1. Bello AE, Holt RJ. Cardiovascular risk with non-steroidal anti-inflammatory drugs: clinical implications. Drug Saf 2014; 37: 897–902.
2. Vaile JH, Davis P. Topical NSAIDs for musculoskeletal conditions: a review of the literature. Drugs 1998; 56 (5): 783–99.
3. Heyneman CA, Lawless-Liday C, Wall GC. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs 2000; 60 (3): 555–74.
4. Derry S, Wiffen PJ, Kalso EA et al. Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. Cochrane Database Syst Rev 2017. Issue 5. Art. No.: CD008609.
5. Cordero JA, Alarcon L, Escribano E et al. Acomparative study of the transdermal penetration of a series of nonsteroidal anti-inflammatory drugs. J Pharm Sci 1997; 86 (4): 503–8.
6. Yano T, Nakagawa A, Tsuji M et al. Skin permeability of various non-steroidal anti-inflammatory drugs in man. Life Sci 1986; 39 (12): 1043–50.
7. Cordero JA, Camachob M, Obacha R et al. In vitro based index of topical anti-inflammatory activity to compare a series of NSAIDs. Eur J Pharm Biopharm 2001; 51: 135–42.
8. Komatsu T, Sakurada T. Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe. Eur J Pharm Sci 2012; 47: 890–5.
9. Folzer E, Gonzalez D, Singh R, Derendorf H. Comparison of skin permeability for three diclofenac topical formulations: an in vitro study. Pharmazie 2014; 69: 27–31.
10. Hagen M, Baker M. Skin penetration and tissue permeation after topical administration of diclofenac. Curr Med Res Opin 2017; 33 (9): 1623–34.
11. Minghetti P, Cilurzo F, Casiraghi A et al. Ex vivo study of transdermal permeation of four diclofenac salts from different vehicles. J Pharm Sci 2007496: 814–23.
12. Riess W, Schmid K, Botta L et al. The percutaneous absorption of diclofenac. Arzneimittelforschung 1986; 36: 1092–6.
13. Müller M, Mascher H, Kikuta C et al. Diclofenac concentrations in defined tissue layers after topical administration. Clin Pharmacol Ther 1997; 62 (3): 293–9.
14. Rainsforda KD, Keanb WF, Ehrlich GE. Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine. Curr Med Res Opin 2008; 24 (10): 2967–92.
15. Gallacchi G, Marcolongo R. Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion. Drugs Exp Clin Res 1993; 19 (3): 95–7.
16. Gschwend MH, Martin W, Arnold P et al. Determination of the transdermal bioavailability of a newly developed diclofenac sodium patch in comparison with a reference preparation. Arzneimittelforschung 2005; 55: 403–13.
17. Predel HG, Koll R, Pabst H et al. Diclofenac patch for topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study. Br J Sports Med 2004; 38: 318–23.
18. Hsieh L-F, Hong C-Z, Chern S-H, Chen C-C. Efficacy and side effects of diclofenac patch in treatment of patients with myofascial pain syndrome of the upper trapezius. J Pain Symptom Manage 2010; 39: 116–25.
19. Dreiser RL, Tisne-Camus M. DHEP plasters as a topical treatment of knee osteoarthritis – a double-blind placebo-controlled study. Drugs Exp Clin Res 1993; 19 (3): 117–23.
20. Brühlmann P, Michel BA. Topical diclofenac patch in patients with knee osteoarthritis: a randomized, double-blind, controlled clinical trial. Clin Exp Rheumatol 2003; 21 (2): 193–8.
21. Bruhlmann P, de Vathaire F, Dreiser RL et al. Short-term treatment with topical diclofenac epolamine plaster in patients with symptomatic knee osteoarthritis: pooled analysis of two randomised clinical studies. Curr Med Res Opin 2006; 22: 2429–38.
22. Galeazzi M, Marcolongo R. A placebo-controlled study of the efficacy and tolerability of a nonsteroidal anti-inflammatory drug, DHEP plaster, in inflammatory peri- and extra-articular rheumatological diseases. Drugs Exp Clin Res 1993; 19: 107–15.
23. Kuehl KS. Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries. Clin Ther 2010; 32 (6): 1001–13.
24. Lionberger DR, Joussellin E, Yanchick J et al. Pooled analysis of clinical trial data evaluating the safety and effectiveness of diclofenac epolamine topical patch 1.3% for the treatment of acute ankle sprain. Open Access J Sports Med 2011; 2: 75–84.
25. Lionberger DR, Lanzarotti A, Pierchala L et al. Analgesic efficacy and safety of diclofenac epolamine topical patch (Flector Patch) by location of injuriy in trials of acute pain: a pooled analysis of five trials. J Applied Research 2010; 10 (3): 97–107.
26. Yanchick J, Sun S, Pirovano P. Safety of diclofenac epolamine topical patch 1.3% evaluated in clinical trials and postmarketing surveillance. International Association for the Study of Pain (IASP) 12th World Congress on Pain; 2008; Glasgow, UK. Poster.
27. Derry S, Moore RA, Gaskell H et al. Topical NSAIDs for acute musculoskeletal pain in adults. Cochrane Database Syst Rev 2015; 6: CD007402.
28. Zeng C, Wei J, Persson MSM et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med 2018; 52: 642–50.
29. Osterwalder A, Reiner V, Reiner G, Lualdi P. Tissue absorption and distribution of ketoprofen after patch application in subjects undergoing knee arthroscopy or endoscopic carpal ligament release. Arzneim.-Forsch. Drug Res 2002; 52 (11): 822–7.
30. Rolf C, Engstrom B, Beauchard C et al. Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy. Rheumatology 1999; 38: 564–7.
31. Sekiya I, Morito T, Hara K et al. Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. AAPS Pharm Sci Tech 2010; 11 (1): 154–8.
32. Adachi H, Ioppolo F, Paoloni M, Santilli V. Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch: a new patch formulation. Eur Rev Med Pharmacol Sci 2011; 15 (7): 823–30.
33. Mazières B. Topical ketoprofen patch. Drugs R D 2005; 6 (6): 337–44.
34. Kawai S, Uchida E, Kondo M et al. Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. J Clin Pharmacol 2010; 50 (10): 1171–9.

М.В. Леонова

Межрегиональная общественная организация «Ассоциация клинических фармакологов России», Москва, Россия