Обзор посвящен химиотерапии интенсивно предлеченного метастатического рака молочной железы. Рассмотрены возможные причины развития антрациклин- и таксан-резистентности, особенности механизма действия эпотилонов, приведены данные об эффективности различных цитостатиков. Обсуждены результаты клинических исследований иксабепилона, демонстрирующие высокую эффективность препарата в монорежиме или в комбинации с капецитабином при резистентности к таксанам и антрациклинам.
Patients with metastatic breast cancer previously treated with anthracycline chemotherapy. Effective treatment options for patients with metastatic breast cancer resistant to anthracyclines and taxanes are limited. The review is devoted to chemotherapy-pretreated metastatic breast cancer, reasons of anthracycline-and taxane-resistance development, epothilones’ mechanisms of action The possible reasons for the development of, especially the mechanism of action of epothilones, data on the effects of cytotoxic drugs in intensive-pretreated metastatic breast cancer. Discussed the results of clinical studies of Ixabepilone showing high efficacy in monotherapy or in combination with capecitabine resistance of anthracyclines and taxanes.
Key words: anthracycline- and/or taxane-resistance, breast cancer, ixabepilone.
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