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Ведение пациентов с хронической сердечной недостаточностью: акцент на анемический синдром - Справочник поликлинического врача №1 (2018)
Ведение пациентов с хронической сердечной недостаточностью: акцент на анемический синдром
Быкова О.В., Орлова Н.В., Соловьева М.В. Ведение пациентов с хронической сердечной недостаточностью: акцент на анемический синдром. Справочник поликлинического врача. 2018; 1: 18–21.
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Аннотация
В статье представлены эпидемиологические данные и результаты клинических исследований, показывающие распространенность анемического синдрома у больных с хронической сердечной недостаточностью (ХСН) и связь прогноза заболевания с выраженностью анемии. Освещены ключевые звенья развития анемического синдрома при ХСН, методы диагностики и лечения дефицита железа у пациентов с ХСН.
Ключевые слова: хроническая сердечная недостаточность, анемический синдром, дефицит железа.
Key words: chronic heart failure, anemic syndrome, iron deficiency.
Ключевые слова: хроническая сердечная недостаточность, анемический синдром, дефицит железа.
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Key words: chronic heart failure, anemic syndrome, iron deficiency.
Полный текст
Список литературы
1. Беленков Ю.Н., Фомин И.В., Мареев В.Ю. и др. Истинная распространенность ХСН в Европейской части Российской Федерации (Исследование ЭПОХА – госпитальный этап). Сердечная недостаточность. 2011; 2: 63–9. / Belenkov Iu.N., Fomin I.V., Mareev V.Iu. i dr. Istinnaia rasprostranennost' KhSN v Evropeiskoi chasti Rossiiskoi Federatsii (Issledovanie EPOKhA – gospital'nyi etap). Serdechnaia nedostatochnost'. 2011; 2: 63–9. [in Russian]
2. Агеев Ф.Т., Беленков Ю.Н., Фомин И.В. и др. Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации – данные ЭПОХА-ХСН. Сердечная недостаточность. 2006; 1: 112–5. / Ageev F.T., Belenkov Iu.N., Fomin I.V. i dr. Rasprostranennost' khronicheskoi serdechnoi nedostatochnosti v Evropeiskoi chasti Rossiiskoi Federatsii – dannye EPOKhA-KhSN. Serdechnaia nedostatochnost'. 2006; 1: 112–5. [in Russian]
3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Эттингер О.А., Ускова О.В., Гендлин Г.Е., Сторожаков Г.И. Анемия у больных с хронической сердечной недостаточностью: роль дефицита железа и его коррекция. Consilium Medicum. 2011; 13 (5): 121–7. / Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
15. Арутюнов Г.П. Анемия у больных с ХСН. Сердечная недостаточность. 2003; 4 (5): 224–8. / Arutiunov G.P. Anemiia u bol'nykh s KhSN. Serdechnaia nedostatochnost'. 2003; 4 (5): 224–8. [in Russian]
16. Стуклов Н.И., Альпидовский В.К., Огурцов П.П. Анемии. Клиника, диагностика и лечение. Учеб. пос. для врачей. М.: МИА, 2013. /Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Стуклов Н.И. Дефицит железа и анемия у больных хронической сердечной недостаточностью. Рациональная фармакотерапия в кардиологии. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 / Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Бобрышев К.А., Воронков Л.Г. Анемия у пациентов с хронической сердечной недостаточностью: как подобрать оптимальную терапию? Серцева недостатність та коморбідністани. 2017; 3: 98–106. / Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
2. Ageev F.T., Belenkov Iu.N., Fomin I.V. i dr. Rasprostranennost' khronicheskoi serdechnoi nedostatochnosti v Evropeiskoi chasti Rossiiskoi Federatsii – dannye EPOKhA-KhSN. Serdechnaia nedostatochnost'. 2006; 1: 112–5. [in Russian]
3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
15. Arutiunov G.P. Anemiia u bol'nykh s KhSN. Serdechnaia nedostatochnost'. 2003; 4 (5): 224–8. [in Russian]
16. Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
2. Агеев Ф.Т., Беленков Ю.Н., Фомин И.В. и др. Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации – данные ЭПОХА-ХСН. Сердечная недостаточность. 2006; 1: 112–5. / Ageev F.T., Belenkov Iu.N., Fomin I.V. i dr. Rasprostranennost' khronicheskoi serdechnoi nedostatochnosti v Evropeiskoi chasti Rossiiskoi Federatsii – dannye EPOKhA-KhSN. Serdechnaia nedostatochnost'. 2006; 1: 112–5. [in Russian]
3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Эттингер О.А., Ускова О.В., Гендлин Г.Е., Сторожаков Г.И. Анемия у больных с хронической сердечной недостаточностью: роль дефицита железа и его коррекция. Consilium Medicum. 2011; 13 (5): 121–7. / Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
15. Арутюнов Г.П. Анемия у больных с ХСН. Сердечная недостаточность. 2003; 4 (5): 224–8. / Arutiunov G.P. Anemiia u bol'nykh s KhSN. Serdechnaia nedostatochnost'. 2003; 4 (5): 224–8. [in Russian]
16. Стуклов Н.И., Альпидовский В.К., Огурцов П.П. Анемии. Клиника, диагностика и лечение. Учеб. пос. для врачей. М.: МИА, 2013. /Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Стуклов Н.И. Дефицит железа и анемия у больных хронической сердечной недостаточностью. Рациональная фармакотерапия в кардиологии. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 / Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Бобрышев К.А., Воронков Л.Г. Анемия у пациентов с хронической сердечной недостаточностью: как подобрать оптимальную терапию? Серцева недостатність та коморбідністани. 2017; 3: 98–106. / Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
________________________________________________
2. Ageev F.T., Belenkov Iu.N., Fomin I.V. i dr. Rasprostranennost' khronicheskoi serdechnoi nedostatochnosti v Evropeiskoi chasti Rossiiskoi Federatsii – dannye EPOKhA-KhSN. Serdechnaia nedostatochnost'. 2006; 1: 112–5. [in Russian]
3. Silverberg DS, Wexler D, Jaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Failure 2002; 4: 681–6.
4. Al-Ahmad A, Rand WM, Manjunath G et al Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001; 38: 955−62.
5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006; 151 (2): 457–62.
6. Adams KF Jr, Patterson JH, Oren RM et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINAHFP) Registry. Am Heart J 2009; 157: 926–32.
7. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–23.
8. Nanas JN, Matsouka C, Karageorgopoulos D et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48 (12): 2485–9.
9. Ettinger O.A., Uskova O.V., Gendlin G.E., Storozhakov G.I. Anemiia u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu: rol' defitsita zheleza i ego korrektsiia. Consilium Medicum. 2011; 13 (5): 121–7. [in Russian]
10. Kosiborod M, Smith GL, Radford MJ et al. The prognostic importance of anemia in patients with heart failure. Am J Med 2003; 114: 112–9.
11. UNICEF. National Iron Plus Initiative Guidelines for Control of IDA. 2013.
12. Anker SD, von Haehling S. Anemia in chronic heart failure. Bremen: UNI-MED, 2008.
13. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 3: 50–5.
14. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46 (4): 387–93.
15. Arutiunov G.P. Anemiia u bol'nykh s KhSN. Serdechnaia nedostatochnost'. 2003; 4 (5): 224–8. [in Russian]
16. Stuklov N.I., Al'pidovskii V.K., Ogurtsov P.P. Anemii. Klinika, diagnostika i lechenie. Ucheb. pos. dliavrachei. M.: MIA, 2013. [in Russian]
17. Stuklov N.I. Defitsit zheleza i anemiia u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu. Ratsional'naia farmakoterapiia v kardiologii. 2017; 13 (5): 651–60. DOI: 10.20996/1819-6446-2017-13-5-651-660 [in Russian]
18. Sikole A, Polenakovic M, Spiroska V et al. Recurrence of left ventricular hypertrophy following cessation of erythropoietin therapy. Artif Organs 2002; 26 (2): 98–102. DOI: 10.1046/j.1525-1594.2002.06839.x
19. So Relle R. Erythropoietin-not at the Olympics but maybe for anemic heart failure patients. Circulation 2003; 107 (2): e9004. DOI: 10.1161/01.CIR.0000057701.80262.5C
20. Pfeffer MA, Burdman EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019–32.
21. Swedberg K, Young JB, Anand IS et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013; 368: 1210–9.
22. Niehaus ED, Malhotra R, Cocca-Spofford D et al. Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure. J Card Fail 2015; 21 (8): 694–7. DOI:10.1016/j.cardfail.2015.05.006
23. Anker SD, Comin Colet J, Filippatos G et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361 (25): 2436–48. DOI: 10.1056/NEJMoa0908355
24. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail 2016; 18: 891–975. DOI: 10.1002/ejhf.592
25. Bobryshev K.A., Voronkov L.G. Anemiia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu: kak podobrat' optimal'nuiu terapiiu? Sertseva nedostatnіst' ta komorbіdnіstani. 2017; 3: 98–106. [in Russian]
Авторы
О.В.Быкова*, Н.В.Орлова, М.В.Соловьева
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*rsmu@rsmu.ru
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*rsmu@rsmu.ru
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*rsmu@rsmu.ru
________________________________________________
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*rsmu@rsmu.ru
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