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Мультидисциплинарный подход в лечении пациента с тяжелым течением синдрома раздраженного кишечника
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Ruchkina I.N., Vyaznikova A.A., Indeykina L.K., et al. Multidisciplinary treatment of the patient with a severe irritable bowel syndrome. Therapeutic Archive. 2020; 92 (2): 81–84. DOI: 10.26442/00403660.2020.02.000523
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Ключевые слова: синдром раздраженного кишечника, антидепрессанты, баллонно-дилатационный тест, висцеральная чувствительность, дулоксетин.
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The patient E., aged 39, was described with a severe form of the irritable bowel syndrome that developed after the stress. In addition to the clinical manifestations of IBS, the patient got the somatoform disorders, which manifested itself with a large number of extraintestinal symptoms and led to a disability. According to the recommendations of the Rome Criteria IV 2016, the main medicines for the treatment of biopsychosocial model of IBS are antidepressants. The remission of the disease with a complete recovery of the patient’s disability was achieved by duloxetine, an antidepressant from the group of serotonin and noradrenaline reuptake inhibitors.
Keywords: irritable bowel syndrome, antidepressants, balloon dilatation test, visceral sensitivity, duloxetine.
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2. Maev IV, Cherjomushkin SV, Kucherjavyj JuA. Irritable bowel syndrome. Rome-IV criteria. The role of visceral hypersensitivity and methods for its correction. Toolkit. Moscow, 2016. 64 p. (In Russ.)
3. Lacy BE, Mearin F, Chang L, et al. Bowel Disorders. Gastroenterology. 2016;150:1393-407. doi: 10.1053/j.gastro.2016.02.031
4. Ivashkin VT, Shelygin YuA, Baranskaya EK, et al. Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):76-93 (In Russ.) doi: 10.22416/1382-4376-2017-27-5-76-93
5. Liu Y, Zhang L, Wang X, Wang Z, Zhang J, Jiang R, et al. Similar fecal microbiota signatures in patients with diarrhea-predominant irritable bowel syndrome and patients with depression. Clin Gastroenterol Hepatol. 2016;14:1602-11. doi: 10.1016/j.cgh.2016.05.033
6. Danilov AnB, Danilov AlB. Сontrol of pain. A guide for doctors of various specialties. Moscow: AMM Press, 2016 (In Russ.)
7. Parfenov AI, Albulova EA, Ruchkina IN. Irritable bowel syndrome in the light of Rome consensus III (2006): 10 years later. Therapeutic Archive. 2016;88(2):4-9 (In Russ.) doi: 10.17116/terarkh20168824-9
8. Oblizajek NR, Gandhi S, Sharma M, Chakraborty S, Muthyala A, Prichard D, et al. Anorectal pressures measured with high-resolution manometry in healthy people – Normal values and asymptomatic pelvic floor dysfunction. J Neurogastroenterol Motil. 2019 Jul;31(7):e13597. doi: 10.1111/nmo.13597
9. Kaplan A, Franzen MD, Nickell PV, Ransom D, Lebovitz PJ. An open-label trial of duloxetine in patients with irritable bowel syndrome and comorbid generalized anxiety disorder. Int J Psychiatry Clin Pract. 2014;18(1):11-5. doi: 10.3109/13651501.2013.838632. Epub 2013 Sep 20.
10. Dyukova GM, Pogromov AP, Leonova ML, et al. Effect of the dual action antidepressant duloxetine in the treatment of functional disorders of the gastrointestinal tract. Medical Council. 2014;(3):78-80 (In Russ.) doi: 10.21518/2079-701X-2014-4-78-81
11. Labus JS, Bolus R, Chang L, Wiklund I, Naesdal J, Mayer EA, et al. The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale. Aliment Pharmacol Ther. 2004 Jul 1;20(1):89-97. doi: 10.1111/j.1365-2036.2004.02007.x
ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения г. Москвы,
Москва, Россия
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I.N. Ruchkina, A.A. Vyaznikova, L.K. Indeykina, D.A. Degterev, A.I. Parfenov
Loginov Moscow Clinical Scientific Practical Center, Moscow, Russia