurray J et al. An epidemiological study of pulmonary arterial hypertension. Eur Respir J 2007; 30: 104–9. DOI: 10.1183/09031936.00092306
33. Ghofrani HA, Voswinckel R, Gall H et al. Riociguat for pulmonary hypertension. Future Cardiol 2010; 6: 155–66.
34. Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 2011; 123: 2263–73.
35. Шмальц А.А., Горбачевский С.В. Риоцигуат и силденафил в лечении легочной гипертензии: сходства и различия. Пульмонология. 2016; 26 (1): 85–91. / Shmal'ts A.A., Gorbachevskii S.V. Riotsiguat i sildenafil v lechenii legochnoi gipertenzii: skhodstva i razlichiia. Pul'monologiia. 2016; 26 (1): 85–91. [in Russian]
36. Guha M. First-in-class guanylate cyclase stimulator approved for PAH. Nat. Biotechnol 2013; 31: 1064.
37. Hemnes AR, Champion HC. Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. Exp Rev Cardiovasc Ther 2006; 4: 293–300.
38. Ghofrani HA, Hoeper MM, Halank M et al. Riociguat for chronic Thromboembolic pulmonary hypertension and pulmonary arterial hypertension: A phase II study. Eur Respir J 2010; 36: 792–9.
39. Мершин К.В., Мартынюк Т.В. Место медикаментозной терапии в лечении хронической тромбоэмболической легочной гипертензии. Евразийский кардиол. журн. 2014; 1: 113–8. [in Russian]
40. Thygesen K, Alpert JS, Jaffe A et al. The ESC/ACC/AHA/WHF Expert Consensus Document. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2018. DOI: 10.1093/eurheartj/ehy462
41. Thygesen K, Mair J, Katus H et al. The Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010; 31: 2197–204.
42. Thygesen K, Mair J, Giannitsis E et al. Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 2012; 33: 2252–7.
43. Mair J, Lindahl B, Hammarsten O et al. European Society of Cardiology (ESC) Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association (ACCA). How is cardiac troponin released from injured myocardium? Eur Heart J Acute Cardiovasc Care. DOI: 10.1177/2048872617748553. Published ahead of print 1 December 2017.
44. Vestergaard KR, Jespersen CB, Arnadottir A et al. Prevalence and significance of troponin elevations in patients without acute coronary disease. Int J Cardiol 2016; 222: 819–25.
45. Schmid J, Liesinger L, Birner-Gruenberger R et al. Elevated cardiac troponin T in skeletal myopathies. J Am Cardiol Coll 2018; 71: 1540–9.
46. Apple FS, Jaffe AS, Collinson P et al. On behalf of the International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem 2015; 48: 201–3.
47. Weil BR, Suzuki G, Young RF et al. Troponin release and reversible left ventricular dysfunction following transient pressure overload: Stressinduced myocardial stunning. J Am Cardiol Coll 2018; 71: 2906–16.
48. Turer AT, Addo TA, Martin JL et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: Insights from a coronary sinus sampling study. J Am Coll Cardiol 2011; 57: 2398–405.
49. Siriwardena M, Campbell V et al. Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clin Chem 2012; 58: 1492–4.
50. White HD. Pathobiology of troponin elevations: Do elevations occur with myocardial ischemia as well as necrosis? J Am Coll Cardiol 2011; 57: 2406–8.
51. Черепанова Н.А., Дупляков Д.В., Кузьмин В.П. и др. Опыт амбулаторной работы центра легочной гипертензии в Самарской области. Комплексные проблемы сердечно-сосудистых заболеваний. 2018; 7 (1): 108–13. DOI: 10.17802/2306-1278-2018-7-1-108-113 / Cherepanova N.A., Dupliakov D.V., Kuz'min V.P. i dr. Opyt ambulatornoi raboty tsentra legochnoi gipertenzii v Samarskoi oblasti. Kompleksnye problemy serdechno-sosudistykh zabolevanii. 2018; 7 (1): 108–13. DOI: 10.17802/2306-1278-2018-7-1-108-113 [in Russian]
52. Akbal OY, Kaymaz C, Tanboga IH et al. Extrinsic compression of left main coronary artery by aneurysmal pulmonary artery in severe pulmonary hypertension: its correlates, clinical impact, and management strategies Eur Heart J Cardiovasc Imaging 2018; 19: 1302–8. DOI: 10.1093/ehjci/jex303
________________________________________________
2. Galie N, Humbert M, Vachiery JL et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Respir J 2015; 46 (4): 903–75.
3. Martyniuk T.V. Legochnaia gipertenziia: diagnostika i lechenie. M., 2018; s. 148. [in Russian]
4. Galiè N, Saia F et al. Left Main Coronary Artery Compression in Patients With Pulmonary Arterial Hypertension and Angina. JACC 2017; 69 (2): 808–17.
5. Rich S, Dantzker D, Ayres S et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216–23.
6. De Jesus Perez VA, Haddad F et al. Angina associated with left main coronary artery compression in pulmonary hypertension. J Heart Lung Transplant 2009; 28: 527–30.
7. Mesquita S, Castro C et al. Likelihood of left main coronary artery compression based on pulmonary trunk diameter in patients with pulmonary hypertension. Am J Med 2004; 116: 369–74.
8. Vaseghi M, Lee J et al. Acute myocardial infarction secondary to left main coronary artery compression by pulmonary artery aneurysm in pulmonary arterial hypertension. J Invasive Cardiol 2007; 19 (12): 375–77.
9. Kajita L, Martinez E, Ambrose J et al. Extrinsic compression of the left main coronary artery by a dilated pulmonary artery: clinical, angiographic, and hemodynamic determinants. Catheter Cardiovasc Interv 2001; 52: 49–54.
10. Corday E, Gold H, Kaplan L. Coronary artery compression: an explanation for the cause of coronary insufficiency in pulmonary hypertension. Trans Am Coll Cardiol 1957; 7: 93–103.
11. Paç FA, Cağdaş DN, Ulaş M et al. Left main coronary artery and aortic root compression associated with atrial septal defect and pulmonary hypertension. Int J Cardiol 2007; 118: e41–e43.
12. Andjelkovic K, Kalimanovska-Ostric D et al. Two rare conditions in an Eisenmenger patient: Left main coronary artery compression and Ortner’s syndrome due to pulmonary artery dilatation. Heart Lung 2013; 42: 382–6.
13. Sivakumar K, Rajan M, Francis G et al. Extrinsic compression of the left coronary ostium by the pulmonary trunk: management in a case of Eisenmenger syndrome. Tex Heart Inst J 2010; 37 (1): 95–8.
14. Rich S, Dantzker DR, Ayres SM et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987; 107: 216–23.
15. Seabra LF, Ribeiro HB et al. Left Main Ostial Compression in a Patient with Pulmonary Hypertension: Dynamic Findings by IVUS. Am J Case Rep 2015; 16: 899–903.
16. Ogiso M, Serizawa N et al. Percutaneous Coronary Intervention for Left Main Compression Syndrome due to Severe Idiopathic Pulmonary Arterial Hypertension: One Year Follow-up Using Intravascular Imaging. Intern Med 2015; 54: 801–4.
17. Salhab KF, Al Kindi AH et al. Percutaneous coronary intervention of the left main coronary artery in a patient with extrinsic compression caused by massive pulmonary artery enlargement. J Thorac Cardiovasc Surg 2012; 144: 1517–8.
18. Vaseghi M, Lee M et al. Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm. Catheter Cardiovasc Interv 2010; 76: 352–6.
19. Lee M, Oyama J et al. Left Main Coronary Artery Compression from Pulmonary Artery Enlargement Due to Pulmonary Hypertension: A Contemporary Review and Argument for Percutaneous Revascularization. Catheter Cardiovasc Interv 2010; 76: 543–50.
20. Caldera A, Cruz-Gonzalez I et al. Endovascular Therapy for Left Main Compression Syndrome, Case Report and Literature Review. CHEST 2009; 135: 1648–50.
21. Godfrey A, Cajigas H et al. A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain. CHEST 2014; 145 (3): 642–5.
22. Albadri K, Jensen J et al. Left main coronary artery compression in pulmonary arterial hypertension. Pulm Circ 2015; 5 (4): 734–6. DOI: 10.1086/683690
23. Yoon-Jung Choi, Ung Kim et al. A Case of Extrinsic Compression of the Left Main Coronary Artery Secondary to Pulmonary Artery Dilatation. J Korean Med Sci 2013; 28: 1543–8.
24. Kawut S, Silvestry FE et al. Extrinsic Compression of the Left Main Coronary Artery by the Pulmonary Artery in Patients With Long-Standing Pulmonary Hypertension. Am J Cardiol 1999; 83.
25. Mitsudo K, Fujino T, Matsunaga K et al. Coronary angiographic findings in the patients with atrial septal defect and pulmonary hypertension-compression of left main coronary artery by pulmoanry trunk. Kokyu To Junkan 1989; 37(6): 649-655. Article in Japanese.
26. Lindsey JB, Brilakis ES, Banerjee S. Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention. Cardiovasc Revasc Med 2008; 9 (1): 47–51.
27. Tespili M, Saino A, Personeni D et al. Life-threatening left main stenosis induced by compression from a dilated pulmonary artery J Cardiovasc Med (Hagerstown) 2009; 10 (2): 183–7.
28. Fujiwara K, Naito Y et al. Left main coronary trunk compression by dilated main pulmonary artery in atrial septal defect. Report of three cases. J Thorac Cardiovasc Surg 1992; 104 (2): 449–52.
29. Pina Y, Exaire J et al. Left main coronary artery extrinsic compression syndrome: a combined intravascular ultrasound and pressure wire. J Invasive Cardiol 2006; 18: 102–4.
30. Badagliacca R, Poscia R et al. Pulmonary arterial dilatation in pulmonary hypertension: prevalence and prognostic relevance. Cardiology 2012; 121 (2): 76–82.
31. Humbert M, Sitbon O, Chaouat A et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023–30. DOI: 10.1164/rccm.200510-1668OC
32. Peacock AJ, Murphy NF, McMurray J et al. An epidemiological study of pulmonary arterial hypertension. Eur Respir J 2007; 30: 104–9. DOI: 10.1183/09031936.00092306
33. Ghofrani HA, Voswinckel R, Gall H et al. Riociguat for pulmonary hypertension. Future Cardiol 2010; 6: 155–66.
34. Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 2011; 123: 2263–73.
35. Shmal'ts A.A., Gorbachevskii S.V. Riotsiguat i sildenafil v lechenii legochnoi gipertenzii: skhodstva i razlichiia. Pul'monologiia. 2016; 26 (1): 85–91. [in Russian]
36. Guha M. First-in-class guanylate cyclase stimulator approved for PAH. Nat. Biotechnol 2013; 31: 1064.
37. Hemnes AR, Champion HC. Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. Exp Rev Cardiovasc Ther 2006; 4: 293–300.
38. Ghofrani HA, Hoeper MM, Halank M et al. Riociguat for chronic Thromboembolic pulmonary hypertension and pulmonary arterial hypertension: A phase II study. Eur Respir J 2010; 36: 792–9.
39. Мершин К.В., Мартынюк Т.В. Место медикаментозной терапии в лечении хронической тромбоэмболической легочной гипертензии. Евразийский кардиол. журн. 2014; 1: 113–8. [in Russian]
40. Thygesen K, Alpert JS, Jaffe A et al. The ESC/ACC/AHA/WHF Expert Consensus Document. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2018. DOI: 10.1093/eurheartj/ehy462
41. Thygesen K, Mair J, Katus H et al. The Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010; 31: 2197–204.
42. Thygesen K, Mair J, Giannitsis E et al. Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 2012; 33: 2252–7.
43. Mair J, Lindahl B, Hammarsten O et al. European Society of Cardiology (ESC) Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association (ACCA). How is cardiac troponin released from injured myocardium? Eur Heart J Acute Cardiovasc Care. DOI: 10.1177/2048872617748553. Published ahead of print 1 December 2017.
44. Vestergaard KR, Jespersen CB, Arnadottir A et al. Prevalence and significance of troponin elevations in patients without acute coronary disease. Int J Cardiol 2016; 222: 819–25.
45. Schmid J, Liesinger L, Birner-Gruenberger R et al. Elevated cardiac troponin T in skeletal myopathies. J Am Cardiol Coll 2018; 71: 1540–9.
46. Apple FS, Jaffe AS, Collinson P et al. On behalf of the International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem 2015; 48: 201–3.
47. Weil BR, Suzuki G, Young RF et al. Troponin release and reversible left ventricular dysfunction following transient pressure overload: Stressinduced myocardial stunning. J Am Cardiol Coll 2018; 71: 2906–16.
48. Turer AT, Addo TA, Martin JL et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: Insights from a coronary sinus sampling study. J Am Coll Cardiol 2011; 57: 2398–405.
49. Siriwardena M, Campbell V et al. Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clin Chem 2012; 58: 1492–4.
50. White HD. Pathobiology of troponin elevations: Do elevations occur with myocardial ischemia as well as necrosis? J Am Coll Cardiol 2011; 57: 2406–8.
51. Cherepanova N.A., Dupliakov D.V., Kuz'min V.P. i dr. Opyt ambulatornoi raboty tsentra legochnoi gipertenzii v Samarskoi oblasti. Kompleksnye problemy serdechno-sosudistykh zabolevanii. 2018; 7 (1): 108–13. DOI: 10.17802/2306-1278-2018-7-1-108-113 [in Russian]
52. Akbal OY, Kaymaz C, Tanboga IH et al. Extrinsic compression of left main coronary artery by aneurysmal pulmonary artery in severe pulmonary hypertension: its correlates, clinical impact, and management strategies Eur Heart J Cardiovasc Imaging 2018; 19: 1302–8. DOI: 10.1093/ehjci/jex303
Авторы
А.Н.Быков*1, М.В.Архипов2, Н.Ф.Климушева1, А.И.Иофин1, В.Я.Крохалев2
1 ГБУЗ СО «Свердловская областная клиническая больница №1». 620102, Россия, Екатеринбург, ул. Волгоградская, д. 185;
2 ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России. 620028, Россия, Екатеринбург, ул. Репина, д. 3
*sashacor83@yandex.ru
1 Sverdlovsk Regional Clinical Hospital №1. 620102, Russian Federation, Ekaterinburg, ul. Volgogradskaia, d. 185;
2 Ural State Medical University of the Ministry of Health of the Russian Federation. 620028, Russian Federation, Yekaterinburg, ul. Repina, d. 3
*sashacor83@yandex.ru
1 ГБУЗ СО «Свердловская областная клиническая больница №1». 620102, Россия, Екатеринбург, ул. Волгоградская, д. 185;
2 ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России. 620028, Россия, Екатеринбург, ул. Репина, д. 3
*sashacor83@yandex.ru
________________________________________________
1 Sverdlovsk Regional Clinical Hospital №1. 620102, Russian Federation, Ekaterinburg, ul. Volgogradskaia, d. 185;
2 Ural State Medical University of the Ministry of Health of the Russian Federation. 620028, Russian Federation, Yekaterinburg, ul. Repina, d. 3
*sashacor83@yandex.ru
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