В обзоре представлено описание рака кожи из клеток Меркеля, возможных этиологических факторов и механизмов развития, методов диагностики, дифференциальной диагностики и вариантов лечения.
Ключевые слова: рак кожи из клеток Меркеля, нейроэндокринный рак кожи, нейронспецифическая енолаза, хромогранин А.
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This review describes merkel cell carcinoma, possible etiological factors and mechanisms of development, methods of diagnosis, differential diagnosis and treatment options.
Key words: merkel cell carcinoma, neuroendocrine carcinoma of the skin, neuronspecific enolase, сhromogranin A.
1. Toker C. Trabecular carcinoma of the skin. Arch dermatology 1972; 105: 107–10.
2. Robert A. Schwartz Skin Cancer. Recognition and Management 2008; 13: 220–5.
3. Iyer J, Thibodeau R, Nghiem P. Merkel Cell Carcinoma. ASCO еducational book 2010; p. 343–8.
4. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Sience 2008; 319: 1096–100.
5. Goessling W, McKee P, Mayer R. Merkel cell carcinoma. J Clin Oncol 2002; 20: 558–98.
6. Rigel DS. Cancer of the skin. Elsevier 2005; p. 323–7.
7. Becker JC. Merkel cell carcinoma. Annals of Oncology 2010; 21 (Suppl. 7).
8. AJCC Cancer Staging Manual. 7th Ed 2010; p. 315.
9. Gould VE, Moll R, Moll I. Neuroendocrine (Merkel) cells of the skin: hyperplasia, dysplasias and neoplasms. Lab Invest 1985; 52 (4): 334–53.
10. Saito A, Tsutsumida A, Furukawa H et al. Merkel cell carcinoma of the face: an analysis of 16 cases in the Japanese. Journal Plast Reconstr Aesthet Surg; 2008. – doi:10.1016/j.bjps.2008.03.027.
11. Dancey AL, Rayatt SS, Soon C et al. Merkel cell carcinoma: a report of 34 cases and literature review. J Plast Reconstr Aesthet Surg 2006; 59: 1294–9.
12. Allen PJ, Bowne WB, Jaques DP et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clini Oncol 2005; 23: 2300–9.
13. Allen PJ, Zhahg ZF, Coit DG. Surgical management of Merkel cell carcinoma. Ann Surg 1999; 229: 97–105.
14. Messina JL, Reintgen DS, Cruse CW et al. Selective lymphadenectomy in patients with Merkel cell (cutaneous neuroendocrine) carcinoma. Ann Surg Oncol 1997; 4: 389–95.
15. Lewis KG, Weinstock MA, Weaver AL et al. Adjuvant local irradiation for Merkel cell carcinoma. Arch Dermatology 2006; 142: 693–700.
16. Eng TY, Boersma MG, Fuller CD et al. A comprehensive review of the treatment of Merkel cell carcinoma. Am J Clini Oncol 2007; 30: 624–36.
17. Samlowski WE, Moon J, Tuthill RJ et al. A phase II trial of imatinib mesylate in Merkel cell carcinoma: a Southwest Oncology Group Study. J Clin Oncol 2009; 27 (Suppl. 20. Abstr. 9056).
18. Davids MS, Charlton A, Ng SS et al. Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma. J Clin Oncol 2009; 27 (26): 97–100.
19. Di Bartolomeo M, Bajetta E, Buzzoni R et al. Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. A study by the Italian Trials in Medical Oncology Group. Cancer 1996; 77: 402–8.
20. Ben Shlomo A, Melmed S. Pasireotide – a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing’s disease. I Drugs 2007; 10: 885–95.
21. Becker J, Mauch С et al. Short German guidelines: Merkel cell carcinoma. J Сompil Blackwell Verlag, Berlin 2008; (Suppl. 1): S15–S16.
Авторы
К.В.Орлова, Н.Ф.Орел, А.А.Маркович, Л.В.Демидов
ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН