Не дайте ей исчезнуть: новые возможности продления жизни пациенток с HR+ HER2- распространенным раком молочной железы. Обзор сателлитного симпозиума, состоявшегося в рамках большой конференции RUSSCO «Рак молочной железы» (в онлайн-формате).

Не дайте ей исчезнуть: новые возможности продления жизни пациенток с HR+ HER2- распространенным раком молочной железы. Современная Онкология. 2021; 23 (1): 53–60.
DOI: 10.26442/18151434.2021.1.200764

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Don't let it disappear: new opportunities to prolong the life of HR+ HER2- advanced breast cancer patients. Journal of Modern Oncology. 2021; 23 (1): 53–60. DOI: 10.26442/18151434.2021.1.200764

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Аннотация

Увеличение продолжительность жизни и сохранение ее качества являются основными целями терапии гормонозависимого HER2-отрицательного распространенного рака молочной железы (HR+ HER2- рРМЖ). 28 января 2021 г. в рамках Большой конференции RUSSCO «Рак молочной железы» состоялся сателлитный симпозиум компании «Новартис Фарма», посвященный преимуществам терапии препаратом Рисарг (рибоциклиб) в комбинации с гормонотерапией. Эксперты-онкологи поделились актуальными данными и своим опытом применения рибоциклиба. Ингибиторы CDK4/6 в комбинации с гормонотерапией стали «золотым стандартом» 1-й линии терапии HR+ HER2- рРМЖ, а выбор конкретного препарата проводится на основании данных клинических исследований и с учетом индивидуальных особенностей пациентки. Результаты исследований рибоциклиба (MONALEESA-3 и MONALEESA-7) демонстрируют достоверное увеличение медианы общей выживаемости и снижение риска смерти на 28 и 30%. Профиль переносимости рибоциклиба является хорошо изученным и управляемым, поэтому благодаря грамотному мониторингу можно снизить риск развития нежелательных явлений и провести необходимую модификацию дозы, что позволяет сохранить высокоэффективную терапию большинству пациентов. Применение рибоциклиба позволяет достичь главные цели терапии – продлить жизнь пациентки и сохранить или улучшить качество жизни.

Ключевые слова: гормонозависимый HER2-отрицательный распространенный рак молочной железы, ингибиторы CDK4/6, рибоциклиб, общая выживаемость, качество жизни

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Increasing life expectancy and maintaining its quality are the main goals of the hormone-dependent HER2-negative advanced breast cancer (HR+ HER2- аBC) therapy. A Satellite Symposium of Novartis Pharma was held on January 28th, 2021, within the framework of the RUSSCO Big Conference "Breast Cancer". It was dedicated to the benefits of Risarg (ribociclib) therapy in combination with hormone therapy (HT). Experts-oncologists shared current data and their experience with ribociclib. The combination of CDK4/6 inhibitors with HT became a gold standard for the 1st line therapy for HR+ HER2- aBC. And the choice of a specific drug is based on the data of clinical studies and is made taking into account the individual characteristics of the patient. The results of ribociclib studies (MONALEESA-3 and MONALEESA-7) demonstrate a significant increase in the median overall survival and a decrease in the risk of death by 28 and 30%. The tolerance profile of ribociclib is well studied and controlled, therefore the risks of adverse events can be reduced by the competent monitoring, and the necessary dose modification can be made, which allows most patients to maintain highly effective therapy. The use of ribociclib allows to achieve the main goals of therapy – to prolong the patient's life and maintain or improve its quality.

Keywords: hormone-dependent HER2-negative advanced breast cancer, CDK4/6 inhibitors, ribociclib, overall survival, quality of life

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Авторы

Эксперты:
Елена Владимировна Артамонова – д-р мед. наук, проф., зав. отд-нием химиотерапии ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
Ирина Владимировна Колядина – д-р мед. наук, проф., проф. каф. онкологии и паллиативной медицины им. акад. А.И. Савицкого ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России на базе ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва

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Experts:
Elena V. Artamonova – D. Sci. (Med.), Prof., Blokhin National Medical Research Center of Oncology, Moscow, Russia
Irina V. Kolyadina – D. Sci. (Med.), Prof., Russian Medical Academy of Continuous Professional Education on the basis of Blokhin National Medical Research Center of Oncology, Moscow, Russia

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