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Современные возможности диагностики и лечения диффузной В-крупноклеточной лимфомы у детей и взрослых (обзор литературы)
Современные возможности диагностики и лечения диффузной В-крупноклеточной лимфомы у детей и взрослых (обзор литературы)
Левашов А.С., Валиев Т.Т., Ковригина А.М. и др. Современные возможности диагностики и лечения диффузной В-крупноклеточной лимфомы у детей и взрослых (обзор литературы). Современная онкология. 2015; 17 (3): 30–41.
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Аннотация
Диффузная В-крупноклеточная лимфома (ДВККЛ) включает разные варианты заболевания, гетерогенные по клиническим, морфологическим, иммунологическим, цитогенетическим и молекулярно-биологическим параметрам. В данной статье представлены результаты лечения детей и взрослых с ДВККЛ по различным программам (AIEOP NHL92, B-NHL-BFM90, POG APO – IDM/HiDAC, B-NHL-BFM95, FAB/LMB96, BNHL03, FAB/LMB96 + ритуксимаб, Б-НХЛ2004м + ритуксимаб, R-CHOP,
DA-EPOCH-R, RB-CHOP, RBV-CHOP). Выделены молекулярно-биологические факторы неблагоприятного прогноза заболевания у взрослых пациентов с ДВККЛ, которые позволят улучшить стратификацию групп риска, уменьшить интенсивность проводимой терапии у некоторых пациентов, но в настоящее время требуют дополнительного изучения у детей. Особое внимание уделено изучению чувствительности опухоли к таргетной терапии, в частности к анти-CD20 моноклональным антителам.
Ключевые слова: диффузная В-крупноклеточная лимфома, диагностика, лечение, дети и взрослые.
Key words: diffuse large B-cell lymphoma, diagnostic, treatment, children and adults.
DA-EPOCH-R, RB-CHOP, RBV-CHOP). Выделены молекулярно-биологические факторы неблагоприятного прогноза заболевания у взрослых пациентов с ДВККЛ, которые позволят улучшить стратификацию групп риска, уменьшить интенсивность проводимой терапии у некоторых пациентов, но в настоящее время требуют дополнительного изучения у детей. Особое внимание уделено изучению чувствительности опухоли к таргетной терапии, в частности к анти-CD20 моноклональным антителам.
Ключевые слова: диффузная В-крупноклеточная лимфома, диагностика, лечение, дети и взрослые.
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Key words: diffuse large B-cell lymphoma, diagnostic, treatment, children and adults.
Полный текст
Список литературы
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Авторы
А.С.Левашов*1, Т.Т.Валиев1, А.М.Ковригина2, А.В.Попа1, Г.Л.Менткевич1
1 ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России. 115478, Россия, Москва, Каширское ш., д. 23;
2 ФГБУ Гематологический научный центр Минздрава России. 125167, Россия, Москва, Новый Зыковский пр., д. 4
*andreyslevashov@mail.ru
1 N.N.Blokhin Russian Cancer Research Center. 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23;
2 National Research Center for Hematology of the Ministry of Health of the Russian Federation. 125167, Russian Federation, Moscow, Novyi Zykovskii pr., d. 4
*andreyslevashov@mail.ru
1 ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России. 115478, Россия, Москва, Каширское ш., д. 23;
2 ФГБУ Гематологический научный центр Минздрава России. 125167, Россия, Москва, Новый Зыковский пр., д. 4
*andreyslevashov@mail.ru
________________________________________________
1 N.N.Blokhin Russian Cancer Research Center. 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23;
2 National Research Center for Hematology of the Ministry of Health of the Russian Federation. 125167, Russian Federation, Moscow, Novyi Zykovskii pr., d. 4
*andreyslevashov@mail.ru
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