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Место нестероидных противовоспалительных препаратов в терапии остеоартроза: в фокусе – мелоксикам
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Gromova M.A., Tsurko V.V., Badokin V.V. Place of non-steroidal anti-inflammatory drugs in the therapy of osteoarthritis: meloxicam in focus. Handbook for Practitioners Doctors. 2017; 5: 64–68.
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Ключевые слова: остеоартроз, коморбидность, нестероидные противовоспалительные препараты, мелоксикам, Мовалис.
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The review presents two clinical cases of patients with osteoarthritis. The disease is widespread in the population, prevalence rates increase with age, reaching 60% in the group over 65, which creates difficulties in the choice of therapy, due to a significant amount of concomitant pathology. Careful analysis of anamnesis, clinical picture and risk factors allows to choose an effective and safe course of therapy in each specific case.
Key words: osteoarthritis, comorbidity, nonsteroidal anti-inflammatory drugs, meloxicam, Movalis.
2. Pereira D, Peleteiro D, Araujo J et al. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthr Cartilage 2011; 19: 1279–85.
3. Галушко Е.А., Большакова Т.В., Виноградова И.Б. и др. Структура ревматических заболеваний среди взрослого населения России по данным эпидемиологического исследования (предварительные результаты). Науч.-практ. ревматология. 2009; 1: 11–7. / Galushko E.A., Bol'shakova T.V., Vinogradova I.B. i dr. Struktura revmaticheskikh zabolevanii sredi vzroslogo naseleniia Rossii po dannym epidemiologicheskogo issledovaniia (predvaritel'nye rezul'taty). Nauch.-prakt. revmatologiia. 2009; 1: 11–7. [in Russian]
4. World Health Statistics 2012. Geneva: World Health Organization.
5. Van Dijk GV, Veenhof C, Schelleviset S et al. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord 2008; 9.
6. McAlindon TE, Bannuru RR, Sullivan MC et al. OARSI Guielines for the non-surgical management of knee osteoarthritis. Ostearthr Cartilage 2014; 22: 363–88.
7. Felson DT. Osteoarthritis of knee. N Engl J Med 2006; 354: 841–8.
8. Каратеев А.Е, Насонов Е.Л., Яхно Н.Н. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». Соврем. ревматология. 2015; 1. / Karateev A.E, Nasonov E.L., Iakhno N.N. i dr. Klinicheskie rekomendatsii “Ratsional'noe primenenie nesteroidnykh protivovospalitel'nykh preparatov (NPVP) v klinicheskoi praktike”. Sovrem. revmatologiia. 2015; 1. [in Russian]
9. Howell DS, Pita JC, Muller FJ et al. Treatment of OA with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the Pond-Nuki canine model. J Rheum 1991; 18 (Suppl. 27): 138–42.
10. Blot L, Marcelis A, Devogelaer JP, Manicourt DH. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human articular cartilage. Br J Pharmacol 2000; 131: 1413–21.
11. Ding C. Do NSAIDs affect the progression of osteoarthritis? Inflammation 2002; 131: 1413–21.
12. Dingle JT. The effect of nonsteroidal anti-inflammatory drugs on human articular cartilage glycosaminoglycan synthesis. Osteoarthritis Cartilage 1999, 7: 313–4.
13. Henroitin Y, Reginster JY. In-vitro differences among nonsteroidal anti-inflammatory drugs in their activities related to osteoarthritis pathophysiology. Ostearthritis Cartilage 1999; 7: 355–7.
14. Makherje P, Rachita C, Aisen PS, Pasinetti GM. Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death. Clin Exp Rheimatol 2001; 19: S7–S11.
15. Бадокин В.В. Мультифакторность механизмов действия НПВП при остеоартрозе. Современная ревматология. 2009; 4: 81–7. / Badokin V.V. Mul'tifaktornost' mekhanizmov deistviia NPVP pri osteoartroze. Sovremennaia revmatologiia. 2009; 4: 81–7. [in Russian]
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1. Bijlsma JW, BerenbaumF, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet 2011; 377: 2115–26.
2. Pereira D, Peleteiro D, Araujo J et al. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthr Cartilage 2011; 19: 1279–85.
3. Galushko E.A., Bol'shakova T.V., Vinogradova I.B. i dr. Struktura revmaticheskikh zabolevanii sredi vzroslogo naseleniia Rossii po dannym epidemiologicheskogo issledovaniia (predvaritel'nye rezul'taty). Nauch.-prakt. revmatologiia. 2009; 1: 11–7. [in Russian]
4. World Health Statistics 2012. Geneva: World Health Organization.
5. Van Dijk GV, Veenhof C, Schelleviset S et al. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord 2008; 9.
6. McAlindon TE, Bannuru RR, Sullivan MC et al. OARSI Guielines for the non-surgical management of knee osteoarthritis. Ostearthr Cartilage 2014; 22: 363–88.
7. Felson DT. Osteoarthritis of knee. N Engl J Med 2006; 354: 841–8.
8. Karateev A.E, Nasonov E.L., Iakhno N.N. i dr. Klinicheskie rekomendatsii “Ratsional'noe primenenie nesteroidnykh protivovospalitel'nykh preparatov (NPVP) v klinicheskoi praktike”. Sovrem. revmatologiia. 2015; 1. [in Russian]
9. Howell DS, Pita JC, Muller FJ et al. Treatment of OA with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the Pond-Nuki canine model. J Rheum 1991; 18 (Suppl. 27): 138–42.
10. Blot L, Marcelis A, Devogelaer JP, Manicourt DH. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human articular cartilage. Br J Pharmacol 2000; 131: 1413–21.
11. Ding C. Do NSAIDs affect the progression of osteoarthritis? Inflammation 2002; 131: 1413–21.
12. Dingle JT. The effect of nonsteroidal anti-inflammatory drugs on human articular cartilage glycosaminoglycan synthesis. Osteoarthritis Cartilage 1999, 7: 313–4.
13. Henroitin Y, Reginster JY. In-vitro differences among nonsteroidal anti-inflammatory drugs in their activities related to osteoarthritis pathophysiology. Ostearthritis Cartilage 1999; 7: 355–7.
14. Makherje P, Rachita C, Aisen PS, Pasinetti GM. Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death. Clin Exp Rheimatol 2001; 19: S7–S11.
15. Badokin V.V. Mul'tifaktornost' mekhanizmov deistviia NPVP pri osteoartroze. Sovremennaia revmatologiia. 2009; 4: 81–7. [in Russian]
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
3 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*margarita-gromov@mail.ru
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M.A.Gromova*1, V.V.Tsurko1,2, V.V.Badokin3
1 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1;
2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
3 Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*margarita-gromov@mail.ru