1. Полищук Ю.И., Летникова З.В. Синдром старческой астении в геронтологии и гериатрии с точки зрения геронтопсихиатрии. Социальная и клиническая психиатрия. 2018; 28 (4): 71–4.
2. Allen VJ, Methven L, Gosney MA. Use of nutritional complete supplements in older adults with dementia: Systematic review and meta-analysis of clinical outcomes. Clin Nutr 2013; 32: 950–7. DOI: 10.1016/j.clnu.2013.03.015
3. Badrasawi M, Shahar S, Zahara AM et al. Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: A double-blind, randomized, placebo-controlled clinical trial. Clin Interv Aging 2016; 11: 1675–86.
4. Bally MR, Yildirim PZB, Bounoure L et al. Nutritional support and outcomes in malnourished medical inpatients: a systematic review and meta-analysis. JAMA Inter Med 2016; 176 (1): 43–53.
5. Bauer JM, Verlaan S, Bautmans I et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: A randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2015; 16: 740–7.
6. Beck AM, Holst M, Rasmussen HH. Oral nutritional support of older (65 years+) medical and surgical patients after discharge from hospital: systematic review and meta-analysis of randomized controlled trials. Clin Rehabil 2013; 27 (1): 19–27.
7. Bhattacharyya N, Kotz T, Shapiro J. The effect of bolus consistency on dysphagia in unilateral vocal cord paralysis. Otolaryngol Head Neck Surg 2003; 129: 632–6.
8. Bo Y, Liu C, Ji Z et al. A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial. Clin Nutr 2019; 38: 159–64.
9. Cawood AL, Elia M, Stratton RJ. Systematic review and meta-analysis of the effects of high protein oral nutritional supplements. Ageing Res Rev 2012; 11: 278–96. DOI: 10.1016/j.arr.2011.12.008
10. Cederholm T, Bosaeus I, Barazzoni R et al. Diagnostic criteria for malnutrition e an ESPEN consensus statement. Clin Nutr 2015; 34: 335–40.
11. Cederholm T, Barazzoni R, Austin P et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr 2017; 36: 49–64. DOI: 10.1016/j.clnu.2016.09.004
12. Challa S, Sharkey JR, Chen M, Phillips CD. Association of resident, facility, and geographic characteristics with chronic under nutrition in a nationally represented sample of older residents in U.S. nursing homes. J Nutr Health Aging 2007; 11 (2): 179–251.
13. Chan D-CD, Tsou H-H, Yang R-S et al. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr 2012; 12: 58.
14. Choban P, Dickerson R, Malone A et al. A.S.P.E.N. Clinical Guidelines: Nutrition Support of Hospitalized Adult Patients With Obesity. J Parent Enter Nutr 2013; 37 (6): 714–44. DOI: 10.1177/0148607113499374
15. Clave P, de Kraa M, Arreola V et al. The effect of bolus viscosity on swallowing function in neurogenic dysphagia. Aliment Pharmacol Ther 2006; 24: 1385–94.
16. Collins PF, Stratton RJ, Elia M. Nutritional support in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Am J Clin Nutr 2012; 95 (6): 1385–95. DOI: 10.3945/ajcn.111.023499
17. Collins PF, Elia M, Stratton RJ. Nutritional support and functional capacity in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respirology (Carlton, Vic) 2013; 18 (4): 616–29. DOI: 10.1111/resp.12070
18. Dennis MS, Lewis SC, Warlow C. Routine oral nutritional supplementation for stroke patients in hospital ­(FOOD): a multicentre randomized controlled trial. Lancet 2005; 365: 755–63.
19. Deutz NE, Matheson EM, Matarese LE et al. Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: a randomized clinical trial. Clin Nutr 2016; 35 (1): 18–26.
20. Diniz PB, Vanin G, Xavier R, Parente MA. Reduced incidence of aspiration with spoon-thick consistency in stroke patients. Nutr Clin Pract 2009; 24: 414–8.
21. Dirks ML, Tieland M, Verdijk LB et al. Protein Supplementation Augments Muscle Fiber Hypertrophy but Does Not Modulate Satellite Cell Content During Prolonged Resistance-Type Exercise Training in Frail Elderly. J Am Med Dir Assoc 2017; 18: 608–15.
22. Elia M, Normand C, Laviano A, Norman K. A systematic review of the cost and cost effectiveness of using standard oral nutritional supplements in community and care home settings. Clin Nutr 2016; 35: 125–37.
23. Elia M, Normand C, Norman K, Laviano A. A systematic review of the cost and cost effectiveness of using standard oral nutritional supplements in the hospital setting. Clin Nutr 2016; 35: 370–80.
24. Foley NC, Martin RE, Salter KL, Teasell RW. A review of the relationship between dysphagia and malnutrition following stroke. J Rehabil Med 2009; 41: 707–13.
25. Gariballa SE, Parker SG, Taub N, Castleden CM. A randomized, controlled, a single-blind trial of nutritional supplementation after acute stroke. JPEN, J Parenter Enteral Nutr 1998; 22: 315–9.
26. Gariballa S, Forster S, Walters S, Powers H. A randomized, double-blind, placebo-controlled trial of nutritional supplementation during acute illness. Am J Med 2006; 119 (8): 693–9.
27. Ha L, Hauge T, Spenning AB, Iversen PO. Individual, nutritional support prevents undernutrition, increases muscle strength and improves QoL among elderly at nutritional risk hospitalized for acute stroke: a randomized, controlled trial. Clin Nutr 2010; 29: 567–73.
28. Holdoway A, Anderson L, McGregor I et al. A Guide to Managing Adult Malnutrition in the Community: Oral Nutritional Supplements (ONS). 2nd Edition, 2017; p. 1–11.
29. Hutchins-Wiese HL, Kleppinger A, Annis K et al. The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. J Nutr Health Aging 2013; 17: 76–80.
30. Ikeda M, Brown J, Holland AJ et al. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosurg Psychiatr 2002; 73 (4): 371–6.
31. Kim CO, Lee KR. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: A community-based randomized controlled study. J Gerontol A Biol Sci Med Sci 2013; 68: 309–16.
32. Kuhlemeier KV, Palmer JB, Rosenberg D. Effect of liquid bolus consistency and delivery method on aspiration and pharyngeal retention in dysphagia patients. ­Dysphagia 2001; 16: 119–22.
33. Lauque S, Arnaud-Battandier F, Gillette S et al. Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer’s disease at risk of malnutrition: a prospective randomized study. J Am Geriatr Soc 2004; 52 (10): 1702–7.
34. Logemann JA, Gensler G, Robbins J et al. A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson’s disease. J Speech Lang Hear Res 2008; 51: 173–83.
35. Millward DJ. Nutrition and sarcopenia: Evidence for an interaction. Proc Nutr Soc 2012; 71: 566–75. DOI: 10.1017/S0029665112000201
36. Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2002; 3: CD003288.
37. Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2005; 2: CD003288.
38. Milne AC, Potter J, Vivanti A, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2009.
39. Morante JJH, Martinez CG, Morillas-Ruiz JM. Dietary Factors Associated with Frailty in Old Adults: A Review of Nutritional Interventions to Prevent Frailty Development. Nutrients 2019; 11: 102. DOI: 10.3390/nu11010102 
40. Nakazawa H, Sekizawa K, Ujiie Y et al. Risk of aspiration pneumonia in the elderly. Chest 1993; 103 (5): 1636–7.
41. Ng TP, Feng L, Nyunt MSZ et al. Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. Am J Med 2015; 128: 1225–36.e1.
42. Niccoli S, Kolobov A, Bon T et al. Whey Protein Supplementation Improves Rehabilitation Outcomes in Hospitalized Geriatric Patients: A Double Blinded, Randomized Controlled Trial J Nutr Gerontol Geriatr 2017; 36: 149–65.
43. Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of diseaserelated malnutrition. Clin Nutr 2008; 27: 5–15.
44. Norman K, Kirchner H, Freudenreich M et al. Three month intervention with protein and energy rich supplements improves muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease – A randomized controlled trial. Clin Nutr 2008; 27: 48–56. DOI: 10.1016/j.clnu.2007.08.011
45. Ozaki K, Kagaya H, Yokoyama M et al. The risk of penetration or aspiration during videofluoroscopic examination of swallowing varies depending on food types. Tohoku J Exp Med 2010; 220: 41–6.
46. Porter Starr KN, Pieper CF, Orenduff MC et al. Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. J Gerontol A Biol Sci Med Sci 2016; 71: 1369–75.
47. Rabadi MH, Coar PL, Lukin M et al. Intensive nutritional supplements can improve outcomes in stroke rehabilitation. Neurology 2008; 71: 1856–61.
48. Roberts HC, Lim SER, Cox NJ, Ibrahim K. The Challenge of Managing Undernutrition in Older People with Frailty. Nutrients 2019; 11: 808. DOI: 10.3390/nu11040808
49. Russell CA, Elia M. Nutrition screening survey in the UK and Republic of Ireland in 2010. In. Published on website 2011 by BAPEN [accessed June 2012, at www.bapen.org.uk].
50. Saka B, Kaya O, Ozturk GB et al. Malnutrition in the elderly and its relationship with other geriatric syndromes. Eur J Clin Nutr 2010; 29 (6): 745–8.
51. Somanchi M, Tao X, Mullin GE et al. The facilitated early enteral and dietary management effectiveness trial in hospitalized patients with malnutrition. JPEN, J Parenter Enteral Nutr 2011; 35: 209–16. DOI: 10.1177/0148607110392234
52. Stratton RJ, Green CJ, Elia M. Disease-related malnutrition: An evidence based approach to treatment. Oxford: CABI Publishing, 2003. DOI: 10.1079/9780851996486.0000
53. Stratton RJ, Ek AC, Engfer M et al. Enteral nutritional support in prevention and treatment of pressure ulcers: a systematic review and meta-analysis. Ageing Res Rev 2005; 4: 422–50.
54. Stratton RJ, Elia M. A review of reviews: a new look at the evidence for oral nutritional supplements in clinical practice. Clin Nutr 2007; 26 (1): 5–23. DOI: 10.1016/j.clnu.2007.04.004
55. Stratton RJ, Hebuterne X, Elia M. A systematic review and meta-analysis of the impact of oral nutritional supplements on hospital readmissions. Ageing Res Rev 2013; 12 (4): 884–97. DOI: 10.1016/j.arr.2013.07.002
56. Stratton RJ, Smith T, Gabe S. Managing malnutrition to improve lives and save money. BAPEN (British Association of Parenteral and Enteral Nutrition) website www.bapen.org.uk. 2018; p. 1–15.
57. Strike SC, Carlisle A, Gibson EL, Dyall SC. A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in OlderWomen: A Randomized, Double-blind, Placebo-controlled Pilot Study. J Gerontol A Biol Sci Med Sci 2016; 71: 236–42.
58. Ulger Z, Halil M, Kalan I et al. Comprehensive assessment of malnutrition risk and related factors in a large group of community-dwelling older adults. Clin Nutr 2010; 29 (4): 507–11.
59. Vanderwee K, Clays E, Bocquaert I et al. Malnutrition and associated factors in elderly hospital patients: a Belgian cross-sectional, multi-centre study. Clin Nutr 2010; 29 (4): 469–76.
60. Vojciechowski AS, Biesek S, Melo Filho J et al. Effects of physical training with the Nintendo Wii Fit Plus (R) and protein supplementation on musculoskeletal function and the risk of falls in pre-frail older women: Protocol for a randomized controlled clinical trial (theWiiProtein study). Maturitas 2018; 111: 53–60.
61. Volkert D, Berner YN, Berry E et al. ESPEN guidelines on enteral nutrition: Geriatrics. Clin .Nutr 2006; 25 (2): 330–60.
62. Volkert D, Beck AM, Cederholm T et al. ESPEN guideline on clinical nutrition and hydration in geriatrics. Clin Nutr 2018; p. 1–38. DOI: 10.1016/j.clnu.2018.05.024
63. Wright L, Cotter D, Hickson M, Frost G. Comparison of energy and protein intakes of older people consuming a texture modified diet with a normal hospital diet. J Hum Nutr Diet 2005; 18: 213–9.
64. Young KW, Greenwood CE, van Reekum R, Binns MA. Providing nutrition supplements to institutionalized seniors with probable Alzheimer’s disease is least beneficial to those with low body weight status. J Am Geriatr Soc 2004; 52 (8): 1305–12.

А.Е. Шестопалов1, А.В. Дмитриев2

1 Национальная ассоциация клинического питания и метаболизма, Москва, Россия;
2 Северо-Западная ассоциация парентерального и энтерального питания, Санкт-Петербург, Россия