Интерферон a (ИФН-a) в сравнении с ИФН-a + октреотид в лечении больных высокодифференцированными нейроэндокринными опухолями различных локализаций
Интерферон a (ИФН-a) в сравнении с ИФН-a + октреотид в лечении больных высокодифференцированными нейроэндокринными опухолями различных локализаций
Емельянова Г.С., Кузьминов А.Е., Орел Н.Ф. и др. Интерферон a (ИФН-a) в сравнении с ИФН-a + октреотид в лечении больных высокодифференцированными нейроэндокринными опухолями различных локализаций. Современная Онкология. 2017; 19 (2): 61–65.
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Yemelyanova G.S., Kuzminov A.E., Orel N.F. et al. Interferon a (IFN-a) vs. the combination IFN-α and octreotide LAR in the treatment of patients with well differentiated neuroendocrine tumors (NET) of various localizations. Journal of Modern Oncology. 2017; 19 (2): 61–65.
Интерферон a (ИФН-a) в сравнении с ИФН-a + октреотид в лечении больных высокодифференцированными нейроэндокринными опухолями различных локализаций
Емельянова Г.С., Кузьминов А.Е., Орел Н.Ф. и др. Интерферон a (ИФН-a) в сравнении с ИФН-a + октреотид в лечении больных высокодифференцированными нейроэндокринными опухолями различных локализаций. Современная Онкология. 2017; 19 (2): 61–65.
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Yemelyanova G.S., Kuzminov A.E., Orel N.F. et al. Interferon a (IFN-a) vs. the combination IFN-α and octreotide LAR in the treatment of patients with well differentiated neuroendocrine tumors (NET) of various localizations. Journal of Modern Oncology. 2017; 19 (2): 61–65.
До настоящего времени нет достаточных данных, имеет ли преимущество комбинация аналогов соматостатина (АС) с интерфероном a (ИФН-a) по сравнению с монотерапией АС в лечении больных высокодифференцированными нейроэндокринными опухолями (НЭО). В нашем исследовании мы сравниваем токсичность и эффективность монотерапии АС и в сочетании с ИФН-a у больных высокодифференцированными НЭО различных локализаций. Выявлена тенденция к увеличению медианы времени до прогрессирования у больных с НЭО легких по сравнению с больными с НЭО желудочно-кишечного тракта и поджелудочной железы. Токсичность значимо не различалась.
Ключевые слова: нейроэндокринные опухоли, интерферон a.
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It is still unknown whether the combination of IFN-a with octreotide has benefit compared with IFN-a alone. We compared efficacy and toxicyty of IFN-a and IFN-a plus octreotide in first line of therapy of patients with NETs. There was trend to longer TTP in lung NETs pts comparing with GEP NETs pts treated with IFN-a. IFN-a may be a therapy of choice in pts with well differentiated lung NETs as first line treatment. IFN-a have a similar toxicity profile comparing with IFN-a combined with octreotide.
1. Hofland LJ, de Herder WW, Lamberts SWJ. Mechanism of action of somatostatin and interferon in gastroenteropancreatic tumours. In The expanding role of octreotide I: advances in oncology. SWJ Lamberts & Dogliotti (eds.) 2002; p. 89–102.
2. Funa К, Alm GV, Rönnblom L, Oberg K. Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon. Clin Exp Immunol 1983; 53 (3): 716–24.
3. Aparicio-Pagés MN, Verspaget HW, Peña AS et al. Natural killer cell activity in patients with neuroendocrine tumours of the gastrointestinal tract; relation with circulating gastrointestinal hormones. Neuropeptides 1991; 20 (1): 1–7.
4. Rosewicz S, Detjen K, Scholz A, von Marschall Z. Interferon-alpha: regulatory effects on cell cycle and angiogenesis. Neuroendocrinology; 2004: 80 (1): 85–93.
5. Oberg K. Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. Ann Oncol 2001; 12 (S1): 111–4.
6. Eriksson В, Oberg K. Interferon therapy of malignant endocrine pancreatic tumors. Endocrine Tumors of the Pancreas: Recent Advanced in Research and Management, 1995; p. 451–60.
7. Oberg K. Interferon in the management of neuroendocrine GEP_tumors. Digest 2000; 62 (Suppl. 1): 92–7.
8. Arnold R, Rinke A, Klose KJ et al. Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol 2005; 3 (8): 761–71.
9. Kolby L, Persson G, Franzen S, Ahren B. Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours. Br J Surg 2003; 90: 687–93.
10. Yao J, Guthrie K, Moran C et al. SWOG S0518: Phase III prospective randomized comparison of depot octreotide plus interferon alpha‐2b versus depot octreotide plus bevacizumab (NSC #704865) in advanced, poor prognosis carcinoid patients (NCT00569127). J Clin Oncol 2015; 33 (Suppl.; abstr 4004).
11. Travis WD, Brambilla E, Müller-Hermelink HK et al (eds.). Pathology & Genetics tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004.
12. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934–59.
13. Yao JC, Hassan M, Phan A et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063–72.
14. Surveillance, Epidemiology, and End Results Program: Lung Cancer histologically confirmed SEER 18 registries research data plus Hurricane Katrina impacted Louisiana cases 1973–2010, November 2012.
15. Sakurai H, Asamura H. Large-cell neuroendocrine carcinoma of the lung: surgical management. Thorac Surg Clin 2014; 24: 305–11.
16. Oberg K, Hellman P, Kwekkeboom D et al. Neuroendocrine bronchial and thymic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21 (Suppl. 5): v220–2.
17. Fink G, Krelbaum T, Yellin A et al. Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001; 119: 1647–51.
18. Filosso PL, Oliaro A, Ruffini E et al. Outcome and prognostic factors in bronchial carcinoids: a single-center experience. J Thorac Oncol 2013; 8: 1282–8.
________________________________________________
1. Hofland LJ, de Herder WW, Lamberts SWJ. Mechanism of action of somatostatin and interferon in gastroenteropancreatic tumours. In The expanding role of octreotide I: advances in oncology. SWJ Lamberts & Dogliotti (eds.) 2002; p. 89–102.
2. Funa К, Alm GV, Rönnblom L, Oberg K. Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon. Clin Exp Immunol 1983; 53 (3): 716–24.
3. Aparicio-Pagés MN, Verspaget HW, Peña AS et al. Natural killer cell activity in patients with neuroendocrine tumours of the gastrointestinal tract; relation with circulating gastrointestinal hormones. Neuropeptides 1991; 20 (1): 1–7.
4. Rosewicz S, Detjen K, Scholz A, von Marschall Z. Interferon-alpha: regulatory effects on cell cycle and angiogenesis. Neuroendocrinology; 2004: 80 (1): 85–93.
5. Oberg K. Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. Ann Oncol 2001; 12 (S1): 111–4.
6. Eriksson В, Oberg K. Interferon therapy of malignant endocrine pancreatic tumors. Endocrine Tumors of the Pancreas: Recent Advanced in Research and Management, 1995; p. 451–60.
7. Oberg K. Interferon in the management of neuroendocrine GEP_tumors. Digest 2000; 62 (Suppl. 1): 92–7.
8. Arnold R, Rinke A, Klose KJ et al. Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol 2005; 3 (8): 761–71.
9. Kolby L, Persson G, Franzen S, Ahren B. Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours. Br J Surg 2003; 90: 687–93.
10. Yao J, Guthrie K, Moran C et al. SWOG S0518: Phase III prospective randomized comparison of depot octreotide plus interferon alpha‐2b versus depot octreotide plus bevacizumab (NSC #704865) in advanced, poor prognosis carcinoid patients (NCT00569127). J Clin Oncol 2015; 33 (Suppl.; abstr 4004).
11. Travis WD, Brambilla E, Müller-Hermelink HK et al (eds.). Pathology & Genetics tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004.
12. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934–59.
13. Yao JC, Hassan M, Phan A et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063–72.
14. Surveillance, Epidemiology, and End Results Program: Lung Cancer histologically confirmed SEER 18 registries research data plus Hurricane Katrina impacted Louisiana cases 1973–2010, November 2012.
15. Sakurai H, Asamura H. Large-cell neuroendocrine carcinoma of the lung: surgical management. Thorac Surg Clin 2014; 24: 305–11.
16. Oberg K, Hellman P, Kwekkeboom D et al. Neuroendocrine bronchial and thymic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21 (Suppl. 5): v220–2.
17. Fink G, Krelbaum T, Yellin A et al. Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001; 119: 1647–51.
18. Filosso PL, Oliaro A, Ruffini E et al. Outcome and prognostic factors in bronchial carcinoids: a single-center experience. J Thorac Oncol 2013; 8: 1282–8.
1 ФГБОУ ВО «Московский медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1;
2 ФГБУ «Российский онкологический научный центр им. Н.Н.Блохина» Минздрава России. 115478, Россия, Москва, Каширское ш., д. 23;
3 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*docgalina@mail.ru
1 A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1;
2 N.N.Blokhin Russian Cancer Reseach Center of the Ministry of Health of the Russian Federation. 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23;
3 Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*docgalina@mail.ru