Результаты хирургического лечения больных диссеминированными гастроинтестинальными стромальными опухолями

Абу-Хайдар О.Б., Неред С.Н., Архири П.П. и др. Результаты хирургического лечения больных диссеминированными гастроинтестинальными стромальными опухолями. Современная Онкология. 2016; 18 (1): 61–66.

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Abouhaidar O.B., Nered S.N., Arkhiri P.P. et al. Outcomes of surgical treatment of advanced gastrointestinal stromal tumors. Journal of Modern Oncology. 2016; 18 (1): 61–66.

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Аннотация

Таргетная терапия иматинибом является стандартом лечения больных метастатическими гастроинтестинальными стромальными опухолями (ГИСО). Роль хирургического метода в лечении больных диссеминированными ГИСО на сегодняшний день остается одним из актуальных и спорных вопросов. Для оценки эффективности хирургического лечения проведен ретроспективный анализ результатов лечения 140 больных диссеминированными ГИСО. Хирургическое лечение в комбинации с таргетной терапией проводилось 98 больным, 42 – лечение исключительно тирозинкиназными ингибиторами. При сравнительном анализе отмечено статистически значимое улучшение отдаленных результатов в группе больных, которым проводилось хирургическое лечение на фоне эффекта терапии тирозинкиназными ингибиторами. Циторедуктивные операции у больных с диффузной прогрессией на фоне терапии иматинибом не приводят к улучшению показателей выживаемости.

Ключевые слова: гастроинтестинальные стромальные опухоли, стромальные опухоли желудочно-кишечного тракта, иматиниб, хирургическое лечение.

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Targeted therapy of imatinib is a standard treatment of patients with metastatic gastrointestinal stromal tumors (GIST). The role of surgical approach in treatment of patients with disseminated GIST is remaining the most important and controversial issues. The retrospective analysis of the treatment of 140 patients with disseminated GIST to assess the efficacy of surgical treatment was carried out. Surgical treatments in combination with targeted therapy were performed in 98 patients and 42 patients were treated using only tyrosine kinase inhibitors. Comparative analysis showed the statistically significant improvement of remote results in the group of patients undergoing surgical operations associated with the effect of therapy using tyrosine kinase inhibitors. Cytoreductive surgery in patients with diffuse progression on imatinib therapy does not improve survival rates.

Key words: gastrointestinal stromal tumors, gastrointestinal stromal tumors of the gastrointestinal tract, imatinib, surgical treatment.

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Авторы

О.Б.Абу-Хайдар*1, С.Н.Неред1,2, П.П.Архири1,2, М.П.Никулин1, И.С.Стилиди1,2

1 ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России. 115478, Россия, Москва, Каширское ш., д. 23;
2 ГБОУ ВПО Российская медицинская академия последипломного образования Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*abouhaidar@yandex.ru

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O.B.Abouhaidar*1, S.N.Nered1,2, P.P.Arkhiri1,2, M.P.Nikulin1, I.S.Stilidi1,2

1 N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation. 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23;
2 Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*abouhaidar@yandex.ru

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