Защитный барьер слизистой оболочки желудка и возможности лекарственной цитопротекции
Защитный барьер слизистой оболочки желудка и возможности лекарственной цитопротекции
Самсонов А.А., Голубев Н.Н., Андреев Н.Г., Щербакова Н.А. Защитный барьер слизистой оболочки желудка и возможности лекарственной цитопротекции. Справочник поликлинического врача. 2018; 6: 40–48.
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Samsonov А.А., Golubev N.N., Andreev N.G., Shcherbakova N.A. The protective barrier of the gastric mucosa and the possibility of drug cytoprotection. Handbook for Practitioners Doctors. 2018; 6: 40–48.
Защитный барьер слизистой оболочки желудка и возможности лекарственной цитопротекции
Самсонов А.А., Голубев Н.Н., Андреев Н.Г., Щербакова Н.А. Защитный барьер слизистой оболочки желудка и возможности лекарственной цитопротекции. Справочник поликлинического врача. 2018; 6: 40–48.
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Samsonov А.А., Golubev N.N., Andreev N.G., Shcherbakova N.A. The protective barrier of the gastric mucosa and the possibility of drug cytoprotection. Handbook for Practitioners Doctors. 2018; 6: 40–48.
Устойчивость слизистой оболочки желудка к постоянному воздействию агрессивных факторов обеспечивается многоуровневой системой протективных механизмов. В обзоре проанализированы основные преэпителиальные, эпителиальные и субэпителиальные компоненты желудочного защитного барьера, цитопротективные эффекты простагландинов. Рассмотрены вопросы повреждения и регенерации слизистой оболочки, качества заживления язв. Описаны возможности и механизмы лекарственной цитопротекции c применением висмута трикалия дицитрата.
The integrity of the gastric mucosa to continuous exposure of aggressive factors provided by a multi-level system of protective mechanisms. The review analyzed the main preepithelial, epithelial and subepithelial components of the gastric protective barrier, the cytoprotective effects of prostaglandins. The processes of damage and regeneration of the mucosa, the quality of healing of ulcers are considered. The possibilities and mechanisms of drug cytoprotection using bismuth tripotassium dicitrate are reviewed.
1. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971; 231 (25): 232–5.
2. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77 (3): 433–43.
3. Robert A, Nezamis JE, Lancaster C et al. Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am J Physiol 1983; 245 (1): G113–21.
4. Mozsik G. Gastric cytoprotection 30 years after its discovery by André Robert: a personal perspective. Inflammopharmacology 2010; 18 (5): 209–21.
5. Tarnawski A, Ahluwalia A, Jones MK. Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids. Curr Pharm Des 2013; 19 (1): 126–32.
6. Wagstaff AJ, Benfield P, Monk JP. Colloidal bismuth subcitrate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs 1988; 36 (2): 132–57.
7. Kusters JG, van Vliet AHM, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 2006; 19 (3): 449–90.
8. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J 2016; 39 (1): 14–23.
9. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol 2005; 96 (2): 94–102.
10. Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology 2017; 152 (4): 706–15.
11. Trifan A, Stanciu C, Girleanu I et al. Proton pump inhibitors therapy and risk of Clostridium difficile infection: systematic review and meta-analysis. World J Gastroenterol 2017; 23 (35): 6500–15.
12. Lichtenberger LM. Gastroduodenal mucosal defense. Curr Opin Gastroenterol 1999; 15 (6): 463–72.
13. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008; 135 (1): 41–60.
14. Allen A, Flemstrom G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 2005; 288 (1): C1–19.
15. Hills BA, Butler BD, Lichtenberger LM. Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol 1983: 244: G561–G568.
16. Atuma C, Strugala V, Allen A et al. The adherent gastric mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol 2001; 280: G922–G929.
17. Ho SB, Takamura K, Anway R et al. The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig Dis Sci 2004; 49: 1598–606.
18. Taylor C, Allen A, Dettmar PW, Pearson JP. The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromolecules 2003; 4: 922–7.
19. Bell AE, Sellers LA, Allen A et al. Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol, and hypertonicity on mucus gel structure. Gastroenterology 1985; 88 (1, part 2): 269–80.
20. Newton J, Jordan N, Oliver L et al. Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier function is not compromised. Gut 1998; 43: 470–5.
21. Sidebotham RL, Batten JJ, Karim QN et al. Breakdown of gastric mucus in presence of Helicobacter pylori. J Clin Pathol 1991; 44 (1): 52–7.
22. Niv Y. Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis. World J Gastroenterol 2015; 21 (31): 9430–6.
23. Wong WM, Poulsom R, Wright NA. Trefoil peptides. Gut 1999; 44: 890–5.
24. Aihara E, Engevik KA, Montrose MH. Trefoil factor peptides and gastrointestinal function. Annu Rev Physiol 2017; 79: 357–80.
25. Phillipson M, Atuma C, Henriksnas J, Holm L. The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 2002; 282 (2): G2119.
26. Hunt RH, Camilleri M, Crowe SE et al. The stomach in health and disease. Gut 2015; 64 (10): 1650–68.
27. Yandrapu H, Sarosiek J. Protective factors of the gastric and duodenal mucosa: an overview. Curr Gastroenterol Rep 2015; 17 (6): 24. DOI: 10.1007/s11894-015-0452-2
28. Lee H-J, Ock CY, Kim S-J, Hahm K-B. Heat shock protein: hard worker or bad offender for gastric diseases. Int J Proteomics 2010. DOI: 10.1155/2010/259163
29. Chiou SK, Tanigawa T, Akahoshi T et al. Survivin: a novel target for indomethacin-induced gastric injury. Gastroenterology. 2005; 128 (1): 63–73.
30. Thim L, Madsen F, Poulsen SS. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 2002; 32 (7): 519–27.
31. Palileo C, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol 2011; 27 (6): 543–8. DOI: 10.1097/MOG.0b013e32834b3fcb
32. Hoffmann W. Current Status on Stem Cells and Cancers of the Gastric Epithelium. Int J Mol Sci 2015; 16 (8): 19153–69.
33. Bartfeld S, Koo BK. Adult gastric stem cells and their niches. Wiley Interdiscip Rev Dev Biol 2017; 6 (2),: e261.
34. Jones MK, Tomikawa M, Mohajer B, Tarnawski AS. Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci 1999; 4: D303–9.
35. Tarnawski A, Szabo IL, Husain SS, Soreghan B. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol Paris 2001; 95 (1–6): 337–44.
36. Kosone T, Takagi H, Kakizaki S et al. Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of gastric mucosal injury. BMC Gastroenterol 2006; 6: 22. DOI: 10.1186/1471-230X-6-22
37. Nguyen T, Chai J, Li A et al. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Am J Pathol 2007; 170 (4): 1219–28.
38. Gannon B, Browning J, O’Brien P, Rogers P. Mucosal microvascular architecture of the fundus and body of the human stomach. Gastroenterology 1984; 86: 866–75.
39. Kawano S, Tsuji S. Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000; 15 (Suppl.): D1–6.
40. Tarnawski AS, Ahluwalia A, Jones MK. The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 2012; 19 (1): 4–15.
41. Brzozowski T, Konturek PC, Konturek SJ et al. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 2005; 56 (Suppl. 5): 33–55.
42. Niv Y, Banic M. Gastric barrier function and toxic damage. Dig Dis 2014; 32 (3): 235–42.
43. Takahashi M, Maeda S, Ogura K et al. The possible role of vascular endothelial growth factor (VEGF) in gastric ulcer healing: effect of sofalcone on VEGF release in vitro. J Clin Gastroenterol 1998; 27 (Suppl. 1): S178–82.
44. Miura S, Tatsuguchi A, Wada K et al. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. Am J Physiol Gastrointest Liver Physiol 2004; 287 (2): G444–51.
45. Martin GR, Wallace JL. Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med (Maywood) 2006; 231 (2): 130–7.
46. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 2008; 88 (4): 1547–65.
47. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology 2008; 134 (7): 1842–60.
48. Alzahrani S, Lina TT, Gonzalez J et al. Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol 2014; 20 (36): 12767–80.
49. Wallace JL, McKnight GW. The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin. Gastroenterology 1990; 99: 295–304.
50. Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 2005; 59 (Suppl. 1): S24–33.
51. Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Update. Curr Medicinal Chem 2012; 19 (1): 16–27.
52. Tarnawski AS, Ahluwalia A, Jones MK. Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging. J Gastroenterol Hepatol 2014; 29 (Suppl. 4): 112–23.
53. Tarnawski A, Stachura J, Krause WJ et al. Quality of gastric ulcer healing – a new, emerging concept. J Clin Gastroenterol 1991; 13 (1): S42–7.
54. Tarnawski A, Douglass TG, Stachura J, Krause WJ. Quality of gastric ulcer healing: histological and ultrastructural assessment. Aliment Pharmacol Therap 1991; 5 (Suppl. 1): 79–90.
55. Аруин Л.И. Качество заживления гастродуоденальных язв: функциональная морфология. Роль методов патогенетической терапии. Эксперим. и клин. гастроэнтерология. 2006; 5: 40–9. / Aruin L.I. Kachestvo zazhivleniia gastroduodenal'nykh iazv: funktsional'naia morfologiia. Rol' metodov patogeneticheskoi terapii. Eksperim. i klin. gastroenterologiia. 2006; 5: 40–9. [in Russian]
56. Arakawa T, Watanabe T, Tanigawa T et al. Quality of ulcer healing in gastrointestinal tract: its pathophysiology and clinical relevance. World J Gastroenterol 2012; 18 (35): 4811–22.
57. Arakawa T, Higuchi K et al. Prostaglandins in the stomach: an update. J Clin Gastroenterol 1998; 27 (Suppl. 1): S1–11.
58. Kobayashi K, Arakawa T, Nakamura H et al. Protective action of endogenous prostacyclin (PGI2) and prostaglandin E2 (PGE2) in endoscopic polypectomy-induced human ulcers. Gastroenterol Jpn 1982; 17 (5): 430–3.
59. Arakawa T, Watanabe T, Fukuda T et al. Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. Dig Dis Sci 1996; 41 (10): 2055–61.
60. Jones MK, Kawanaka H, Baatar D et al. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 2001; 121 (5): 1040–7.
61. Arakawa T, Kobayashi K. Quality of ulcer healing – a new concept to rank healed peptic ulcers. Gastroenterol Jpn 1993; 28 (Suppl. 5): 158–62.
62. Nebiki H, Arakawa T, Higuchi K, Kobayashi K. Quality of ulcer healing influences the relapse of gastric ulcers in humans. J Gastroenterol Hepatol 1997; 12 (2): 109–14.
63. Arakawa T, Watanabe T, Fukuda T et al. Ulcer recurrence: cytokines and inflammatory response-dependent process. Dig Dis Sci 1998; 43 (Suppl. 9): 61S–66S.
64. Ливзан М.А., Кононов А.В., Мозговой С.И. Течение хронического гастрита, ассоциированного с Helicobacter pylori в постэрадикационном периоде. Эксперим. и клин. гастроэнтерология. 2007; 5: 116–23. / Livzan M.A., Kononov A.V., Mozgovoi S.I. Techenie khronicheskogo gastrita, assotsiirovannogo s Helicobacter pylori v posteradikatsionnom periode. Eksperim. i klin. gastroenterologiia. 2007; 5: 116–23. [in Russian]
65. Musumba C, Jorgensen A, Sutton L et al. The relative contribution of NSAIDs and Helicobacter pylori to the etiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. Aliment Pharmacol Ther 2012; 36 (1): 48–56.
66. Genta RM, Sonnenberg A. Helicobacter-negative gastritis: a distinct entity unrelated to Helicobacter pylori infection. Aliment Pharmacol Ther 2015; 41 (2): 218–26.
67. Chung CS, Chiang TH, Lee YC. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med 2015; 30 (5): 559–70.
68. Shiota S, Thrift AP, Green L et al. Clinical manifestations of Helicobacter pylori-negative gastritis. Clin Gastroenterol Hepatol 2017; 15 (7): 1037–46.
69. Szabo S. “Gastric cytoprotection” is still relevant. Gastroenterol Hepatol 2014; 29 (Suppl. 4): 124–32.
70. Hall DW, van den Hoven WE. Protective properties of colloidal bismuth subcitrate on gastric mucosa. Scand J Gastroenterol Suppl 1986; 122: 11–3.
71. Konturek SJ, Radecki T, Piastucki I et al. Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins. Gut 1987; 28 (2): 201–5.
72. Hinsull SM, Bellamy D. Effect of repeated colloidal bismuth subcitrate treatment on the response of the rat gastric mucosa to the presence of luminal ethanol. Gut 1990; 31 (4): 389–96.
73. Van den Hoven WE, Birtwhistle RD, Hall DW. Morphologic evaluation of gastric mucosal protection by colloidal bismuth subcitrate (De-Nol). Int J Tissue React 1988; 10 (5): 297–304.
74. Winters C, Hinsull SM, Gregory Z. A scanning electron microscopic morphological and semi-quantitative evaluation of rat stomach treated with colloidal bismuth subcitrate and alcohol. Scanning Microsc 1991; 5 (2): 541–7.
75. Konturek SJ, Bilski J, Kwiecien N et al. De-Nol stimulates gastric and duodenal alkaline secretion through prostaglandin dependent mechanism. Gut 1987; 28 (12): 1557–63.
76. Konturek SJ, Kwiecien N, Obtulowicz W et al. Effects of protective drugs on gastric alkaline secretion in man. Scand J Gastroenterol 1987; 22 (9): 1059–63.
77. Mertz-Nielsen A, Steenberg P, Neumark T et al. Colloidal bismuth subcitrate causes sustained release of gastric mucosal prostaglandin E2. Aliment Pharmacol Ther 1991; 5 (2): 127–33.
78. Estela R, Feller A, Backhouse C et al. Effects of colloidal bismuth subcitrate and aluminum hydroxide on gastric and duodenal levels of prostaglandin E2. Rev Med Chil 1984; 112 (10): 975–81.
79. Wagstaff AJ, Benfield P, Monk JP. Colloidal bismuth subcitrate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs 1988; 36 (2): 132–57.
80. Crampton JR, Gibbons LC, Rees WD. Effect of certain ulcer-healing agents on amphibian gastroduodenal bicarbonate secretion. Scand J Gastroenterol 1986; 21 (Suppl. 125): 113–8.
81. Shorrock CJ, Crampton JR, Gibbons LC, Rees WD. Effect of bismuth subcitrate on amphibian gastroduodenal bicarbonate secretion. Gut 1989; 30 (7): 917–21.
82. Lee SP. A potential mechanism of action of colloidal bismuth subcitrate: diffusion barrier to hydrochloric acid. Scand J Gastroenterol Suppl 1982; 80: 17–21.
83. Tasman-Jones C, Maher C, Thomsen L et al. Mucosal defenses and gastroduodenal disease. Digestion 1987; 37 (Suppl. 2): 1–7.
84. Piotrowski J, Bilski J, Nishikawa H et al. Enhancement in gastric mucus gel qualities with colloidal bismuth subcitrate administration. Eur J Pharmacol 1990; 184 (1): 55–63.
85. Hollanders D, Morrissey SM, Mehta J. Mucus secretion in gastric ulcer patients treated with tripotassium dicitrato bismuthate (De-Nol). Br J Clin Pract 1983; 37 (3): 112–4.
86. Weiss G, Kallmeyer JC. Pilot trial of a colloidal bismuth preparation in the treatment of peptic ulcer. S Afr Med J 1968; 42 (13): 317–20.
87. Koo J, Ho J, Lam SK et al. Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. Gastroenterology 1982; 82: 864–70.
88. Soutar RL, Coghill SB. Interaction of tripotassium dicitrato bismuthate with macrophages in the rat and in vitro. Gastroenterology 1986; 91 (1): 84–93.
89. Konturek SJ, Dembinski A, Warzecha Z et al. Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats. Gut 1988; 29 (7): 894–902.
90. Slomiany BL, Nishikawa H, Bilski J, Slomiany A. Colloidal bismuth subcitrate inhibits peptic degradation of gastric mucus and epidermal growth factor in vitro. Am J Gastroenterol 1990; 85 (4): 390–3.
91. Konturek JW, Brzozowski T, Konturek SJ. Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J Clin Gastroenterol 1991; 13 (Suppl. 1): S88–97.
92. Konturek JW, Brzozowski T, Konturek SJ. Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J Clin Gastroenterol 1991; 13 (Suppl. 1): S88–97.
93. Eleftheriadis E, Kotzampassi K, Tzartinoglou E et al. Colloidal bismuth subcitrate-induced changes on gastric mucosal hemodynamics in the rat: gastric mucosal blood flow after CBS treatment. Gastroenterol Jpn 1991; 26 (3): 283–6.
94. Bagchi D, McGinn TR, Ye X et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci 1999; 44 (12): 2419–28.
95. Bagchi D, Carryl OR, Tran MX et al. Protection against chemically-induced oxidative gastrointestinal tissue injury in rats by bismuth salts. Dig Dis Sci 1997; 42 (9): 1890–900.
96. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 2008; 88 (4): 1547–65.
97. Ahmed A, Salmon PR, Cairns CR et al. Eicosanoid synthesis in duodenal ulcer disease: decrease in leukotriene C4 by colloidal bismuth subcitrate. Gut 1992; 33 (2): 159–63.
98. Rokkas T, Pursey C, Uzoechina E et al. Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacter pylori. Gut 1988; 29 (10): 1386–91.
99. Loffeld RJ, Potters HV, Stobberingh E et al. Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloidal bismuth subcitrate. Gut 1989; 30 (9): 1206–12.
100. Kang JY, Tay HH, Wee A, Guan R et al. Effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. A double blind placebo controlled study. Gut 1990; 31 (4): 476–80.
101. Goh KL, Parasakthi N, Peh SC et al. Helicobacter pylori infection and non-ulcer dyspepsia: the effect of treatment with colloidal bismuth subcitrate. Scand J Gastroenterol 1991; 26 (11): 1123–31.
102. Vaira D, Holton J, Ainley C et al. Double blind trial of colloidal bismuth subcitrate versus placebo in Helicobacter pylori positive patients with non-ulcer dyspepsia. Ital J Gastroenterol 1992; 24 (7): 400–4.
103. Fischbach LA, Correa P, Ramirez H et al. Anti-inflammatory and tissue protectant drug effects: results from a randomized placebo-controlled trial of gastritis patients at high risk for gastric cancer. Aliment Pharmacol Ther 2001; 15 (6): 831–41.
104. Кононов А.В., Мозговой С.И., Рыбкина Л.Б. и др. Оценка цитопротективного влияния висмута трикалия дицитрата на слизистую оболочку желудка при эрадикации H. pylori. Рос. журн. гастроэнтерологии, гепатологии и колопроктологии. 2014; 24 (6): 21–8. / Kononov A.V., Mozgovoi S.I., Rybkina L.B. i dr. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2014; 24 (6): 21–8. [in Russian]
105. Рыбкина Л.Б., Назаров А.Н., Владимирова А.В. Клинико-морфологическое обоснование продолженной терапии препаратом висмута трикалия дицитратом при хроническом Helicobacter pylori-ассоциированном гастрите с синдромом диспепсии. Молодой ученый. 2015; 22 (102): 285–95. / Rybkina L.B., Nazarov A.N., Vladimirova A.V. Kliniko-morfologicheskoe obosnovanie prodolzhennoi terapii preparatom vismuta trikaliia ditsitratom pri khronicheskom Helicobacter pylori-assotsiirovannom gastrite s sindromom dispepsii. Molodoi uchenyi. 2015; 22 (102): 285–95. [in Russian]
106. Бордин Д.С., Машарова А.А., Хомерики С.Г. Хронический гастрит: современный взгляд на старую проблему. Эксперим. и клин. гастроэнтерология. 2012; 5: 99–106. / Bordin D.S., Masharova A.A., Khomeriki S.G. Khronicheskii gastrit: sovremennyi vzgliad na staruiu problemu. Eksperim. i klin. gastroenterologiia. 2012; 5: 99–106. [in Russian]
107. Handa O, Naito Y, Yoshikawa T. Redox biology and gastric carcinogenesis: the role of Helicobacter pylori. Redox Rep 2011; 16 (1): 1–7.
108. Kalisperati P, Spanou E, Pateras IS et al. Inflammation, DNA damage, Helicobacter pylori and gastric tumorigenesis. Front Genet 2017; 8: 20. DOI: 10.3389/fgene.2017.00020
109. Кононов А.В. Роль патологоанатомического заключения «Хронический гастрит» в системе персонифицированной канцерпревенции. Рос. журн. гастроэнтерологии, гепатологии и колопроктологии. 2018; 28 (4): 91–101. / Kononov A.V. Rol' patologoanatomicheskogo zakliucheniia "Khronicheskii gastrit" v sisteme personifitsirovannoi kantserpreventsii. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2018; 28 (4): 91–101. [in Russian]
110. Lee SP. The mode of action of colloidal bismuth subcitrate. Scand J Gastroenterol Suppl 1991; 185: 1–6.
111. Beil W, Bierbaum S, Sewing KF. Studies on the mechanism of action of colloidal bismuth subcitrate. II. Interaction with pepsin. Pharmacology 1993; 47 (2): 141–4.
112. Baron JH, Barr J, Batten J et al. Acid, pepsin, and mucus secretion in patients with gastric and duodenal ulcer before and after colloidal bismuth subcitrate (De-Nol). Gut 1986; 27 (5): 486–90.
113. Marshall BJ, Armstrong JA, Francis GJ et al. Antibacterial action of bismuth in relation to Campylobacter pyloridis colonization and gastritis. Digestion 1987; 37 (Suppl. 2): 16–30.
114. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut 2016; 65 (5): 870–8.
115. Goodwin CS, Armstrong JA, Cooper M. Colloidal bismuth subcitrate inhibits the adherence of H. pylori to epithelial cells. Ital J Gastroenterology 1991; 23 (Suppl. 2): 40.
116. Маев И.В., Кучерявый Ю.А., Андреев Д.Н. Актуальные возможности оптимизации антихеликобактерной терапии. Лечащий врач. 2014; 4: 73–9. / Maev I.V., Kucheriavyi Yu.A., Andreev D.N. Aktual'nye vozmozhnosti optimizatsii antikhelikobakternoi terapii. Lechashchii vrach. 2014; 4: 73–9. [in Russian]
117. Ge R, Chen Z, Zhou Q. The actions of bismuth in the treatment of Helicobacter pylori infections: an update. Metallomics 2012; 4 (3): 239–43.
118. Marcus EA, Sachs G, Scott DR. Colloidal bismuth subcitrate impedes proton entry into Helicobacter pylori and increases the efficacy of growth-dependent antibiotics. Aliment Pharmacol Ther 2015; 42: 922–33.
119. Malfertheiner P, Megraud F, O’Morain CA et al. Management of Helicobacter pylori infection Maastricht V/Florence Consensus Report. Gut 2016; 66: 6–30.
120. Graham DY, Dore MP. Helicobacter pylori therapy: a paradigm shift. Expert Rev Anti Infect Ther 2016; 14 (6): 577–85.
121. Gisbert JP, McNicholl AG. Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies. Helicobacter 2017; e12392.
122. Graham DY, Dore MP, Lu H. Understanding treatment guidelines with bismuth and non-bismuth quadruple Helicobacter pylori eradication therapies. Expert Rev Anti Infect Ther 2018; 16 (9): 679–87.
123. Ивашкин В.Т., Маев И.В., Лапина Т.Л. Рекомендации Российской Гастроэнтерологической Ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых. Рос. журн. гастроэнтерологии, гепатологии и колопроктологии. 2012; 22 (1): 87–9. / Ivashkin V.T., Maev I.V., Lapina T.L. Rekomendatsii Rossiiskoi Gastroenterologicheskoi Assotsiatsii po diagnostike i lecheniiu infektsii Helicobacter pylori u vzroslykh. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2012; 22 (1): 87–9. [in Russian]
124. Лазебник Л.Б., Ткаченко Е.И., Абдулганиева Д.И. и др. VI Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacter pylori заболеваний (VI Московские соглашения). Эксперим. и клин. гастроэнтерология. 2017; 2 (138): 3–21. / Lazebnik L.B., Tkachenko E.I., Abdulganieva D.I. i dr. VI Natsional'nye rekomendatsii po diagnostike i lecheniiu kislotozavisimykh i assotsiirovannykh s Helicobacter pylori zabolevanii (VI Moskovskie soglasheniia). Eksperim. i klin. gastroenterologiia. 2017; 2 (138): 3–21. [in Russian]
125. Sun H. Biological Chemistry of Arsenic, Antimony and Bismuth. USA, NJ: John Wiley & Sons: Hoboken, 2011.
________________________________________________
1. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971; 231 (25): 232–5.
2. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77 (3): 433–43.
3. Robert A, Nezamis JE, Lancaster C et al. Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am J Physiol 1983; 245 (1): G113–21.
4. Mozsik G. Gastric cytoprotection 30 years after its discovery by André Robert: a personal perspective. Inflammopharmacology 2010; 18 (5): 209–21.
5. Tarnawski A, Ahluwalia A, Jones MK. Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids. Curr Pharm Des 2013; 19 (1): 126–32.
6. Wagstaff AJ, Benfield P, Monk JP. Colloidal bismuth subcitrate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs 1988; 36 (2): 132–57.
7. Kusters JG, van Vliet AHM, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 2006; 19 (3): 449–90.
8. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J 2016; 39 (1): 14–23.
9. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol 2005; 96 (2): 94–102.
10. Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology 2017; 152 (4): 706–15.
11. Trifan A, Stanciu C, Girleanu I et al. Proton pump inhibitors therapy and risk of Clostridium difficile infection: systematic review and meta-analysis. World J Gastroenterol 2017; 23 (35): 6500–15.
12. Lichtenberger LM. Gastroduodenal mucosal defense. Curr Opin Gastroenterol 1999; 15 (6): 463–72.
13. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008; 135 (1): 41–60.
14. Allen A, Flemstrom G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 2005; 288 (1): C1–19.
15. Hills BA, Butler BD, Lichtenberger LM. Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol 1983: 244: G561–G568.
16. Atuma C, Strugala V, Allen A et al. The adherent gastric mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol 2001; 280: G922–G929.
17. Ho SB, Takamura K, Anway R et al. The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig Dis Sci 2004; 49: 1598–606.
18. Taylor C, Allen A, Dettmar PW, Pearson JP. The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromolecules 2003; 4: 922–7.
19. Bell AE, Sellers LA, Allen A et al. Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol, and hypertonicity on mucus gel structure. Gastroenterology 1985; 88 (1, part 2): 269–80.
20. Newton J, Jordan N, Oliver L et al. Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier function is not compromised. Gut 1998; 43: 470–5.
21. Sidebotham RL, Batten JJ, Karim QN et al. Breakdown of gastric mucus in presence of Helicobacter pylori. J Clin Pathol 1991; 44 (1): 52–7.
22. Niv Y. Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis. World J Gastroenterol 2015; 21 (31): 9430–6.
23. Wong WM, Poulsom R, Wright NA. Trefoil peptides. Gut 1999; 44: 890–5.
24. Aihara E, Engevik KA, Montrose MH. Trefoil factor peptides and gastrointestinal function. Annu Rev Physiol 2017; 79: 357–80.
25. Phillipson M, Atuma C, Henriksnas J, Holm L. The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 2002; 282 (2): G2119.
26. Hunt RH, Camilleri M, Crowe SE et al. The stomach in health and disease. Gut 2015; 64 (10): 1650–68.
27. Yandrapu H, Sarosiek J. Protective factors of the gastric and duodenal mucosa: an overview. Curr Gastroenterol Rep 2015; 17 (6): 24. DOI: 10.1007/s11894-015-0452-2
28. Lee H-J, Ock CY, Kim S-J, Hahm K-B. Heat shock protein: hard worker or bad offender for gastric diseases. Int J Proteomics 2010. DOI: 10.1155/2010/259163
29. Chiou SK, Tanigawa T, Akahoshi T et al. Survivin: a novel target for indomethacin-induced gastric injury. Gastroenterology. 2005; 128 (1): 63–73.
30. Thim L, Madsen F, Poulsen SS. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 2002; 32 (7): 519–27.
31. Palileo C, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol 2011; 27 (6): 543–8. DOI: 10.1097/MOG.0b013e32834b3fcb
32. Hoffmann W. Current Status on Stem Cells and Cancers of the Gastric Epithelium. Int J Mol Sci 2015; 16 (8): 19153–69.
33. Bartfeld S, Koo BK. Adult gastric stem cells and their niches. Wiley Interdiscip Rev Dev Biol 2017; 6 (2),: e261.
34. Jones MK, Tomikawa M, Mohajer B, Tarnawski AS. Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci 1999; 4: D303–9.
35. Tarnawski A, Szabo IL, Husain SS, Soreghan B. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol Paris 2001; 95 (1–6): 337–44.
36. Kosone T, Takagi H, Kakizaki S et al. Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of gastric mucosal injury. BMC Gastroenterol 2006; 6: 22. DOI: 10.1186/1471-230X-6-22
37. Nguyen T, Chai J, Li A et al. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Am J Pathol 2007; 170 (4): 1219–28.
38. Gannon B, Browning J, O’Brien P, Rogers P. Mucosal microvascular architecture of the fundus and body of the human stomach. Gastroenterology 1984; 86: 866–75.
39. Kawano S, Tsuji S. Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000; 15 (Suppl.): D1–6.
40. Tarnawski AS, Ahluwalia A, Jones MK. The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 2012; 19 (1): 4–15.
41. Brzozowski T, Konturek PC, Konturek SJ et al. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 2005; 56 (Suppl. 5): 33–55.
42. Niv Y, Banic M. Gastric barrier function and toxic damage. Dig Dis 2014; 32 (3): 235–42.
43. Takahashi M, Maeda S, Ogura K et al. The possible role of vascular endothelial growth factor (VEGF) in gastric ulcer healing: effect of sofalcone on VEGF release in vitro. J Clin Gastroenterol 1998; 27 (Suppl. 1): S178–82.
44. Miura S, Tatsuguchi A, Wada K et al. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. Am J Physiol Gastrointest Liver Physiol 2004; 287 (2): G444–51.
45. Martin GR, Wallace JL. Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med (Maywood) 2006; 231 (2): 130–7.
46. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 2008; 88 (4): 1547–65.
47. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology 2008; 134 (7): 1842–60.
48. Alzahrani S, Lina TT, Gonzalez J et al. Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol 2014; 20 (36): 12767–80.
49. Wallace JL, McKnight GW. The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin. Gastroenterology 1990; 99: 295–304.
50. Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 2005; 59 (Suppl. 1): S24–33.
51. Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Update. Curr Medicinal Chem 2012; 19 (1): 16–27.
52. Tarnawski AS, Ahluwalia A, Jones MK. Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging. J Gastroenterol Hepatol 2014; 29 (Suppl. 4): 112–23.
53. Tarnawski A, Stachura J, Krause WJ et al. Quality of gastric ulcer healing – a new, emerging concept. J Clin Gastroenterol 1991; 13 (1): S42–7.
54. Tarnawski A, Douglass TG, Stachura J, Krause WJ. Quality of gastric ulcer healing: histological and ultrastructural assessment. Aliment Pharmacol Therap 1991; 5 (Suppl. 1): 79–90.
55. Aruin L.I. Kachestvo zazhivleniia gastroduodenal'nykh iazv: funktsional'naia morfologiia. Rol' metodov patogeneticheskoi terapii. Eksperim. i klin. gastroenterologiia. 2006; 5: 40–9. [in Russian]
56. Arakawa T, Watanabe T, Tanigawa T et al. Quality of ulcer healing in gastrointestinal tract: its pathophysiology and clinical relevance. World J Gastroenterol 2012; 18 (35): 4811–22.
57. Arakawa T, Higuchi K et al. Prostaglandins in the stomach: an update. J Clin Gastroenterol 1998; 27 (Suppl. 1): S1–11.
58. Kobayashi K, Arakawa T, Nakamura H et al. Protective action of endogenous prostacyclin (PGI2) and prostaglandin E2 (PGE2) in endoscopic polypectomy-induced human ulcers. Gastroenterol Jpn 1982; 17 (5): 430–3.
59. Arakawa T, Watanabe T, Fukuda T et al. Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. Dig Dis Sci 1996; 41 (10): 2055–61.
60. Jones MK, Kawanaka H, Baatar D et al. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 2001; 121 (5): 1040–7.
61. Arakawa T, Kobayashi K. Quality of ulcer healing – a new concept to rank healed peptic ulcers. Gastroenterol Jpn 1993; 28 (Suppl. 5): 158–62.
62. Nebiki H, Arakawa T, Higuchi K, Kobayashi K. Quality of ulcer healing influences the relapse of gastric ulcers in humans. J Gastroenterol Hepatol 1997; 12 (2): 109–14.
63. Arakawa T, Watanabe T, Fukuda T et al. Ulcer recurrence: cytokines and inflammatory response-dependent process. Dig Dis Sci 1998; 43 (Suppl. 9): 61S–66S.
64. Livzan M.A., Kononov A.V., Mozgovoi S.I. Techenie khronicheskogo gastrita, assotsiirovannogo s Helicobacter pylori v posteradikatsionnom periode. Eksperim. i klin. gastroenterologiia. 2007; 5: 116–23. [in Russian]
65. Musumba C, Jorgensen A, Sutton L et al. The relative contribution of NSAIDs and Helicobacter pylori to the etiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. Aliment Pharmacol Ther 2012; 36 (1): 48–56.
66. Genta RM, Sonnenberg A. Helicobacter-negative gastritis: a distinct entity unrelated to Helicobacter pylori infection. Aliment Pharmacol Ther 2015; 41 (2): 218–26.
67. Chung CS, Chiang TH, Lee YC. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med 2015; 30 (5): 559–70.
68. Shiota S, Thrift AP, Green L et al. Clinical manifestations of Helicobacter pylori-negative gastritis. Clin Gastroenterol Hepatol 2017; 15 (7): 1037–46.
69. Szabo S. “Gastric cytoprotection” is still relevant. Gastroenterol Hepatol 2014; 29 (Suppl. 4): 124–32.
70. Hall DW, van den Hoven WE. Protective properties of colloidal bismuth subcitrate on gastric mucosa. Scand J Gastroenterol Suppl 1986; 122: 11–3.
71. Konturek SJ, Radecki T, Piastucki I et al. Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins. Gut 1987; 28 (2): 201–5.
72. Hinsull SM, Bellamy D. Effect of repeated colloidal bismuth subcitrate treatment on the response of the rat gastric mucosa to the presence of luminal ethanol. Gut 1990; 31 (4): 389–96.
73. Van den Hoven WE, Birtwhistle RD, Hall DW. Morphologic evaluation of gastric mucosal protection by colloidal bismuth subcitrate (De-Nol). Int J Tissue React 1988; 10 (5): 297–304.
74. Winters C, Hinsull SM, Gregory Z. A scanning electron microscopic morphological and semi-quantitative evaluation of rat stomach treated with colloidal bismuth subcitrate and alcohol. Scanning Microsc 1991; 5 (2): 541–7.
75. Konturek SJ, Bilski J, Kwiecien N et al. De-Nol stimulates gastric and duodenal alkaline secretion through prostaglandin dependent mechanism. Gut 1987; 28 (12): 1557–63.
76. Konturek SJ, Kwiecien N, Obtulowicz W et al. Effects of protective drugs on gastric alkaline secretion in man. Scand J Gastroenterol 1987; 22 (9): 1059–63.
77. Mertz-Nielsen A, Steenberg P, Neumark T et al. Colloidal bismuth subcitrate causes sustained release of gastric mucosal prostaglandin E2. Aliment Pharmacol Ther 1991; 5 (2): 127–33.
78. Estela R, Feller A, Backhouse C et al. Effects of colloidal bismuth subcitrate and aluminum hydroxide on gastric and duodenal levels of prostaglandin E2. Rev Med Chil 1984; 112 (10): 975–81.
79. Wagstaff AJ, Benfield P, Monk JP. Colloidal bismuth subcitrate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs 1988; 36 (2): 132–57.
80. Crampton JR, Gibbons LC, Rees WD. Effect of certain ulcer-healing agents on amphibian gastroduodenal bicarbonate secretion. Scand J Gastroenterol 1986; 21 (Suppl. 125): 113–8.
81. Shorrock CJ, Crampton JR, Gibbons LC, Rees WD. Effect of bismuth subcitrate on amphibian gastroduodenal bicarbonate secretion. Gut 1989; 30 (7): 917–21.
82. Lee SP. A potential mechanism of action of colloidal bismuth subcitrate: diffusion barrier to hydrochloric acid. Scand J Gastroenterol Suppl 1982; 80: 17–21.
83. Tasman-Jones C, Maher C, Thomsen L et al. Mucosal defenses and gastroduodenal disease. Digestion 1987; 37 (Suppl. 2): 1–7.
84. Piotrowski J, Bilski J, Nishikawa H et al. Enhancement in gastric mucus gel qualities with colloidal bismuth subcitrate administration. Eur J Pharmacol 1990; 184 (1): 55–63.
85. Hollanders D, Morrissey SM, Mehta J. Mucus secretion in gastric ulcer patients treated with tripotassium dicitrato bismuthate (De-Nol). Br J Clin Pract 1983; 37 (3): 112–4.
86. Weiss G, Kallmeyer JC. Pilot trial of a colloidal bismuth preparation in the treatment of peptic ulcer. S Afr Med J 1968; 42 (13): 317–20.
87. Koo J, Ho J, Lam SK et al. Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. Gastroenterology 1982; 82: 864–70.
88. Soutar RL, Coghill SB. Interaction of tripotassium dicitrato bismuthate with macrophages in the rat and in vitro. Gastroenterology 1986; 91 (1): 84–93.
89. Konturek SJ, Dembinski A, Warzecha Z et al. Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats. Gut 1988; 29 (7): 894–902.
90. Slomiany BL, Nishikawa H, Bilski J, Slomiany A. Colloidal bismuth subcitrate inhibits peptic degradation of gastric mucus and epidermal growth factor in vitro. Am J Gastroenterol 1990; 85 (4): 390–3.
91. Konturek JW, Brzozowski T, Konturek SJ. Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J Clin Gastroenterol 1991; 13 (Suppl. 1): S88–97.
92. Konturek JW, Brzozowski T, Konturek SJ. Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J Clin Gastroenterol 1991; 13 (Suppl. 1): S88–97.
93. Eleftheriadis E, Kotzampassi K, Tzartinoglou E et al. Colloidal bismuth subcitrate-induced changes on gastric mucosal hemodynamics in the rat: gastric mucosal blood flow after CBS treatment. Gastroenterol Jpn 1991; 26 (3): 283–6.
94. Bagchi D, McGinn TR, Ye X et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci 1999; 44 (12): 2419–28.
95. Bagchi D, Carryl OR, Tran MX et al. Protection against chemically-induced oxidative gastrointestinal tissue injury in rats by bismuth salts. Dig Dis Sci 1997; 42 (9): 1890–900.
96. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 2008; 88 (4): 1547–65.
97. Ahmed A, Salmon PR, Cairns CR et al. Eicosanoid synthesis in duodenal ulcer disease: decrease in leukotriene C4 by colloidal bismuth subcitrate. Gut 1992; 33 (2): 159–63.
98. Rokkas T, Pursey C, Uzoechina E et al. Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacter pylori. Gut 1988; 29 (10): 1386–91.
99. Loffeld RJ, Potters HV, Stobberingh E et al. Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloidal bismuth subcitrate. Gut 1989; 30 (9): 1206–12.
100. Kang JY, Tay HH, Wee A, Guan R et al. Effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. A double blind placebo controlled study. Gut 1990; 31 (4): 476–80.
101. Goh KL, Parasakthi N, Peh SC et al. Helicobacter pylori infection and non-ulcer dyspepsia: the effect of treatment with colloidal bismuth subcitrate. Scand J Gastroenterol 1991; 26 (11): 1123–31.
102. Vaira D, Holton J, Ainley C et al. Double blind trial of colloidal bismuth subcitrate versus placebo in Helicobacter pylori positive patients with non-ulcer dyspepsia. Ital J Gastroenterol 1992; 24 (7): 400–4.
103. Fischbach LA, Correa P, Ramirez H et al. Anti-inflammatory and tissue protectant drug effects: results from a randomized placebo-controlled trial of gastritis patients at high risk for gastric cancer. Aliment Pharmacol Ther 2001; 15 (6): 831–41.
104. Kononov A.V., Mozgovoi S.I., Rybkina L.B. i dr. Otsenka tsitoprotektivnogo vliianiia vismuta trikaliia ditsitrata na slizistuiu obolochku zheludka pri eradikatsii H. pylori. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2014; 24 (6): 21–8. [in Russian]
105. Rybkina L.B., Nazarov A.N., Vladimirova A.V. Kliniko-morfologicheskoe obosnovanie prodolzhennoi terapii preparatom vismuta trikaliia ditsitratom pri khronicheskom Helicobacter pylori-assotsiirovannom gastrite s sindromom dispepsii. Molodoi uchenyi. 2015; 22 (102): 285–95. [in Russian]
106. Bordin D.S., Masharova A.A., Khomeriki S.G. Khronicheskii gastrit: sovremennyi vzgliad na staruiu problemu. Eksperim. i klin. gastroenterologiia. 2012; 5: 99–106. [in Russian]
107. Handa O, Naito Y, Yoshikawa T. Redox biology and gastric carcinogenesis: the role of Helicobacter pylori. Redox Rep 2011; 16 (1): 1–7.
108. Kalisperati P, Spanou E, Pateras IS et al. Inflammation, DNA damage, Helicobacter pylori and gastric tumorigenesis. Front Genet 2017; 8: 20. DOI: 10.3389/fgene.2017.00020
109. Kononov A.V. Rol' patologoanatomicheskogo zakliucheniia "Khronicheskii gastrit" v sisteme personifitsirovannoi kantserpreventsii. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2018; 28 (4): 91–101. [in Russian]
110. Lee SP. The mode of action of colloidal bismuth subcitrate. Scand J Gastroenterol Suppl 1991; 185: 1–6.
111. Beil W, Bierbaum S, Sewing KF. Studies on the mechanism of action of colloidal bismuth subcitrate. II. Interaction with pepsin. Pharmacology 1993; 47 (2): 141–4.
112. Baron JH, Barr J, Batten J et al. Acid, pepsin, and mucus secretion in patients with gastric and duodenal ulcer before and after colloidal bismuth subcitrate (De-Nol). Gut 1986; 27 (5): 486–90.
113. Marshall BJ, Armstrong JA, Francis GJ et al. Antibacterial action of bismuth in relation to Campylobacter pyloridis colonization and gastritis. Digestion 1987; 37 (Suppl. 2): 16–30.
114. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut 2016; 65 (5): 870–8.
115. Goodwin CS, Armstrong JA, Cooper M. Colloidal bismuth subcitrate inhibits the adherence of H. pylori to epithelial cells. Ital J Gastroenterology 1991; 23 (Suppl. 2): 40.
116. Maev I.V., Kucheriavyi Yu.A., Andreev D.N. Aktual'nye vozmozhnosti optimizatsii antikhelikobakternoi terapii. Lechashchii vrach. 2014; 4: 73–9. [in Russian]
117. Ge R, Chen Z, Zhou Q. The actions of bismuth in the treatment of Helicobacter pylori infections: an update. Metallomics 2012; 4 (3): 239–43.
118. Marcus EA, Sachs G, Scott DR. Colloidal bismuth subcitrate impedes proton entry into Helicobacter pylori and increases the efficacy of growth-dependent antibiotics. Aliment Pharmacol Ther 2015; 42: 922–33.
119. Malfertheiner P, Megraud F, O’Morain CA et al. Management of Helicobacter pylori infection Maastricht V/Florence Consensus Report. Gut 2016; 66: 6–30.
120. Graham DY, Dore MP. Helicobacter pylori therapy: a paradigm shift. Expert Rev Anti Infect Ther 2016; 14 (6): 577–85.
121. Gisbert JP, McNicholl AG. Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies. Helicobacter 2017; e12392.
122. Graham DY, Dore MP, Lu H. Understanding treatment guidelines with bismuth and non-bismuth quadruple Helicobacter pylori eradication therapies. Expert Rev Anti Infect Ther 2018; 16 (9): 679–87.
123. Ivashkin V.T., Maev I.V., Lapina T.L. Rekomendatsii Rossiiskoi Gastroenterologicheskoi Assotsiatsii po diagnostike i lecheniiu infektsii Helicobacter pylori u vzroslykh. Ros. zhurn. gastroenterologii, gepatologii i koloproktologii. 2012; 22 (1): 87–9. [in Russian]
124. Lazebnik L.B., Tkachenko E.I., Abdulganieva D.I. i dr. VI Natsional'nye rekomendatsii po diagnostike i lecheniiu kislotozavisimykh i assotsiirovannykh s Helicobacter pylori zabolevanii (VI Moskovskie soglasheniia). Eksperim. i klin. gastroenterologiia. 2017; 2 (138): 3–21. [in Russian]
125. Sun H. Biological Chemistry of Arsenic, Antimony and Bismuth. USA, NJ: John Wiley & Sons: Hoboken, 2011.
1 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1;
2 ФГБУ «Поликлиника №3» Управления делами Президента Российской Федерации. 129090, Россия, Москва, пер. Грохольский, д. 31 *nngolubev@mail.ru
1 A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1;
2 Polyclinic №3 General Management Department of the Presidential Administration of the President of Russian Federation. 129090, Russian Federation, Moscow, per. Grokhol'skii, d. 31 *nngolubev@mail.ru