Основные терапевтические подходы к лечению цереброваскулярной патологии

1. Гусев Е.И., Скворцова В.И. Ишемия головного мозга. М., 2001.
2. Гусев Е.И., Камчатнов П.Р. Пластичность головного мозга в норме и патологии. Журн. неврологии и психиатрии. 2004; 2: 73–80.
3. Mir C, Clotet J, Aledo R. CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons. J Mol Neurosci 2003; 20: 53–60.
4. Wurtman R, Regan M, Ulus I, Yu L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol 2000; 60: 989–95.
5. Rao A, Hatcher J. Does CDP-choline modulate phospholipase activities after transient forebrain ischemia. Brain Res 2001; 893: 268–72.
6. Hurtado O, Moro MA, Cardenas A et al. Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis 2005; 18: 336–45.
7. Fiedorowicz М, Makarewicz D, Stańczak-Mrozek К, Grieb Р. CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. Acta Neurobiol Exp 2008; 68: 389–97.
8. Schuettauf F, Rejdak R, Thaler S et al. Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat. Exp Eye Res 2006; 83: 1128–34.
9. Garcia-Bonilla L, Giralt D, Bustamante A et al. Citicoline in pre-clinical animal models of stroke: A meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem 2012. Doi: 10.1111/j.1471-4159.2012.07891.x.
10. Lee H-J, Kang JS, Kim YI. Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion. J Clin Neurol 2009; 5: 33–8.
11. Secades J, Lorenzo J. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol 2006; 28 (Suppl. B): 1–56.
12. Zafonte R, Friedewald W, Lee S et al. The citicoline brain injury treatment (COBRIT) trial: design and methods. J Neurotrauma 2009; 26 (12): 2207–16.
13. Dávalos А, Castillo А, Álvarez-Sabín М. Oral Citicoline in acute ischemic stroke. An individual patient data pooling Analysis of clinical trials. Stroke 2002; 33: 2850–7.
14. Clark W. Efficacy of citicoline as an acute stroke treatment. Expert Opin Pharmacother 2009; 10 (5): 839–46.
15. Dávalos А, Álvarez-Sabín J, Castillo J et al. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet 2012; 380 (9839): 349–57.
16. Мартынов М.Ю., Бойко А.Н., Камчатнов П.Р. и др. Нейропротективная терапия цитиколином. Журн. неврологии и психиатрии. Инсульт. 2012; 112 (3): 16–21.
17. Bruce S, Werner K, Preston B, Baker L. Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage. Int J Food Sci Nutr 2014; 6: 1–5.
18. Putignano S, Gareri P, Castagna A et al. Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome. Clinical Interventions in Aging 2012; 7: 113–8.
19. Rejdak R, Toczołowski J, Solski J et al. Citicoline treatment increases retinal dopamine content in rabbits. Ophtalmic Res 2002; 34: 146–9.
20. Álvarez-Sabín J, Roman G. Citicoline in vascular cognitive impairment and vascular dementia after stroke. Stroke 2011; 42 (Suppl. 1): S40–S43.
21. Hurtado O, Lizasoain I, Moro M. Neuroprotection and recovery: recent data at the bench on citicoline. Stroke 2011; 42 (Suppl. 1): S33–S35.
22. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP choline) for cognitive and behavioral disturbances associated with chronic cerebral disorders in the elderly (Cochrane Methodology Review). In: The Cochrane Library, Issue ft., 2003.
23. Álvarez-Sabín J, Ortega G, Jacas C et al. Long-term treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovasc Dis 2013; 35 (2): 146–54.
24. Zafonte R, Bagiella E, Ansel B et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA 2012; 308 (19): 1993–2000.
25. Ottobelli L, Manni G, Centofanti M et al. Citicoline oral solution in glaucoma: is there a role in slowing disease progression? Ophthalmologica 2013; 229: 219–26.

Х.Я.Умарова1, А.В.Чугунов2

1 ФГБОУ ВПО Чеченский государственный университет, Грозный;
2 ГБОУ ВПО РНИМУ им. Н.И.Пирогова Минздрава России, Москва