Цель исследования. Оценка динамики основных параметров электрокардиограммы (ЭКГ) у пациентов с острым коронарным синдромом (ОКС) как возможных предикторов исхода в стационаре. Материалы и методы. Использованы данные 277 пациентов с ОКС. С помощью кардиоанализатора ЭК12К-01 исследована длительность интервала QT, рассчитаны сумма отклонения сегмента ST (ΣST), сумма подъема (ΣST+) и сумма снижения (ΣST–) сегмента ST, корригированная дисперсия интервала QT (DQTc). Результаты. Получены высокодостоверные различия ΣST во всех группах пациентов при госпитализации и различия DQTc у пациентов с ОКС с подъемом сегмента ST и ОКС без подъема сегмента ST. Выживаемость пациентов достоверно различалась в зависимости от таких параметров ЭКГ, как ΣST, ΣST–, DQTc. Заключение. Кардиоанализатор позволяет в автоматическом режиме улучшить оценку динамики ЭКГ в стационаре и определить предикторы исхода ОКС.
Aim. To estimate the time course of changes in basic electrocardiographic (ECG) parameters in patients with acute coronary syndrome (ACS) as possible predictors of in-hospital outcomes. Materials and methods. The data of 277 patients with acute coronary syndrome (ACS) were used; QT-interval duration was studied by means of an EC12C-01 cardioanalyzer; ST-segment deviation (ΣST), elevation (ΣST-E), and depression (ΣST-D) sums, and corrected QT-interval dispersion (DQTc) were calculated. Results. There were highly significant differences of ΣST in all the patients groups at admission and differences of DQTc in ACS patients with and without ST-segment elevation. The survival rates were significantly different depending on the value of ECG parameters, such as ΣST, ΣST-D, and DQTc. Conclusion. The cardioanalyzer can automatically improve the estimation of in-hospital ECG changes and to determine predictors of an ACS outcome.
Мравян С.Р., Федорова С.И. ЭКГ-феномен подъема сегмента ST, его причины и клиническое значение. Клин мед 2006; 5: 12-18.
Langer A., Krucoff M.W., Klootwijk P. et al. Prognostic significance of ST segment shift early after resolution of ST elevation in patients with myocardial infarction treated with thrombolytic therapy: the GUSTO-I ST Segment Monitoring Substudy. J Am Coll Cardiol 1998; 31: 783-789.
Тепляков А.Т., Камаев Д.Ю., Калюжин В.В. и др. Прогностическое значение дисперсии интервала QT электрокардиограммы у больных инфарктом миокарда. Бюл Сиб мед 2006; 1: 91-96.
Kligfield P., Gettes L.S., Bailey J.J. et al. AHA/ACC/HRS SCIENTIFIC STATEMENT Recommendations for the Standardization and Interpretation of the Electrocardiogram Part I: The Electrocardiogram and Its Technology A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 2007; 49: 1109-1127.
Ипатов П.В., Овсянников В.В., Кутепов Ю.С. Изменения ЭКГ при внутригоспитальном инфаркте миокарда. Военно-мед журн 2006; 5: 65-66.
Atar S., Birnbaum Y. Ischemia-induced ST-segment elevation: classification, prognosis, and therapy. J Electrocardiol 2005; 38 (4 Suppl): 1-7.
Sanchis J., Bodí V., Núñez J. et al. New risk score for patients with acute chest pain, non-ST-segment deviation, and normal troponin concentrations: a comparison with the TIMI risk score. J Am Coll Cardiol 2005; 46 (3): 443-449.
The GRACE Investigators. Rationale and design of the GRACE (Global Registry of Acute Coronary Events) Project: a multinational registry of patients hospitalized with acute coronary syndromes. Am Heart J 2001; 141: 190-199.
de Araújo Gonçalves P., Ferreira J., Aguiar C. et al. TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J 2005; 26 (9): 865-872.
Wagner G.S., Macfarlane P., Wellens H. et al. AHA/ACCF/HRS EXPERT CONSENSUS DOCUMENT AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part VI: Acute Ischemia/Infarction A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 2009; 53: 1003-1011.
Bluzaite I., Brazdzionyte J., Zaliūnas R. et al. QT dispersion and heart rate variability in sudden death risk stratification in patients with ischemic heart disease. Medicine (Kaunas) 2006; 42 (6): 450-454.
Rautaharju P.M., Surawicz B., Gettes L.S. AHA/ACCF/HRS EXPERT CONSENSUS DOCUMENT AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part IV: The ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 2009; 53: 982-991.
Авторы
В.М. ПРОВОТОРОВ1, И.И. ШЕВЧЕНКО2
1 ГБОУ «Воронежская государственная медицинская академии им. Н.Н. Бурденко»;
2 МУЗ «Городская клиническая больница скорой медицинской помощи №10», Воронеж
________________________________________________
V.M. PROVOTOROV1, I.I. SHEVCHENKO2
1 N.N. Burdenko Voronezh State Medical Academy;
2 Municipal Emergency Hospital Ten, Voronezh