Роль тонкой кишки в патогенезе общей вариабельной иммунной недостаточности
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Ключевые слова: иммуноглобулины, узелковая лимфоидная гиперплазия, плазматические клетки, гипогаммаглобулинемическая спру.
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The article presents the results of examination of 32 patients with common variable immune deficiency (barn) with involvement in the pathological process of the digestive system. The features of the clinical picture, the content of immunoglobulins in the blood serum, morphological structure of the mucosa of small intestine as well as treatment. Special attention is paid to the small intestine in the pathogenesis of the barn.
Keywords: immunoglobulins, nodular lymphoid hyperplasia, plasma cells, hypogammaglobulinemia sprue.
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2. Latysheva TV, Sedikova NKh, Latysheva EA, Dmitrieva AV, Yurenkova AV. Primary immunodeficiencies in adults. Problems of diagnosis, treatment. The experience with the drug of intravenous immunoglobulin intratech. Rossiiskii Allergologicheskii Zhurnal = Russian Allergological Journal. 2011;(6):58-67 (In Russ.)
3. Latysheva EA. Primary immunodeficiency: the state of the problem today. JMF-centers in Russia. Voprosy Sovremennoi Pediatrii = Current Pediatrics. 2013;12(6):73-7 (In Russ.)
4. Parfenov AI. Enterologiya [Enterology]. Moscow; 2009. 880 p. (In Russ.)
5. Krums LM, Sabelnikova EA. Hronicheskie bolezni tonkoi kishki [Chronic disease of the small intestine]. Moscow; 2014. P. 97 (In Russ.)
6. Wei Lü, Zheng-Yin Liu, Tai-Sheng Li. Common variable immunodeficiency: report of 12 cases and revive of literature. Zhonghua Nei Ke Za Zhi. 2008;47(5):378-81 (In Chin.)].
7. Oksenhendler E, Gerard L, Fieschi C, et al. Infections in 252 patients with common variable immunodeficiency. Clin Infect Dis. 2008 46:1547-54.
8. Pan-Hammarström Q, Salzer U, Du L, et al. Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. Nat Genet. 2007;39:429-30. doi: 10.1038/ ng0407-42
9. Tam JS, Routes JM. Common variable immunodeficiency. Am J Rhinol Allergy. 2013 Jul-Aug;27(4):260-5. doi: 10.2500/ajra.2013.27.3899
10. Arnold DF, Wiggins J, Cunningham-Rundles C, et al. Granulomatous disease: Distinguishing primary antibody disease from sarcoidosis. Clin Immunol. 2008;128:18-22. doi: 10.1016/j.clim.2008.03.510
11. Cunningham-Rundles C. Autoimmune manifestations in common variable immunodeficiency. J Clin Immunol. 2008;28:42-5.
12. Latysheva EA, Latysheva TV. The use of intravenous immunoglobulins in clinical practice. Pediatricheskaya Farmakologiya = Pediatric Pharmacology. 2013;10(1):26-30 (In Russ.)
13. Pinegin BV, Latysheva TV. Immunodeficiency: possible applications of immunomodulators. Lechashchii Vrach. 2001;(3):48-50 (In Russ.)
ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения Москвы», Москва, Россия
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L.M. Krums, A.I. Parfenov, R.B. Gudkova, S.V. Bykova, e.a. Sabelnikova
A.S. Loginov Moscow clinical scientific practical center, Moscow healthcare Department, Moscow, Russia