Российский консенсус по экзо- и эндокринной недостаточности поджелудочной железы после хирургического лечения

1. Andren-Sandberg A, Hardt PD. Second Giessen International Workshop on Interactions of Exocrine and Endocrine Pancreatic Diseases. Castle of Rauischholzhausen of the Justus-Liebig-university, Giessen (Rauischholzhausen), Germany. March 7-8, 2008. JOP. 2008 Jul 10;9(4):541-575.
2. Хатьков И.Е., Маев И.В., Абдулхаков С.Р. и др. Российский консенсус по диагностике и лечению хронического панкреатита. Терапевтический архив. 2017;2:105-113 [Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskiy Arkhiv. 2017;89(2):105-113 (In Russ.)] doi: 10.17116/terarkh2017892105-113
3. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081
4. Sabater L, Ausania F, Bakker OJ, et al Evidence-based guidelines for the management of exocrine pancreatic insufficiency after pancreatic surgery. Ann Surg. 2016;264(6):949-958. doi: 10.1097/SLA.0000000000001732
5. Linstone H, Turoff M. The Delphi method: Techniques and applications. URL: http://www.is.njit.edu/pubs/delphibook
6. Symersky T, van Hoorn B, Masclee AA The outcome of a long-term follow-up of pancreatic function after recovery from acute pancreatitis. JOP. 2006 Sep 10;7(5):447-453.
7. Rana SS, Bhasin DK, Rao C, et al. Comparative evaluation of structural and functional changes in pancreas after endoscopic and surgical management of pancreatic necrosis. Ann Gastroenterol. 2014;27:162-166.
8. Gupta R, Wig JD, Bhasin DK, et al. Severe acute pancreatitis: the life after. J Gastrointest Surg. 2009;13(7):1328-1336. doi: 10.1007/s11605-009-0901-z. Epub 2009 May 5.
9. Boreham B, Ammori BJ. A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 2003;3(4):303-308. doi: 10.1159/000071768
10. Garip G, Sarandöl E, Kaya E. Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis. World J Gastroenterol. 2013 Nov 28;19(44):8065-8070. doi: 10.3748/wjg.v19.i44.8065
11. Омельянович Д.А. Отдаленные результаты лечения тяжелого острого панкреатита. Дисс... к.м.н. Москва; 2015 [Omelyanovich DA. Otdalennye rezul’taty lecheniya tyazhelogo ostrogo pankreatita [Long-term results of treatment of severe acute pancreatitis]. Thesis for the degree of candidate of medical sciences. Moscow; 2015 (In Russ.)].
12. Bornman PC, Botha JF, Ramos JM, et al. Guideline for the diagnosis and treatment of chronic pancreatitis. S Afr Med J. 2010;100(12):845-860.
13. Chakraborty PP, Chowdhury S. A look inside the pancreas: The «Endocrine-exocrine Cross-talk». Endocrinol Metab Synd. 2015;4(1):160-164.
14. Pezzilli R, Andriulli A, Bassi C, et al. Exocrine Pancreatic Insufficiency collaborative (EPIc) Group. Exocrine pancreatic insufficiency in adults: A shared position statement of the Italian association for the study of the pancreas. World J Gastroenterol. 2013;19(44):7930-7946. doi: 10.3748/wjg.v19.i44.7930
15. Czakó L, Hegyi P, Rakonczay Z Jr, et al. Interactions between the endocrine and exocrine pancreas and their clinical relevance. Pancreatology. 2009;9(4):351-359. doi: 10.1159/000181169
16. De-Madaria E, Abad-González A, Aparicio JR, et al. The Spanish Pancreatic Club’s recommendations for the diagnosis and treatment of chronic pancreatitis: part 2 (treatment). Pancreatology. 2013;13(1):18-28. doi: 10.1016/j.pan.2012.11.310
17. Шевченко Б.Ф., Бабий А.М., Макарчук В.А. Морфофункциональное состояние поджелудочной железы на этапах ее фиброзной трансформации при хроническом панкреатите. Вісник проблем біології і медицини. 2014;4(113):305-312 [Shevchenko BF, Babiy AM, Makarchuk VA. Morphofunctional state of the pancreas at the stages of its fibrous transformation in chronic pancreatitis. Vіsnik problem bіologії і meditsini = Bulletin of Problems of Biology and Medicine. 2014;4(113):305-312 (In Russ.)].
18. Matsumoto J, Traverso LW. Exocrine function following the Whipple operation as assessed by stool elastase. J Gastrointest Surg. 2006;10(9):1225-1229. doi: 10.1016/j.gassur.2006.08.001
19. Roeyen G, Berrevoet F. Pancreatic exocrine insufficiency after pancreaticoduodenectomy is more prevalent with pancreaticogastrostomy than with pancreaticojejunostomy. A retrospective multicenter observational cohort study. HPB (Oxford). 2016;18(12):1017-1022. 
doi: 10.1016/j.hpb.2016.09.002
20. Sikkens EC, Cahen DL, de Wit J, et al. A prospective assessment of the natural course of the exocrine pancreatic function in patients with a pancreatic head tumor. J Clin Gastroenterol. 2014;48(5):e43-е46. 
doi: 10.1097/MCG.0b013e31829f56e7
21. Yuasa Y, Murakami Y, Nakamura H, Uemura K, Ohge H, Sudo T, Hashimoto Y, Nakashima A, Hiyama E, Sueda T. Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery. Pancreas. 2012;41(6):928-933. doi: 10.1097/MPA. 0b013e31823d837d
22. Halloran CM, Cox TF, Chauhan S, et al. Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study. Pancreatology. 2011;11:535-545. doi: 10.1159/000333308
23. Speicher JE, Traverso LW. Pancreatic exocrine function is preserved after distal pancreatectomy. PMID: 20387129. doi: 10.1007/s11605-010-1184-0
24. Bartel MJ, Asbun H, Stauffer J, Raimondo M. Pancreatic exocrine insufficiency in pancreatic cancer: A review of the literature. Dig Liver Dis. 2015;47(12):1013-1020. doi: 10.1016/j.dld.2015.06.015
25. Vincent A, Herman J, Schulick R, et al. Pancreatic cancer. Lancet. 2011;378(9791):607-620. doi: 10.1016/S0140-6736(10)62307-0
26. Hart PA, Chari ST. Diabetes mellitus and pancreatic cancer: why the association matters? Pancreas. 2013;42(8):1207-1209. doi: 10.1097/ MPA. 0b013e3182a7c963
27. Muniraj T, Chari ST. Diabetes and pancreatic cancer. Minerva Gastroenterol Dietol. 2012;58(4):331-345.
28. Schmied BM, Ulrich AB, Matsuzaki H, et al. Alteration of the Langerhans islets n pancreatic cancer patients. Int J Pancreatol. 2000;28:187-197.
29. Wu X, Zhang Q, Wang X, et al. Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS One. 2012;7(8):e41976. doi: 10.1371/journal.pone.0041976
30. Partelli S, Frulloni L, Minniti C, et al. Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer. Dig Liver Dis. 2012;44(11):945-951. doi: 10.1016/j.dld.2012.05.017. Epub 2012 Jun 28.
31. Tseng DS, Molenaar IQ, Besselink MG, et al. Pancreatic Exocrine Insufficiencyin Patients With Pancreatic or Periampullary Cancer: A Systematic Review. Pancreas. 2016;45(3):325-330. doi: 10.1097/MPA. 0000000000000473
32. Ghaneh P, Neoptolemos JP. Exocrine pancreatic function following pancreatectomy. Ann N Y Acad Sci. 1999;880:308-318.
33. Lemaire E, O’Toole D, Sauvanet A, et al. Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis. Br J Surg. 2000;87(4):434-438.
34. Dominguez-Munoz JE. Pancreatic exocrine insufficiency: diagnosis and treatment. J Gastroenterol Hepatol. 2011;26 Suppl 2:12-16. 
doi: 10.1111/j.1440-1746.2010.06600.x
35. Kahl S, Malfertheiner P. Exocrine and endocrine pancreatic insufficiency after pancreatic surgery. Best Pract Res Clin Gastroenterol. 2004;18(5):947-955.
36. Yang CJ, Bliss LA, Schapira EF, et al. Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention. J Gastrointest Surg. 2014;18(10):1863-1869. 
doi: 10.1007/s11605-014-2571-8
37. Винокурова Л.В., Бордин Д.С., Дубцова Е.А. и др. Некоторые аспекты лечения больных после операций на поджелудочной железе. Consilium Medicum. 2015;(8):38-41 [Vinokurova LV, Bordin DS, Dubtsova EA, et al. Some aspects of treatment of patients after operations on the pancreas. Consilium Medicum. 2015;8:38-41 (In Russ.)].
38. Phillips ME. Pancreatic exocrine insufficiency following pancreatic resection. Pancreatology. 2015;15(5):449-455. doi: 10.1016/j.pan.2015.06.003
39. Morera-Ocon FJ, Sabater-Orti L, Muñoz-Forner E, et al. Considerations on pancreatic exocrine function after pancreaticoduodenectomy. World J Gastrointest Oncol. 2014;6(9):325-329. doi: 10.4251/wjgo. v6.i9.325
40. Kang CM, Lee JH. Pathophysiology after pancreaticoduodenectomy. World J Gastroenterol. 2015;21(19):5794-5804. doi: 10.3748/wjg. v21.i19.5794
41. Lim PW, Dinh KH, Sullivan M, et al. Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection. HPB. 2016;18(4):360-366. doi: 10.1016/j.hpb.2015.11.003
42. Nakamura H, Murakami Y, Uemura K, et al. Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. J Gastrointest Surg. 2009;13(7):1321-1327. doi: 10.1007/s11605-009-0896-5
43. Валиев Р.К., Файнштейн И.А., Нечушкин М.И., Нурбердыев М.Б. Оценка внешнесекреторной функции поджелудочной железы после панкреатодуоденальной резекции. Вестник ФГБУ РОНЦ им. Н.Н. Блохина. 2015;26(1):59-61 [Valiev RK, Fainstein IA, Nechushkin MI, Nurberdyev MB. Evaluation of the exocrine function of the pancreas after pancreatoduodenal resection. Bulletin of the FGBU RCRC n.a. NN Blokhin. 2015;26(1):59-61 (In Russ.)].
44. Лядов В.К., Новожилов Н.В. Лекарственная терапия после операций на поджелудочной железе: обзор литературы. Гастроэнтерология. 2015;(2):21-25 [Lyadov VK, Novozhilov NV. Drug therapy after operations on the pancreas: a review of the literature. Gastroenterologiya = Gastroenterology. 2015;(2):21-25 (In Russ.)].
45. Nakamura H, Murakami Y, Uemura K, et al. Reduced pancreatic parenchymal thickness indicates exocrine pancreatic insufficiency after pancreatoduodenectomy. J Surg Res. 2011;171(2):473-478. doi: 10. 1016/j.jss.2010.03.052
46. Российское общество хирургов. Ассоциация гепатопанкреатобилиарных хирургов стран СНГ. Клинические рекомендации по хирургическому лечению больных хроническим панкреатитом, 2014 [Russian Society of Surgeons. Association of hepatopancreatobiliary surgeons of CIS countries. Clinical recommendations for surgical treatment of patients with chronic pancreatitis, 2014 (In Russ.)]. Доступно по ссылке: http://xn——9sbdbejx7bdduahou3a5d.xn—p1ai/stranica-pravlenija/unkr/abdominalnaja-hirurgija/klinichesk.... html
47. Frulloni L, Falconi M, Gabbrielli A, et al. Italian consensus guidelines for chronic pancreatitis. Dig Liver Dis. 2010;42 Suppl 6:S381-406. doi: 10.1016/S1590-8658(10)60682-2
48. Bachmann K, Tomkoetter L, Erbes J, et al. Beger and Frey procedures for treatment of chronic pancreatitis: comparison of jutcomes at 16-year follow-up. J Am Coll Surg. 2014;219(2):208-216. doi: 10.1016/
j.jamcollsurg.2014.03.040
49. Müller MW, Friess H, Martin DJ, et al. Long-term follow-up of a randomized clinical trial comparing Beger with pylorus-preserving Whipple procedure for chronic pancreatitis. Br J Surg. 2008;95(3):350-356.
50. Strate T, Bachmann K, Busch P, et al. Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomizedtrial. Gastroenterology. 2008;134(5):1406-1411. doi: 10.1053/j.gastro. 2008.02.056
51. Zhou Y, Zhao M, Wu L, et al. Short- and long-term outcomes after enucleation of pancreatic tumors: An evidence-based assessment. Pancreatology. 2016;16(6):1092-1098. doi: 10.1016/j.pan.2016.07.006
52. Jilesen AP, van Eijck CH, Busch OR, et al. Postoperative Outcomes of Enucleation and Standard Resections in Patients with a Pancreatic Neuroendocrine Tumor. World J Surg. 2016;40(3):715-728. doi: 10.1007/ s00268-015-3341-9
53. Crippa S, Bassi C, Warshaw AL, et al. Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg. 2007;246(1):69-76. doi: 10.1097/01.sla.0000262790.51512.57
54. Keim V, Klar E, et al. Postoperative care following pancreatic surgery: surveillance and treatment. Deut Arzteblatt Intern. 2009;106(48):789-794. doi: 10.3238/arztebl.2009.0789
55. Kang JS, Jang JY, Kang MJ, et al. Endocrine Function Impairment After Distal Pancreatectomy: Incidence and Related Factors. World 
J Surg. 2016;40(2):440-446. doi: 10.1007/s00268-015-3228-9
56. Dominguez-Munoz JE, Iglesias-Garcia J, Vilarino-Insua M, Iglesias-Rey M. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2007;5(4):484-488. doi: 10.1016/j.cgh.2007.01.004
57. Ивашкин В.Т., Маев И.В., Охлобыстин А.В. и др. Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению хронического панкреатита. Российский журнал гастроэнтерологии, гепатологии и колопроктологии. 2014; 24(4):70-97 [Ivashkin VT, Maev IV, Okhlobystin AV, et al. Guidelines of the Russian gastroenterological association on diagnostics and treatment of a chronic pancreatitis. Rossiyskiy Zhurnal Gastroenterologii, Gepatologii i Koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014; 24(4):70-97 (In Russ.)].
58. Lohr JM. Exocrine pancreatic insufficiency. Bremen: UNI-MED; 2010. 91 p.
59. Sikkens EC, Cahen DL, van Eijck C, et al. Patients with exocrine insufficiency due to chronic pancreatitis are undertreated: a Dutch national survey. Pancreatology. 2012;12(1):71-73. doi: 10.1016/j.pan .2011.12.010
60. Forsmark CE. Chronic pancreatitis and malabsorption. Am J Gastroenterol. 2004;99(7):1355-1357. doi: 10.1111/j.1572-0241.2004.70661.x
61. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-132.
62. Nils Ewald N, Hardt PD. Diagnosis and treatment of diabetes mellitus in chronic pancreatitis. World J Gastroenterol. 2013;19(42):7276-7281. doi: 10.3748/wjg.v19.i42.7276
63. Rickels MR, Bellin M, Toledo FG, et al. PancreasFest Recommendation Conference Participants. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from Pancreas Fest 2012. Pancreatology. 2013;13(4):336-342. doi: 10.1016/ j.pan.2013.05.002
64. Meier JJ, Giese A. Diabetes Associated With Pancreatic Diseases. 
Curr Opin Gastroenterol. 2015;31(5):400-406. doi: 10.1097/MOG. 0000000000000199
65. Makuk J. Management of pancreatogenic diabetes: challenges and solutions. Diabetes Metab Syndr Obes. 2016;9:311-315. doi: 10.2147/ DMSO.S99701. eCollection 2016
66. Olson DE, Rhee MK, Herrick K, et al. Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria. Diabetes Care. 2010;33(10):2184-2189. doi: 10.2337/dc10-0433
67. Kondrup J, Rasmussen HH, Hamberg O, Stanga Z. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22:321-336.
68. Sorensen J, Kondrup J, Prokopowicz J, et al. EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome. Clin Nutr. 2008;27(3):340-349. doi: 10.1016/ j.clnu.2008.03.012
69. Ockenga J. Importance of nutritional management in diseases with exocrine pancreatic insufficiency. HPB (Oxford). 2009;11 Suppl 3:11-15. doi: 10.1111/j.1477-2574.2009.00134.x
70. Goess R, Ceyhan GO, Friess H. Pancreatic exocrine insufficiency after pancreatic surgery. Panminerva Med. 2016;58(2):151-159.
71. Hashimoto D, Chikamoto A, Ohmuraya M, et al. Impact of postoperative weight loss on survival after resection for pancreatic cancer. JPEN. 2015;39(5):598-603. doi: 10.1177/0148607114520992
72. Augustin T, Burstein MD, Schneider EB, et al. Frailty predicts risk of life-threating complications and mortality after pancreatic resections. Surgery. 2016;160(4):987-996. doi: 10.1016/j.surg.2016.07.010
73. Onesti JK, Wright GP, Kenning SE, et al. Sarcopenia and survival in patients undergoing pancretic resection. Pancreatology. 2016;16(2):284-289. doi: 10.1016/j.pan.2016.01.009
74. Lohr JM, Oliver MR, Frulloni L. Synopsis of recent guidelines on pancreatic exocrine insufficiency. UEGJ. 2013;1(2):79-83. doi: 10.1177/ 2050640613476500
75. Earthman C, Traughber D, Dobratz J, Howell W. Bioimpedance spectroscopy for clinical assessment of fluid distribution and body cell mass. Nutr Clin Pract. 2007;22(4):389-405. doi: 10.1177/ 0115426507022004389
76. Mulasi U, Kuchnia AJ, Cole AJ, Earthman CP. Bioimpedance at the bedside: current applications, limitations, and opportunities. Nutr Clin Pract. 2015;30(2):180-193. doi: 10.1177/0884533614568155
77. Armstrong T, Strommer L, Ruiz-Jasbon F, et al. Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficiencies. Pancreatology. 2007;7(1):37-44. doi: 10.1159/000101876
78. Duggan SN, Smyth ND, O’Sullivan M, et al. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis. Nutr Clin Prac. 2014;29(3):348-354. doi: 10.1177/0884533614528361
79. Nakamura T, Takebe K, Imamura K, et al. Fatsoluble vitamins in patients with chronic pancreatitis (pancreatic insufficiency). Acta Gastroenterol Belg. 1996;59(1):10-14.
80. Klapdor S, Richter E, Klapdor R. Vitamin D status and per-oral vitamin D supplementation in patients suffering from chronic pancreatitis and pancreatic cancer disease. Anticancer Res. 2012;32(5):1991-1998.
81. Lindkvist B, Domínguez-Munoz JE, Luaces-Regueira M, et al. Serum nutritional markers for prediction of pancreatic exocrinein sufficiency in chronic pancreatitis. Pancreatology. 2012;12(4):305-310. doi: 10. 1016/j.pan.2012.04.006
82. Park JS, Chung HK, Hwang HK, et al. Postoperative nutritional effects of early enteral feeding compared with total parental nutrition in pancreaticoduodectomy patients: a prosepective, randomized study. J Korean Med Sci. 2012;27(3):261-267. doi: 10.3346/jkms.2012.27.3.261
83. Berry AJ. Pancreatic surgery: indications, complications, and implications for nutrition intervention. Nutr Clin Pract. 2013;28(3):330-357. doi: 10.1177/0884533612470845
84. Кучерявый Ю. А., Маев И. В., Москалева А. Б. и др. Влияние нутритивного статуса на течение хронического панкреатита. Медицинский совет. 2012;(2):100-104 [Kucheryavy YuA, Maev IV, Moskaleva AB, et al. Influence of the nutritional status on the course of chronic pancreatitis. Medical Council. 2012;(2):100-104 (In Russ.)].
85. Dujsikova H, Dite P, Tomandl J, et al. Occurrence of metabolic osteopathy in patients with chronic pancreatitis. Pancreatology. 2008;8(6):583-586. doi: 10.1159/000159845
86. Чернышова И.В., Дроздов В.Н., Винокурова Л.В. и др. Экзокринная недостаточность поджелудочной железы и нарушения минеральной плотности костной ткани у больных хроническим панкреатитом. Вестник клуба панкреатологов. 2010;(1):52-54 [Chernyshova IV, Drozdov VN, Vinokurova LV, et al. Exocrine pancreatic insufficiency and bone mineral density disorders in patients with chronic pancreatitis. Vestnik Kluba Pankreatologov = Bulletin of the Club of Pancreatologists. 2010;(1):52-54 (In Russ.)].
87. Duggan SN, O’Sullivan M, Hamilton S, et al. Patients with chronic pancreatitis are at increased risk for osteoporosis. Pancreas. 2012;41(7):1119-1124. doi: 10.1097/MPA.0b013e31824abb4d
88. Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts. A populationbased study. Lancet Oncol. 2008;9(7):629-635. doi: 10.1016/S1470-2045(08)70153-0
89. Mourtzakis M, Prado CM, Lieffers JR, et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008;33(5):997-1006. doi: 10.1139/H08-075
90. Gomez-Perez SL, Haus JM, Sheean P, et al. Measuring Abdominal Circumference and Skeletal Muscle From a Single Cross-Sectional Computed Tomography Image: A Step-by-Step Guide for Clinicians Using National Institutes of Health Image. J Parenter Enteral Nutr. 2016;40(3):308-318. doi: 10.1177/0148607115604149
91. Kilgour RD, Cardiff K, Rosenthall L, et al. Use of prediction equations to determine the accuracy of whole-body fat and fat-free mass and appendicular skeletal muscle mass measurements from a single abdominal image using computed tomography in advanced cancer patients. Appl Physiol Nutr Metab. 2016;41(1):70-75. doi: 10.1139/apnm-2015-0068
92. Baker ST, Strauss BJ, Prendergast LA, et al. Estimating dual-energy X-ray absorptiometry-derived total body skeletal muscle mass using single-slice abdominal magnetic resonance imaging in obese subjects with and without diabetes: a pilot study. Eur J Clin Nutr. 2012;66(5):628-632. doi: 10.1038/ejcn.2012.3
93. Hoffmeister A, Mayerle J, Beglinge C, et al. English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis. Z Gastroenterol. 2015;53(12): 1447-1495. doi: 10.1055/s-0041-107379
94. Smith RC, Smith SF, Wilson J, et al. Summary and recommendations from the Australasian guidelines for the management of pancreatic exocrine insufficiency. Working Party of the Australasian Pancreatic Club. Pancreatology. 2016;16(2):164-180. doi: 10.1016/j.pan.2015. 12.006
95. Хатьков И.Е., Маев И.В., Бордин Д.С. и др. Российский консенсус по диагностике и лечению хронического панкреатита: заместительная ферментная терапия. Терапевтический архив. 2017;89(8):80-87 [Khatkov IE, Maev IV, Bordin DS, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis: Enzyme replacement therapy. Terapevticheskiy Arkhiv. 2017;89(8):80-87 (In Russ.)]. doi: 10.17116/terarkh201789880-87
96. Somaraju UR, Solis-Moya A. Pancreatic enzyme replacement therapy for people with cystic fibrosis. Cochrane Database Syst Rev. 2014;10:CD008227. doi: 10.1002/14651858.CD008227.pub2
97. Dominguez-Munoz JE. Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. HPB (Oxford). 2009;11 Suppl 3:3-6. doi: 10.1111/j.1477-2574.2009.00132.x
98. Conwell DL, Lee LS, Yadav D, et al. American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43(8):1143-1162. doi: 10.1097/ MPA.0000000000000237
99. Ito T, Ishiguro H, Ohara H, et al. Evidence-based clinical practice guidelines for chronic pancreatitis 2015. J Gastroenterol. 2016;51(2):85-92. doi: 10.1007/s00535-015-1149-x
100. Sadeghi N, Abbruzzese JL, Yeung SC, et al. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res. 2012;18:2905-2912.
101. Delhaye M, van Steenbergen W, Cesmeli E, et al. Belgian consensus on chronic pancreatitis in adults and children: statements on diagnosis and nutritional, medical, and surgical treatment. Acta Gastroenterol Belg. 2014;77(1):47-65.
102. Forsmark CE. Management of Chronic Pancreatitis. Gastroenterology. 2013;144(6):1282-1291.e3. doi: 10.1053/j.gastro.2013.02.008
103. Karpoff H, Klimstra DS, Brennan MF, Conlon KC. Results of total pancreatectomy for adenocarcinoma of the pancreas. Arch Surg. 2001;136(1):44-47.
104. Егоров В.И., Вишневский В.А., Коваленко З.А. и др. Тотальная панкреатэктомия. Хирургия. Журнал имени Н.И. Пирогова. 2012;(7):85-92 [Egorov VI, Vishnevsky VA, Kovalenko ZA, et al. Total pancreatectomy. Khirurgiya. Zhurnal imeni N.I. Pirogova = Surgery. Journal n.a. N.I. Pirogov. 2012;(7):85-92 (In Russ.)].
105. Кучерявый Ю.А. Внешнесекреторная панкреатическая недостаточность после оперативных вмешательств на желудке и поджелудочной железе. Хирургия. Приложение к журналу Consilium Medicum. 2012;(1):42-46 [Kucheryavyy YuA. External secretory pancreatic insufficiency after surgical interventions on the stomach and pancreas. Khirurgiya. Prilozhenie k zhurnalu Consilium Medicum = Surgery. Supplement to the journal Consilium Medicum. 2012;(1):42-46 (In Russ.)].
106. Tran TC, van Hof G, Kazemier G, et al. Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy. Dig Surg. 2008;25(4):311-318. doi: 10.1159/000158596
107. Ito K. Duodenum preservation in pancreatic head resection to maintain pancreatic exocrine function (determined by pancreatic function diagnostant test and cholecystokinin secretion). J Hepatobiliary Pancreat Surg. 2005;12(2):123-128. doi: 10.1007/s00534-004-0954-z

________________________________________________

1. Andren-Sandberg A, Hardt PD. Second Giessen International Workshop on Interactions of Exocrine and Endocrine Pancreatic Diseases. Castle of Rauischholzhausen of the Justus-Liebig-university, Giessen (Rauischholzhausen), Germany. March 7-8, 2008. JOP. 2008 Jul 10;9(4):541-575.
2.  [Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskiy Arkhiv. 2017;89(2):105-113 (In Russ.)] doi: 10.17116/terarkh2017892105-113
3. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081
4. Sabater L, Ausania F, Bakker OJ, et al Evidence-based guidelines for the management of exocrine pancreatic insufficiency after pancreatic surgery. Ann Surg. 2016;264(6):949-958. doi: 10.1097/SLA.0000000000001732
5. Linstone H, Turoff M. The Delphi method: Techniques and applications. URL: http://www.is.njit.edu/pubs/delphibook
6. Symersky T, van Hoorn B, Masclee AA The outcome of a long-term follow-up of pancreatic function after recovery from acute pancreatitis. JOP. 2006 Sep 10;7(5):447-453.
7. Rana SS, Bhasin DK, Rao C, et al. Comparative evaluation of structural and functional changes in pancreas after endoscopic and surgical management of pancreatic necrosis. Ann Gastroenterol. 2014;27:162-166.
8. Gupta R, Wig JD, Bhasin DK, et al. Severe acute pancreatitis: the life after. J Gastrointest Surg. 2009;13(7):1328-1336. doi: 10.1007/s11605-009-0901-z. Epub 2009 May 5.
9. Boreham B, Ammori BJ. A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 2003;3(4):303-308. doi: 10.1159/000071768
10. Garip G, Sarandöl E, Kaya E. Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis. World J Gastroenterol. 2013 Nov 28;19(44):8065-8070. doi: 10.3748/wjg.v19.i44.8065
11.  [Omelyanovich DA. Otdalennye rezul’taty lecheniya tyazhelogo ostrogo pankreatita [Long-term results of treatment of severe acute pancreatitis]. Thesis for the degree of candidate of medical sciences. Moscow; 2015 (In Russ.)].
12. Bornman PC, Botha JF, Ramos JM, et al. Guideline for the diagnosis and treatment of chronic pancreatitis. S Afr Med J. 2010;100(12):845-860.
13. Chakraborty PP, Chowdhury S. A look inside the pancreas: The «Endocrine-exocrine Cross-talk». Endocrinol Metab Synd. 2015;4(1):160-164.
14. Pezzilli R, Andriulli A, Bassi C, et al. Exocrine Pancreatic Insufficiency collaborative (EPIc) Group. Exocrine pancreatic insufficiency in adults: A shared position statement of the Italian association for the study of the pancreas. World J Gastroenterol. 2013;19(44):7930-7946. doi: 10.3748/wjg.v19.i44.7930
15. Czakó L, Hegyi P, Rakonczay Z Jr, et al. Interactions between the endocrine and exocrine pancreas and their clinical relevance. Pancreatology. 2009;9(4):351-359. doi: 10.1159/000181169
16. De-Madaria E, Abad-González A, Aparicio JR, et al. The Spanish Pancreatic Club’s recommendations for the diagnosis and treatment of chronic pancreatitis: part 2 (treatment). Pancreatology. 2013;13(1):18-28. doi: 10.1016/j.pan.2012.11.310
17. [Shevchenko BF, Babiy AM, Makarchuk VA. Morphofunctional state of the pancreas at the stages of its fibrous transformation in chronic pancreatitis. Vіsnik problem bіologії і meditsini = Bulletin of Problems of Biology and Medicine. 2014;4(113):305-312 (In Russ.)].
18. Matsumoto J, Traverso LW. Exocrine function following the Whipple operation as assessed by stool elastase. J Gastrointest Surg. 2006;10(9):1225-1229. doi: 10.1016/j.gassur.2006.08.001
19. Roeyen G, Berrevoet F. Pancreatic exocrine insufficiency after pancreaticoduodenectomy is more prevalent with pancreaticogastrostomy than with pancreaticojejunostomy. A retrospective multicenter observational cohort study. HPB (Oxford). 2016;18(12):1017-1022. 
doi: 10.1016/j.hpb.2016.09.002
20. Sikkens EC, Cahen DL, de Wit J, et al. A prospective assessment of the natural course of the exocrine pancreatic function in patients with a pancreatic head tumor. J Clin Gastroenterol. 2014;48(5):e43-е46. 
doi: 10.1097/MCG.0b013e31829f56e7
21. Yuasa Y, Murakami Y, Nakamura H, Uemura K, Ohge H, Sudo T, Hashimoto Y, Nakashima A, Hiyama E, Sueda T. Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery. Pancreas. 2012;41(6):928-933. doi: 10.1097/MPA. 0b013e31823d837d
22. Halloran CM, Cox TF, Chauhan S, et al. Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study. Pancreatology. 2011;11:535-545. doi: 10.1159/000333308
23. Speicher JE, Traverso LW. Pancreatic exocrine function is preserved after distal pancreatectomy. PMID: 20387129. doi: 10.1007/s11605-010-1184-0
24. Bartel MJ, Asbun H, Stauffer J, Raimondo M. Pancreatic exocrine insufficiency in pancreatic cancer: A review of the literature. Dig Liver Dis. 2015;47(12):1013-1020. doi: 10.1016/j.dld.2015.06.015
25. Vincent A, Herman J, Schulick R, et al. Pancreatic cancer. Lancet. 2011;378(9791):607-620. doi: 10.1016/S0140-6736(10)62307-0
26. Hart PA, Chari ST. Diabetes mellitus and pancreatic cancer: why the association matters? Pancreas. 2013;42(8):1207-1209. doi: 10.1097/ MPA. 0b013e3182a7c963
27. Muniraj T, Chari ST. Diabetes and pancreatic cancer. Minerva Gastroenterol Dietol. 2012;58(4):331-345.
28. Schmied BM, Ulrich AB, Matsuzaki H, et al. Alteration of the Langerhans islets n pancreatic cancer patients. Int J Pancreatol. 2000;28:187-197.
29. Wu X, Zhang Q, Wang X, et al. Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS One. 2012;7(8):e41976. doi: 10.1371/journal.pone.0041976
30. Partelli S, Frulloni L, Minniti C, et al. Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer. Dig Liver Dis. 2012;44(11):945-951. doi: 10.1016/j.dld.2012.05.017. Epub 2012 Jun 28.
31. Tseng DS, Molenaar IQ, Besselink MG, et al. Pancreatic Exocrine Insufficiencyin Patients With Pancreatic or Periampullary Cancer: A Systematic Review. Pancreas. 2016;45(3):325-330. doi: 10.1097/MPA. 0000000000000473
32. Ghaneh P, Neoptolemos JP. Exocrine pancreatic function following pancreatectomy. Ann N Y Acad Sci. 1999;880:308-318.
33. Lemaire E, O’Toole D, Sauvanet A, et al. Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis. Br J Surg. 2000;87(4):434-438.
34. Dominguez-Munoz JE. Pancreatic exocrine insufficiency: diagnosis and treatment. J Gastroenterol Hepatol. 2011;26 Suppl 2:12-16. 
doi: 10.1111/j.1440-1746.2010.06600.x
35. Kahl S, Malfertheiner P. Exocrine and endocrine pancreatic insufficiency after pancreatic surgery. Best Pract Res Clin Gastroenterol. 2004;18(5):947-955.
36. Yang CJ, Bliss LA, Schapira EF, et al. Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention. J Gastrointest Surg. 2014;18(10):1863-1869. 
doi: 10.1007/s11605-014-2571-8
37. [Vinokurova LV, Bordin DS, Dubtsova EA, et al. Some aspects of treatment of patients after operations on the pancreas. Consilium Medicum. 2015;8:38-41 (In Russ.)].
38. Phillips ME. Pancreatic exocrine insufficiency following pancreatic resection. Pancreatology. 2015;15(5):449-455. doi: 10.1016/j.pan.2015.06.003
39. Morera-Ocon FJ, Sabater-Orti L, Muñoz-Forner E, et al. Considerations on pancreatic exocrine function after pancreaticoduodenectomy. World J Gastrointest Oncol. 2014;6(9):325-329. doi: 10.4251/wjgo. v6.i9.325
40. Kang CM, Lee JH. Pathophysiology after pancreaticoduodenectomy. World J Gastroenterol. 2015;21(19):5794-5804. doi: 10.3748/wjg. v21.i19.5794
41. Lim PW, Dinh KH, Sullivan M, et al. Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection. HPB. 2016;18(4):360-366. doi: 10.1016/j.hpb.2015.11.003
42. Nakamura H, Murakami Y, Uemura K, et al. Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. J Gastrointest Surg. 2009;13(7):1321-1327. doi: 10.1007/s11605-009-0896-5
43. [Valiev RK, Fainstein IA, Nechushkin MI, Nurberdyev MB. Evaluation of the exocrine function of the pancreas after pancreatoduodenal resection. Bulletin of the FGBU RCRC n.a. NN Blokhin. 2015;26(1):59-61 (In Russ.)].
44. [Lyadov VK, Novozhilov NV. Drug therapy after operations on the pancreas: a review of the literature. Gastroenterologiya = Gastroenterology. 2015;(2):21-25 (In Russ.)].
45. Nakamura H, Murakami Y, Uemura K, et al. Reduced pancreatic parenchymal thickness indicates exocrine pancreatic insufficiency after pancreatoduodenectomy. J Surg Res. 2011;171(2):473-478. doi: 10. 1016/j.jss.2010.03.052
46.  [Russian Society of Surgeons. Association of hepatopancreatobiliary surgeons of CIS countries. Clinical recommendations for surgical treatment of patients with chronic pancreatitis, 2014 (In Russ.)]. Доступно по ссылке: http://xn——9sbdbejx7bdduahou3a5d.xn—p1ai/stranica-pravlenija/unkr/abdominalnaja-hirurgija/klinichesk.... html
47. Frulloni L, Falconi M, Gabbrielli A, et al. Italian consensus guidelines for chronic pancreatitis. Dig Liver Dis. 2010;42 Suppl 6:S381-406. doi: 10.1016/S1590-8658(10)60682-2
48. Bachmann K, Tomkoetter L, Erbes J, et al. Beger and Frey procedures for treatment of chronic pancreatitis: comparison of jutcomes at 16-year follow-up. J Am Coll Surg. 2014;219(2):208-216. doi: 10.1016/
j.jamcollsurg.2014.03.040
49. Müller MW, Friess H, Martin DJ, et al. Long-term follow-up of a randomized clinical trial comparing Beger with pylorus-preserving Whipple procedure for chronic pancreatitis. Br J Surg. 2008;95(3):350-356.
50. Strate T, Bachmann K, Busch P, et al. Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomizedtrial. Gastroenterology. 2008;134(5):1406-1411. doi: 10.1053/j.gastro. 2008.02.056
51. Zhou Y, Zhao M, Wu L, et al. Short- and long-term outcomes after enucleation of pancreatic tumors: An evidence-based assessment. Pancreatology. 2016;16(6):1092-1098. doi: 10.1016/j.pan.2016.07.006
52. Jilesen AP, van Eijck CH, Busch OR, et al. Postoperative Outcomes of Enucleation and Standard Resections in Patients with a Pancreatic Neuroendocrine Tumor. World J Surg. 2016;40(3):715-728. doi: 10.1007/ s00268-015-3341-9
53. Crippa S, Bassi C, Warshaw AL, et al. Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg. 2007;246(1):69-76. doi: 10.1097/01.sla.0000262790.51512.57
54. Keim V, Klar E, et al. Postoperative care following pancreatic surgery: surveillance and treatment. Deut Arzteblatt Intern. 2009;106(48):789-794. doi: 10.3238/arztebl.2009.0789
55. Kang JS, Jang JY, Kang MJ, et al. Endocrine Function Impairment After Distal Pancreatectomy: Incidence and Related Factors. World 
J Surg. 2016;40(2):440-446. doi: 10.1007/s00268-015-3228-9
56. Dominguez-Munoz JE, Iglesias-Garcia J, Vilarino-Insua M, Iglesias-Rey M. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2007;5(4):484-488. doi: 10.1016/j.cgh.2007.01.004
57.[Ivashkin VT, Maev IV, Okhlobystin AV, et al. Guidelines of the Russian gastroenterological association on diagnostics and treatment of a chronic pancreatitis. Rossiyskiy Zhurnal Gastroenterologii, Gepatologii i Koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014; 24(4):70-97 (In Russ.)].
58. Lohr JM. Exocrine pancreatic insufficiency. Bremen: UNI-MED; 2010. 91 p.
59. Sikkens EC, Cahen DL, van Eijck C, et al. Patients with exocrine insufficiency due to chronic pancreatitis are undertreated: a Dutch national survey. Pancreatology. 2012;12(1):71-73. doi: 10.1016/j.pan .2011.12.010
60. Forsmark CE. Chronic pancreatitis and malabsorption. Am J Gastroenterol. 2004;99(7):1355-1357. doi: 10.1111/j.1572-0241.2004.70661.x
61. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-132.
62. Nils Ewald N, Hardt PD. Diagnosis and treatment of diabetes mellitus in chronic pancreatitis. World J Gastroenterol. 2013;19(42):7276-7281. doi: 10.3748/wjg.v19.i42.7276
63. Rickels MR, Bellin M, Toledo FG, et al. PancreasFest Recommendation Conference Participants. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from Pancreas Fest 2012. Pancreatology. 2013;13(4):336-342. doi: 10.1016/ j.pan.2013.05.002
64. Meier JJ, Giese A. Diabetes Associated With Pancreatic Diseases. 
Curr Opin Gastroenterol. 2015;31(5):400-406. doi: 10.1097/MOG. 0000000000000199
65. Makuk J. Management of pancreatogenic diabetes: challenges and solutions. Diabetes Metab Syndr Obes. 2016;9:311-315. doi: 10.2147/ DMSO.S99701. eCollection 2016
66. Olson DE, Rhee MK, Herrick K, et al. Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria. Diabetes Care. 2010;33(10):2184-2189. doi: 10.2337/dc10-0433
67. Kondrup J, Rasmussen HH, Hamberg O, Stanga Z. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22:321-336.
68. Sorensen J, Kondrup J, Prokopowicz J, et al. EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome. Clin Nutr. 2008;27(3):340-349. doi: 10.1016/ j.clnu.2008.03.012
69. Ockenga J. Importance of nutritional management in diseases with exocrine pancreatic insufficiency. HPB (Oxford). 2009;11 Suppl 3:11-15. doi: 10.1111/j.1477-2574.2009.00134.x
70. Goess R, Ceyhan GO, Friess H. Pancreatic exocrine insufficiency after pancreatic surgery. Panminerva Med. 2016;58(2):151-159.
71. Hashimoto D, Chikamoto A, Ohmuraya M, et al. Impact of postoperative weight loss on survival after resection for pancreatic cancer. JPEN. 2015;39(5):598-603. doi: 10.1177/0148607114520992
72. Augustin T, Burstein MD, Schneider EB, et al. Frailty predicts risk of life-threating complications and mortality after pancreatic resections. Surgery. 2016;160(4):987-996. doi: 10.1016/j.surg.2016.07.010
73. Onesti JK, Wright GP, Kenning SE, et al. Sarcopenia and survival in patients undergoing pancretic resection. Pancreatology. 2016;16(2):284-289. doi: 10.1016/j.pan.2016.01.009
74. Lohr JM, Oliver MR, Frulloni L. Synopsis of recent guidelines on pancreatic exocrine insufficiency. UEGJ. 2013;1(2):79-83. doi: 10.1177/ 2050640613476500
75. Earthman C, Traughber D, Dobratz J, Howell W. Bioimpedance spectroscopy for clinical assessment of fluid distribution and body cell mass. Nutr Clin Pract. 2007;22(4):389-405. doi: 10.1177/ 0115426507022004389
76. Mulasi U, Kuchnia AJ, Cole AJ, Earthman CP. Bioimpedance at the bedside: current applications, limitations, and opportunities. Nutr Clin Pract. 2015;30(2):180-193. doi: 10.1177/0884533614568155
77. Armstrong T, Strommer L, Ruiz-Jasbon F, et al. Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficiencies. Pancreatology. 2007;7(1):37-44. doi: 10.1159/000101876
78. Duggan SN, Smyth ND, O’Sullivan M, et al. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis. Nutr Clin Prac. 2014;29(3):348-354. doi: 10.1177/0884533614528361
79. Nakamura T, Takebe K, Imamura K, et al. Fatsoluble vitamins in patients with chronic pancreatitis (pancreatic insufficiency). Acta Gastroenterol Belg. 1996;59(1):10-14.
80. Klapdor S, Richter E, Klapdor R. Vitamin D status and per-oral vitamin D supplementation in patients suffering from chronic pancreatitis and pancreatic cancer disease. Anticancer Res. 2012;32(5):1991-1998.
81. Lindkvist B, Domínguez-Munoz JE, Luaces-Regueira M, et al. Serum nutritional markers for prediction of pancreatic exocrinein sufficiency in chronic pancreatitis. Pancreatology. 2012;12(4):305-310. doi: 10. 1016/j.pan.2012.04.006
82. Park JS, Chung HK, Hwang HK, et al. Postoperative nutritional effects of early enteral feeding compared with total parental nutrition in pancreaticoduodectomy patients: a prosepective, randomized study. J Korean Med Sci. 2012;27(3):261-267. doi: 10.3346/jkms.2012.27.3.261
83. Berry AJ. Pancreatic surgery: indications, complications, and implications for nutrition intervention. Nutr Clin Pract. 2013;28(3):330-357. doi: 10.1177/0884533612470845
84. [Kucheryavy YuA, Maev IV, Moskaleva AB, et al. Influence of the nutritional status on the course of chronic pancreatitis. Medical Council. 2012;(2):100-104 (In Russ.)].
85. Dujsikova H, Dite P, Tomandl J, et al. Occurrence of metabolic osteopathy in patients with chronic pancreatitis. Pancreatology. 2008;8(6):583-586. doi: 10.1159/000159845
86.  [Chernyshova IV, Drozdov VN, Vinokurova LV, et al. Exocrine pancreatic insufficiency and bone mineral density disorders in patients with chronic pancreatitis. Vestnik Kluba Pankreatologov = Bulletin of the Club of Pancreatologists. 2010;(1):52-54 (In Russ.)].
87. Duggan SN, O’Sullivan M, Hamilton S, et al. Patients with chronic pancreatitis are at increased risk for osteoporosis. Pancreas. 2012;41(7):1119-1124. doi: 10.1097/MPA.0b013e31824abb4d
88. Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts. A populationbased study. Lancet Oncol. 2008;9(7):629-635. doi: 10.1016/S1470-2045(08)70153-0
89. Mourtzakis M, Prado CM, Lieffers JR, et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008;33(5):997-1006. doi: 10.1139/H08-075
90. Gomez-Perez SL, Haus JM, Sheean P, et al. Measuring Abdominal Circumference and Skeletal Muscle From a Single Cross-Sectional Computed Tomography Image: A Step-by-Step Guide for Clinicians Using National Institutes of Health Image. J Parenter Enteral Nutr. 2016;40(3):308-318. doi: 10.1177/0148607115604149
91. Kilgour RD, Cardiff K, Rosenthall L, et al. Use of prediction equations to determine the accuracy of whole-body fat and fat-free mass and appendicular skeletal muscle mass measurements from a single abdominal image using computed tomography in advanced cancer patients. Appl Physiol Nutr Metab. 2016;41(1):70-75. doi: 10.1139/apnm-2015-0068
92. Baker ST, Strauss BJ, Prendergast LA, et al. Estimating dual-energy X-ray absorptiometry-derived total body skeletal muscle mass using single-slice abdominal magnetic resonance imaging in obese subjects with and without diabetes: a pilot study. Eur J Clin Nutr. 2012;66(5):628-632. doi: 10.1038/ejcn.2012.3
93. Hoffmeister A, Mayerle J, Beglinge C, et al. English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis. Z Gastroenterol. 2015;53(12): 1447-1495. doi: 10.1055/s-0041-107379
94. Smith RC, Smith SF, Wilson J, et al. Summary and recommendations from the Australasian guidelines for the management of pancreatic exocrine insufficiency. Working Party of the Australasian Pancreatic Club. Pancreatology. 2016;16(2):164-180. doi: 10.1016/j.pan.2015. 12.006
95. [Khatkov IE, Maev IV, Bordin DS, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis: Enzyme replacement therapy. Terapevticheskiy Arkhiv. 2017;89(8):80-87 (In Russ.)]. doi: 10.17116/terarkh201789880-87
96. Somaraju UR, Solis-Moya A. Pancreatic enzyme replacement therapy for people with cystic fibrosis. Cochrane Database Syst Rev. 2014;10:CD008227. doi: 10.1002/14651858.CD008227.pub2
97. Dominguez-Munoz JE. Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. HPB (Oxford). 2009;11 Suppl 3:3-6. doi: 10.1111/j.1477-2574.2009.00132.x
98. Conwell DL, Lee LS, Yadav D, et al. American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43(8):1143-1162. doi: 10.1097/ MPA.0000000000000237
99. Ito T, Ishiguro H, Ohara H, et al. Evidence-based clinical practice guidelines for chronic pancreatitis 2015. J Gastroenterol. 2016;51(2):85-92. doi: 10.1007/s00535-015-1149-x
100. Sadeghi N, Abbruzzese JL, Yeung SC, et al. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res. 2012;18:2905-2912.
101. Delhaye M, van Steenbergen W, Cesmeli E, et al. Belgian consensus on chronic pancreatitis in adults and children: statements on diagnosis and nutritional, medical, and surgical treatment. Acta Gastroenterol Belg. 2014;77(1):47-65.
102. Forsmark CE. Management of Chronic Pancreatitis. Gastroenterology. 2013;144(6):1282-1291.e3. doi: 10.1053/j.gastro.2013.02.008
103. Karpoff H, Klimstra DS, Brennan MF, Conlon KC. Results of total pancreatectomy for adenocarcinoma of the pancreas. Arch Surg. 2001;136(1):44-47.
104. [Egorov VI, Vishnevsky VA, Kovalenko ZA, et al. Total pancreatectomy. Khirurgiya. Zhurnal imeni N.I. Pirogova = Surgery. Journal n.a. N.I. Pirogov. 2012;(7):85-92 (In Russ.)].
105. [Kucheryavyy YuA. External secretory pancreatic insufficiency after surgical interventions on the stomach and pancreas. Khirurgiya. Prilozhenie k zhurnalu Consilium Medicum = Surgery. Supplement to the journal Consilium Medicum. 2012;(1):42-46 (In Russ.)].
106. Tran TC, van Hof G, Kazemier G, et al. Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy. Dig Surg. 2008;25(4):311-318. doi: 10.1159/000158596
107. Ito K. Duodenum preservation in pancreatic head resection to maintain pancreatic exocrine function (determined by pancreatic function diagnostant test and cholecystokinin secretion). J Hepatobiliary Pancreat Surg. 2005;12(2):123-128. doi: 10.1007/s00534-004-0954-z

И.Е. Хатьков 1,2, И.В. Маев 2, С.Р. Абдулхаков 3,4, С.А. Алексеенко 5, Р.Б. Алиханов 1, И.Г. Бакулин 6, Н.В. Бакулина 6, А.Ю. Барановский 7, Е.В. Белобородова 8, Е.А. Белоусова 9, С.Э. Восканян 10, Л.В. Винокурова 1, В.Б. Гриневич 11, В.В. Дарвин 12, Е.А. Дубцова 1, T.Г. Дюжева 13, В.И. Егоров 14, М.Г. Ефанов 1, Р.Е. Израилов 1, В.Л. Коробка 15, Б.Н. Котив 11, Н.Ю. Коханенко 16, Ю.А. Кучерявый 2, М.А. Ливзан 17, В.К. Лядов 18, К.А. Никольская 1, М.Ф. Осипенко 19, В.Д. Пасечников 20, Е.Ю. Плотникова 21, О.А. Саблин 22, В.И. Симаненков 6, В.В. Цвиркун 1, В.В. Цуканов 23, А.В. Шабунин 24, Д.С. Бордин 1,25; Профессиональное медицинское сообщество «Панкреатологический клуб»

1 ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» (МКНЦ) Департамента здравоохранения г. Москвы, Москва, Россия; 
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия; 
3 ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России, Казань, Россия;
4 ФГАОУ ВО «Казанский (Приволжский) федеральный университет», Казань, Россия;
5 ФГБОУ ВО «Дальневосточный государственный медицинский университет» Минздрава России, Хабаровск, Россия; 
6 ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-Петербург, Россия;
7 ФГБОУ ВО «Санкт-Петербургский государственный университет», Санкт-Петербург, Россия;
8 ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России, Томск, Россия; 
9 ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Россия; 
10 ФГБУ «Государственный научный центр Российской Федерации – Федеральный медицинский биофизический центр им. А.И. Бурназяна» ФМБА России, Москва, Россия; 
11 ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны России, Санкт-Петербург, Россия;
12 Медицинский институт БУ ВО ХМАО-Югры «Сургутский государственный университет», Сургут, Россия; 
13 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
14 ГБУЗ «Городская клиническая больница имени братьев Бахрушиных» ДЗМ, Москва, Россия; 
15 ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России, Ростов-на-Дону, Россия;
16 ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург, Россия;
17 ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия; 
18 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, 
Россия; 
19 ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава России, Новосибирск, Россия; 
20 ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава России, Ставрополь, Россия; 
21 ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия; 
22 ФГБУ «Всероссийский центр экстренной и радиационной медицины им. А.М. Никифорова» МЧС России, Санкт-Петербург, Россия; 
23 ФГБНУ Федеральный исследовательский центр «Красноярский научный центр Сибирского отделения Российской академии наук», НИИ медицинских проблем Севера, Красноярск, Россия; 
24 ГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина» Департамента здравоохранения г. Москвы, Москва, Россия; 
25 ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава России, Тверь, Россия

________________________________________________

I.E. Khatkov 1,2, I.V. Maev 2, S.R. Abdulkhakov 3,4, S.A. Alekseenko 5, R.B. Alikhanov 1, I.G. Bakulin 6, N.V. Bakulina 6, A.Yu. Baranovskiy 7, E.V. Beloborodova 8, E.A. Belousova 9, S.E. Voskanyan 10, L.V. Vinokurova 1, V.B. Grinevich 11, V.V. Darvin 12, E.A. Dubtsova 1, T.G. Dyuzheva 13, V.I. Egorov 14, M.G. Efanov 1, R.E. Izrailov1, V.L. Korobka 15, B.N. Kotiv 11, N.Yu. Kokhanenko 16, Yu.A. Kucheryavyy 2, M.A. Livzan17, V.K. Lyadov 18, K.A. Nikolskaya 1, M.F. Osipenko 19, V.D. Pasechnikov 20, E.Yu. Plotnikova 21, O.A. Sablin 22, V.I. Simanenkov 6, V.V. Tsvirkun 1, V.V. Tsukanov 23, A.V. Shabunin 24, D.S. Bordin 1,25; Professional medical society “Pancreatic Club Russia”

1 A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia;
2 A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia;
3 Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia;
4 Kazan Federal University, Kazan, Russia;
5 The Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia;
6 I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint-Petersburg, Russia;
7 Saint-Petersburg University, Saint-Petersburg, Russia;
8 Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia;
9 M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russia;
10 A.I. Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia;
11 S.M. Kirov Military Medical Academy, Ministry of Defence of Russia, Saint-Petersburg, Russia;
12 Medical Institute of Surgut State University, Surgut, Russia;
13 I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia;
14 City Clinical Hospital named after the Bakhrushin Brothers, Moscow, Russia;
15 Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia;
16 Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint-Petersburg, Russia;
17 Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia;
18 Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, Moscow, Russia;
19 Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia;
20 Stavropol State Medical University, Ministry of Health of Russia, Stavropol, Russia;
21 Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo, Russia;
22 A.M. Nikiforov All-Russian Center for Emergency and Radiation Medicine, Russian Ministry for Emergency Situations, Saint-Petersburg, Russia;
23 Krasnoyarsk Scientific Center of Siberian Branch in Russian Academy of Sciences, Krasnoyarsk, Russia;
24 S.P. Botkin City Hospital, Moscow Healthcare Department, Moscow, Russia;
25 Tver State Medical University, Ministry of Health of Russia, Tver, Russia