Сравнительная эффективность витаминно-минеральных комплексов железа в коррекции железодефицита у женщин в амбулаторных условиях

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Аннотация

Цель исследования. Сравнение эффективности профилактического назначения минерально-витаминных комплексов «Фероглобин-В12» и «Компливит железо» с разной степенью валентности железа.
Материалы и методы. Обследовано 120 лиц женского пола. Для определения качества жизни пользовались опросником SF-36. Наличие тревоги определяли по Шкале тревоги Спилбергера–Ханина. Тридцать женщин с дефицитом железа разделили на две группы, по 15 человек в каждой. Первая группа получала «Фероглобин-В12», 2-я – «Компливит железо» в течение месяца.
Результаты. Через месяц после начала профилактической терапии у женщин 1-й группы достигнута нормализация содержания железа в сыворотке крови. Во 2-й группе его концентрация приближалась к контрольным значениям. При этом разница в содержании железа в 1-й и 2-й группах носила достоверный характер.
Заключение. Прием «Фероглобина-В12» не сопровождался побочными эффектами, а показатели работоспособности, социальной активности и психического здоровья достигали контрольных значений, в отличие от группы пациентов, принимающих «Компливит железо».

Ключевые слова: дефицит железа, профилактика, «Фероглобин-В12», цитрат железа-аммония.

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Аim. To compare the efficacy of prophylactic administration of mineral-vitamin complexes "Feroglobin-B12" and "Complivit iron" with different degrees of Fe valence.
Materials and methods. 120 female subjects were examined. To determine the quality of life, the SF-36 questionnaire was used. The presence of anxiety was determined on the Spielberger-Khanin Alarm Scale. 30 women with a deficit of Fe were divided into 2 groups of 15 people each. The first group received "Ferroglobin-B12", the second – "Complivit iron" for a month.
Results. In a month after the initiation of preventive therapy in women of the 1 group the content of Fe serum was normalized. In the second group, its concentration approached the control values. The difference in Fe content in the 1 and 2 groups was of a reliable nature.
Conclusion. The intake of "Ferroglobin-B12" was not accompanied by side effects, and performance indicators, social activity and mental health reached control values, unlike the group of patients taking Complivit iron.

Keywords: iron deficiency, prophylaxis, "Feroglobin-B12", ferric ammonium citrate.

Список литературы

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2. Iron and Health. Scientific Advisory Committee on Nutrition. 2010. London: TSO. P. 3. Published by TSO (The Stationery Office). Available from: https://www.tsoshop.co.uk/
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19. Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutrit. 2009;90(5):1252-63. doi: 10.3945/ajcn.2008.27016
20. Bird JK, Murphy RA, Ciappio ED, McBurney MI. Risk of Deficiency in Multiple Concurrent Micronutrients in Children and Adults in the United States. Nutrients. 2017;9(7):655. doi: 10.3390/nu9070655
21. Ахрем А.А., Андреюк Г.М., Киселева С.И., Кисель М.А., Киселев П.А., Дальнова Т.С., Колб В.Г., Светлицкая С.Г. Определение гемоглобина крови с использованием додецилсульфата натрия. Лабораторное дело. 1989;(5):13-5 [Akhrem AA, Andreyuk GM, Kiseleva SI, Kisel' MA, Kiselev PA, Dal'nova TS, Kolb VG, Svetlitskaya SG. Determination of blood hemoglobin using sodium dodecyl sulfate. Laboratornoe Delo. 1989;(5):13-5 (In Russ.)].
22. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care. 1992;30(6):473-83. doi: 10.1097/00005650-199206000-00002
23. Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, Haya-Palazuelos J, Ciria-Recasens M, Manasanch J, Perez-Edo L. Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin. 2013;29(4):291-303. doi: 10.1185/03007995.2012.761599
24. Zhang H, Onning G, Oste R, Gramatkovski E, Hulthén L. Improved iron bioavailability in an oat-based beverage: the combined effect of citric acid addition, dephytinization and iron supplementation. Eur J Nutrit. 2007;46(2):95-102. doi: 10.1007/s00394-006-0637-4
25. Fukushima T, Sia AK, Allred BE, Nichiporuk R, Zhou Z, Andersen UN, Raymondet KN. Bacillus cereus iron uptake protein fishes out an unstable ferric citrate trimer. Proceed Nat Acad Sci. 2012;109(42):16829-34. doi: 10.1073/pnas.1210131109
26. Rellán-Alvarez R, Giner-Martínez-Sierra J, Orduna J, Orera I, Rodríguez-Castrillón JA, García-Alonso JI, Abadía J, Alvarez-Fernández A. Identification of a tri-iron(III), tri-citrate complex in the xylem sap of iron-deficient tomato resupplied with iron: new insights into plant iron long-distance transport. Plant Cell Physiol. 2009;51(1):91-102. doi: 10.1093/pcp/pcp170
27. Wang H, Li Z, Niu J, Xu Y, Ma L, Lu A, Wang X, Qian Z, Huang Z, Jin X, Leng Q, Wang J, Zhong J, Sun B, Meng G. Antiviral effects of ferric ammonium citrate. Cell Discov. 2018;4(1):14. doi: 10.1038/s41421-018-0013-6
28. Guo X, Zheng H, Guo Y, Wang Y, Anderson GJ, Ci Y, Yu P, Geng L, Chang YZ. Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain. J Nanobiotechnol. 2017;15(1):1. doi: 10.1186/s12951-017-0277-2

________________________________________________

1. Worldwide prevalence of anaemia 1993–2005: WHO global database on anaemia. Geneva, Switzerland: World Health Organization; 2008.
2. Iron and Health. Scientific Advisory Committee on Nutrition. 2010. London: TSO. P. 3. Published by TSO (The Stationery Office). Available from: https://www.tsoshop.co.uk/
3. Wilson K, Sloan JM. Iron-Deficiency Anemia. New Engl J Med (NEJM/MMS). 2015;373(5):484-6. doi: 10.1056/nejmc1507104
4. Pereira DI, Bruggraber SF, Faria N, Poots LK, Tagmount MA, Aslam MF, Frazer DM, Vulpe CD, Anderson GJ, Powell JJ. Nanoparticulate iron (III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans. Nanomedicine. 2014;10:1877-86. doi: 10.1016/j.nano.2014.06.012
5. World Health Organization. Global targets indicators: what is measured gets done [online]. Geneva, Switzerland: WHO; 2014. Accessed on April 19, 2018. Available from: http://www.who.int/nutrition/globaltargets_indicators/en/
6. World Health Organization. The global prevalence of anaemia in 2011. Accessed on April 19, 2018. Available from: http://apps.who.int/iris/bitstream/10665/177094/1/9789241564960_eng.pdf
7. Roman Viñas B, Ribas Barba L, Ngo J, Gurinovic M, Novakovic R, Cavelaars A, de Groot LC, van’t Veer P, Matthys C, Serra Majem L. Projected prevalence of inadequate nutrient intakes in Europe. Ann Nutr Metabol. 2011;59(2-4):84-95. doi: 10.1159/000332762
8. Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr. 2010;91(5):1461S-7S. doi: 10.3945/ajcn.2010.28674f
9. Sharp PA. Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors. Intern J Vitamin Nutrit Res. 2010;80(45):231-42. doi: 10.1024/0300-9831/a000029
10. Flour Fortification Innitiative (FFI). Wheat Flour Fortification Status – December 2016. Map of Global Progress. Countries with Mandatory Wheat Flour Fortification Regulations. Online: http://www.ffinetwork.org/global_progress/index.php. Accessed on April 19, 2018.
11. Pasricha S-R, Low M, Thompson J, Farrell A, De-Regil L-M. Iron Supplementation Benefits Physical Performance in Women of Reproductive Age: A Systematic Review and Meta-Analysis. J Nutrit. 2014;144(6):906-14. doi: 10.3945/jn.113.189589
12. Moreiras O, Carvajal A, Cabrera L, Cuadrado C. Tablas de Composición de los Alimentos. Ingestas Recomendadas de Energía y Nutrientes Para la Población Española (Revisadas 2015). Madrid, Spain: Pirámide; 2015. P. 258-9 (In Span.).
13. Institute of Medicine. 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press; 2001. doi: 10.17226/10026
14. Harvey-Leeson S, Karakochuk CD, Hawes M, Tugirimana PL, Bahizire E, Akilimali PZ, Michaux KD, Lynd LD, Whitfield KC, Moursi M, Boy E, Foley J, McLean J, Houghton LA, Gibson RS, Green TJ. Anemia and Micronutrient Status of Women of Childbearing Age and Children 6–59 Months in the Democratic Republic of the Congo. Nutrients. 2016;8(2):98. doi: 10.3390/nu8020098
15. Karakochuk CD, Whitfield KC, Barr SI, Lamers Y, Devlin AM, Vercauteren SM, Kroeun H, Talukder A, McLean J, Green TJ. Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia. J Nutrit. 2014;145(1):134-42. doi: 10.3945/jn.114.198945
16. [Stuklov NI, Semenova EN. Iron-deficiency anemia. Modern tactics of diagnosis and treatment, the effectiveness of therapy. Klinicheskaya Meditsina. 2013;(12):61-7 (In Russ.)].
17. Lane DJ, Richardson DR. The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption! Free Radical Biol Med. 2014;75:69-83. doi: 10.1016/j.freeradbiomed.2014.07.007
18. [Gromova OA, Torshin IYu, Khadzhidis AK. Analysis of molecular mechanisms of action of iron (II), copper, manganese in the pathogenesis of iron deficiency anemia. Klinicheskaya Farmakologiya i Farmaekonomika. 2010;(1):1-9 (In Russ.)].
19. Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutrit. 2009;90(5):1252-63. doi: 10.3945/ajcn.2008.27016
20. Bird JK, Murphy RA, Ciappio ED, McBurney MI. Risk of Deficiency in Multiple Concurrent Micronutrients in Children and Adults in the United States. Nutrients. 2017;9(7):655. doi: 10.3390/nu9070655
21. [Akhrem AA, Andreyuk GM, Kiseleva SI, Kisel' MA, Kiselev PA, Dal'nova TS, Kolb VG, Svetlitskaya SG. Determination of blood hemoglobin using sodium dodecyl sulfate. Laboratornoe Delo. 1989;(5):13-5 (In Russ.)].
22. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care. 1992;30(6):473-83. doi: 10.1097/00005650-199206000-00002
23. Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, Haya-Palazuelos J, Ciria-Recasens M, Manasanch J, Perez-Edo L. Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin. 2013;29(4):291-303. doi: 10.1185/03007995.2012.761599
24. Zhang H, Onning G, Oste R, Gramatkovski E, Hulthén L. Improved iron bioavailability in an oat-based beverage: the combined effect of citric acid addition, dephytinization and iron supplementation. Eur J Nutrit. 2007;46(2):95-102. doi: 10.1007/s00394-006-0637-4
25. Fukushima T, Sia AK, Allred BE, Nichiporuk R, Zhou Z, Andersen UN, Raymondet KN. Bacillus cereus iron uptake protein fishes out an unstable ferric citrate trimer. Proceed Nat Acad Sci. 2012;109(42):16829-34. doi: 10.1073/pnas.1210131109
26. Rellán-Alvarez R, Giner-Martínez-Sierra J, Orduna J, Orera I, Rodríguez-Castrillón JA, García-Alonso JI, Abadía J, Alvarez-Fernández A. Identification of a tri-iron(III), tri-citrate complex in the xylem sap of iron-deficient tomato resupplied with iron: new insights into plant iron long-distance transport. Plant Cell Physiol. 2009;51(1):91-102. doi: 10.1093/pcp/pcp170
27. Wang H, Li Z, Niu J, Xu Y, Ma L, Lu A, Wang X, Qian Z, Huang Z, Jin X, Leng Q, Wang J, Zhong J, Sun B, Meng G. Antiviral effects of ferric ammonium citrate. Cell Discov. 2018;4(1):14. doi: 10.1038/s41421-018-0013-6
28. Guo X, Zheng H, Guo Y, Wang Y, Anderson GJ, Ci Y, Yu P, Geng L, Chang YZ. Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain. J Nanobiotechnol. 2017;15(1):1. doi: 10.1186/s12951-017-0277-2

Авторы

А.А. Свистунов, М.А. Осадчук, Н.В. Киреева, А.Е. Лазарева, Д.А. Шорина, И.Н. Васильева, Т.С. Савина, Е.М. Туаева

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), кафедра поликлинической терапии лечебного факультета, Москва, Россия

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A.A. Svistunov, M.A. Osadchuk, N.V. Kireeva, A.E. Lazareva, D.A. Shorina, I.N. Vasil'eva, T.S. Savina, E.M. Tuaeva

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Department of Polyclinic Therapy of the Faculty of Medicine, Moscow, Russia

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