1. Давыдов М.И., Аксель Е.М. Стандартизованные показатели онкоэпидемиологической ситуации 2015 г. Евразийский онкологический журн. 2017; 5 (2): 261–317. / Davydov M.I., Aksel E.M. Standartizovannye pokazateli onkoepidemiologicheskoi situatsii 2015 g. Evraziiskii onkologicheskii zhurn. 2017; 5 (2): 261–317. [in Russian]
2. ESGO guidelines for ovarian cancer surgery. URL: https://guidelines. esgo.org/media/2017/03/ESGO_ovarian_cancer_surgery_brA5_V01-website.pdf
3. Pecorelli S, Ngan HYS, Hacker NF. Staging classifications and clinical practice guidelines for gynaecological cancers. URL: https://www.figo.org
4. Prat J. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. J Gynaecol Obstet 2014; 124: 1–5.
5. Sainz de la Cuesta R, Goff BA, Fuller AFJr et al. Prognostic importance of intraoperative rupture of malignant ovarian epithelial neoplasms. Obstet Gynecol 1994; 84 (1): 1–7.
6. Higashi M, Kajiyama H, Shibata K et al. Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types. Gynecol Oncol 2011; 123 (3): 474–8.
7. Paulsen T, Kaern J, Trope C. Improved 5-year disease-free survival for FIGO stage I epithelial ovarian cancer patients without tumor rupture during surgery. Gynecol Oncol 2011; 122: 83–8.
8. Тюляндин С.А., Коломиец Л.А., Морхов К.Ю. и др. Практические рекомендации по лекарственному лечению РЯ, первичного рака брюшины и рака маточных труб. Злокачественные опухоли. 2017; 3 (Прил. 2): 135–45. / Tiuliandin S.A., Kolomiets L.A., Morkhov K.Yu. i dr. Prakticheskie rekomendatsii po lekarstvennomu lecheniiu raka iaichnikov, pervichnogo raka briushiny i raka matochnykh trub. Zlokachestvennye opukholi. 2017; 3 (Pril. 2): 135–45. [in Russian]
9. Young RC, Decker DG, Wharton JT et al. Staging laparotomy in early ovarian cancer. JAMA 1983; 250 (22): 3072–6.
10. Buchsbaum HJ, Brady MF, Delgado G et al. Surgical staging of carcinoma of the ovaries. Surg Gynecol Obstet 1989; 169 (3): 226–32.
11. Arie AB, McNally L, Kapp DS, Teng NN. The omentum and omentectomy in epithelial ovarian cancer: a reappraisal: part II – The role of omentectomy in the staging and treatment of apparent early stage epithelial ovarian cancer. Gynecol Oncol 2013; 131 (3): 784–90.
12. Lee JY, Kim HS, Chung HH et al. The role of omentectomy and random peritoneal biopsies as part of comprehensive surgical staging in apparent early-stage epithelial ovarian cancer. Ann Surg Oncol 2014; 21 (8): 2762–6.
13. Timmers PJ, Zwinderman K, Coens C et al. Lymph node sampling and taking of blind biopsies are important elements of the surgical staging of early ovarian cancer. Int J Gynecol Cancer 2010; 20 (7): 1142–7.
14. Verleye L, Ottevanger PB, van der Graaf W et al.; Gynaecological Cancer Group (GCG) of European Organisation for Research and Treatment of Cancer (EORTC). EORTC-GCG process quality indicators for ovarian cancer surgery. Eur J Cancer 2009; 45 (4): 517–26.
15. Ayhan A, Gultekin M, Celik NY et al. Occult metastasis in early ovarian cancers: risk factors and associated prognosis. Am J Obstet Gynecol 2007; 196 (1): e1–6.
16. Fournier M, Stoeckle E, Guyon F et al. Lymph node involvement in epithelial ovarian cancer: sites and risk factors in a series of 355 patients. Int J Gynecol Cancer 2009; 19 (8): 1307–13.
17. Morice P, Joulie F, Camatte S et al. Lymph node involvement in epithelial ovarian cancer: analysis of 276 pelvic and paraaortic lymphadenectomies and surgical implications. J Am Coll Surg 2003; 197 (2): 198–205.
18. Schmeler KM, Tao X, Frumovitz M et al. Prevalence of lymph node metastasis in primary mucinous carcinoma of the ovary. Obstet Gynecol 2010; 116 (2): 269–73.
19. Garcia-Soto AE, Boren T, Wingo SN et al. Is comprehensive surgical staging needed for thorough evaluation of early-stage ovarian carcinoma? Am J Obstet Gynecol 2012; 206 (3): 242.
20. Le T, Adolph A, Krepart GV et al. The benefits of comprehensive surgical staging in the management of early-stage epithelial ovarian carcinoma. Gynecol Oncol 2002; 85 (2): 351–5.
21. Timmers PJ, Zwinderman AH, Coens C et al. Understanding the problem of inadequately staging early ovarian cancer. Eur J Cancer 2010; 46 (5): 880–4.
22. Mayer AR, Chambers SK, Graves E et al. Ovarian cancer staging: does it require a gynecologic oncologist? Gynecol Oncol 1992; 47 (2): 223–7.
23. Signorelli M, Fruscio R, Ceppi L et al. The role of pelvic and aortic lymphadenectomy at second look surgery in apparent early stage ovarian cancer after inadequate surgical staging followed by adjuvant chemotherapy. Gynecol Oncol 2014; 132 (2): 312–5.
24. Trimbos JB, Vergote I, Bolis G et al. European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm. Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial. J Natl Cancer Inst 2003; 95 (2): 113–25.
25. Trimbos B, Timmers P, Pecorelli S et al. Surgical staging and treatment of early ovarian cancer: long-term analysis from a randomized trial. J Natl Cancer Inst 2010; 102 (13): 982–7.
26. Chan JK, Tian C, Teoh D et al. Survival after recurrence in early-stage high-risk epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecol Oncol 2010; 116 (3): 307–11.
27. Travis LB, Curtis RE, Boice JD et al. Second malignant neoplasms among long-term survivors of ovarian cancer. Cancer Res 1996; 56 (7): 1564–70.
28. Chi DS, Abu-Rustum NR, Sonoda Y et al. The safety and efficacy of laparoscopic surgical staging of apparent stage I ovarian and fallopian tube cancers. Am J Obstet Gynecol 2005; 192 (5): 1614–9.
29. Zivanovic O, Sonoda Y, Diaz JP et al. The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease. Gynecol Oncol 2008; 111 (3): 431–7. 
30. Duska LR, Chang YC, Flynn CE et al. Epithelial ovarian carcinoma in the reproductive age group. Cancer 1999; 85 (12): 2623–9.
31. Plaxe SC, Braly PS, Freddo JL et al. Profiles of women age 30–39 and age less than 30 with epithelial ovarian cancer. Obstet Gynecol 1993; 81 (5): 651–4.
32. Rodriguez M, Nguyen HN, Averette HE et al. National survey of ovarian carcinoma XII. Epithelial ovarian malignancies in women less than or equal to 25 years of age. Cancer 1994; 73 (4): 1245–50.
33. Huber D, Cimorelli V, Usel M et al. How many ovarian cancer patients are eligible for fertility-sparing surgery? Eur J Obstet Gynecol Reprod Biol 2013; 170 (1): 270–4.
34. Schilder JM, Thompson AM, DePriest PD et al. Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy. Gynecol Oncol 2002; 87 (1): 1–7.
35. Zanetta G, Chiari S, Rota S et al. Conservative surgery for stage I ovarian carcinoma in women of childbearing age. Br J Obstet Gynaecol 1997; 104 (9): 1030–5.
36. Park JW, Kim DY, Suh DS et al. Outcomes of fertility-sparing surgery for invasive epithelial ovarian cancer: oncologic safety and reproductive outcomes. Gynecol Oncol 2008; 110 (3): 345–53.
37. Schlaerth AC, Chi DS, Poynor EA et al. Long-term survival after fertility-sparing surgery for epithelial ovarian cancer. Int J Gynecol Cancer 2009; 19 (7): 1199–204.
38. Anchezar JP, Sardi J, Soderini A. Long-term follow-up results of fertility sparing surgery in patients with epithelial ovarian cancer. J Surg Oncol 2009; 100 (1): 55–8.
39. Kajiyama H, Shibata K, Suzuki S et al. Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary? Gynecol Oncol 2008; 111 (3): 523–6.
40. Fruscio R, Corso S, Ceppi L et al. Conservative management of early-stage epithelial ovarian cancer: results of a large retrospective series. Ann Oncol 2013; 24 (1): 138–44.
41. Kajiyama H, Mizuno M, Shibata K et al. Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study. Eur J Obstet Gynecol Reprod Biol 2014; 175: 97–102.
42. Ditto A, Martinelli F, Lorusso D et al. Fertility sparing surgery in early stage epithelial ovarian cancer. J Gynecol Oncol 2014; 25 (4): 320–7.
43. Kajiyama H, Shibata K, Mizuno M et al. Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery. Br J Cancer 2011; 105 (9): 1288–94.
44. Satoh T, Hatae M, Watanabe Y et al. Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection. J Clin Oncol 2010; 28 (10): 1727–32.
45. Wright JD, Shah M, Mathew L et al. Fertility preservation in young women with epithelial ovarian cancer. Cancer 2009; 115 (18): 4118–26.

________________________________________________

1. Davydov M.I., Aksel E.M. Standartizovannye pokazateli onkoepidemiologicheskoi situatsii 2015 g. Evraziiskii onkologicheskii zhurn. 2017; 5 (2): 261–317. [in Russian]
2. ESGO guidelines for ovarian cancer surgery. URL: https://guidelines. esgo.org/media/2017/03/ESGO_ovarian_cancer_surgery_brA5_V01-website.pdf
3. Pecorelli S, Ngan HYS, Hacker NF. Staging classifications and clinical practice guidelines for gynaecological cancers. URL: https://www.figo.org
4. Prat J. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. J Gynaecol Obstet 2014; 124: 1–5.
5. Sainz de la Cuesta R, Goff BA, Fuller AFJr et al. Prognostic importance of intraoperative rupture of malignant ovarian epithelial neoplasms. Obstet Gynecol 1994; 84 (1): 1–7.
6. Higashi M, Kajiyama H, Shibata K et al. Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types. Gynecol Oncol 2011; 123 (3): 474–8.
7. Paulsen T, Kaern J, Trope C. Improved 5-year disease-free survival for FIGO stage I epithelial ovarian cancer patients without tumor rupture during surgery. Gynecol Oncol 2011; 122: 83–8.
8. Tiuliandin S.A., Kolomiets L.A., Morkhov K.Yu. i dr. Prakticheskie rekomendatsii po lekarstvennomu lecheniiu raka iaichnikov, pervichnogo raka briushiny i raka matochnykh trub. Zlokachestvennye opukholi. 2017; 3 (Pril. 2): 135–45. [in Russian]
9. Young RC, Decker DG, Wharton JT et al. Staging laparotomy in early ovarian cancer. JAMA 1983; 250 (22): 3072–6.
10. Buchsbaum HJ, Brady MF, Delgado G et al. Surgical staging of carcinoma of the ovaries. Surg Gynecol Obstet 1989; 169 (3): 226–32.
11. Arie AB, McNally L, Kapp DS, Teng NN. The omentum and omentectomy in epithelial ovarian cancer: a reappraisal: part II – The role of omentectomy in the staging and treatment of apparent early stage epithelial ovarian cancer. Gynecol Oncol 2013; 131 (3): 784–90.
12. Lee JY, Kim HS, Chung HH et al. The role of omentectomy and random peritoneal biopsies as part of comprehensive surgical staging in apparent early-stage epithelial ovarian cancer. Ann Surg Oncol 2014; 21 (8): 2762–6.
13. Timmers PJ, Zwinderman K, Coens C et al. Lymph node sampling and taking of blind biopsies are important elements of the surgical staging of early ovarian cancer. Int J Gynecol Cancer 2010; 20 (7): 1142–7.
14. Verleye L, Ottevanger PB, van der Graaf W et al.; Gynaecological Cancer Group (GCG) of European Organisation for Research and Treatment of Cancer (EORTC). EORTC-GCG process quality indicators for ovarian cancer surgery. Eur J Cancer 2009; 45 (4): 517–26.
15. Ayhan A, Gultekin M, Celik NY et al. Occult metastasis in early ovarian cancers: risk factors and associated prognosis. Am J Obstet Gynecol 2007; 196 (1): e1–6.
16. Fournier M, Stoeckle E, Guyon F et al. Lymph node involvement in epithelial ovarian cancer: sites and risk factors in a series of 355 patients. Int J Gynecol Cancer 2009; 19 (8): 1307–13.
17. Morice P, Joulie F, Camatte S et al. Lymph node involvement in epithelial ovarian cancer: analysis of 276 pelvic and paraaortic lymphadenectomies and surgical implications. J Am Coll Surg 2003; 197 (2): 198–205.
18. Schmeler KM, Tao X, Frumovitz M et al. Prevalence of lymph node metastasis in primary mucinous carcinoma of the ovary. Obstet Gynecol 2010; 116 (2): 269–73.
19. Garcia-Soto AE, Boren T, Wingo SN et al. Is comprehensive surgical staging needed for thorough evaluation of early-stage ovarian carcinoma? Am J Obstet Gynecol 2012; 206 (3): 242.
20. Le T, Adolph A, Krepart GV et al. The benefits of comprehensive surgical staging in the management of early-stage epithelial ovarian carcinoma. Gynecol Oncol 2002; 85 (2): 351–5.
21. Timmers PJ, Zwinderman AH, Coens C et al. Understanding the problem of inadequately staging early ovarian cancer. Eur J Cancer 2010; 46 (5): 880–4.
22. Mayer AR, Chambers SK, Graves E et al. Ovarian cancer staging: does it require a gynecologic oncologist? Gynecol Oncol 1992; 47 (2): 223–7.
23. Signorelli M, Fruscio R, Ceppi L et al. The role of pelvic and aortic lymphadenectomy at second look surgery in apparent early stage ovarian cancer after inadequate surgical staging followed by adjuvant chemotherapy. Gynecol Oncol 2014; 132 (2): 312–5.
24. Trimbos JB, Vergote I, Bolis G et al. European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm. Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial. J Natl Cancer Inst 2003; 95 (2): 113–25.
25. Trimbos B, Timmers P, Pecorelli S et al. Surgical staging and treatment of early ovarian cancer: long-term analysis from a randomized trial. J Natl Cancer Inst 2010; 102 (13): 982–7.
26. Chan JK, Tian C, Teoh D et al. Survival after recurrence in early-stage high-risk epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecol Oncol 2010; 116 (3): 307–11.
27. Travis LB, Curtis RE, Boice JD et al. Second malignant neoplasms among long-term survivors of ovarian cancer. Cancer Res 1996; 56 (7): 1564–70.
28. Chi DS, Abu-Rustum NR, Sonoda Y et al. The safety and efficacy of laparoscopic surgical staging of apparent stage I ovarian and fallopian tube cancers. Am J Obstet Gynecol 2005; 192 (5): 1614–9.
29. Zivanovic O, Sonoda Y, Diaz JP et al. The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease. Gynecol Oncol 2008; 111 (3): 431–7. 
30. Duska LR, Chang YC, Flynn CE et al. Epithelial ovarian carcinoma in the reproductive age group. Cancer 1999; 85 (12): 2623–9.
31. Plaxe SC, Braly PS, Freddo JL et al. Profiles of women age 30–39 and age less than 30 with epithelial ovarian cancer. Obstet Gynecol 1993; 81 (5): 651–4.
32. Rodriguez M, Nguyen HN, Averette HE et al. National survey of ovarian carcinoma XII. Epithelial ovarian malignancies in women less than or equal to 25 years of age. Cancer 1994; 73 (4): 1245–50.
33. Huber D, Cimorelli V, Usel M et al. How many ovarian cancer patients are eligible for fertility-sparing surgery? Eur J Obstet Gynecol Reprod Biol 2013; 170 (1): 270–4.
34. Schilder JM, Thompson AM, DePriest PD et al. Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy. Gynecol Oncol 2002; 87 (1): 1–7.
35. Zanetta G, Chiari S, Rota S et al. Conservative surgery for stage I ovarian carcinoma in women of childbearing age. Br J Obstet Gynaecol 1997; 104 (9): 1030–5.
36. Park JW, Kim DY, Suh DS et al. Outcomes of fertility-sparing surgery for invasive epithelial ovarian cancer: oncologic safety and reproductive outcomes. Gynecol Oncol 2008; 110 (3): 345–53.
37. Schlaerth AC, Chi DS, Poynor EA et al. Long-term survival after fertility-sparing surgery for epithelial ovarian cancer. Int J Gynecol Cancer 2009; 19 (7): 1199–204.
38. Anchezar JP, Sardi J, Soderini A. Long-term follow-up results of fertility sparing surgery in patients with epithelial ovarian cancer. J Surg Oncol 2009; 100 (1): 55–8.
39. Kajiyama H, Shibata K, Suzuki S et al. Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary? Gynecol Oncol 2008; 111 (3): 523–6.
40. Fruscio R, Corso S, Ceppi L et al. Conservative management of early-stage epithelial ovarian cancer: results of a large retrospective series. Ann Oncol 2013; 24 (1): 138–44.
41. Kajiyama H, Mizuno M, Shibata K et al. Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study. Eur J Obstet Gynecol Reprod Biol 2014; 175: 97–102.
42. Ditto A, Martinelli F, Lorusso D et al. Fertility sparing surgery in early stage epithelial ovarian cancer. J Gynecol Oncol 2014; 25 (4): 320–7.
43. Kajiyama H, Shibata K, Mizuno M et al. Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery. Br J Cancer 2011; 105 (9): 1288–94.
44. Satoh T, Hatae M, Watanabe Y et al. Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection. J Clin Oncol 2010; 28 (10): 1727–32.
45. Wright JD, Shah M, Mathew L et al. Fertility preservation in young women with epithelial ovarian cancer. Cancer 2009; 115 (18): 4118–26. 

В.М.Нечушкина*1,2, К.Ю.Морхов1, З.Т.Абдурагимова1,3, В.В.Кузнецов1, В.Ю.Сельчук3, В.Н.Дмитриев4,5

1 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н.Блохина» Минздрава России. 115478, Россия, Москва, Каширское ш., д. 23;
2 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
3 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1;
4 ФГАОУ ВО «Белгородский государственный национальный исследовательский университет» Минобрнауки России. 308015, Россия, Белгород, ул. Победы, д. 85;
5 ОГБУЗ «Белгородский онкологический диспансер». 308010, Россия, Белгород, ул. Куйбышева, д. 1
*drnechushkina@mail.ru

________________________________________________

V.M.Nechushkina*1,2, K.Yu.Morkhov1, Z.T.Abduragimova1,3, V.V.Kuznetsov1, V.Yu.Selchuk1,3, V.N.Dmitriev4,5

1 N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation. 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23;
2 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1;
3 A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1;
4 Belgorod State National Research University. 308015, Russian Federation, Belgorod, ul. Pobedy, d. 85;
5 Belgorod Oncology Dispensary. 308015, Russian Federation, Belgorod, ul. Kuibysheva, d. 1
*drnechushkina@mail.ru