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Диагностика синдрома растущей тератомы
Нечушкина И.В., Сусулева Н.А., Бойченко Е.И., Нечушкина В.М., Керимов П.А., Рябов А.Б. Диагностика синдрома растущей тератомы. Современная Онкология. 2024;26(4):438–440. DOI: 10.26442/18151434.2024.4.202903
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
Nechushkina IV, Susuleva NA, Boychenko EI, Nechushkina VM, Kerimov PA, Ryabov AB. Diagnosis of growing teratoma syndrome: A review. Journal of Modern Oncology. 2024;26(4):438–440. DOI: 10.26442/18151434.2024.4.202903
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Аннотация
Большое внимание в последние годы уделяется изучению клинического течения и своевременной диагностики синдрома растущей тератомы. Исследования показали, что поздняя диагностика процесса ведет к невозможности оперативного удаления опухоли, основного метода лечения больных с синдромом. В литературном обзоре указаны основные критерии для диагностики синдрома. Дифференциальная диагностика проводится с глиоматозом брюшины и злокачественными герминогенными опухолями. Огромное значение для правильной диагностики и своевременного выбора лечения имеет комплексное обследование.
Ключевые слова: синдром растущей тератомы, герминогенные опухоли, онкология, диагностика
Ключевые слова: синдром растущей тератомы, герминогенные опухоли, онкология, диагностика
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In recent years a lot of attention has been paid to the research of the clinical course and timely diagnosis of the growing teratoma syndrome. Late diagnosis makes surgery (which is the main treatment for the patients) impossible. The literature review presents the main diagnostic criteria of the syndrome. Differential diagnosis includes peritoneal gliomatosis and malignant germ cell tumors. A comprehensive evaluation is of great importance for the correct diagnosis and timely treatment.
Keywords: growing teratoma syndrome, germ cell tumors, oncology, diagnosis
Полный текст
Список литературы
1. Желудкова О.Г., Шишкина А.В., Коновалов А.Н., и др. Синдром растущей тератомы у пациента с интракраниальной герминативно-клеточной опухолью. Журнал «Вопросы нейрохирургии» им. Н.Н. Бурденко. 2015;79(3):69-74 [Zheludkova OG, Shishkina LV, Konovalov AN, et al. Growing teratoma syndrome in patient with intracranial germ cell tumor. Burdenko’s Journal of Neurosurgery. 2015;79(3):69-74 (in Russian)]. DOI:10.17116/neiro201579369-74
2. Синиченкова К.Ю., Тютикова У.С., Ликарь Ю.Н., и др. Сложности диагностики синдома растущей тератомы на примере двух клинических наблюдений. Вопросы гематологии/онкологии и иммунологии в педиатрии. 2020;19(4):126-52 [Sinichenkova KYu, Tyutikova ES, Likar YuN, et al. Challenges in the diagnosis of growing teratoma syndrome: two case reports. Pediatric Hematology/Oncology and Immunopathology. 2020;19(4):126-52 (in Russian)]. DOI:10.2428/1726-1708-2020-19-4-126-132
3. Калимуллин Б.А., Осипова И.В., Шапиро В.Ю., и др. Клинический случай синдрома растущей тератомы у подростка с герминогенной опухолью яичка. Вопросы гематологии/онкологии и иммунологии в педиатрии. 2023;22(4):144-50 [Kalimullin BA, Osipova IV, Shapiro VYu, et al. Growing teratoma syndrome in an adolescent with a testicular germ cell tumor: a case report. Pediatric Hematology/Oncology and Immunopathology. 2023;22(4):144-50 (in Russian)]. DOI:10.24287/1726-1708-2023-22-4-144-150
4. Logothetis CJ, Samuels MI, Trindade A, Johnson DE. The growing teratome syndrome. Cancer. 1982;50(8):1629-35.
5. Jeffery GM, Theaker JM, Lee AH, et al. The growing teratoma syndrome. Br J Urol. 1991;67(2):195-202.
6. Tangjtgamol S, Manusirivithaya S, Leelahakom S, et al. The growing teratoma syndrome: a case report and a review of literature. Int J Gynecol Cancer. 2006;16):384-90.
7. Soufi M, Lupinacci RM, Godiris-Petit G, et al. Growing teratoma syndrome of the ovary presenting with liver metastasis: report of a case. Eur J Gynecol Oncol. 2015;36(4):473-6.
8. Moscovic E, Jobling T, Fisher C, et al. Retroconversion of immature teratoma of the ovary: CT appearances. Clin Radiol. 1991;43(6):402-8.
9. Andre F, Fizazi K, Culine S, et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36(11):1389-94.
10. Tongaonkar HB, Deshmane VH, Dalal AV, et al. Growing teratoma syndrome. J Surg Oncol. 1994;55(1):56-60.
11. Nimkin K, Gupta P, McCauley R, et al. The growing teratoma syndrome. Pediatr Radiol. 2004;34(3):259-62.
12. Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: tumor types and imaging characteristics. Radiographics . 2001;21:475-90.
13. Lee DJ, Djaladat H, Tadros NN, et al. Growing teratoma syndrome: clinical and radiographic characteristics. Int J Urol. 2014;21:905-8. DOI:10.1111/iju.12466
14. Aide N, Comoz F, Sevin E. Enlarging residual mass after treatment of a nonseminomatous germ cell tumor: growing teratoma syndrome or cancer recurrence? J Clin Oncol. 2007;25:4494-6. DOI:10.1200/JCO.2007.12.7530
15. Hariprasad R, Kumar L, Janga D, et al. Growing teratoma syndrome of ovary. Int J Clin Oncol. 2008;13:83-7.
16. Kikawa S, Todo Y, Minobe S, et al. Growing teratoma syndrome of the ovary: a case report with FDG-PET findings. J Obstet Gynaecol Res. 2011;37(7):926-32.
17. Best DH, Butz GM, Moller K, et al. Molecular analysis of an immature ovarian teratoma with gliomatosis peritonei and recurrence suggest genetic independence of multiple tumors. Int J Oncol. 2004;25(1):17-25.
18. Kwan MY, Kalle W, Lau GT, Chan JK. Is gliomatosis peritonei derived from the associated ovarian teratoma. Hum Pathol. 2004;35:685-8.
19. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
20. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
21. Nogales EF, Preda O, Dulcey I. Gliomatosis peritonei as a natural experiment in tissue differentiation. Int J Dev Biol. 2012;56:969-74.
22. Maucksch C, Jones KS, Connor B. Concise review: the involvement of Sox2 in direct reprogramming of induced neural stem/precursor cell. Stem Cells Transl Med. 2013;2:579-83.
23. Liang L, Zhang Y, Malpica A, et al. Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Mod Pathol. 2015;28:1613-20.
24. Zhao T, Liu Y, Jiang H, et al. Management of bilateral malignant ovarian germ cell tumors: Experience of a single institute. Mol Clin Oncol. 2016;5(2):383-7.
25. Phi JH, Park SH, Paek SH, et al. Expression of SOX2 in mature and immature teratomas of central nervous system. Mod Pathol. 2007;20:742-8. DOI;10.1038/modpathol.3800793
26. Truong LD, Jurco S, McGavran MH. Gliomatosis Peritonei: report of two cases and review of the literature. Am J Surg Pathol. 1982;6:443-9.
27. Gu S, Wu YM, Hong L, et al. Glial fibrillary acidic protein expression is an indicator of teratoma maturation in children. World J Pediatr. 2011;7:262-5.
28. Wang D, Jia CW, Feng RE, et al. Gliomatosis peritonei: a series of eight cases and review of the literature. J Ovarian Res. 2016;9(1):45-51. DOI:10.1186/s13048-016-0256-5
29. Tullius BP, Shankar SP, Cole S, et al. Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowing in two-year-old female. Pediatr Blood Cancer. 2019:e27788. DOI:10.1002/pbc.27788
30. Willis GW, Hajdu SI. Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. Am J Clin Pathol. 1973;59(3):338-43.
31. Spiess PE, Kassouf W, Brown GA, et al. Surgical management of growing teratoma syndrome: the M.D. Anderson cancer center experience. J Urol. 2007;177(4):1330-4.
32. Gorbatiy V, Spiess PE, Pisters LL. The growing teratoma syndrome: current review of the literature. Indian J Urol. 2009;25:186-9.
33. Scavuzzo A, Santana Rios ZA, Noveron NR, Jimenez Rios MA. Growing teratoma syndrome. Case Rep Urol. 2014;2014:139425. DOI:10.1155/2014/139425
34. Matsushita H, Arai K, Fukase M, et al. Growing teratoma syndrome of the ovary after fertility-sparing surgery and successful pregnancy. Gynecol Obstet Invest. 2010;69(4):221-3. DOI:10.1159/000273205
2. Синиченкова К.Ю., Тютикова У.С., Ликарь Ю.Н., и др. Сложности диагностики синдома растущей тератомы на примере двух клинических наблюдений. Вопросы гематологии/онкологии и иммунологии в педиатрии. 2020;19(4):126-52 [Sinichenkova KYu, Tyutikova ES, Likar YuN, et al. Challenges in the diagnosis of growing teratoma syndrome: two case reports. Pediatric Hematology/Oncology and Immunopathology. 2020;19(4):126-52 (in Russian)]. DOI:10.2428/1726-1708-2020-19-4-126-132
3. Калимуллин Б.А., Осипова И.В., Шапиро В.Ю., и др. Клинический случай синдрома растущей тератомы у подростка с герминогенной опухолью яичка. Вопросы гематологии/онкологии и иммунологии в педиатрии. 2023;22(4):144-50 [Kalimullin BA, Osipova IV, Shapiro VYu, et al. Growing teratoma syndrome in an adolescent with a testicular germ cell tumor: a case report. Pediatric Hematology/Oncology and Immunopathology. 2023;22(4):144-50 (in Russian)]. DOI:10.24287/1726-1708-2023-22-4-144-150
4. Logothetis CJ, Samuels MI, Trindade A, Johnson DE. The growing teratome syndrome. Cancer. 1982;50(8):1629-35.
5. Jeffery GM, Theaker JM, Lee AH, et al. The growing teratoma syndrome. Br J Urol. 1991;67(2):195-202.
6. Tangjtgamol S, Manusirivithaya S, Leelahakom S, et al. The growing teratoma syndrome: a case report and a review of literature. Int J Gynecol Cancer. 2006;16):384-90.
7. Soufi M, Lupinacci RM, Godiris-Petit G, et al. Growing teratoma syndrome of the ovary presenting with liver metastasis: report of a case. Eur J Gynecol Oncol. 2015;36(4):473-6.
8. Moscovic E, Jobling T, Fisher C, et al. Retroconversion of immature teratoma of the ovary: CT appearances. Clin Radiol. 1991;43(6):402-8.
9. Andre F, Fizazi K, Culine S, et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36(11):1389-94.
10. Tongaonkar HB, Deshmane VH, Dalal AV, et al. Growing teratoma syndrome. J Surg Oncol. 1994;55(1):56-60.
11. Nimkin K, Gupta P, McCauley R, et al. The growing teratoma syndrome. Pediatr Radiol. 2004;34(3):259-62.
12. Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: tumor types and imaging characteristics. Radiographics . 2001;21:475-90.
13. Lee DJ, Djaladat H, Tadros NN, et al. Growing teratoma syndrome: clinical and radiographic characteristics. Int J Urol. 2014;21:905-8. DOI:10.1111/iju.12466
14. Aide N, Comoz F, Sevin E. Enlarging residual mass after treatment of a nonseminomatous germ cell tumor: growing teratoma syndrome or cancer recurrence? J Clin Oncol. 2007;25:4494-6. DOI:10.1200/JCO.2007.12.7530
15. Hariprasad R, Kumar L, Janga D, et al. Growing teratoma syndrome of ovary. Int J Clin Oncol. 2008;13:83-7.
16. Kikawa S, Todo Y, Minobe S, et al. Growing teratoma syndrome of the ovary: a case report with FDG-PET findings. J Obstet Gynaecol Res. 2011;37(7):926-32.
17. Best DH, Butz GM, Moller K, et al. Molecular analysis of an immature ovarian teratoma with gliomatosis peritonei and recurrence suggest genetic independence of multiple tumors. Int J Oncol. 2004;25(1):17-25.
18. Kwan MY, Kalle W, Lau GT, Chan JK. Is gliomatosis peritonei derived from the associated ovarian teratoma. Hum Pathol. 2004;35:685-8.
19. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
20. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
21. Nogales EF, Preda O, Dulcey I. Gliomatosis peritonei as a natural experiment in tissue differentiation. Int J Dev Biol. 2012;56:969-74.
22. Maucksch C, Jones KS, Connor B. Concise review: the involvement of Sox2 in direct reprogramming of induced neural stem/precursor cell. Stem Cells Transl Med. 2013;2:579-83.
23. Liang L, Zhang Y, Malpica A, et al. Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Mod Pathol. 2015;28:1613-20.
24. Zhao T, Liu Y, Jiang H, et al. Management of bilateral malignant ovarian germ cell tumors: Experience of a single institute. Mol Clin Oncol. 2016;5(2):383-7.
25. Phi JH, Park SH, Paek SH, et al. Expression of SOX2 in mature and immature teratomas of central nervous system. Mod Pathol. 2007;20:742-8. DOI;10.1038/modpathol.3800793
26. Truong LD, Jurco S, McGavran MH. Gliomatosis Peritonei: report of two cases and review of the literature. Am J Surg Pathol. 1982;6:443-9.
27. Gu S, Wu YM, Hong L, et al. Glial fibrillary acidic protein expression is an indicator of teratoma maturation in children. World J Pediatr. 2011;7:262-5.
28. Wang D, Jia CW, Feng RE, et al. Gliomatosis peritonei: a series of eight cases and review of the literature. J Ovarian Res. 2016;9(1):45-51. DOI:10.1186/s13048-016-0256-5
29. Tullius BP, Shankar SP, Cole S, et al. Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowing in two-year-old female. Pediatr Blood Cancer. 2019:e27788. DOI:10.1002/pbc.27788
30. Willis GW, Hajdu SI. Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. Am J Clin Pathol. 1973;59(3):338-43.
31. Spiess PE, Kassouf W, Brown GA, et al. Surgical management of growing teratoma syndrome: the M.D. Anderson cancer center experience. J Urol. 2007;177(4):1330-4.
32. Gorbatiy V, Spiess PE, Pisters LL. The growing teratoma syndrome: current review of the literature. Indian J Urol. 2009;25:186-9.
33. Scavuzzo A, Santana Rios ZA, Noveron NR, Jimenez Rios MA. Growing teratoma syndrome. Case Rep Urol. 2014;2014:139425. DOI:10.1155/2014/139425
34. Matsushita H, Arai K, Fukase M, et al. Growing teratoma syndrome of the ovary after fertility-sparing surgery and successful pregnancy. Gynecol Obstet Invest. 2010;69(4):221-3. DOI:10.1159/000273205
________________________________________________
1. Zheludkova OG, Shishkina LV, Konovalov AN, et al. Growing teratoma syndrome in patient with intracranial germ cell tumor. Burdenko’s Journal of Neurosurgery. 2015;79(3):69-74 (in Russian). DOI:10.17116/neiro201579369-74
2. Sinichenkova KYu, Tyutikova ES, Likar YuN, et al. Challenges in the diagnosis of growing teratoma syndrome: two case reports. Pediatric Hematology/Oncology and Immunopathology. 2020;19(4):126-52 (in Russian). DOI:10.2428/1726-1708-2020-19-4-126-132
3. Kalimullin BA, Osipova IV, Shapiro VYu, et al. Growing teratoma syndrome in an adolescent with a testicular germ cell tumor: a case report. Pediatric Hematology/Oncology and Immunopathology. 2023;22(4):144-50 (in Russian). DOI:10.24287/1726-1708-2023-22-4-144-150
4. Logothetis CJ, Samuels MI, Trindade A, Johnson DE. The growing teratome syndrome. Cancer. 1982;50(8):1629-35.
5. Jeffery GM, Theaker JM, Lee AH, et al. The growing teratoma syndrome. Br J Urol. 1991;67(2):195-202.
6. Tangjtgamol S, Manusirivithaya S, Leelahakom S, et al. The growing teratoma syndrome: a case report and a review of literature. Int J Gynecol Cancer. 2006;16):384-90.
7. Soufi M, Lupinacci RM, Godiris-Petit G, et al. Growing teratoma syndrome of the ovary presenting with liver metastasis: report of a case. Eur J Gynecol Oncol. 2015;36(4):473-6.
8. Moscovic E, Jobling T, Fisher C, et al. Retroconversion of immature teratoma of the ovary: CT appearances. Clin Radiol. 1991;43(6):402-8.
9. Andre F, Fizazi K, Culine S, et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36(11):1389-94.
10. Tongaonkar HB, Deshmane VH, Dalal AV, et al. Growing teratoma syndrome. J Surg Oncol. 1994;55(1):56-60.
11. Nimkin K, Gupta P, McCauley R, et al. The growing teratoma syndrome. Pediatr Radiol. 2004;34(3):259-62.
12. Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: tumor types and imaging characteristics. Radiographics . 2001;21:475-90.
13. Lee DJ, Djaladat H, Tadros NN, et al. Growing teratoma syndrome: clinical and radiographic characteristics. Int J Urol. 2014;21:905-8. DOI:10.1111/iju.12466
14. Aide N, Comoz F, Sevin E. Enlarging residual mass after treatment of a nonseminomatous germ cell tumor: growing teratoma syndrome or cancer recurrence? J Clin Oncol. 2007;25:4494-6. DOI:10.1200/JCO.2007.12.7530
15. Hariprasad R, Kumar L, Janga D, et al. Growing teratoma syndrome of ovary. Int J Clin Oncol. 2008;13:83-7.
16. Kikawa S, Todo Y, Minobe S, et al. Growing teratoma syndrome of the ovary: a case report with FDG-PET findings. J Obstet Gynaecol Res. 2011;37(7):926-32.
17. Best DH, Butz GM, Moller K, et al. Molecular analysis of an immature ovarian teratoma with gliomatosis peritonei and recurrence suggest genetic independence of multiple tumors. Int J Oncol. 2004;25(1):17-25.
18. Kwan MY, Kalle W, Lau GT, Chan JK. Is gliomatosis peritonei derived from the associated ovarian teratoma. Hum Pathol. 2004;35:685-8.
19. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
20. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
21. Nogales EF, Preda O, Dulcey I. Gliomatosis peritonei as a natural experiment in tissue differentiation. Int J Dev Biol. 2012;56:969-74.
22. Maucksch C, Jones KS, Connor B. Concise review: the involvement of Sox2 in direct reprogramming of induced neural stem/precursor cell. Stem Cells Transl Med. 2013;2:579-83.
23. Liang L, Zhang Y, Malpica A, et al. Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Mod Pathol. 2015;28:1613-20.
24. Zhao T, Liu Y, Jiang H, et al. Management of bilateral malignant ovarian germ cell tumors: Experience of a single institute. Mol Clin Oncol. 2016;5(2):383-7.
25. Phi JH, Park SH, Paek SH, et al. Expression of SOX2 in mature and immature teratomas of central nervous system. Mod Pathol. 2007;20:742-8. DOI;10.1038/modpathol.3800793
26. Truong LD, Jurco S, McGavran MH. Gliomatosis Peritonei: report of two cases and review of the literature. Am J Surg Pathol. 1982;6:443-9.
27. Gu S, Wu YM, Hong L, et al. Glial fibrillary acidic protein expression is an indicator of teratoma maturation in children. World J Pediatr. 2011;7:262-5.
28. Wang D, Jia CW, Feng RE, et al. Gliomatosis peritonei: a series of eight cases and review of the literature. J Ovarian Res. 2016;9(1):45-51. DOI:10.1186/s13048-016-0256-5
29. Tullius BP, Shankar SP, Cole S, et al. Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowing in two-year-old female. Pediatr Blood Cancer. 2019:e27788. DOI:10.1002/pbc.27788
30. Willis GW, Hajdu SI. Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. Am J Clin Pathol. 1973;59(3):338-43.
31. Spiess PE, Kassouf W, Brown GA, et al. Surgical management of growing teratoma syndrome: the M.D. Anderson cancer center experience. J Urol. 2007;177(4):1330-4.
32. Gorbatiy V, Spiess PE, Pisters LL. The growing teratoma syndrome: current review of the literature. Indian J Urol. 2009;25:186-9.
33. Scavuzzo A, Santana Rios ZA, Noveron NR, Jimenez Rios MA. Growing teratoma syndrome. Case Rep Urol. 2014;2014:139425. DOI:10.1155/2014/139425
34. Matsushita H, Arai K, Fukase M, et al. Growing teratoma syndrome of the ovary after fertility-sparing surgery and successful pregnancy. Gynecol Obstet Invest. 2010;69(4):221-3. DOI:10.1159/000273205
Авторы
И.В. Нечушкина*1, Н.А. Сусулева1,2, Е.И. Бойченко1,2, В.М. Нечушкина3,4, П.А. Керимов2, А.Б. Рябов5
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия;
3АНО «Научно-образовательный центр “Евразийская онкологическая программа “ЕАФО”», Москва, Россия;
4ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия;
5ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Москва, Россия
*ivnechushkina@mail.ru
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия;
3АНО «Научно-образовательный центр “Евразийская онкологическая программа “ЕАФО”», Москва, Россия;
4ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия;
5ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Москва, Россия
*ivnechushkina@mail.ru
________________________________________________
Innesa V. Nechushkina*1, Natalja A. Susuleva1,2, Elena I. Boychenko1,2, Valentina M. Nechushkina3,4, Polad A. Kerimov2, Andrey B. Ryabov5
1Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2Blokhin National Medical Research Center of Oncology, Moscow, Russia;
3Educational and Research Center “Eurasian Oncology Program “EAFO” ANO, Moscow, Russia;
4Privolzhsky Research Medical University, Nizhny Novgorod, Russia;
5National Medical Research Radiological Centre, Moscow, Russia
*ivnechushkina@mail.ru
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