Первичные саркомы перикарда относят к крайне редким злокачественным опухолям сердца. Показано, что риск возникновения сарком сердца возрастает у больных после лучевой терапии на область грудной клетки. Особенностями представленного случая являются сложность и многоэтапность диагностики недифференцированной веретеноклеточной саркомы с локализацией в перикарде, а также несомненная связь данной патологии с проведенной 20 лет назад лучевой терапией по поводу лимфомы Ходжкина.
Primary sarcomas of the pericardium are extremely rare malignant tumors of the heart. The incidence of sarcoma increases after radiation therapy in the field of breast. The specific features of this case report are the difficulties in diagnostics of undifferentiated spindle-cell sarcoma of the pericardium and the connection between the disease and the radiation therapy for Hodgkin’s lymphoma.
Keywords: sarcoma of the pericardium, undifferentiated spindle-cell sarcoma, postradiation fibrosis pericarditis, radiation therapy, Hodgkin’s lymphoma, lymphogranulomatosis.
Список литературы
1. Maleszewski JJ, Anavekar NS. Neoplastic pericardial disease. Cardiol Clin. 2017;35(4):589-600. doi: 10.1016/j.ccl.2017.07.011
2. Neragi-Miadoab S, Kim J, Vlahakes GJ. Malignant tumors of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol. 2007;19(10):748-756. doi: 10.1016/j.clon.2007.06.009
3. Hoffmeler A, Sindermann JR, Scheld HH, Martens S. Cardiac tumors – diagnosis and surgical treatment. Deutsches Arzteblatt International. 2014;111(12):205-211. doi: 10.3238/arztebl.2014.0205
4. Burke A, Tavora F. The 2015 WHO classification of tumors of the heart and pericardium. J Thorac Oncol. 2015;11(4):441-452. doi: 10.1016/j. jtho.2015.11.009
5. Pacheco GN, Marcos G, Garciperezde Vargas FJ, et al. Intrapericardial paraganglioma. Revista Espan Cardiol. 2010;63(1):116-117.
doi: 10.1016/s.1885-5857(10).70020-7
6. Restrepo CS, Vargas D, Ocazionez D, et al. Primary pericardial tumors. RadioGraphics.2013;33(6):1613-1630. doi: 10.1148/rg.336135512
7. Barreiro M, Renilla A, Jimenez JM, et al. Primary cardiac tumors: 32 years of experience from Spanish tertiary surgical center. Cardiovasc Pathol. 2013:22(6):424-427. doi: 10.1016/j.carpath.2013.04.006
8. Burazor I, Aviel-Ronen S, Imazio M, et al. Primary malignancies of the heart and pericardium. Clin Cardiol. 2014:37(9):582-588. doi: 10.1002/clc.22295
9. Killion MJ, Brodovsky HS, Schwarting R. Pericardial angiosarcoma after mediastinal irradiation for seminoma. A case report and a review of the literature. Cancer. 1996;78(4):912-917. doi: 10.1002/(SICI)1097-0142(19960815)78:4<912::AID-CNCR31>3.0.CO;2-W
10. Sharma A, De Valeria PA, Scherber RM, et al. Angiosarcoma causing cardiac constriction late after radiation therapy for breast carcinoma. Tex Heart Inst J. 2016;43(1):81-83. doi: 10.14503/THIJ-14-4549
11. Rosai J. Rosai and Ackerman’s Surgical Pathology. 10th ed. Elsevier Mosby; 2011. Vol. 2. P. 2271-2306.
12. Agaimy A, Rosch J, Weyand M, Strecker T. Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center. Intern J Clin Exper Pathol. 2012;5(9):928-938.
13. Kumar AA. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Elsevier; 2015. P. 265-340.
14. Kirova YM, Vilcoq JR, Asselin B, et al. Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review. Cancer. 2005;104(4):856-863. doi: 10.1002/cncr.21223
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1. Maleszewski JJ, Anavekar NS. Neoplastic pericardial disease. Cardiol Clin. 2017;35(4):589-600. doi: 10.1016/j.ccl.2017.07.011
2. Neragi-Miadoab S, Kim J, Vlahakes GJ. Malignant tumors of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol. 2007;19(10):748-756. doi: 10.1016/j.clon.2007.06.009
3. Hoffmeler A, Sindermann JR, Scheld HH, Martens S. Cardiac tumors – diagnosis and surgical treatment. Deutsches Arzteblatt International. 2014;111(12):205-211. doi: 10.3238/arztebl.2014.0205
4. Burke A, Tavora F. The 2015 WHO classification of tumors of the heart and pericardium. J Thorac Oncol. 2015;11(4):441-452. doi: 10.1016/j. jtho.2015.11.009
5. Pacheco GN, Marcos G, Garciperezde Vargas FJ, et al. Intrapericardial paraganglioma. Revista Espan Cardiol. 2010;63(1):116-117.
doi: 10.1016/s.1885-5857(10).70020-7
6. Restrepo CS, Vargas D, Ocazionez D, et al. Primary pericardial tumors. RadioGraphics.2013;33(6):1613-1630. doi: 10.1148/rg.336135512
7. Barreiro M, Renilla A, Jimenez JM, et al. Primary cardiac tumors: 32 years of experience from Spanish tertiary surgical center. Cardiovasc Pathol. 2013:22(6):424-427. doi: 10.1016/j.carpath.2013.04.006
8. Burazor I, Aviel-Ronen S, Imazio M, et al. Primary malignancies of the heart and pericardium. Clin Cardiol. 2014:37(9):582-588. doi: 10.1002/clc.22295
9. Killion MJ, Brodovsky HS, Schwarting R. Pericardial angiosarcoma after mediastinal irradiation for seminoma. A case report and a review of the literature. Cancer. 1996;78(4):912-917. doi: 10.1002/(SICI)1097-0142(19960815)78:4<912::AID-CNCR31>3.0.CO;2-W
10. Sharma A, De Valeria PA, Scherber RM, et al. Angiosarcoma causing cardiac constriction late after radiation therapy for breast carcinoma. Tex Heart Inst J. 2016;43(1):81-83. doi: 10.14503/THIJ-14-4549
11. Rosai J. Rosai and Ackerman’s Surgical Pathology. 10th ed. Elsevier Mosby; 2011. Vol. 2. P. 2271-2306.
12. Agaimy A, Rosch J, Weyand M, Strecker T. Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center. Intern J Clin Exper Pathol. 2012;5(9):928-938.
13. Kumar AA. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Elsevier; 2015. P. 265-340.
14. Kirova YM, Vilcoq JR, Asselin B, et al. Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review. Cancer. 2005;104(4):856-863. doi: 10.1002/cncr.21223
1 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
1 I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia;
2 N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia