Хирургическое лечение трофобластической болезни. Современная концепция и противоречия (обзор литературы)

1. Мещерякова Л.А., Козаченко В.П., Кузнецов В.В. Трофобластическая болезнь. Клиническая онкогинекология. Под ред. В.П. Козаченко. Изд. 2-е, перераб. и доп. М.: Бином, 2016; с. 324–68.
[Meshcheryakova L.A., Kozachenko V.P., Kuznetsov V.V. Trophoblastic disease. Clinical oncogynecology. Ed. V.P. Kozachenko. 2nd ed., revised and supplemented. Moscow: Binom, 2016; p. 324–68 (in Russian).]
2. Мещерякова Л.А. Злокачественные трофобластические опухоли: современная диагностика, лечение и прогноз. Дис. … д-ра мед. наук. М., 2005.
[Meshcheriakova L.A. Zlokachestvennye trofoblasticheskie opukholi: sovremennaia diagnostika, lechenie i prognoz. Dis. … d-ra med. nauk. Moscow, 2005 (in Russian).]
3. Савельева Г.М. Акушерство. Национальное руководство. Под ред. Г.М. Савельевой, Г.Т. Сухих, В.Н. Серова, В.Е. Радзинского. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2018.
[Savelyeva G.M. Obstetrics. National leadership. Ed. G.M. Savelyeva, G.T. Sukhikh, V.N. Serov, V.E. Radzinsky. 2nd ed., revised and supplemented. Moscow: GEOTAR-Media, 2018 (in Russian).]
4. Tidу JA, Gellespie AM, Bright N et al. Gestational trophoblastic disease: A study of mode evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309–12.
5. Fisher PM, Hancock BW. Gestational trophoblastic diseases and their treatment. Cancer Treat Rev 1997; 23 (1): 1–16.
6. Doll KM, Soper JT. The role of surgery in the management of gestational trophoblastic neoplasia. Obstet Gynecol Surv 2013; 68 (7): 533–7.
7. Lao TT, Lee FH, Yeung SS. Repeat curettage after evacuation of hydatidiform mole. An appraisal. Acta Obstet Gynecol Scand 1987; 66: 305–7.
8. Flam F, Lundstrom V. The value of endometrial curettage in the follow-up of hydatidiform mole. Acta Obstet Gynecol Scand 1988; 67: 649–51.
9. Schlaerth JB, Morrow CP, Rodriguez M. Diagnostic and therapeutic curettage in gestational trophoblastic disease. Am J Obstet Gynecol 1990; 162 (6): 1465–70.
10. Pezeshki M, Hancock BW, Silcocks P et al. The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. Gynecol Oncol 2004; 95: 423–9.
11. Тихоновская М.Н., Быстрицкая Д.А., Кузнецов В.В. и др. Персистирующие трофобластические опухоли. Опухоли женской репродуктивной системы. 2013; 1–2: 53.
[Tikhonovskaia M.N., Bystritskaia D.A., Kuznetsov V.V. et al. Persistiruiushchie trofoblasticheskie opukholi. Opukholi zhenskoi reproduktivnoi sistemy. 2013; 1–2: 53 (in Russian).]
12. Тихоновская М.Н. Персистирующие трофобластические опухоли (диагностика и лечение). Дис. … канд. мед. наук. 2015.
[Tikhonovskaia M.N. Persistiruiushchie trofoblasticheskie opukholi (diagnostika i lechenie). Dis. … kand. med. nauk. 2015 (in Russian).]
13. Lao TT, Lee FH, Yeung SS. Repeat curettage after evacuation of hydatidiform mole. Act Obstet Gynecol Scand 1987; 66 (4): 305–7.
14. Tow WS. The place of hysterotomy in the treatment of hydatidiform mole. Aust N Z J Obstet Gynaecol 1967; 7: 97–8.
15. Curry SL, Hammond CB, Tyrey L et al. Hydatidiform mole: diagnosis, management, and long-term follow up of 347 patients. Obstet Gynecol 1975; 45: 1–8.
16. Bandy LC, Clarke-Pearson DL, Hammond CB. Malignant potential of gestational trophoblastic disease at the extreme ages of reproductive life. Obstet Gynecol 1984; 64: 395–9.
17. Tsukamoto N, Iwasaka T, Kashimura Y et al. Gestational trophoblastic disease in women aged 50 or more. Gynecol Oncol 1985; 20: 53–61.
18. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254–8.
19. Мещерякова Л.А. Стандартное лечение трофобластической болезни. Практическая онкология. 2008; 9 (3): 164–5.
[Meshcheriakova L.A. Standartnoe lechenie trofoblasticheskoi bolezni. Prakticheskaia onkologiia. 2008; 9 (3): 164–5 (in Russian).]
20. Быстрицкая Д.А., Тихоновская М.Н., Мещерякова Л.А. и др. Трофобластические опухоли: к вопросу о классификации и факторах прогноза (часть II). Рос. онкол. журн. 2014; 3: 33.
[Bystritskaia D.A., Tikhonovskaia M.N., Meshcheriakova L.A. et al. Trofoblasticheskie opukholi: k voprosu o klassifikatsii i faktorakh prognoza (chast' II). Ros. onkol. zhurn. 2014; 3: 33 (in Russian).]
21. Григорова Т.М. Трофобластическая болезнь. М.: Медицина, 1985.
[Grigorova T.M. Trophoblastic disease. Moscow: Medicine, 1985 (in Russian).]
22. Савинова В.Ф. Диагностика и лечение хорионэпителиомы матки. Дис. … д-ра мед. наук. М., 1971.
[Savinova V.F. Diagnostika i lechenie khorionepiteliomy matki. Dis. … d-ra med. nauk. Мoscow, 1971 (in Russian).]
23. Цип Н.П., Воробьева Л.И. Хирургический метод в лечении трофобластических опухолей. Практическая онкология. 2008; 
9 (3): 179–84.
[Tsip N.P., Vorob'eva L.I. Khirurgicheskii metod v lechenii trofoblasticheskikh opukholei. Prakticheskaia onkologiia. 2008; 9 (3): 179–84 (in Russian).]
24. Мещерякова Л.А., Козаченко В.П. Трофобластические опухоли: возможности хирургического лечения. Вестн. РОНЦ. 2003; 4: 36–42.
[Meshcheriakova L.A., Kozachenko V.P. Trofoblasticheskie opukholi: vozmozhnosti khirurgicheskogo lecheniia. Vestn. RONTs. 2003; 4: 36–42 (in Russian).]
25. Behtash N, Ansari S, Sarvi F. Successful pregnancy after localized resection of perforated uterus in choriocarcinoma and a literature review. Int J Gynаecol Cancer 2006; 16 (Suppl. 1): 445–8.
26. Xiang Y, Yang X, Du J, Song H. The role of hysterectomy in the therapy of gestational trophoblastic tumor. Chin Med Sci J 2000; 15 (1): 45–8.
27. Hanna RK, Soper JT. The Role of Surgery and Radiation Therapy in the Management of Gestational Trophoblastic Disease. Oncologist 2010; 15: 593–600.
28. Suzuka K, Matsui H, Iitsuka Y et al. Adjuvant hysterectomy in low-risk gestational trophoblastic disease Obstet. Gynecol 2001; 97: 431–4.
29. Doumplis D, Al-Khatib K, Sieunarine K et al. A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006. BJOG 2007; 114: 1168–71.
30. Mutch DG, Soper JT, Babcock CJ et al. Recurrent gestational trophoblastic disease. Experience of the Southeastern Regional Trophoblastic Disease Center. Cancer 1990; 66: с978–982.
31. Alazzam M, Hancock BW, Tidy J. Role of hysterectomy in managing persistent gestational trophoblastic disease. J Reprod Med 2008; 53 (7): 519–24.
32. Feng FZ, Xiang Y, Cao Y et al. Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm. Zhonghua Fu Chan Ke Za Zhi 2008; 43 (10): 728–31.
33. Eysbouts YK, Massuger LFAG, IntHout J. The added value of hysterectomy in the management of gestational trophoblastic neoplasia. Gynecol Oncol 2017; 145 (3): 536–42.
34. Feng F, Xiang Y. Surgical management of chemotherapy-resistant gestational trophoblastic neoplasia. Expert Rev Anticancer Ther 2010; 10 (1): 71–80.
35. Гасанбекова З.А. Ошибки в диагностики и лечении злокачественной трофобластической опухоли.  Дис. … канд. мед. наук. 2019.
[Gasanbekova Z.A. Oshibki v diagnostiki i lechenii zlokachestvennoi trofoblasticheskoi opukholi. Dis. … kand. med. nauk. 2019 (in Russian).]
36. Papadopoulos AJ, Foskett M, Seckl MJ et al. Twenty-five years’ clinical experience with placental site trophoblastic tumors. J Reprod Med 2002; 47: 460–4.
37. Moutte A, Doret M, Hajri T et al. Placental site and epithelioid trophoblastic tumours: diagnostic pitfalls. Gynecol Oncol 2013; 128 (3): 568–72.
38. El-Lamie IK, Sheeta NA, Abou-Loz SK. Experience on the Gynаecologic Oncology Unit at Ain Shams University in the treatment of gestational trophoblastic Tumours. Int J Gynaecol Oncol 2000; 10: 488–96.
39. Jones WB, Romain K, Erlandson RA et al. Thoracotomv in the management of gestational choriocarcinoma. Cancer 1993; 72: 2175–81.
39. Мещерякова Л.А., Козаченко В.П. Трофобластические опухоли: возможности хирургического лечения. Вестн. РОНЦ. 2003; 
4: 36–42.
[Meshcheriakova L.A., Kozachenko V.P. Trofoblasticheskie opukholi: vozmozhnosti khirurgicheskogo lecheniia. Vestn. RONTs. 2003; 
4: 36–42 (in Russian).]
40. Jones WB, Wolchok J, Lewis JL. The role of surgery in management of gestational trophoblastic disease. Int J Gynaecol Cancer 1996; 
6: 261–6.
41. Kanis MJ, Lurain JR. Pulmonary Resection in the Management of High-Risk Gestational Trophoblastic Neoplasia. Int J Gynecol Cancer 2016; 26 (4): 796–800.
42. Aydiner A, Keskin S, Berkman S. The roles of surgery and EMA/CO chemotherapy regimen in primary refractory and non-refractory gestational trophoblastic neoplasia. J Cancer Res Clin Oncol 2012; 138 (6): 971–7.
43. Cao Y, Xiang Y, Feng F et al. Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia. Int J Gynecol Cancer 2009; 19 (4): 798–801.
44. Lurain JR, Singh DK, Schink JC. Role of surgery in the management of high-risk gestational trophoblastic neoplasia. J Reprod Med 2006; 51 (10): 773–6.
45. Eoh KJ, Chung YS, Yim GW et al. Role of surgical therapy in the management of gestational trophoblastic neoplasia. Obstet Gynecol Sci 2015; 58 (4): 227–83.

________________________________________________

1. Meshcheryakova L.A., Kozachenko V.P., Kuznetsov V.V. Trophoblastic disease. Clinical oncogynecology. Ed. V.P. Kozachenko. 2nd ed., revised and supplemented. Moscow: Binom, 2016; p. 324–68 (in Russian).
2. Meshcheriakova L.A. Zlokachestvennye trofoblasticheskie opukholi: sovremennaia diagnostika, lechenie i prognoz. Dis. … d-ra med. nauk. Moscow, 2005 (in Russian).
3. Savelyeva G.M. Obstetrics. National leadership. Ed. G.M. Savelyeva, G.T. Sukhikh, V.N. Serov, V.E. Radzinsky. 2nd ed., revised and supplemented. Moscow: GEOTAR-Media, 2018 (in Russian).
4. Tidу JA, Gellespie AM, Bright N et al. Gestational trophoblastic disease: A study of mode evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309–12.
5. Fisher PM, Hancock BW. Gestational trophoblastic diseases and their treatment. Cancer Treat Rev 1997; 23 (1): 1–16.
6. Doll KM, Soper JT. The role of surgery in the management of gestational trophoblastic neoplasia. Obstet Gynecol Surv 2013; 68 (7): 533–7.
7. Lao TT, Lee FH, Yeung SS. Repeat curettage after evacuation of hydatidiform mole. An appraisal. Acta Obstet Gynecol Scand 1987; 66: 305–7.
8. Flam F, Lundstrom V. The value of endometrial curettage in the follow-up of hydatidiform mole. Acta Obstet Gynecol Scand 1988; 67: 649–51.
9. Schlaerth JB, Morrow CP, Rodriguez M. Diagnostic and therapeutic curettage in gestational trophoblastic disease. Am J Obstet Gynecol 1990; 162 (6): 1465–70.
10. Pezeshki M, Hancock BW, Silcocks P et al. The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. Gynecol Oncol 2004; 95: 423–9.
11. Tikhonovskaia M.N., Bystritskaia D.A., Kuznetsov V.V. et al. Persistiruiushchie trofoblasticheskie opukholi. Opukholi zhenskoi reproduktivnoi sistemy. 2013; 1–2: 53 (in Russian).
12. Tikhonovskaia M.N. Persistiruiushchie trofoblasticheskie opukholi (diagnostika i lechenie). Dis. … kand. med. nauk. 2015 (in Russian).
13. Lao TT, Lee FH, Yeung SS. Repeat curettage after evacuation of hydatidiform mole. Act Obstet Gynecol Scand 1987; 66 (4): 305–7.
14. Tow WS. The place of hysterotomy in the treatment of hydatidiform mole. Aust N Z J Obstet Gynaecol 1967; 7: 97–8.
15. Curry SL, Hammond CB, Tyrey L et al. Hydatidiform mole: diagnosis, management, and long-term follow up of 347 patients. Obstet Gynecol 1975; 45: 1–8.
16. Bandy LC, Clarke-Pearson DL, Hammond CB. Malignant potential of gestational trophoblastic disease at the extreme ages of reproductive life. Obstet Gynecol 1984; 64: 395–9.
17. Tsukamoto N, Iwasaka T, Kashimura Y et al. Gestational trophoblastic disease in women aged 50 or more. Gynecol Oncol 1985; 20: 53–61.
18. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254–8.
19. Meshcheriakova L.A. Standartnoe lechenie trofoblasticheskoi bolezni. Prakticheskaia onkologiia. 2008; 9 (3): 164–5 (in Russian).
20. Bystritskaia D.A., Tikhonovskaia M.N., Meshcheriakova L.A. et al. Trofoblasticheskie opukholi: k voprosu o klassifikatsii i faktorakh prognoza (chast' II). Ros. onkol. zhurn. 2014; 3: 33 (in Russian).
21. Grigorova T.M. Trophoblastic disease. Moscow: Medicine, 1985 (in Russian).
22. Savinova V.F. Diagnostika i lechenie khorionepiteliomy matki. Dis. … d-ra med. nauk. Мoscow, 1971 (in Russian).
23. Tsip N.P., Vorob'eva L.I. Khirurgicheskii metod v lechenii trofoblasticheskikh opukholei. Prakticheskaia onkologiia. 2008; 9 (3): 179–84 (in Russian).
24. Meshcheriakova L.A., Kozachenko V.P. Trofoblasticheskie opukholi: vozmozhnosti khirurgicheskogo lecheniia. Vestn. RONTs. 2003; 4: 36–42 (in Russian).
25. Behtash N, Ansari S, Sarvi F. Successful pregnancy after localized resection of perforated uterus in choriocarcinoma and a literature review. Int J Gynаecol Cancer 2006; 16 (Suppl. 1): 445–8.
26. Xiang Y, Yang X, Du J, Song H. The role of hysterectomy in the therapy of gestational trophoblastic tumor. Chin Med Sci J 2000; 15 (1): 45–8.
27. Hanna RK, Soper JT. The Role of Surgery and Radiation Therapy in the Management of Gestational Trophoblastic Disease. Oncologist 2010; 15: 593–600.
28. Suzuka K, Matsui H, Iitsuka Y et al. Adjuvant hysterectomy in low-risk gestational trophoblastic disease Obstet. Gynecol 2001; 97: 431–4.
29. Doumplis D, Al-Khatib K, Sieunarine K et al. A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006. BJOG 2007; 114: 1168–71.
30. Mutch DG, Soper JT, Babcock CJ et al. Recurrent gestational trophoblastic disease. Experience of the Southeastern Regional Trophoblastic Disease Center. Cancer 1990; 66: с978–982.
31. Alazzam M, Hancock BW, Tidy J. Role of hysterectomy in managing persistent gestational trophoblastic disease. J Reprod Med 2008; 53 (7): 519–24.
32. Feng FZ, Xiang Y, Cao Y et al. Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm. Zhonghua Fu Chan Ke Za Zhi 2008; 43 (10): 728–31.
33. Eysbouts YK, Massuger LFAG, IntHout J. The added value of hysterectomy in the management of gestational trophoblastic neoplasia. Gynecol Oncol 2017; 145 (3): 536–42.
34. Feng F, Xiang Y. Surgical management of chemotherapy-resistant gestational trophoblastic neoplasia. Expert Rev Anticancer Ther 2010; 10 (1): 71–80.
35. Gasanbekova Z.A. Oshibki v diagnostiki i lechenii zlokachestvennoi trofoblasticheskoi opukholi. Dis. … kand. med. nauk. 2019 (in Russian).
36. Papadopoulos AJ, Foskett M, Seckl MJ et al. Twenty-five years’ clinical experience with placental site trophoblastic tumors. J Reprod Med 2002; 47: 460–4.
37. Moutte A, Doret M, Hajri T et al. Placental site and epithelioid trophoblastic tumours: diagnostic pitfalls. Gynecol Oncol 2013; 128 (3): 568–72.
38. El-Lamie IK, Sheeta NA, Abou-Loz SK. Experience on the Gynаecologic Oncology Unit at Ain Shams University in the treatment of gestational trophoblastic Tumours. Int J Gynaecol Oncol 2000; 10: 488–96.
39. Jones WB, Romain K, Erlandson RA et al. Thoracotomv in the management of gestational choriocarcinoma. Cancer 1993; 72: 2175–81.
39. Meshcheriakova L.A., Kozachenko V.P. Trofoblasticheskie opukholi: vozmozhnosti khirurgicheskogo lecheniia. Vestn. RONTs. 2003; 
4: 36–42 (in Russian).
40. Jones WB, Wolchok J, Lewis JL. The role of surgery in management of gestational trophoblastic disease. Int J Gynaecol Cancer 1996; 
6: 261–6.
41. Kanis MJ, Lurain JR. Pulmonary Resection in the Management of High-Risk Gestational Trophoblastic Neoplasia. Int J Gynecol Cancer 2016; 26 (4): 796–800.
42. Aydiner A, Keskin S, Berkman S. The roles of surgery and EMA/CO chemotherapy regimen in primary refractory and non-refractory gestational trophoblastic neoplasia. J Cancer Res Clin Oncol 2012; 138 (6): 971–7.
43. Cao Y, Xiang Y, Feng F et al. Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia. Int J Gynecol Cancer 2009; 19 (4): 798–801.
44. Lurain JR, Singh DK, Schink JC. Role of surgery in the management of high-risk gestational trophoblastic neoplasia. J Reprod Med 2006; 51 (10): 773–6.
45. Eoh KJ, Chung YS, Yim GW et al. Role of surgical therapy in the management of gestational trophoblastic neoplasia. Obstet Gynecol Sci 2015; 58 (4): 227–83.

А.Ф. Масленников*, Л.А. Мещерякова, В.В. Кузнецов, В.П. Козаченко, И.Г. Комаров

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
*rihterfm@mail.ru

________________________________________________

Aleksandr F. Maslennikov*, Liudmila A. Meshcheriakova, Viktor V. Kuznetsov, Vladimir P. Kozachenko, Igor G. Komarov

Blokhin National Medical Research Center of Oncology, Moscow, Russia
*rihterfm@mail.ru