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Первичные неходжкинские лимфомы костей
Первичные неходжкинские лимфомы костей
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Аннотация
Неходжкинские лимфомы (НХЛ) костей встречаются не более чем в 7% случаев всех злокачественных опухолей костей и от 3 до 7% – среди всех экстранодальных НХЛ. Авторами описаны 90 случаев лимфомы костей. Химиотерапию на основе антрациклинсодержащих режимов ± ритуксимаб получили 35 (39%) больных. Сочетание химио- и лучевой терапии использовано в 44 (49%) случаев. Ранний рецидив наблюдался у 17 (35%) больных, из них генерализованный – у 7. Поздний рецидив отмечен у 32 (65%) пациентов, из них диссеминация процесса наблюдалась у 19.
Ключевые слова: неходжкинские лимфомы, химиотерапия, кости.
Key words: primary non-Hodgkin's bone lymphoma, polychemotherapy.
Ключевые слова: неходжкинские лимфомы, химиотерапия, кости.
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Key words: primary non-Hodgkin's bone lymphoma, polychemotherapy.
Полный текст
Список литературы
1. Sugisawa N, Suzuki T, Hiroi N et al. Primary bone malignant lymphoma: radiographic and magnetic resonance images. Intern Med 2006; 9 (45): 665–6.
2. Parker F, Jackson H. Primary reticulum cell sarcoma of bone. Surgery Gynecology Obstet 1939; 68: 45.
3. Robledo C, Garcia JL, Caballero D et al. Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive diffuse large B-cell lymphomas. Cancer 2009; 115: 3728–37.
4. Hogendoorn PCW, Heyning FH, Kramer MH et al. Primary lymphoma of bone: extranodal lymphoma with favourable survival independent of germinal centre, post-germinal centre or indeterminate phenotype. J Clin Pathol 2009; 62: 820–4.
5. Abdelwahab IF, Hoch B, Hermann G et al. Primary periostal lymphoma – rare and unusual. Skelet Radiol 2007; 4 (36): 335–9.
6. Fanale M. Monoclonal antibodies in the treatment of non-Hodgkin’s lymphoma. Younes Drugs 2007; 3 (67): 333–50.
7. Takasaki H, Kanamori H, Takabayashi M et al. Non-Hodgkin’s lymphoma presenting as multiple bone lesions and hypercalcemia. Am J Haematol 2006; 81: 439–42.
8. Primary lymphomas of bone / Anticancer Res. 2006; 26: 1A. 325–337.
9. Kitsoulis P, Vlychou M, Papoudou-Bai A et al. Primary bone lymphoma: a retrospective analysis. Int J Oncol 2006; 6 (28): 1571–5.
10. Power DG, McVey GP, Korpanty G et al. Primary bone lymphoma: single institution case series. Ir J Med Science 2008; 3 (177): 247–51.
11. Mengiardi B, Honneger H, Hodler J et al. Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment. Am J Roentgenol 2005; 1 (184): 185–92.
12. Rossi S, Szuhai K, Ijszenga M et al. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res 2007; 13: 7322–8.
13. Jansen PM, Heyning FH, Hogendoorn PCW. Array-based comparative genomic hybridisation analysis reveals recurrent chromosomal alterations in primary diffuse large B-cell lymphoma of bone. J Clin Pathol 2010; 63: 1095–100.
14. Zucca E, Conconi A. Annual of Lymphoid malignancies. J Clin Oncol 2006; 58: 150–65.
15. Rouveirol C, Stransky N, Hupe P et al.Computation of recurrent minimal genomic alterations from array-CGH data. Bioinformatics 2006; 22: 849–56.
16. Kirsch J, Ilaslan H, Bauer TW, Sundaram Skeletal Radiol M. The incidence of imaging findings, and the distribution of skeletal lymphoma in a consecutive patient population seen over 5 years 2006; 8 (35): 590–4.
17. Schaefer NG, Strobel K, Taverna C, Hany TF. Bone involvement in patient with lymphoma: the role of FDG-PET/CT. Eur J Nucl Med Mol Imaging 2007; 1 (34): 60–7.
18. Ferreri AJ, Reni M, Bolognesi A et al. Combined therapy for primary central nervous system lymphoma in immunocompetent patients. Eur J Cancer 1995; 31A: 2008–12.
19. Non-Hodgkin’s lymphoma involving the liver: clinical and therapeutic considerations. Salmon JS, Thompson MA, Arildsen RC et al. Clin Lymphoma&Myeloma 2006; 6: 273–80.
20. Morgner A, Miehlke S, Fischbach W et al. Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. J Clin Oncol 2001; 19: 2041–8.
21. Aozasa K. Pyothorax-associated lymphoma. J Clini Exp Hematop 2006; 46: 5–10.
2. Parker F, Jackson H. Primary reticulum cell sarcoma of bone. Surgery Gynecology Obstet 1939; 68: 45.
3. Robledo C, Garcia JL, Caballero D et al. Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive diffuse large B-cell lymphomas. Cancer 2009; 115: 3728–37.
4. Hogendoorn PCW, Heyning FH, Kramer MH et al. Primary lymphoma of bone: extranodal lymphoma with favourable survival independent of germinal centre, post-germinal centre or indeterminate phenotype. J Clin Pathol 2009; 62: 820–4.
5. Abdelwahab IF, Hoch B, Hermann G et al. Primary periostal lymphoma – rare and unusual. Skelet Radiol 2007; 4 (36): 335–9.
6. Fanale M. Monoclonal antibodies in the treatment of non-Hodgkin’s lymphoma. Younes Drugs 2007; 3 (67): 333–50.
7. Takasaki H, Kanamori H, Takabayashi M et al. Non-Hodgkin’s lymphoma presenting as multiple bone lesions and hypercalcemia. Am J Haematol 2006; 81: 439–42.
8. Primary lymphomas of bone / Anticancer Res. 2006; 26: 1A. 325–337.
9. Kitsoulis P, Vlychou M, Papoudou-Bai A et al. Primary bone lymphoma: a retrospective analysis. Int J Oncol 2006; 6 (28): 1571–5.
10. Power DG, McVey GP, Korpanty G et al. Primary bone lymphoma: single institution case series. Ir J Med Science 2008; 3 (177): 247–51.
11. Mengiardi B, Honneger H, Hodler J et al. Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment. Am J Roentgenol 2005; 1 (184): 185–92.
12. Rossi S, Szuhai K, Ijszenga M et al. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res 2007; 13: 7322–8.
13. Jansen PM, Heyning FH, Hogendoorn PCW. Array-based comparative genomic hybridisation analysis reveals recurrent chromosomal alterations in primary diffuse large B-cell lymphoma of bone. J Clin Pathol 2010; 63: 1095–100.
14. Zucca E, Conconi A. Annual of Lymphoid malignancies. J Clin Oncol 2006; 58: 150–65.
15. Rouveirol C, Stransky N, Hupe P et al.Computation of recurrent minimal genomic alterations from array-CGH data. Bioinformatics 2006; 22: 849–56.
16. Kirsch J, Ilaslan H, Bauer TW, Sundaram Skeletal Radiol M. The incidence of imaging findings, and the distribution of skeletal lymphoma in a consecutive patient population seen over 5 years 2006; 8 (35): 590–4.
17. Schaefer NG, Strobel K, Taverna C, Hany TF. Bone involvement in patient with lymphoma: the role of FDG-PET/CT. Eur J Nucl Med Mol Imaging 2007; 1 (34): 60–7.
18. Ferreri AJ, Reni M, Bolognesi A et al. Combined therapy for primary central nervous system lymphoma in immunocompetent patients. Eur J Cancer 1995; 31A: 2008–12.
19. Non-Hodgkin’s lymphoma involving the liver: clinical and therapeutic considerations. Salmon JS, Thompson MA, Arildsen RC et al. Clin Lymphoma&Myeloma 2006; 6: 273–80.
20. Morgner A, Miehlke S, Fischbach W et al. Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. J Clin Oncol 2001; 19: 2041–8.
21. Aozasa K. Pyothorax-associated lymphoma. J Clini Exp Hematop 2006; 46: 5–10.
Авторы
О.П.Сотникова1, Е.Н.Сорокин2, А.М.Ковригина2, Д.А.Быков3, Е.А.Османов2, И.В.Поддубная1
1 ГБОУ ДПО Российская медицинская академия последипломного образования Минздравсоцразвития РФ;
2 ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН;
3 ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздравсоцразвития РФ
1 ГБОУ ДПО Российская медицинская академия последипломного образования Минздравсоцразвития РФ;
2 ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН;
3 ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздравсоцразвития РФ
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