Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском
Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском
Чазова И.Е., Жернакова Ю.В., Кисляк О.А. и др. Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском. Системные гипертензии. 2019; 16 (4): 8–21. DOI: 10.26442/2075082X.2019.4.190686
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Chazova I.E., Zhernakova Ju.V., Kisliak O.A. et al. Consensus on patients with hyperuricemia and high cardiovascular risk treatment. Systemic Hypertension. 2019; 16 (4): 8–21.
DOI: 10.26442/2075082X.2019.4.190686
Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском
Чазова И.Е., Жернакова Ю.В., Кисляк О.А. и др. Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском. Системные гипертензии. 2019; 16 (4): 8–21. DOI: 10.26442/2075082X.2019.4.190686
________________________________________________
Chazova I.E., Zhernakova Ju.V., Kisliak O.A. et al. Consensus on patients with hyperuricemia and high cardiovascular risk treatment. Systemic Hypertension. 2019; 16 (4): 8–21.
DOI: 10.26442/2075082X.2019.4.190686
Значительное количество эпидемиологических исследований продемонстрировало, что гиперурикемия в высокой степени связана с риском развития сердечно-сосудистых заболеваний, хронической болезни почек и сахарного диабета, в связи с чем необходимо повышенное внимание к мониторингу уровня мочевой кислоты в сыворотке крови у пациентов не только с точки зрения ревматических болезней, но также и в отношении снижения сердечно-сосудистого и почечного риска. Эксперты Европейского общества кардиологов и Российского медицинского общества по артериальной гипертонии включили в рутинные тесты измерение концентрации мочевой кислоты в сыворотке крови у больных артериальной гипертонией. Важным шагом на пути улучшения контроля гиперурикемии в клинической практике являются повышение осведомленности о гиперурикемии как о факторе риска сердечно-сосудистых заболеваний, разработка алгоритма ведения больных с гиперурикемией и высоким сердечно-сосудистым риском, повышение приверженности рекомендациям. Снижение уровня мочевой кислоты в сыворотке крови, достигнутое посредством лечения пациентов уратснижающими препаратами, главным образом ингибитором ксантиноксидазы, связано с улучшением контроля артериального давления и уменьшением частоты нежелательных сердечно-сосудистых событий.
Substantial amount of epidemiologic studies showed that hyperuricemia is highly associated with cardiovascular disorders, chronic renal disease, and diabetes mellitus development risk. This fact shows necessity of increased focus on uric acid level in serum not only in relation to rheumatic disorders but also in relation to cardiovascular and renal risk. European Society of Cardiology and Russian Arterial Hypertension Society experts included tests on uric acid level serum concentration in routine tests for hypertensive patients. Important steps in increase of hyperuricemia control in clinical practice are increase of awareness as a risk factor of cardiovascular disorders, development of risk management algorithm for patients with hyperuricemia and high cardiovascular risk, and increase of treatment adherence. Decrease of uric acid level in serum achieved after treatment with urate decreasing therapy mostly with xanthine oxidase inhibitor is associated with improvement of blood pressure control and decrease of cardiovascular adverse events frequency.
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Авторы
И.Е. Чазова*1, Ю.В. Жернакова1, О.А. Кисляк2, С.В. Недогода3, В.И. Подзолков4, Е.В. Ощепкова1, И.В. Медведева5, О.Ю. Миронова4, Н.В. Блинова1
1ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России, Москва, Россия;
2ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
3ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России, Волгоград, Россия;
4ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
5ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России, Тюмень, Россия
*c34h@yandex.ru
________________________________________________
Irina E. Chazova*1, Juliya V. Zhernakova1, Oksana A. Kisliak2, Sergey V. Nedogoda3, Valery I. Podzolkov4, Elena V. Oshchepkova1, Irina V. Medvedeva5, Olga Iu. Mironova4, Nataliia V. Blinova1
1National Medical Research Center of Cardiology, Moscow, Russia;
2Pirogov Russian National Research Medical University, Moscow, Russia;
3Volgograd State Medical University, Volgograd, Russia;
4Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
5Tyumen State Medical University, Tyumen, Russia
*c34h@yandex.ru