Bykova O.V., Orlova N.V., Soloveva M.V. Management of patients with chronic heart failure: an emphasis on anemic syndrome. Handbook for Practitioners Doctors. 2018; 1: 18–21.
Ведение пациентов с хронической сердечной недостаточностью: акцент на анемический синдром
Bykova O.V., Orlova N.V., Soloveva M.V. Management of patients with chronic heart failure: an emphasis on anemic syndrome. Handbook for Practitioners Doctors. 2018; 1: 18–21.
В статье представлены эпидемиологические данные и результаты клинических исследований, показывающие распространенность анемического синдрома у больных с хронической сердечной недостаточностью (ХСН) и связь прогноза заболевания с выраженностью анемии. Освещены ключевые звенья развития анемического синдрома при ХСН, методы диагностики и лечения дефицита железа у пациентов с ХСН.
The article presents epidemiological data and the results of clinical studies showing the prevalence of anemic syndrome in patients with chronic heart failure (CHF) and the relationship of the disease prognosis with the severity of anemia. The key links in the development of anemic syndrome in CHF, methods of diagnosis and treatment of iron deficiency in patients with CHF are highlighted.
Key words: chronic heart failure, anemic syndrome, iron deficiency.
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3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Эттингер О.А., Ускова О.В., Гендлин Г.Е., Сторожаков Г.И. Анемия у больных с хронической сердечной недостаточностью: роль дефицита железа и его коррекция. Consilium Medicum. 2011; 13 (5): 121–7. / Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
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16. Стуклов Н.И., Альпидовский В.К., Огурцов П.П. Анемии. Клиника, диагностика и лечение. Учеб. пос. для врачей. М.: МИА, 2013. /Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Стуклов Н.И. Дефицит железа и анемия у больных хронической сердечной недостаточностью. Рациональная фармакотерапия в кардиологии. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 / Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Бобрышев К.А., Воронков Л.Г. Анемия у пациентов с хронической сердечной недостаточностью: как подобрать оптимальную терапию? Серцева недостатність та коморбідністани. 2017; 3: 98–106. / Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
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1. Belenkov Iu.N., Fomin I.V., Mareev V.Iu. i dr. Istinnaia rasprostranennost' KhSN v Evropeiskoi chasti Rossiiskoi Federatsii (Issledovanie EPOKhA – gospital'nyi etap). Serdechnaia nedostatochnost'. 2011; 2: 63–9. [in Russian]
2. Ageev F.T., Belenkov Iu.N., Fomin I.V. i dr. Rasprostranennost' khronicheskoi serdechnoi nedostatochnosti v Evropeiskoi chasti Rossiiskoi Federatsii – dannye EPOKhA-KhSN. Serdechnaia nedostatochnost'. 2006; 1: 112–5. [in Russian]
3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
15. Arutiunov G.P. Anemiia u bol'nykh s KhSN. Serdechnaia nedostatochnost'. 2003; 4 (5): 224–8. [in Russian]
16. Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
Авторы
О.В.Быкова*, Н.В.Орлова, М.В.Соловьева
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1 *rsmu@rsmu.ru
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O.V.Bykova*, N.V.Orlova, M.V.Soloveva
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1 *rsmu@rsmu.ru