Для цитирования: Фомин В.В., Бровко М.Ю., Калашников М.В. и др. Поражение печени при саркоидозе. Терапевтический архив. 2019; 91 (4): #–12. DOI: 10.26442/00403660.2019.04.000179
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Fomin V.V., Brovko M.Yu., Kalashnikov M.V., et al. Hepatic involvement in sarcoidosis. Therapeutic Archive. 2019; 91 (4):
#–12. DOI: 10.26442/00403660.2019.04.000179
Поражение печени при саркоидозе
Для цитирования: Фомин В.В., Бровко М.Ю., Калашников М.В. и др. Поражение печени при саркоидозе. Терапевтический архив. 2019; 91 (4): #–12. DOI: 10.26442/00403660.2019.04.000179
________________________________________________
Fomin V.V., Brovko M.Yu., Kalashnikov M.V., et al. Hepatic involvement in sarcoidosis. Therapeutic Archive. 2019; 91 (4):
#–12. DOI: 10.26442/00403660.2019.04.000179
Саркоидоз – гранулематозное заболевание неизвестной этиологии с мультисистемным поражением. Одним из наиболее часто вовлекаемых в патологический процесс органов является печень. При саркоидном поражении печени может наблюдаться широкий спектр клинических проявлений: от бессимптомного течения с нормальными показателями ферментов печеночного профиля до развития цирроза печени и портальной гипертензии. Ключевая роль в постановке диагноза саркоидоза печени принадлежит биопсии. При постановке морфологического диагноза необходимо исключать другие варианты гранулематозного поражения печени, чаще всего – первичный билиарный холангит. В настоящее время отсутствуют общепринятые протоколы лечения саркоидного поражения печени, что затрудняет ведение таких пациентов.
Ключевые слова: саркоидоз, гранулематозное поражение печени, первичный билиарный холангит.
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Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Liver is frequently involved in the pathological process. Wide range of clinical manifestations can be seen: from asymptomatic lesion with normal liver function tests to cirrhosis with portal hypertension. Biopsy plays the key role in diagnosis of the hepatic sarcoidosis. It is essential for morphological diagnosis to exclude other causes of granulomatous liver disease, most often – primary biliary cholangitis. Nowadays there are no standard treatment protocols for patients with hepatic sarcoidosis.
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1 Кафедра факультетской терапии №1 лечебного факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 Клиника им. Е.М. Тареева ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3 Кафедра внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
4 Кафедра внутренних болезней факультета фундаментальной медицины ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
5 Кафедра патологической анатомии им. А.И. Струкова ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Faculty of Medicine, Department of Internal Medicine No.1, Moscow, Russia;
2 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), E.M. Tareev Clinic of Internal Diseases, Moscow, Russia;
3 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Medical and Preventive Faculty, Department of Internal, Occupational Diseases and Rheumatology, Moscow, Russia;
4 M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal Medicine, Moscow, Russia;
5 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), A.I. Strukov Department of Pathological Anatomy, Moscow, Russia