Сравнительный анализ овариального резерва у женщин с ожирением в репродуктивном периоде
Сравнительный анализ овариального резерва у женщин с ожирением в репродуктивном периоде
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Аннотация
Цель исследования – сравнить овариальный резерв у женщин с ожирением и здоровых женщин репродуктивного возраста.
Материалы и методы. Обследовано 500 женщин молодого репродуктивного возраста (от 20 до 30 лет). Участницы разделены на равные группы (n=250) в зависимости от индекса массы тела (ИМТ): основная группа больных ожирением (ИМТ ≥30 кг/м2) и группа сравнения (ИМТ <30 кг/м2). На 2–3-й день менструального цикла определяли маркеры овариального резерва: сывороточные уровни антимюллерова гормона (АМГ), ингибина В, фолликулостимулирующего гормона, лютеинизирующего гормона, эстрадиола, тестостерона и прогестерона, а также на 5–7-й день менструального цикла ультразвуковые параметры – количество антральных фолликулов и объем яичников.
Результаты и обсуждение. Статистически достоверно различались такие параметры овариального резерва, как уровень АМГ (2,7±0,47 нг/мл в основной группе против 3,8±0,63 нг/мл в группе контроля; p<0,05), тестостерона (1,4±0,3 нмоль/л в основной группе, 0,7±0,2 нмоль/л – в группе контроля; p<0,01), объем яичников (7,2±1,9 см3 в основной группе и 9,5±1,7 см3 – в группе контроля; p<0,05), а также количество антральных фолликулов (13,3±4,5 в основной группе и 20,7±7,2 – в группе сравнения; p<0,01).
Заключение. Для больных ожирением женщин молодого репродуктивного возраста характерно снижение показателей овариального резерва по сравнению со здоровыми женщинами, однако значения оцениваемых параметров у больных ожирением остаются в пределах референсных значений.
Ключевые слова: антимюллеров гормон, количество антральных фолликулов, объем яичников, овариальный резерв, ожирение.
Materials and methods. This study evaluated 500 caucasian women, age 20–30 years, 250 with obesity (body mass index, BMI ≥30 kg/m2) and 250 without obesity (BMI <30 kg/m2). Anthropometrics, serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and testosterone were compared as ovarian volume (cm3) and antral follicle count (AFC), determined by ovarian transvaginal ultrasonography.
Results and discussion. We reveal statistically significant difference in following parameters: AMH (2.7±0.47 ng/ml vs. 3.8±0.63 ng/ml; p<0.05), testosterone (1.4±0.3 nmol/l vs. 0.7±0.2 nmol/l; p<0.01), ovarian volume (7.2±1.9 cm3 vs 9.5±1.7 cm3; p<0.05), and AFC (13.3±4.5 vs 20.7±7.2; p<0.01) in obesity group vs. control group respectively.
Conclusion. Ovarian reserve function is significantly lower in obese patients than in healthy control subjects of young reproductive age, but ovarian reserve parameters are in normal reference range even in obese patients.
Keywords: anti-Mullerian hormone, antral follicle count, obesity, ovarian reserve, ovarian volume.
Материалы и методы. Обследовано 500 женщин молодого репродуктивного возраста (от 20 до 30 лет). Участницы разделены на равные группы (n=250) в зависимости от индекса массы тела (ИМТ): основная группа больных ожирением (ИМТ ≥30 кг/м2) и группа сравнения (ИМТ <30 кг/м2). На 2–3-й день менструального цикла определяли маркеры овариального резерва: сывороточные уровни антимюллерова гормона (АМГ), ингибина В, фолликулостимулирующего гормона, лютеинизирующего гормона, эстрадиола, тестостерона и прогестерона, а также на 5–7-й день менструального цикла ультразвуковые параметры – количество антральных фолликулов и объем яичников.
Результаты и обсуждение. Статистически достоверно различались такие параметры овариального резерва, как уровень АМГ (2,7±0,47 нг/мл в основной группе против 3,8±0,63 нг/мл в группе контроля; p<0,05), тестостерона (1,4±0,3 нмоль/л в основной группе, 0,7±0,2 нмоль/л – в группе контроля; p<0,01), объем яичников (7,2±1,9 см3 в основной группе и 9,5±1,7 см3 – в группе контроля; p<0,05), а также количество антральных фолликулов (13,3±4,5 в основной группе и 20,7±7,2 – в группе сравнения; p<0,01).
Заключение. Для больных ожирением женщин молодого репродуктивного возраста характерно снижение показателей овариального резерва по сравнению со здоровыми женщинами, однако значения оцениваемых параметров у больных ожирением остаются в пределах референсных значений.
Ключевые слова: антимюллеров гормон, количество антральных фолликулов, объем яичников, овариальный резерв, ожирение.
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Materials and methods. This study evaluated 500 caucasian women, age 20–30 years, 250 with obesity (body mass index, BMI ≥30 kg/m2) and 250 without obesity (BMI <30 kg/m2). Anthropometrics, serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and testosterone were compared as ovarian volume (cm3) and antral follicle count (AFC), determined by ovarian transvaginal ultrasonography.
Results and discussion. We reveal statistically significant difference in following parameters: AMH (2.7±0.47 ng/ml vs. 3.8±0.63 ng/ml; p<0.05), testosterone (1.4±0.3 nmol/l vs. 0.7±0.2 nmol/l; p<0.01), ovarian volume (7.2±1.9 cm3 vs 9.5±1.7 cm3; p<0.05), and AFC (13.3±4.5 vs 20.7±7.2; p<0.01) in obesity group vs. control group respectively.
Conclusion. Ovarian reserve function is significantly lower in obese patients than in healthy control subjects of young reproductive age, but ovarian reserve parameters are in normal reference range even in obese patients.
Keywords: anti-Mullerian hormone, antral follicle count, obesity, ovarian reserve, ovarian volume.
Список литературы
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4. Marshall NE, Spong CY. Obesity, pregnancy complications, and birth outcomes. Semin Reprod Med. 2012;30(6):465-471. doi: 10.1055/s-0032-1328874
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7. Rittenberg V, Seshadri S, Sunkara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of bodymass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online. 2011;23(4):421-439. doi: 10.1016/j.rbmo.2011.06.018
8. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
9. Боярский К.Ю., Гайдуков С.Н., Чинчаладзе А.С. Факторы, определяющие овариальный резерв женщины. Журнал акушерства и женских болезней. 2009;LVIII(2):65-71 [Boyarskii KYu, Gaidukov SN, Chinchaladze AS. Factors, predicted women’s ovarian reserve. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s Diseases. 2009;LVIII(2):65-71 (In Russ.)].
10. Jamil Z, Fatima SS, Ahmed K, Malik R. Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers. Dis Markers. 2016;2016:5246217. doi: 10.1155/2016/5246217
11. Committee opinion no. 618: Ovarian reserve testing. Committee on Gynecologic Practice. Obstet Gynecol. 2015 Jan;125(1):268-273. doi: 10.1097/01.AOG.0000459864.68372.ec
12. Franks S. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab. 2006 Mar;91(3):786-789. doi: 10.1210/jc.2005-2501
13. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491-497. doi: 10.1001/jama.2012.39
14. Shaw CM, Stanczyk FZ, Egleston BL, Kahle LL, Spittle CS, Godwin AK, et al. Serum antimullerian hormone in healthy premenopausal women. Fertil Steril. 2011;95(8):2718-2721. doi: 10.1016/j.fertnstert.2011.05.051
15. Sahmay S, Usta T, Erel CT, Imamoglu M, Kucuk M, Atakul N, et al. Is there any correlation between amh and obesity in premenopausal women? Arch Gynecol Obstet. 2012;286(3):661-665. doi: 10.1007/s00404-012-2363-x
16. Altaee H, Al-Madfai ZAM, Alkhafaji ZH. Effect of obesity on ovarian reserve parameters in mid-reproductive age women. Fac Med Baghdad. 2012;54(2):185-189. doi: 10.12688/f1000research.1-43.v1
17. Freeman EW, Gracia CR, Sammel MD, Lin H, Lim LC, Strauss 3rd JF. Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril. 2007;87(1):101-106. doi: 10. 1016/j.fertnstert.2006.05.074
18. Bernardi LA, Carnethon MR, de Chavez PJ, Ikhena DE, Neff LM, Baird DD, et al. Relationship between obesity and anti-Müllerian hormone in reproductive-aged African American women. Obesity (Silver Spring). 2017;25(1):229-235. doi: 10.1002/oby.21681
19. Moy V, Jindal S, Lieman H, Buyuk E. Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women. J Assist Reprod Genet. 2015;32(9):1305-1311. doi: 10.1007/s10815-015-0538-7
20. Balkan F, Cetin N, Usluogullari CA, Unal OK, Usluogullari B. Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups. J Ovarian Res. 2014;7:63. doi: 10.1186/1757-2215-7-63
21. Halawaty S, ElKattan E, Azab H, ElGhamry N. Al-Inany H. Effect of obesity on parameters of ovarian reserve in premenopausal women. J Obstet Gynaecol Can. 2010;32(7):687-690. doi: 10.1016/s1701-2163(16)34573-x
22. Дурманова А.К., Отарбаев Н.К., Кайырлыкызы А., Жангазиева К.Х., Ибраева Ж.Н., Доненбаева Г.Б. и др. Овариальный резерв яичников и содержание адипокинов у женщин репродуктивного возраста с ожирением. Терапевтический архив. 2016;88(10):46-50 [Durmanova AK, Otarbaev NK, Kaiyrlykyzy A, Zhangazieva KKh, Ibraeva ZhN, Donenbaeva GB, et al. Ovarial reserve and adipokines concentration in reproductive age women with obesity. Terapevticheskii Arkhiv = Therapeutic Archive. 2016;88(10):46-50 (In Russ.)]. doi: 10.17116/terarkh2016881046-50
23. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
24. Robker RL, Wu LL, Yang X. Inflammatory pathways linking obesity and ovarian dysfunction. J Reprod Immunol. 2011;88(2):142-148. doi: 10.1016/j.jri.2011.01.008
25. Merhi Z, Buyuk E, Berger DS, Zapantis A, Israel DD, Chua Jr S, et al. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF. Hum Reprod. 2013;28(6):1661-1669. doi: 10.1093/humrep/det072
26. Гаспаров А.С., Гажонова В.Е., Дорохов С.И., Титов Д.С., Барабанова О.Э., Тер-Овакимян А.Э. Оценка овариального резерва яичника с доброкачественными опухолями после разных видов хирургического лечения. Кремлевская медицина. Клинический вестник. 2013;(1):100-105 [Gasparov AS, Gazhonova VE, Dorokhov SI, Titov DS, Barabanova OE, Ter-Ovakimyan AE. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya Meditsina. Klinicheskii Vestnik = Kremlin Medicine. Clinical Annals. 2013;(1):100-105 (In Russ.)].
27. Боярский К.Ю., Гайдуков С.Н., Машкова Е.А. Роль антимюллерова гормона (АМГ) в норме и при различных гинекологических заболеваниях. Журнал акушерства и женских болезней. 2009; LVIII(3):75-85 [Boyarskii KYu, Gaidukov SN, Mashkova EA. Role of Anti-Mullerian hormone (AMH) in norm and different gynecological diseases. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s. 2009;LVIII(3):75-85 (In Russ.)].
2. Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14(6):482-487. doi: 10.1097/MED.0b013e3282f1d6cb
3. Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, Weiss NS. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol. 2008;168(6):563-570. doi: 10.1093/aje/kwn168
4. Marshall NE, Spong CY. Obesity, pregnancy complications, and birth outcomes. Semin Reprod Med. 2012;30(6):465-471. doi: 10.1055/s-0032-1328874
5. Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007;22(2):414-420. doi: 10.1093/humrep/del400
6. Van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Burggraaff JM, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod. 2008;23(2):324-328. doi: 10.1093/humrep/dem371
7. Rittenberg V, Seshadri S, Sunkara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of bodymass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online. 2011;23(4):421-439. doi: 10.1016/j.rbmo.2011.06.018
8. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
9. [Boyarskii KYu, Gaidukov SN, Chinchaladze AS. Factors, predicted women’s ovarian reserve. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s Diseases. 2009;LVIII(2):65-71 (In Russ.)].
10. Jamil Z, Fatima SS, Ahmed K, Malik R. Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers. Dis Markers. 2016;2016:5246217. doi: 10.1155/2016/5246217
11. Committee opinion no. 618: Ovarian reserve testing. Committee on Gynecologic Practice. Obstet Gynecol. 2015 Jan;125(1):268-273. doi: 10.1097/01.AOG.0000459864.68372.ec
12. Franks S. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab. 2006 Mar;91(3):786-789. doi: 10.1210/jc.2005-2501
13. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491-497. doi: 10.1001/jama.2012.39
14. Shaw CM, Stanczyk FZ, Egleston BL, Kahle LL, Spittle CS, Godwin AK, et al. Serum antimullerian hormone in healthy premenopausal women. Fertil Steril. 2011;95(8):2718-2721. doi: 10.1016/j.fertnstert.2011.05.051
15. Sahmay S, Usta T, Erel CT, Imamoglu M, Kucuk M, Atakul N, et al. Is there any correlation between amh and obesity in premenopausal women? Arch Gynecol Obstet. 2012;286(3):661-665. doi: 10.1007/s00404-012-2363-x
16. Altaee H, Al-Madfai ZAM, Alkhafaji ZH. Effect of obesity on ovarian reserve parameters in mid-reproductive age women. Fac Med Baghdad. 2012;54(2):185-189. doi: 10.12688/f1000research.1-43.v1
17. Freeman EW, Gracia CR, Sammel MD, Lin H, Lim LC, Strauss 3rd JF. Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril. 2007;87(1):101-106. doi: 10. 1016/j.fertnstert.2006.05.074
18. Bernardi LA, Carnethon MR, de Chavez PJ, Ikhena DE, Neff LM, Baird DD, et al. Relationship between obesity and anti-Müllerian hormone in reproductive-aged African American women. Obesity (Silver Spring). 2017;25(1):229-235. doi: 10.1002/oby.21681
19. Moy V, Jindal S, Lieman H, Buyuk E. Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women. J Assist Reprod Genet. 2015;32(9):1305-1311. doi: 10.1007/s10815-015-0538-7
20. Balkan F, Cetin N, Usluogullari CA, Unal OK, Usluogullari B. Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups. J Ovarian Res. 2014;7:63. doi: 10.1186/1757-2215-7-63
21. Halawaty S, ElKattan E, Azab H, ElGhamry N. Al-Inany H. Effect of obesity on parameters of ovarian reserve in premenopausal women. J Obstet Gynaecol Can. 2010;32(7):687-690. doi: 10.1016/s1701-2163(16)34573-x
22. [Durmanova AK, Otarbaev NK, Kaiyrlykyzy A, Zhangazieva KKh, Ibraeva ZhN, Donenbaeva GB, et al. Ovarial reserve and adipokines concentration in reproductive age women with obesity. Terapevticheskii Arkhiv = Therapeutic Archive. 2016;88(10):46-50 (In Russ.)]. doi: 10.17116/terarkh2016881046-50
23. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
24. Robker RL, Wu LL, Yang X. Inflammatory pathways linking obesity and ovarian dysfunction. J Reprod Immunol. 2011;88(2):142-148. doi: 10.1016/j.jri.2011.01.008
25. Merhi Z, Buyuk E, Berger DS, Zapantis A, Israel DD, Chua Jr S, et al. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF. Hum Reprod. 2013;28(6):1661-1669. doi: 10.1093/humrep/det072
26. [Gasparov AS, Gazhonova VE, Dorokhov SI, Titov DS, Barabanova OE, Ter-Ovakimyan AE. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya Meditsina. Klinicheskii Vestnik = Kremlin Medicine. Clinical Annals. 2013;(1):100-105 (In Russ.)].
27. [Boyarskii KYu, Gaidukov SN, Mashkova EA. Role of Anti-Mullerian hormone (AMH) in norm and different gynecological diseases. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s. 2009;LVIII(3):75-85 (In Russ.)].
2. Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14(6):482-487. doi: 10.1097/MED.0b013e3282f1d6cb
3. Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, Weiss NS. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol. 2008;168(6):563-570. doi: 10.1093/aje/kwn168
4. Marshall NE, Spong CY. Obesity, pregnancy complications, and birth outcomes. Semin Reprod Med. 2012;30(6):465-471. doi: 10.1055/s-0032-1328874
5. Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007;22(2):414-420. doi: 10.1093/humrep/del400
6. Van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Burggraaff JM, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod. 2008;23(2):324-328. doi: 10.1093/humrep/dem371
7. Rittenberg V, Seshadri S, Sunkara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of bodymass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online. 2011;23(4):421-439. doi: 10.1016/j.rbmo.2011.06.018
8. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
9. Боярский К.Ю., Гайдуков С.Н., Чинчаладзе А.С. Факторы, определяющие овариальный резерв женщины. Журнал акушерства и женских болезней. 2009;LVIII(2):65-71 [Boyarskii KYu, Gaidukov SN, Chinchaladze AS. Factors, predicted women’s ovarian reserve. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s Diseases. 2009;LVIII(2):65-71 (In Russ.)].
10. Jamil Z, Fatima SS, Ahmed K, Malik R. Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers. Dis Markers. 2016;2016:5246217. doi: 10.1155/2016/5246217
11. Committee opinion no. 618: Ovarian reserve testing. Committee on Gynecologic Practice. Obstet Gynecol. 2015 Jan;125(1):268-273. doi: 10.1097/01.AOG.0000459864.68372.ec
12. Franks S. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab. 2006 Mar;91(3):786-789. doi: 10.1210/jc.2005-2501
13. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491-497. doi: 10.1001/jama.2012.39
14. Shaw CM, Stanczyk FZ, Egleston BL, Kahle LL, Spittle CS, Godwin AK, et al. Serum antimullerian hormone in healthy premenopausal women. Fertil Steril. 2011;95(8):2718-2721. doi: 10.1016/j.fertnstert.2011.05.051
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19. Moy V, Jindal S, Lieman H, Buyuk E. Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women. J Assist Reprod Genet. 2015;32(9):1305-1311. doi: 10.1007/s10815-015-0538-7
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21. Halawaty S, ElKattan E, Azab H, ElGhamry N. Al-Inany H. Effect of obesity on parameters of ovarian reserve in premenopausal women. J Obstet Gynaecol Can. 2010;32(7):687-690. doi: 10.1016/s1701-2163(16)34573-x
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14. Shaw CM, Stanczyk FZ, Egleston BL, Kahle LL, Spittle CS, Godwin AK, et al. Serum antimullerian hormone in healthy premenopausal women. Fertil Steril. 2011;95(8):2718-2721. doi: 10.1016/j.fertnstert.2011.05.051
15. Sahmay S, Usta T, Erel CT, Imamoglu M, Kucuk M, Atakul N, et al. Is there any correlation between amh and obesity in premenopausal women? Arch Gynecol Obstet. 2012;286(3):661-665. doi: 10.1007/s00404-012-2363-x
16. Altaee H, Al-Madfai ZAM, Alkhafaji ZH. Effect of obesity on ovarian reserve parameters in mid-reproductive age women. Fac Med Baghdad. 2012;54(2):185-189. doi: 10.12688/f1000research.1-43.v1
17. Freeman EW, Gracia CR, Sammel MD, Lin H, Lim LC, Strauss 3rd JF. Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril. 2007;87(1):101-106. doi: 10. 1016/j.fertnstert.2006.05.074
18. Bernardi LA, Carnethon MR, de Chavez PJ, Ikhena DE, Neff LM, Baird DD, et al. Relationship between obesity and anti-Müllerian hormone in reproductive-aged African American women. Obesity (Silver Spring). 2017;25(1):229-235. doi: 10.1002/oby.21681
19. Moy V, Jindal S, Lieman H, Buyuk E. Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women. J Assist Reprod Genet. 2015;32(9):1305-1311. doi: 10.1007/s10815-015-0538-7
20. Balkan F, Cetin N, Usluogullari CA, Unal OK, Usluogullari B. Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups. J Ovarian Res. 2014;7:63. doi: 10.1186/1757-2215-7-63
21. Halawaty S, ElKattan E, Azab H, ElGhamry N. Al-Inany H. Effect of obesity on parameters of ovarian reserve in premenopausal women. J Obstet Gynaecol Can. 2010;32(7):687-690. doi: 10.1016/s1701-2163(16)34573-x
22. [Durmanova AK, Otarbaev NK, Kaiyrlykyzy A, Zhangazieva KKh, Ibraeva ZhN, Donenbaeva GB, et al. Ovarial reserve and adipokines concentration in reproductive age women with obesity. Terapevticheskii Arkhiv = Therapeutic Archive. 2016;88(10):46-50 (In Russ.)]. doi: 10.17116/terarkh2016881046-50
23. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. doi: 10.1210/jc.2008-2648
24. Robker RL, Wu LL, Yang X. Inflammatory pathways linking obesity and ovarian dysfunction. J Reprod Immunol. 2011;88(2):142-148. doi: 10.1016/j.jri.2011.01.008
25. Merhi Z, Buyuk E, Berger DS, Zapantis A, Israel DD, Chua Jr S, et al. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF. Hum Reprod. 2013;28(6):1661-1669. doi: 10.1093/humrep/det072
26. [Gasparov AS, Gazhonova VE, Dorokhov SI, Titov DS, Barabanova OE, Ter-Ovakimyan AE. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya Meditsina. Klinicheskii Vestnik = Kremlin Medicine. Clinical Annals. 2013;(1):100-105 (In Russ.)].
27. [Boyarskii KYu, Gaidukov SN, Mashkova EA. Role of Anti-Mullerian hormone (AMH) in norm and different gynecological diseases. Zhurnal Akusherstva i Zhenskikh Boleznei = Journal of Obstetrics and Women’s. 2009;LVIII(3):75-85 (In Russ.)].
Авторы
О.Р. Григорян 1, Р.К. Михеев 1,2, Е.Н. Андреева 1,2, И.И. Дедов 1
1 ФГБУ «Эндокринологический научный центр» Минздрава России, Москва, Россия;
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
1 Scientific Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia;
2 A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of Russia, Moscow, Russia
1 ФГБУ «Эндокринологический научный центр» Минздрава России, Москва, Россия;
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
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1 Scientific Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia;
2 A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of Russia, Moscow, Russia
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