Новые пероральные антикоагулянты широко используют в кардиологической практике для профилактики инсульта и тромбоэмболических осложнений. Их эффективность не уступает варфарину. Вместе с тем они имеют ряд неоспоримых преимуществ. Обсуждаются вопросы возможного выбора среди новых оральных антикоагулянтов и место апиксабана в проведении противотромботической терапии.
Ключевые слова: апиксабан, новые пероральные антикоагулянты, фибрилляция предсердий.
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New oral anticoagulants are widely used in cardiac practice for the prevention of stroke and thromboembolic complications. Their effectiveness is not inferior to warfarin. At the same time, they have a number of undeniable advantages. Issues of possible choice among new oral anticoagulants and the place of apixaban in conducting antithrombotic therapy are discussed.
Key words: apixaban, new oral anticoagulants, atrial fibrillation.
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6. Lip GYH, Larsen TB, Skjoth F et al. Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation. J Am Coll Cardiol 2012; 60: 738–46.
7. Granger CB, Alexander JH, Mc Murray et al. Rivaroxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365 (11): 981–92.
8. ROCKET-AF Stady Investigators. Rivaroxaban – once daily, oral, direct factor Xa inhibition compared with vitamin K antagonists for prevention of stroke and embolism in atrial fibrillation: rationale and design of the ROCKET-AF Study. Am Heart J 2010; 159: 340–7.
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1. Camm AJ, Lip GYH, De Caterina R et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation. Eur Heart J 2012; 33: 2719–47.
2. Ansell J, Hirsh J, Hylek E et al. Pharmacology and management of the vitamin K antagonists. Chest 2008; 133: 160S–198S.
3. Diagnostika i lechenie fibrilliatsii predserdii. Rekomendatsii RKO, VNOA i ASSKh, 2012. [in Russian]
4. Connolly SJ, Eikelboom J, Joyner C et al. l. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364: 806–17.
5. Connolly SJ, Ezekowitz MD, Yusuf S et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139–51.
6. Lip GYH, Larsen TB, Skjoth F et al. Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation. J Am Coll Cardiol 2012; 60: 738–46.
7. Granger CB, Alexander JH, Mc Murray et al. Rivaroxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365 (11): 981–92.
8. ROCKET-AF Stady Investigators. Rivaroxaban – once daily, oral, direct factor Xa inhibition compared with vitamin K antagonists for prevention of stroke and embolism in atrial fibrillation: rationale and design of the ROCKET-AF Study. Am Heart J 2010; 159: 340–7.
Авторы
В.Н.Буторов
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1 butorovvn@gmail.com
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V.N.Butorov
Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1 butorovvn@gmail.com