Развитие цитостатической терапии в 1-й линии лечения рака яичников происходит медленно, и, как следствие, в последние годы основной поиск исследований направлен на изучение биологии данного заболевания. Ангиогенез является одним из основных факторов микроокружения опухоли, приводящим к росту и метастазированию заболевания. В связи с этим начали появляться препараты, ингибирующие ангиогенез. Одним из первых препаратов, изучаемых в III фазе рандомизированных исследований, был бевацизумаб, который продемонстрировал достоверное увеличение как выживаемости без прогрессирования, так и продолжительности жизни в группе высокого риска больных. Другие антиангиогенные препараты, такие как пазопаниб, нинтенаниб, также демонстрируют высокую эффективность у пациенток с раком яичников.
Ключевые слова: VEGF, бевацизумаб, рак яичников.
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Development of first-line cytostatic therapy in ovarian cancer is slow, and as a result, the main research aim today is to study the biology of the disease. Angiogenesis is one of the main factors of the tumor microenvironment, resulting in growth and metastasis. As a result have been investigated the drugs inhibiting angiogenesis. The first drug being studied in phase III trial of the randomized studies was bevacizumab, which demonstrated the significant increase in both progression-free survival and survival in the high risk group. Other antiangiogenics such as pazopanib, nintenanib, also demonstrated high efficacy in patients with ovarian cancer.
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Авторы
С.В.Хохлова
ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН