Поражение печени при саркоидозе - Журнал Терапевтический архив №4 Вопросы диагностики внутренних болезней 2019
Поражение печени при саркоидозе
Для цитирования: Фомин В.В., Бровко М.Ю., Калашников М.В. и др. Поражение печени при саркоидозе. Терапевтический архив. 2019; 91 (4): #–12. DOI: 10.26442/00403660.2019.04.000179
#–12. DOI: 10.26442/00403660.2019.04.000179
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#–12. DOI: 10.26442/00403660.2019.04.000179
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Аннотация
Саркоидоз – гранулематозное заболевание неизвестной этиологии с мультисистемным поражением. Одним из наиболее часто вовлекаемых в патологический процесс органов является печень. При саркоидном поражении печени может наблюдаться широкий спектр клинических проявлений: от бессимптомного течения с нормальными показателями ферментов печеночного профиля до развития цирроза печени и портальной гипертензии. Ключевая роль в постановке диагноза саркоидоза печени принадлежит биопсии. При постановке морфологического диагноза необходимо исключать другие варианты гранулематозного поражения печени, чаще всего – первичный билиарный холангит. В настоящее время отсутствуют общепринятые протоколы лечения саркоидного поражения печени, что затрудняет ведение таких пациентов.
Ключевые слова: саркоидоз, гранулематозное поражение печени, первичный билиарный холангит.
Keywords: sarcoidosis, granulomatous liver disease, primary biliary cholangitis.
Ключевые слова: саркоидоз, гранулематозное поражение печени, первичный билиарный холангит.
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Keywords: sarcoidosis, granulomatous liver disease, primary biliary cholangitis.
Список литературы
1. Мухин Н.А., редактор. Саркоидоз. Клинические рекомендации. М.: ИМА-ПРЕСС; 2009: 54 [Mukhin NA, editor. Sarkoidoz. Klinicheskie rekomendatsii [Sarcoidosis. Clinical guidelines]. Moscow: IMA-PRESS; 2009: 54 (In Russ.)].
2. Kahi CJ, Saxena R, Temkit M. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis Diffuse Lung Dis. 2006;23(2):117-23.
3. Визель А.А., Амиров Н.Б. Саркоидоз и поражение органов системы пищеварения. Вестник современной клинической медицины. 2010;(1):43-50 [Vizel' AA, Amirov NB. Sarcoidosis and organ damage in the digestive system. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2010;(1):43-50 (In Russ.)].
4. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155-67. doi: 10.1016/S0140-6736(13)60680-7
5. Hardman T, Sharma R, Dubrey S, Shah S. Sarcoidosis: the links between epidemiology and aetiology. Postgrad Med J. 2014;90(1068):582-9. doi: 10.1136/postgradmedj-2014-132584
6. Dumas O, Abramovitz L, Wiley AS, Cozier YC, Camargo CA Jr. Epidemiology of sarcoidosis in a prospective cohort study of U.S. women. Ann Am Thorac Soc. 2016;13(1):67-71. doi: 10.1513/AnnalsATS.201508-568BC
7. Визель А.А., Визель И.Ю., Амиров Н.Б. Эпидемиология саркоидоза в Российской Федерации. Вестник современной клинической медицины. 2017;(5):66-73 [Vizel' AA, Vizel' IYu, Amirov NB. Epidemiology of sarcoidosis in the Russian Federation. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2017;(5):66-73 (In Russ.)]. doi: 10.20969/VSKM.2017.10(5).66-73
8. Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, Trilla A, Stone JH, Khamashta MA, Shoenfeld Y. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015;14(8):670-9. doi: 10.1016/j.autrev.2015.03.008
9. Hillerdal G, Nöu E, Osterman K, Schmekel B. Sarcoidosis: epidemiology and prognosis. A 15-year European study. Am Rev Respir Dis. 1984;130(1):29-32.
10. Sawahata M, Sugiyama Y, Nakamura Y, Nakayama M, Mato N, Yamasawa H, Bando M. Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Respir Med. 2015;109(2):272-8. doi: 10.1016/j.rmed.2014.12.012
11. Holmes J, Lazarus A. Sarcoidosis: extrathoracic manifestations. Dis Mon. 2009;55:675-92. doi: 10.1016/j.disamonth.2009.05.002
12. Baughman R, Baughman RP, Teirstein AS, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885-9. doi: 10.1164/ajrccm.164.10.2104046
13. Scadding J. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br Med J. 1961;2(5261):1165-72.
14. Терпигорев С.А., Эльзейн Б.А., Верещагина В.М. и др. Саркоидоз и проблемы его классификации. Вестник Российской медицинской академии наук. 2012;(5):30-7 [Terpigorev SA, El'zein BA, Vereshchagina VM, et al. Sarcoidosis and its classification problems. Vestnik Rossiiskoi Meditsinskoi Akademii Nauk. 2012;(5):30-7 (In Russ.)].
15. Maddrey WC, Johns CJ, Boitnott JK, Iber FL. Sarcoidosis and chronic hepatic disease: a clinical and pathologic study of 20 patients. Medicine (Baltimore). 1970;49(5):375-95. doi: 10.1097/00005792-197009000-00002
16. Culver D. Sarcoidosis. Immunol Allergy Clin North Am. 2012;32(4):487-511. doi: 10.1016/j.iac.2012.08.005
17. Zissel G, Prasse A, Müller-Quernheim J. Immunologic response of sarcoidosis. Semin Respir Crit Care Med. 2010;31(4):390-403. doi: 10.1055/s-0030-1262208
18. Lazarus A. Sarcoidosis: epidemiology, etiology, pathogenesis, and genetics. Dis Mon. 2009;55(11):649-60. doi: 10.1016/j.disamonth.2009.04.008
19. Chen E, Moller D. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365-77. doi: 10.1007/s12016-015-8481-z
20. Suzuki Y, Uchida K, Takemura T. Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. PLoS One. 2018;13(2). Accessed Nov 5, 2018. doi: 10.1371/journal.pone.0192408
21. Vihlborg P, Bryngelsson IL, Andersson L, Graff P. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. BMJ Open. 2017;7:1-7. doi: 10.1136/bmjopen-2017-016839
22. Лопаткина Т.Н., Пономарев А.Б., Попова Е.Н. и др. Интерферон-индуцированный (лекарственный) саркоидоз. Клиническая фармакология и терапия. 2008;(5):45-8 [Lopatkina TN, Ponomarev AB, Popova EN, et al. Interferon-induced (drug) sarcoidosis. Klinicheskaya farmakologiya i terapiya. 2008;(5):45-8 (In Russ.)].
23. Alazemi S. Interferon-induced sarcoidosis. Int J ClinPract. 2006;60(2):201-11. doi: 10.1111/j.1742-1241.2005.00651.x
24. Fiel MI, Shukla D, Saraf N. Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation. Transpl Infect Dis. 2008;10:184-9. doi: 10.1111/j.1399-3062.2007.00258.x
25. Lamps L. Hepatic granulomas. A review with emphasis on infectious cause. Arch Pathol Lab Med. 2015;139:867-75. doi: 10.5858/arpa.2014-0123-RA
26. Costabel U, Hunninghake G. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders. Eur Respir J. 1999;14(4):735-7.
27. Kennedy P, Zakaria N, Modawi SB, Papadopoulou AM, Murray-Lyon I, du Bois RM, Jervoise N, Andreyev H, Devlin J. Natural history of hepatic sarcoidosis and its response to treatment. Eur J Gastroenterol Hepatol. 2006;18(7):721-6. doi: 10.1097/01.meg.0000223911.85739.38
28. Modaresi E, Culver D, Plesec T, John B. Clinical presentation and protocol for management of hepatic sarcoidosis. Expert Rev Gastroenterol Hepatol. 2015;9(3):349-58. doi: 10.1586/17474124.2015.958468
29. Drebber U, Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. Hepatic granulomas: histological and molecular pathological approach to differential diagnosis – a study of 442 cases. Liver Int. 2008;28(6):828-34. doi: 10.1111/j.1478-3231.2008.01695.x
30. Dourakis SP, Saramadou R, Alexopoulou A. Hepatic granulomas: a 6-year experience in a single center in Greece. Eur J Gastroenterol Hepatol. 2007;19(2):101-4. doi: 10.1097/01.meg.0000243882.09820.d2
31. Lewis J. Histopathology of granulomatous liver disease. Clin Liv Dis. 2018;11(3):77-80. doi: 10.1002/cld.695
32. Yee AM. Sarcoidosis: rheumatology perspective. Best Pract Res Clin Rheumatol. 2016;30(2):334-56. doi: 10.1016/j.berh.2016.07.001
33. Tadros M, Forouhar F, Wu G. Hepatic sarcoidosis. J Clin Transl Hepatol. 2013;2:87-93. doi: 10.14218/JCTH.2013.00016
34. Karagiannidis A, Karavalaki M, Koulaouzidis A. Hepatic sarcoidosis. Ann Hepatol. 2006;5(4):251-6.
35. Лебедева М.В., Попова Е.Н., Пономарев А.Б. и др. Внелегочные проявления саркоидоза. Врач. 2011;(3):43-5 [Lebedeva MV, Popova EN, Ponomarev AB, et al. Extrapulmonary manifestations of sarcoidosis. Vrach. 2011;(3):43-5 (In Russ.)].
36. Dulai PS, Rothstein RI. Disseminated Sarcoidosis Presenting as Granulomatous Gastritis. A Clinical Review of the Gastrointestinal and Hepatic Manifestations of Sarcoidosis. J Clin Gastroenterol. 2012;46(5):367-74. doi: 10.1097/MCG.0b013e318247106b
37. Mueller S. Extrapulmonary sarcoidosis primarily diagnosed in the liver. Scand J Gastroenterol. 2000;35:1003-8. doi: 10.3748/wjg.v13.i17.2504
38. Greenwood R. Atypical Presentation of Hepatic Sarcoidosis. Hawaii J Med Public Health. 2013;72(9):55.
39. Farooq PD, Potosky DR. The Klatskin Tumor That Wasn’t: An Unusual Presentation of Sarcoidosis. ACG Case Rep J. 2016;3(4):1-4. doi: 10.14309/crj.2016.114
40. Gaduputieti V. Extrahepatic Biliary Obstruction: An Unusual Presentation of Hepatic Sarcoidosis. Clin Med Insights Gastroenterol. 2015;8:19-22. doi: 10.4137/CGast.S22809
41. Rezeig MA, Fashir BM. Biliary tract obstruction due to sarcoidosis: a case report. Am J Gastroenterol. 1997;92(3):527-8.
42. Suzuki I, Zenichi M, Shinpei F, Yoshinao T, Chinatsu T, Tadashi K, Masahiro I, Atsushi S. Hepatic Sarcoidosis Mimicking Hilar Cholangiocarcinoma: Case Report and Review of the Literature. Case Rep Gastroenterol. 2011;5(1):152-8. doi: 10.1159/000323546
43. Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN. Mimics of Cholangiocarcinoma: Spectrum of Disease. RadioGraphics. 2008;28(4):1115-29. doi: 10.1148/rg.284075148
44. Philips CA, Kalal CR, Kumar A. Sarcoidosis Presenting as Acute on Chronic Liver Failure – Report of the First Case. Med Sci. 2016;5(2):655-65. doi: 10.5455/medscience.2015.04.8325
45. Judson M, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M. Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J. 2008;31(6):1189-96. doi: 10.1183/09031936.00051907
46. Ayyala U, Padilla M. Diagnosis and treatment of hepatic sarcoidosis. Curr Treat Options Gastroenterol. 2006;9(6):475-83.
47. Cremers J, Drent M, Baughman RP, Wijnen PA, Koek GH. Therapeutic approach of hepatic sarcoidosis. Curr Opin Pulm Med. 2012;18(5):472-87. doi: 10.1097/MCP.0b013e3283541626
48. Syed U, Alkhawam H, Bakhit M, Ching Companioni R, Walfish A. Hepatic sarcoidosis: pathogenesis, clinical context, and treatment options. Scand J Gastroenterol. 2016;51(9):1025-30. doi: 10.1080/00365521.2016.1177856
49. Baughman R. Sarcoidosis usual and unusual manifestations. Chest. 1988;94:165-70.
50. Sharma OP. Vitamin D, calcium, and sarcoidosis. Chest. 1996;109:535-9.
51. Inui N, Murayama A. Correlation between 25-hydroxyvitamin D3 1-alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med. 2001;110:687-93.
52. Ackermann D. Hypercalcemia in sarcoidosis-case report, prevalence, pathophysiology and therapeutic options. Ther Umsch. 2007;64:281-6. doi: 10.1024/0040-5930.64.5.281
53. Yanardag H, Pehlivan M, Bilir M, Tetikkurt C. Clinical Features and Prognostic Significance of Liver Involvement in Sarcoidosis. Eur Respir Pulmon Dis. 2016;2(1):26-9. doi: 10.4081/monaldi.2017.893
54. Kessler A, Mitchell D, Israel H, Goldberg B. Hepatic and splenic sarcoidosis: ultrasound and MR imaging. Abdom Imaging. 1993;18(2):159-63.
55. Ebert E, Kierson M, Hagspiel K. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol. 2008;103(12):3184-92. doi: 10.1111/j.1572-0241.2008.02202.x
56. Gezer N, Başara I, Altay C, Harman M, Rocher L, Karabulut N, Seçil M. Abdominal sarcoidosis: cross-sectional imaging findings. Diagn Interv Radiol. 2015;21(2):111-7. doi: 10.5152/dir.2014.14210
57. Karaosmanoğlu A, Onur MR, Saini S, Taberi A, Karcaaltincaba M. Imaging of hepatobiliary involvement in sarcoidosis. Abdom Imaging. 2015;40(8):3330-7. doi: 10.1007/s00261-015-0533-6
58. Tana C, Dietrich C, Schiavone C. Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice [WEB resousce]. Biomed Res Int. 2014:926203. Accessed November 5, 2018. https://www.hindawi.com/journals/bmri/2014/926203/. doi: 10.1155/2014/926203
59. Grzelak P. Diagnostic potential of contrast-enhanced ultrasound (CEUS) in the assessment of spleen and liver granulomas in the course of sarcoidosis. Pneumonol Alergol Pol. 2013;81(5):424-8.
60. Naschitz J, Enat R, Yeshurun D, Eisenberg D, Baruch Y, Bassan L, Misselevitch I, Boss JH. Massive subcapsular fibrosis of the liver: ultrasonic and computed tomographic characteristics. J Clin Gastroenterol. 1991;13(2):470-4.
61. Ferreira A, Ramalho M, de Campos RO, Heredia V, Roque A, Vaidean G, Semelka RC. Hepatic sarcoidosis: MR appearances in patients with chronic liver disease. Magn Reson Imaging. 2013;31(3):432-8. doi: 10.1016/j.mri.2012.08.005
62. Jung G, Brill N, Poll LW, Koch JA, Wettstein M. MRI of hepatic sarcoidosis: large confluent lesions mimicking malignancy. AJR Am J Roentgenol. 2004;183(1):171-3. doi: 10.2214/ajr.183.1.1830171
63. Warshauer D, Dumbleton SA, Molina PL, Yankaskas BC, Parker LA, Woosley JT. Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 1994;192(1):93-8. doi: 10.1148/radiology.192.1.8208972
64. Saito H, Ohmori M, Iwamuro M, Tanaka T, Wada N, Yasunaka T, Takaki A. Hepatic and gastric involvement in a case of systemic sarcoidosis presenting with rupture of esophageal varices. Intern Med. 2017;56(19):2583-8. doi: 10.2169/internalmedicine.8768-16
65. Heinle R, Chang C. Diagnostic criteria for sarcoidosis. Autoimmun Rev. 2014;13(5):383-7. doi: 10.1016/j.autrev.2014.01.035
66. Stanca CM, Fiel MI, Allina J, Caracta CF, Odin JA. Liver failure in an antimitochondrial antibody-positive patient with sarcoidosis: primary biliary cirrhosis or hepatic sarcoidosis? Semin Liver Dis. 2005;25:364-70. doi: 10.1055/s-2005-916327
67. Gur C, Lalazar G, Doviner V, Lalazar G, Doviner V, Fridlender ZG, Molcho V, Abu-Much S, Shalit M, Elinav E. Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis. J Clin Gastroenterol. 2007;41:329-32. doi: 10.1097/01.mcg.0000212653.51397.f6
68. Kishor Turner ML, Borg BB, Kleiner DE, Cowen EW. Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases? J Am Acad Dermatol. 2007;38(2):326-35. doi: 10.1016/j.jaad.2007.07.031
69. Koulentaki M, Ioannidou D, Stefanidou M, Maraki S, Drigiannakis I, Dimoulios P. Dermatological manifestations in primary biliary cirrhosis patients: a case control study. Am J Gastroenterol. 2006;101:541-6. doi: 10.1111/j.1572-0241.2006.00423.x
70. Sherman S, Nieland N, van Thiel D. Sarcoidosis and primary biliary cirrhosis: coexistence in a single patient. Dig Dis Sci. 1988;33:368-74.
71. Leff JA, Ready JB, Repetto C, Goff JS, Schwarz M. Coexistence of primary biliary cirrhosis and sarcoidosis. West J Med. 1990;153:439-41.
72. Asvesti C, Hadziyannis SJ, Papadopoulos S, Giakoumoglou T, Hadziolou E, Trichia E. Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. Dermatology. 1994;189:198-202.
73. Keefe EB. Sarcoidosis and primary biliary cirrhosis: literature review and illustrative case. Am J Med. 1987;83:977-80.
74. Harrington AC, Fitzpatrick JE. Cutaneous sarcoidal granulomas in a patient with primary biliary cirrhosis. Cutis. 1992;49:271-4.
75. Jardine DL, Chambers ST, Hart DJ, Chapman BA. Primary biliary cirrhosis presenting with granulomatous skin lesions. Gut. 1994;35:564-6.
76. Hughes P, McGavin CR. Sarcoidosis and primary biliary cirrhosis with coexisting myositis. Thorax. 1997;52:201-2.
77. Попова Е.Н., Некрасова Т.П., Танащук Е.Л. и др. Вариантная форма аутоиммунного гепатита/первичного билиарного цирроза в сочетании с генерализованным саркоидозом. Доказательная гастроэнтерология. 2017;(3):51-9 [Popova EN, Nekrasova TP, Tanashchuk EL, et al. A variant form of autoimmune hepatitis / primary biliary cirrhosis in combination with generalized sarcoidosis. Dokazatel'naya gastroenterologiya. 2017;(3):51-9 (In Russ.)].
78. Al-Kofahi K, Korsten P, Ascoli C, Virupannavar S, Mirsaeidi M, Chang I, Qaqish N, Saketkoo LA, Baughman RP, Sweiss NJ. Management of extrapulmonary sarcoidosis: challenges and solutions. Ther Clin Risk Manag. 2016;12:1623-34. doi: 10.2147/TCRM.S74476
79. Bakker G, Haan Y, Maillette de Buy Wenniger L, Beuers U. Sarcoidosis of the liver: to treat or not to treat? Neth J Med. 2012;70(8):349-56.
80. Cremers J, Drent M, Driessen A, Nieman F, Wijnen P, Baughman R, Koek G. Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 2012;24(1):17-24. doi: 10.1097/MEG.0b013e32834c7b71
81. Alenezi B, Lamoureux E, Alpert L, Szilagyi A. Effect of ursodeoxycholic acid on granulomatous liver disease due to sarcoidosis. Dig Dis Sci. 2005;50(1):196-200.
82. Baratta L, Cascino A, Delfino M, Giorgino F, Vitolo D, Laganà B, Urani C, Rossi Fanelli F. Ursodeoxycholic acid treatment in abdominal sarcoidosis. Dig Dis Sci. 2000;45(8):1559-62.
83. Baughman R, Lynch J. Difficult treatment issues in sarcoidosis. J Intern Med. 2003;253(1):41-5.
84. Bécheur H, Dall'osto H, Chatellier G, Charton-Bain MC, Aubertin JM, Attar A, Bloch F, Petite JP. Effect of ursodeoxycholic acid on chronic intrahepatic cholestasis due to sarcoidosis. Dig Dis Sci. 1997;42(4):789-91.
85. Heuman D. Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology. 1993;104(6):1865-70.
86. Wan Y. TPMT testing before azathioprine therapy? Drug Ther Bull. 2009;47(1):9-12. doi: 10.1136/dtb.2008.12.0033
87. Ulbricht K, Stoll M, Bierwirth J, Witte T, Schmidt RE. Successful tumor necrosis factor alpha blockade treatment in therapy-resistant sarcoidosis. Arthritis Rheum. 2003;48(12):3542-3. doi: 10.1002/art.11357
88. Doty J, Mazur J, Judson M. Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064-71. doi: 10.1378/chest.127.3.1064
89. Saleh S, Ghodsian S, Yakimova V, Henderson J, Sharma OP. Effectiveness of infliximab in treating selected patients with sarcoidosis. Respir Med. 2006;100(11):2053-9. doi: 10.1016/j.rmed.2006.02.017
90. Denys B, Bogaerts Y, Coenegrachts K, De Vriese A. Steroid-resistant sarcoidosis: is antagonism of TNF-alpha the answer? Clin Sci (Lond). 2007;112(5):281-9. doi: 10.1042/CS20060094
91. Costabel U. Sarcoidosis: clinical update. Eur Respir J Suppl. 2001;32:56-68.
92. Cengiz C, Rodriguez-Davalos M, de Boccardo G, Fiel MI, Rodriguez-Laiz G, Kovacevic M, Emre S, Schiano T. Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature. Liver Transpl. 2005;11(12):1611-4. doi: 10.1002/lt.20626
93. Bilal M, Satapathy S, Ismail M, Vanatta J. Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience. J Clin Exp Hepatol. 2016;6(2):94-9. doi: 10.1016/j.jceh.2016.02.005
94. Lipson E, Fiel M, Florman S, Korenblat K. Patient and graft outcomes following liver transplantation for sarcoidosis. Clin Transplant. 2005;19(4):487-91. doi: 10.1111/j.1399-0012.2005.00372.x
95. Casavilla F, Gordon R, Wright H. Clinical course after liver transplantation in patients with sarcoidosis. Ann Intern Med. 1993;118(11):865-66.
2. Kahi CJ, Saxena R, Temkit M. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis Diffuse Lung Dis. 2006;23(2):117-23.
3. Vizel' AA, Amirov NB. Sarcoidosis and organ damage in the digestive system. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2010;(1):43-50 (In Russ.).
4. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155-67. doi: 10.1016/S0140-6736(13)60680-7
5. Hardman T, Sharma R, Dubrey S, Shah S. Sarcoidosis: the links between epidemiology and aetiology. Postgrad Med J. 2014;90(1068):582-9. doi: 10.1136/postgradmedj-2014-132584
6. Dumas O, Abramovitz L, Wiley AS, Cozier YC, Camargo CA Jr. Epidemiology of sarcoidosis in a prospective cohort study of U.S. women. Ann Am Thorac Soc. 2016;13(1):67-71. doi: 10.1513/AnnalsATS.201508-568BC
7. Vizel' AA, Vizel' IYu, Amirov NB. Epidemiology of sarcoidosis in the Russian Federation. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2017;(5):66-73 (In Russ.). doi: 10.20969/VSKM.2017.10(5).66-73
8. Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, Trilla A, Stone JH, Khamashta MA, Shoenfeld Y. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015;14(8):670-9. doi: 10.1016/j.autrev.2015.03.008
9. Hillerdal G, Nöu E, Osterman K, Schmekel B. Sarcoidosis: epidemiology and prognosis. A 15-year European study. Am Rev Respir Dis. 1984;130(1):29-32.
10. Sawahata M, Sugiyama Y, Nakamura Y, Nakayama M, Mato N, Yamasawa H, Bando M. Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Respir Med. 2015;109(2):272-8. doi: 10.1016/j.rmed.2014.12.012
11. Holmes J, Lazarus A. Sarcoidosis: extrathoracic manifestations. Dis Mon. 2009;55:675-92. doi: 10.1016/j.disamonth.2009.05.002
12. Baughman R, Baughman RP, Teirstein AS, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885-9. doi: 10.1164/ajrccm.164.10.2104046
13. Scadding J. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br Med J. 1961;2(5261):1165-72.
14. Terpigorev SA, El'zein BA, Vereshchagina VM, et al. Sarcoidosis and its classification problems. Vestnik Rossiiskoi Meditsinskoi Akademii Nauk. 2012;(5):30-7 (In Russ.).
15. Maddrey WC, Johns CJ, Boitnott JK, Iber FL. Sarcoidosis and chronic hepatic disease: a clinical and pathologic study of 20 patients. Medicine (Baltimore). 1970;49(5):375-95. doi: 10.1097/00005792-197009000-00002
16. Culver D. Sarcoidosis. Immunol Allergy Clin North Am. 2012;32(4):487-511. doi: 10.1016/j.iac.2012.08.005
17. Zissel G, Prasse A, Müller-Quernheim J. Immunologic response of sarcoidosis. Semin Respir Crit Care Med. 2010;31(4):390-403. doi: 10.1055/s-0030-1262208
18. Lazarus A. Sarcoidosis: epidemiology, etiology, pathogenesis, and genetics. Dis Mon. 2009;55(11):649-60. doi: 10.1016/j.disamonth.2009.04.008
19. Chen E, Moller D. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365-77. doi: 10.1007/s12016-015-8481-z
20. Suzuki Y, Uchida K, Takemura T. Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. PLoS One. 2018;13(2). Accessed Nov 5, 2018. doi: 10.1371/journal.pone.0192408
21. Vihlborg P, Bryngelsson IL, Andersson L, Graff P. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. BMJ Open. 2017;7:1-7. doi: 10.1136/bmjopen-2017-016839
22. Lopatkina TN, Ponomarev AB, Popova EN, et al. Interferon-induced (drug) sarcoidosis. Klinicheskaya farmakologiya i terapiya. 2008;(5):45-8 (In Russ.).
23. Alazemi S. Interferon-induced sarcoidosis. Int J ClinPract. 2006;60(2):201-11. doi: 10.1111/j.1742-1241.2005.00651.x
24. Fiel MI, Shukla D, Saraf N. Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation. Transpl Infect Dis. 2008;10:184-9. doi: 10.1111/j.1399-3062.2007.00258.x
25. Lamps L. Hepatic granulomas. A review with emphasis on infectious cause. Arch Pathol Lab Med. 2015;139:867-75. doi: 10.5858/arpa.2014-0123-RA
26. Costabel U, Hunninghake G. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders. Eur Respir J. 1999;14(4):735-7.
27. Kennedy P, Zakaria N, Modawi SB, Papadopoulou AM, Murray-Lyon I, du Bois RM, Jervoise N, Andreyev H, Devlin J. Natural history of hepatic sarcoidosis and its response to treatment. Eur J Gastroenterol Hepatol. 2006;18(7):721-6. doi: 10.1097/01.meg.0000223911.85739.38
28. Modaresi E, Culver D, Plesec T, John B. Clinical presentation and protocol for management of hepatic sarcoidosis. Expert Rev Gastroenterol Hepatol. 2015;9(3):349-58. doi: 10.1586/17474124.2015.958468
29. Drebber U, Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. Hepatic granulomas: histological and molecular pathological approach to differential diagnosis – a study of 442 cases. Liver Int. 2008;28(6):828-34. doi: 10.1111/j.1478-3231.2008.01695.x
30. Dourakis SP, Saramadou R, Alexopoulou A. Hepatic granulomas: a 6-year experience in a single center in Greece. Eur J Gastroenterol Hepatol. 2007;19(2):101-4. doi: 10.1097/01.meg.0000243882.09820.d2
31. Lewis J. Histopathology of granulomatous liver disease. Clin Liv Dis. 2018;11(3):77-80. doi: 10.1002/cld.695
32. Yee AM. Sarcoidosis: rheumatology perspective. Best Pract Res Clin Rheumatol. 2016;30(2):334-56. doi: 10.1016/j.berh.2016.07.001
33. Tadros M, Forouhar F, Wu G. Hepatic sarcoidosis. J Clin Transl Hepatol. 2013;2:87-93. doi: 10.14218/JCTH.2013.00016
34. Karagiannidis A, Karavalaki M, Koulaouzidis A. Hepatic sarcoidosis. Ann Hepatol. 2006;5(4):251-6.
35. Lebedeva MV, Popova EN, Ponomarev AB, et al. Extrapulmonary manifestations of sarcoidosis. Vrach. 2011;(3):43-5 (In Russ.).
36. Dulai PS, Rothstein RI. Disseminated Sarcoidosis Presenting as Granulomatous Gastritis. A Clinical Review of the Gastrointestinal and Hepatic Manifestations of Sarcoidosis. J Clin Gastroenterol. 2012;46(5):367-74. doi: 10.1097/MCG.0b013e318247106b
37. Mueller S. Extrapulmonary sarcoidosis primarily diagnosed in the liver. Scand J Gastroenterol. 2000;35:1003-8. doi: 10.3748/wjg.v13.i17.2504
38. Greenwood R. Atypical Presentation of Hepatic Sarcoidosis. Hawaii J Med Public Health. 2013;72(9):55.
39. Farooq PD, Potosky DR. The Klatskin Tumor That Wasn’t: An Unusual Presentation of Sarcoidosis. ACG Case Rep J. 2016;3(4):1-4. doi: 10.14309/crj.2016.114
40. Gaduputieti V. Extrahepatic Biliary Obstruction: An Unusual Presentation of Hepatic Sarcoidosis. Clin Med Insights Gastroenterol. 2015;8:19-22. doi: 10.4137/CGast.S22809
41. Rezeig MA, Fashir BM. Biliary tract obstruction due to sarcoidosis: a case report. Am J Gastroenterol. 1997;92(3):527-8.
42. Suzuki I, Zenichi M, Shinpei F, Yoshinao T, Chinatsu T, Tadashi K, Masahiro I, Atsushi S. Hepatic Sarcoidosis Mimicking Hilar Cholangiocarcinoma: Case Report and Review of the Literature. Case Rep Gastroenterol. 2011;5(1):152-8. doi: 10.1159/000323546
43. Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN. Mimics of Cholangiocarcinoma: Spectrum of Disease. RadioGraphics. 2008;28(4):1115-29. doi: 10.1148/rg.284075148
44. Philips CA, Kalal CR, Kumar A. Sarcoidosis Presenting as Acute on Chronic Liver Failure – Report of the First Case. Med Sci. 2016;5(2):655-65. doi: 10.5455/medscience.2015.04.8325
45. Judson M, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M. Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J. 2008;31(6):1189-96. doi: 10.1183/09031936.00051907
46. Ayyala U, Padilla M. Diagnosis and treatment of hepatic sarcoidosis. Curr Treat Options Gastroenterol. 2006;9(6):475-83.
47. Cremers J, Drent M, Baughman RP, Wijnen PA, Koek GH. Therapeutic approach of hepatic sarcoidosis. Curr Opin Pulm Med. 2012;18(5):472-87. doi: 10.1097/MCP.0b013e3283541626
48. Syed U, Alkhawam H, Bakhit M, Ching Companioni R, Walfish A. Hepatic sarcoidosis: pathogenesis, clinical context, and treatment options. Scand J Gastroenterol. 2016;51(9):1025-30. doi: 10.1080/00365521.2016.1177856
49. Baughman R. Sarcoidosis usual and unusual manifestations. Chest. 1988;94:165-70.
50. Sharma OP. Vitamin D, calcium, and sarcoidosis. Chest. 1996;109:535-9.
51. Inui N, Murayama A. Correlation between 25-hydroxyvitamin D3 1-alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med. 2001;110:687-93.
52. Ackermann D. Hypercalcemia in sarcoidosis-case report, prevalence, pathophysiology and therapeutic options. Ther Umsch. 2007;64:281-6. doi: 10.1024/0040-5930.64.5.281
53. Yanardag H, Pehlivan M, Bilir M, Tetikkurt C. Clinical Features and Prognostic Significance of Liver Involvement in Sarcoidosis. Eur Respir Pulmon Dis. 2016;2(1):26-9. doi: 10.4081/monaldi.2017.893
54. Kessler A, Mitchell D, Israel H, Goldberg B. Hepatic and splenic sarcoidosis: ultrasound and MR imaging. Abdom Imaging. 1993;18(2):159-63.
55. Ebert E, Kierson M, Hagspiel K. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol. 2008;103(12):3184-92. doi: 10.1111/j.1572-0241.2008.02202.x
56. Gezer N, Başara I, Altay C, Harman M, Rocher L, Karabulut N, Seçil M. Abdominal sarcoidosis: cross-sectional imaging findings. Diagn Interv Radiol. 2015;21(2):111-7. doi: 10.5152/dir.2014.14210
57. Karaosmanoğlu A, Onur MR, Saini S, Taberi A, Karcaaltincaba M. Imaging of hepatobiliary involvement in sarcoidosis. Abdom Imaging. 2015;40(8):3330-7. doi: 10.1007/s00261-015-0533-6
58. Tana C, Dietrich C, Schiavone C. Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice [WEB resousce]. Biomed Res Int. 2014:926203. Accessed November 5, 2018. https://www.hindawi.com/journals/bmri/2014/926203/. doi: 10.1155/2014/926203
59. Grzelak P. Diagnostic potential of contrast-enhanced ultrasound (CEUS) in the assessment of spleen and liver granulomas in the course of sarcoidosis. Pneumonol Alergol Pol. 2013;81(5):424-8.
60. Naschitz J, Enat R, Yeshurun D, Eisenberg D, Baruch Y, Bassan L, Misselevitch I, Boss JH. Massive subcapsular fibrosis of the liver: ultrasonic and computed tomographic characteristics. J Clin Gastroenterol. 1991;13(2):470-4.
61. Ferreira A, Ramalho M, de Campos RO, Heredia V, Roque A, Vaidean G, Semelka RC. Hepatic sarcoidosis: MR appearances in patients with chronic liver disease. Magn Reson Imaging. 2013;31(3):432-8. doi: 10.1016/j.mri.2012.08.005
62. Jung G, Brill N, Poll LW, Koch JA, Wettstein M. MRI of hepatic sarcoidosis: large confluent lesions mimicking malignancy. AJR Am J Roentgenol. 2004;183(1):171-3. doi: 10.2214/ajr.183.1.1830171
63. Warshauer D, Dumbleton SA, Molina PL, Yankaskas BC, Parker LA, Woosley JT. Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 1994;192(1):93-8. doi: 10.1148/radiology.192.1.8208972
64. Saito H, Ohmori M, Iwamuro M, Tanaka T, Wada N, Yasunaka T, Takaki A. Hepatic and gastric involvement in a case of systemic sarcoidosis presenting with rupture of esophageal varices. Intern Med. 2017;56(19):2583-8. doi: 10.2169/internalmedicine.8768-16
65. Heinle R, Chang C. Diagnostic criteria for sarcoidosis. Autoimmun Rev. 2014;13(5):383-7. doi: 10.1016/j.autrev.2014.01.035
66. Stanca CM, Fiel MI, Allina J, Caracta CF, Odin JA. Liver failure in an antimitochondrial antibody-positive patient with sarcoidosis: primary biliary cirrhosis or hepatic sarcoidosis? Semin Liver Dis. 2005;25:364-70. doi: 10.1055/s-2005-916327
67. Gur C, Lalazar G, Doviner V, Lalazar G, Doviner V, Fridlender ZG, Molcho V, Abu-Much S, Shalit M, Elinav E. Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis. J Clin Gastroenterol. 2007;41:329-32. doi: 10.1097/01.mcg.0000212653.51397.f6
68. Kishor Turner ML, Borg BB, Kleiner DE, Cowen EW. Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases? J Am Acad Dermatol. 2007;38(2):326-35. doi: 10.1016/j.jaad.2007.07.031
69. Koulentaki M, Ioannidou D, Stefanidou M, Maraki S, Drigiannakis I, Dimoulios P. Dermatological manifestations in primary biliary cirrhosis patients: a case control study. Am J Gastroenterol. 2006;101:541-6. doi: 10.1111/j.1572-0241.2006.00423.x
70. Sherman S, Nieland N, van Thiel D. Sarcoidosis and primary biliary cirrhosis: coexistence in a single patient. Dig Dis Sci. 1988;33:368-74.
71. Leff JA, Ready JB, Repetto C, Goff JS, Schwarz M. Coexistence of primary biliary cirrhosis and sarcoidosis. West J Med. 1990;153:439-41.
72. Asvesti C, Hadziyannis SJ, Papadopoulos S, Giakoumoglou T, Hadziolou E, Trichia E. Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. Dermatology. 1994;189:198-202.
73. Keefe EB. Sarcoidosis and primary biliary cirrhosis: literature review and illustrative case. Am J Med. 1987;83:977-80.
74. Harrington AC, Fitzpatrick JE. Cutaneous sarcoidal granulomas in a patient with primary biliary cirrhosis. Cutis. 1992;49:271-4.
75. Jardine DL, Chambers ST, Hart DJ, Chapman BA. Primary biliary cirrhosis presenting with granulomatous skin lesions. Gut. 1994;35:564-6.
76. Hughes P, McGavin CR. Sarcoidosis and primary biliary cirrhosis with coexisting myositis. Thorax. 1997;52:201-2.
77. Popova EN, Nekrasova TP, Tanashchuk EL, et al. A variant form of autoimmune hepatitis / primary biliary cirrhosis in combination with generalized sarcoidosis. Dokazatel'naya gastroenterologiya. 2017;(3):51-9 (In Russ.).
78. Al-Kofahi K, Korsten P, Ascoli C, Virupannavar S, Mirsaeidi M, Chang I, Qaqish N, Saketkoo LA, Baughman RP, Sweiss NJ. Management of extrapulmonary sarcoidosis: challenges and solutions. Ther Clin Risk Manag. 2016;12:1623-34. doi: 10.2147/TCRM.S74476
79. Bakker G, Haan Y, Maillette de Buy Wenniger L, Beuers U. Sarcoidosis of the liver: to treat or not to treat? Neth J Med. 2012;70(8):349-56.
80. Cremers J, Drent M, Driessen A, Nieman F, Wijnen P, Baughman R, Koek G. Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 2012;24(1):17-24. doi: 10.1097/MEG.0b013e32834c7b71
81. Alenezi B, Lamoureux E, Alpert L, Szilagyi A. Effect of ursodeoxycholic acid on granulomatous liver disease due to sarcoidosis. Dig Dis Sci. 2005;50(1):196-200.
82. Baratta L, Cascino A, Delfino M, Giorgino F, Vitolo D, Laganà B, Urani C, Rossi Fanelli F. Ursodeoxycholic acid treatment in abdominal sarcoidosis. Dig Dis Sci. 2000;45(8):1559-62.
83. Baughman R, Lynch J. Difficult treatment issues in sarcoidosis. J Intern Med. 2003;253(1):41-5.
84. Bécheur H, Dall'osto H, Chatellier G, Charton-Bain MC, Aubertin JM, Attar A, Bloch F, Petite JP. Effect of ursodeoxycholic acid on chronic intrahepatic cholestasis due to sarcoidosis. Dig Dis Sci. 1997;42(4):789-91.
85. Heuman D. Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology. 1993;104(6):1865-70.
86. Wan Y. TPMT testing before azathioprine therapy? Drug Ther Bull. 2009;47(1):9-12. doi: 10.1136/dtb.2008.12.0033
87. Ulbricht K, Stoll M, Bierwirth J, Witte T, Schmidt RE. Successful tumor necrosis factor alpha blockade treatment in therapy-resistant sarcoidosis. Arthritis Rheum. 2003;48(12):3542-3. doi: 10.1002/art.11357
88. Doty J, Mazur J, Judson M. Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064-71. doi: 10.1378/chest.127.3.1064
89. Saleh S, Ghodsian S, Yakimova V, Henderson J, Sharma OP. Effectiveness of infliximab in treating selected patients with sarcoidosis. Respir Med. 2006;100(11):2053-9. doi: 10.1016/j.rmed.2006.02.017
90. Denys B, Bogaerts Y, Coenegrachts K, De Vriese A. Steroid-resistant sarcoidosis: is antagonism of TNF-alpha the answer? Clin Sci (Lond). 2007;112(5):281-9. doi: 10.1042/CS20060094
91. Costabel U. Sarcoidosis: clinical update. Eur Respir J Suppl. 2001;32:56-68.
92. Cengiz C, Rodriguez-Davalos M, de Boccardo G, Fiel MI, Rodriguez-Laiz G, Kovacevic M, Emre S, Schiano T. Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature. Liver Transpl. 2005;11(12):1611-4. doi: 10.1002/lt.20626
93. Bilal M, Satapathy S, Ismail M, Vanatta J. Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience. J Clin Exp Hepatol. 2016;6(2):94-9. doi: 10.1016/j.jceh.2016.02.005
94. Lipson E, Fiel M, Florman S, Korenblat K. Patient and graft outcomes following liver transplantation for sarcoidosis. Clin Transplant. 2005;19(4):487-91. doi: 10.1111/j.1399-0012.2005.00372.x
95. Casavilla F, Gordon R, Wright H. Clinical course after liver transplantation in patients with sarcoidosis. Ann Intern Med. 1993;118(11):865-66.
2. Kahi CJ, Saxena R, Temkit M. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis Diffuse Lung Dis. 2006;23(2):117-23.
3. Визель А.А., Амиров Н.Б. Саркоидоз и поражение органов системы пищеварения. Вестник современной клинической медицины. 2010;(1):43-50 [Vizel' AA, Amirov NB. Sarcoidosis and organ damage in the digestive system. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2010;(1):43-50 (In Russ.)].
4. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155-67. doi: 10.1016/S0140-6736(13)60680-7
5. Hardman T, Sharma R, Dubrey S, Shah S. Sarcoidosis: the links between epidemiology and aetiology. Postgrad Med J. 2014;90(1068):582-9. doi: 10.1136/postgradmedj-2014-132584
6. Dumas O, Abramovitz L, Wiley AS, Cozier YC, Camargo CA Jr. Epidemiology of sarcoidosis in a prospective cohort study of U.S. women. Ann Am Thorac Soc. 2016;13(1):67-71. doi: 10.1513/AnnalsATS.201508-568BC
7. Визель А.А., Визель И.Ю., Амиров Н.Б. Эпидемиология саркоидоза в Российской Федерации. Вестник современной клинической медицины. 2017;(5):66-73 [Vizel' AA, Vizel' IYu, Amirov NB. Epidemiology of sarcoidosis in the Russian Federation. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2017;(5):66-73 (In Russ.)]. doi: 10.20969/VSKM.2017.10(5).66-73
8. Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, Trilla A, Stone JH, Khamashta MA, Shoenfeld Y. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015;14(8):670-9. doi: 10.1016/j.autrev.2015.03.008
9. Hillerdal G, Nöu E, Osterman K, Schmekel B. Sarcoidosis: epidemiology and prognosis. A 15-year European study. Am Rev Respir Dis. 1984;130(1):29-32.
10. Sawahata M, Sugiyama Y, Nakamura Y, Nakayama M, Mato N, Yamasawa H, Bando M. Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Respir Med. 2015;109(2):272-8. doi: 10.1016/j.rmed.2014.12.012
11. Holmes J, Lazarus A. Sarcoidosis: extrathoracic manifestations. Dis Mon. 2009;55:675-92. doi: 10.1016/j.disamonth.2009.05.002
12. Baughman R, Baughman RP, Teirstein AS, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885-9. doi: 10.1164/ajrccm.164.10.2104046
13. Scadding J. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br Med J. 1961;2(5261):1165-72.
14. Терпигорев С.А., Эльзейн Б.А., Верещагина В.М. и др. Саркоидоз и проблемы его классификации. Вестник Российской медицинской академии наук. 2012;(5):30-7 [Terpigorev SA, El'zein BA, Vereshchagina VM, et al. Sarcoidosis and its classification problems. Vestnik Rossiiskoi Meditsinskoi Akademii Nauk. 2012;(5):30-7 (In Russ.)].
15. Maddrey WC, Johns CJ, Boitnott JK, Iber FL. Sarcoidosis and chronic hepatic disease: a clinical and pathologic study of 20 patients. Medicine (Baltimore). 1970;49(5):375-95. doi: 10.1097/00005792-197009000-00002
16. Culver D. Sarcoidosis. Immunol Allergy Clin North Am. 2012;32(4):487-511. doi: 10.1016/j.iac.2012.08.005
17. Zissel G, Prasse A, Müller-Quernheim J. Immunologic response of sarcoidosis. Semin Respir Crit Care Med. 2010;31(4):390-403. doi: 10.1055/s-0030-1262208
18. Lazarus A. Sarcoidosis: epidemiology, etiology, pathogenesis, and genetics. Dis Mon. 2009;55(11):649-60. doi: 10.1016/j.disamonth.2009.04.008
19. Chen E, Moller D. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365-77. doi: 10.1007/s12016-015-8481-z
20. Suzuki Y, Uchida K, Takemura T. Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. PLoS One. 2018;13(2). Accessed Nov 5, 2018. doi: 10.1371/journal.pone.0192408
21. Vihlborg P, Bryngelsson IL, Andersson L, Graff P. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. BMJ Open. 2017;7:1-7. doi: 10.1136/bmjopen-2017-016839
22. Лопаткина Т.Н., Пономарев А.Б., Попова Е.Н. и др. Интерферон-индуцированный (лекарственный) саркоидоз. Клиническая фармакология и терапия. 2008;(5):45-8 [Lopatkina TN, Ponomarev AB, Popova EN, et al. Interferon-induced (drug) sarcoidosis. Klinicheskaya farmakologiya i terapiya. 2008;(5):45-8 (In Russ.)].
23. Alazemi S. Interferon-induced sarcoidosis. Int J ClinPract. 2006;60(2):201-11. doi: 10.1111/j.1742-1241.2005.00651.x
24. Fiel MI, Shukla D, Saraf N. Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation. Transpl Infect Dis. 2008;10:184-9. doi: 10.1111/j.1399-3062.2007.00258.x
25. Lamps L. Hepatic granulomas. A review with emphasis on infectious cause. Arch Pathol Lab Med. 2015;139:867-75. doi: 10.5858/arpa.2014-0123-RA
26. Costabel U, Hunninghake G. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders. Eur Respir J. 1999;14(4):735-7.
27. Kennedy P, Zakaria N, Modawi SB, Papadopoulou AM, Murray-Lyon I, du Bois RM, Jervoise N, Andreyev H, Devlin J. Natural history of hepatic sarcoidosis and its response to treatment. Eur J Gastroenterol Hepatol. 2006;18(7):721-6. doi: 10.1097/01.meg.0000223911.85739.38
28. Modaresi E, Culver D, Plesec T, John B. Clinical presentation and protocol for management of hepatic sarcoidosis. Expert Rev Gastroenterol Hepatol. 2015;9(3):349-58. doi: 10.1586/17474124.2015.958468
29. Drebber U, Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. Hepatic granulomas: histological and molecular pathological approach to differential diagnosis – a study of 442 cases. Liver Int. 2008;28(6):828-34. doi: 10.1111/j.1478-3231.2008.01695.x
30. Dourakis SP, Saramadou R, Alexopoulou A. Hepatic granulomas: a 6-year experience in a single center in Greece. Eur J Gastroenterol Hepatol. 2007;19(2):101-4. doi: 10.1097/01.meg.0000243882.09820.d2
31. Lewis J. Histopathology of granulomatous liver disease. Clin Liv Dis. 2018;11(3):77-80. doi: 10.1002/cld.695
32. Yee AM. Sarcoidosis: rheumatology perspective. Best Pract Res Clin Rheumatol. 2016;30(2):334-56. doi: 10.1016/j.berh.2016.07.001
33. Tadros M, Forouhar F, Wu G. Hepatic sarcoidosis. J Clin Transl Hepatol. 2013;2:87-93. doi: 10.14218/JCTH.2013.00016
34. Karagiannidis A, Karavalaki M, Koulaouzidis A. Hepatic sarcoidosis. Ann Hepatol. 2006;5(4):251-6.
35. Лебедева М.В., Попова Е.Н., Пономарев А.Б. и др. Внелегочные проявления саркоидоза. Врач. 2011;(3):43-5 [Lebedeva MV, Popova EN, Ponomarev AB, et al. Extrapulmonary manifestations of sarcoidosis. Vrach. 2011;(3):43-5 (In Russ.)].
36. Dulai PS, Rothstein RI. Disseminated Sarcoidosis Presenting as Granulomatous Gastritis. A Clinical Review of the Gastrointestinal and Hepatic Manifestations of Sarcoidosis. J Clin Gastroenterol. 2012;46(5):367-74. doi: 10.1097/MCG.0b013e318247106b
37. Mueller S. Extrapulmonary sarcoidosis primarily diagnosed in the liver. Scand J Gastroenterol. 2000;35:1003-8. doi: 10.3748/wjg.v13.i17.2504
38. Greenwood R. Atypical Presentation of Hepatic Sarcoidosis. Hawaii J Med Public Health. 2013;72(9):55.
39. Farooq PD, Potosky DR. The Klatskin Tumor That Wasn’t: An Unusual Presentation of Sarcoidosis. ACG Case Rep J. 2016;3(4):1-4. doi: 10.14309/crj.2016.114
40. Gaduputieti V. Extrahepatic Biliary Obstruction: An Unusual Presentation of Hepatic Sarcoidosis. Clin Med Insights Gastroenterol. 2015;8:19-22. doi: 10.4137/CGast.S22809
41. Rezeig MA, Fashir BM. Biliary tract obstruction due to sarcoidosis: a case report. Am J Gastroenterol. 1997;92(3):527-8.
42. Suzuki I, Zenichi M, Shinpei F, Yoshinao T, Chinatsu T, Tadashi K, Masahiro I, Atsushi S. Hepatic Sarcoidosis Mimicking Hilar Cholangiocarcinoma: Case Report and Review of the Literature. Case Rep Gastroenterol. 2011;5(1):152-8. doi: 10.1159/000323546
43. Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN. Mimics of Cholangiocarcinoma: Spectrum of Disease. RadioGraphics. 2008;28(4):1115-29. doi: 10.1148/rg.284075148
44. Philips CA, Kalal CR, Kumar A. Sarcoidosis Presenting as Acute on Chronic Liver Failure – Report of the First Case. Med Sci. 2016;5(2):655-65. doi: 10.5455/medscience.2015.04.8325
45. Judson M, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M. Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J. 2008;31(6):1189-96. doi: 10.1183/09031936.00051907
46. Ayyala U, Padilla M. Diagnosis and treatment of hepatic sarcoidosis. Curr Treat Options Gastroenterol. 2006;9(6):475-83.
47. Cremers J, Drent M, Baughman RP, Wijnen PA, Koek GH. Therapeutic approach of hepatic sarcoidosis. Curr Opin Pulm Med. 2012;18(5):472-87. doi: 10.1097/MCP.0b013e3283541626
48. Syed U, Alkhawam H, Bakhit M, Ching Companioni R, Walfish A. Hepatic sarcoidosis: pathogenesis, clinical context, and treatment options. Scand J Gastroenterol. 2016;51(9):1025-30. doi: 10.1080/00365521.2016.1177856
49. Baughman R. Sarcoidosis usual and unusual manifestations. Chest. 1988;94:165-70.
50. Sharma OP. Vitamin D, calcium, and sarcoidosis. Chest. 1996;109:535-9.
51. Inui N, Murayama A. Correlation between 25-hydroxyvitamin D3 1-alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med. 2001;110:687-93.
52. Ackermann D. Hypercalcemia in sarcoidosis-case report, prevalence, pathophysiology and therapeutic options. Ther Umsch. 2007;64:281-6. doi: 10.1024/0040-5930.64.5.281
53. Yanardag H, Pehlivan M, Bilir M, Tetikkurt C. Clinical Features and Prognostic Significance of Liver Involvement in Sarcoidosis. Eur Respir Pulmon Dis. 2016;2(1):26-9. doi: 10.4081/monaldi.2017.893
54. Kessler A, Mitchell D, Israel H, Goldberg B. Hepatic and splenic sarcoidosis: ultrasound and MR imaging. Abdom Imaging. 1993;18(2):159-63.
55. Ebert E, Kierson M, Hagspiel K. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol. 2008;103(12):3184-92. doi: 10.1111/j.1572-0241.2008.02202.x
56. Gezer N, Başara I, Altay C, Harman M, Rocher L, Karabulut N, Seçil M. Abdominal sarcoidosis: cross-sectional imaging findings. Diagn Interv Radiol. 2015;21(2):111-7. doi: 10.5152/dir.2014.14210
57. Karaosmanoğlu A, Onur MR, Saini S, Taberi A, Karcaaltincaba M. Imaging of hepatobiliary involvement in sarcoidosis. Abdom Imaging. 2015;40(8):3330-7. doi: 10.1007/s00261-015-0533-6
58. Tana C, Dietrich C, Schiavone C. Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice [WEB resousce]. Biomed Res Int. 2014:926203. Accessed November 5, 2018. https://www.hindawi.com/journals/bmri/2014/926203/. doi: 10.1155/2014/926203
59. Grzelak P. Diagnostic potential of contrast-enhanced ultrasound (CEUS) in the assessment of spleen and liver granulomas in the course of sarcoidosis. Pneumonol Alergol Pol. 2013;81(5):424-8.
60. Naschitz J, Enat R, Yeshurun D, Eisenberg D, Baruch Y, Bassan L, Misselevitch I, Boss JH. Massive subcapsular fibrosis of the liver: ultrasonic and computed tomographic characteristics. J Clin Gastroenterol. 1991;13(2):470-4.
61. Ferreira A, Ramalho M, de Campos RO, Heredia V, Roque A, Vaidean G, Semelka RC. Hepatic sarcoidosis: MR appearances in patients with chronic liver disease. Magn Reson Imaging. 2013;31(3):432-8. doi: 10.1016/j.mri.2012.08.005
62. Jung G, Brill N, Poll LW, Koch JA, Wettstein M. MRI of hepatic sarcoidosis: large confluent lesions mimicking malignancy. AJR Am J Roentgenol. 2004;183(1):171-3. doi: 10.2214/ajr.183.1.1830171
63. Warshauer D, Dumbleton SA, Molina PL, Yankaskas BC, Parker LA, Woosley JT. Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 1994;192(1):93-8. doi: 10.1148/radiology.192.1.8208972
64. Saito H, Ohmori M, Iwamuro M, Tanaka T, Wada N, Yasunaka T, Takaki A. Hepatic and gastric involvement in a case of systemic sarcoidosis presenting with rupture of esophageal varices. Intern Med. 2017;56(19):2583-8. doi: 10.2169/internalmedicine.8768-16
65. Heinle R, Chang C. Diagnostic criteria for sarcoidosis. Autoimmun Rev. 2014;13(5):383-7. doi: 10.1016/j.autrev.2014.01.035
66. Stanca CM, Fiel MI, Allina J, Caracta CF, Odin JA. Liver failure in an antimitochondrial antibody-positive patient with sarcoidosis: primary biliary cirrhosis or hepatic sarcoidosis? Semin Liver Dis. 2005;25:364-70. doi: 10.1055/s-2005-916327
67. Gur C, Lalazar G, Doviner V, Lalazar G, Doviner V, Fridlender ZG, Molcho V, Abu-Much S, Shalit M, Elinav E. Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis. J Clin Gastroenterol. 2007;41:329-32. doi: 10.1097/01.mcg.0000212653.51397.f6
68. Kishor Turner ML, Borg BB, Kleiner DE, Cowen EW. Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases? J Am Acad Dermatol. 2007;38(2):326-35. doi: 10.1016/j.jaad.2007.07.031
69. Koulentaki M, Ioannidou D, Stefanidou M, Maraki S, Drigiannakis I, Dimoulios P. Dermatological manifestations in primary biliary cirrhosis patients: a case control study. Am J Gastroenterol. 2006;101:541-6. doi: 10.1111/j.1572-0241.2006.00423.x
70. Sherman S, Nieland N, van Thiel D. Sarcoidosis and primary biliary cirrhosis: coexistence in a single patient. Dig Dis Sci. 1988;33:368-74.
71. Leff JA, Ready JB, Repetto C, Goff JS, Schwarz M. Coexistence of primary biliary cirrhosis and sarcoidosis. West J Med. 1990;153:439-41.
72. Asvesti C, Hadziyannis SJ, Papadopoulos S, Giakoumoglou T, Hadziolou E, Trichia E. Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. Dermatology. 1994;189:198-202.
73. Keefe EB. Sarcoidosis and primary biliary cirrhosis: literature review and illustrative case. Am J Med. 1987;83:977-80.
74. Harrington AC, Fitzpatrick JE. Cutaneous sarcoidal granulomas in a patient with primary biliary cirrhosis. Cutis. 1992;49:271-4.
75. Jardine DL, Chambers ST, Hart DJ, Chapman BA. Primary biliary cirrhosis presenting with granulomatous skin lesions. Gut. 1994;35:564-6.
76. Hughes P, McGavin CR. Sarcoidosis and primary biliary cirrhosis with coexisting myositis. Thorax. 1997;52:201-2.
77. Попова Е.Н., Некрасова Т.П., Танащук Е.Л. и др. Вариантная форма аутоиммунного гепатита/первичного билиарного цирроза в сочетании с генерализованным саркоидозом. Доказательная гастроэнтерология. 2017;(3):51-9 [Popova EN, Nekrasova TP, Tanashchuk EL, et al. A variant form of autoimmune hepatitis / primary biliary cirrhosis in combination with generalized sarcoidosis. Dokazatel'naya gastroenterologiya. 2017;(3):51-9 (In Russ.)].
78. Al-Kofahi K, Korsten P, Ascoli C, Virupannavar S, Mirsaeidi M, Chang I, Qaqish N, Saketkoo LA, Baughman RP, Sweiss NJ. Management of extrapulmonary sarcoidosis: challenges and solutions. Ther Clin Risk Manag. 2016;12:1623-34. doi: 10.2147/TCRM.S74476
79. Bakker G, Haan Y, Maillette de Buy Wenniger L, Beuers U. Sarcoidosis of the liver: to treat or not to treat? Neth J Med. 2012;70(8):349-56.
80. Cremers J, Drent M, Driessen A, Nieman F, Wijnen P, Baughman R, Koek G. Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 2012;24(1):17-24. doi: 10.1097/MEG.0b013e32834c7b71
81. Alenezi B, Lamoureux E, Alpert L, Szilagyi A. Effect of ursodeoxycholic acid on granulomatous liver disease due to sarcoidosis. Dig Dis Sci. 2005;50(1):196-200.
82. Baratta L, Cascino A, Delfino M, Giorgino F, Vitolo D, Laganà B, Urani C, Rossi Fanelli F. Ursodeoxycholic acid treatment in abdominal sarcoidosis. Dig Dis Sci. 2000;45(8):1559-62.
83. Baughman R, Lynch J. Difficult treatment issues in sarcoidosis. J Intern Med. 2003;253(1):41-5.
84. Bécheur H, Dall'osto H, Chatellier G, Charton-Bain MC, Aubertin JM, Attar A, Bloch F, Petite JP. Effect of ursodeoxycholic acid on chronic intrahepatic cholestasis due to sarcoidosis. Dig Dis Sci. 1997;42(4):789-91.
85. Heuman D. Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology. 1993;104(6):1865-70.
86. Wan Y. TPMT testing before azathioprine therapy? Drug Ther Bull. 2009;47(1):9-12. doi: 10.1136/dtb.2008.12.0033
87. Ulbricht K, Stoll M, Bierwirth J, Witte T, Schmidt RE. Successful tumor necrosis factor alpha blockade treatment in therapy-resistant sarcoidosis. Arthritis Rheum. 2003;48(12):3542-3. doi: 10.1002/art.11357
88. Doty J, Mazur J, Judson M. Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064-71. doi: 10.1378/chest.127.3.1064
89. Saleh S, Ghodsian S, Yakimova V, Henderson J, Sharma OP. Effectiveness of infliximab in treating selected patients with sarcoidosis. Respir Med. 2006;100(11):2053-9. doi: 10.1016/j.rmed.2006.02.017
90. Denys B, Bogaerts Y, Coenegrachts K, De Vriese A. Steroid-resistant sarcoidosis: is antagonism of TNF-alpha the answer? Clin Sci (Lond). 2007;112(5):281-9. doi: 10.1042/CS20060094
91. Costabel U. Sarcoidosis: clinical update. Eur Respir J Suppl. 2001;32:56-68.
92. Cengiz C, Rodriguez-Davalos M, de Boccardo G, Fiel MI, Rodriguez-Laiz G, Kovacevic M, Emre S, Schiano T. Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature. Liver Transpl. 2005;11(12):1611-4. doi: 10.1002/lt.20626
93. Bilal M, Satapathy S, Ismail M, Vanatta J. Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience. J Clin Exp Hepatol. 2016;6(2):94-9. doi: 10.1016/j.jceh.2016.02.005
94. Lipson E, Fiel M, Florman S, Korenblat K. Patient and graft outcomes following liver transplantation for sarcoidosis. Clin Transplant. 2005;19(4):487-91. doi: 10.1111/j.1399-0012.2005.00372.x
95. Casavilla F, Gordon R, Wright H. Clinical course after liver transplantation in patients with sarcoidosis. Ann Intern Med. 1993;118(11):865-66.
________________________________________________
2. Kahi CJ, Saxena R, Temkit M. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis Diffuse Lung Dis. 2006;23(2):117-23.
3. Vizel' AA, Amirov NB. Sarcoidosis and organ damage in the digestive system. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2010;(1):43-50 (In Russ.).
4. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Müller-Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155-67. doi: 10.1016/S0140-6736(13)60680-7
5. Hardman T, Sharma R, Dubrey S, Shah S. Sarcoidosis: the links between epidemiology and aetiology. Postgrad Med J. 2014;90(1068):582-9. doi: 10.1136/postgradmedj-2014-132584
6. Dumas O, Abramovitz L, Wiley AS, Cozier YC, Camargo CA Jr. Epidemiology of sarcoidosis in a prospective cohort study of U.S. women. Ann Am Thorac Soc. 2016;13(1):67-71. doi: 10.1513/AnnalsATS.201508-568BC
7. Vizel' AA, Vizel' IYu, Amirov NB. Epidemiology of sarcoidosis in the Russian Federation. Vestnik Sovremennoi Klinicheskoi Meditsiny. 2017;(5):66-73 (In Russ.). doi: 10.20969/VSKM.2017.10(5).66-73
8. Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, Trilla A, Stone JH, Khamashta MA, Shoenfeld Y. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015;14(8):670-9. doi: 10.1016/j.autrev.2015.03.008
9. Hillerdal G, Nöu E, Osterman K, Schmekel B. Sarcoidosis: epidemiology and prognosis. A 15-year European study. Am Rev Respir Dis. 1984;130(1):29-32.
10. Sawahata M, Sugiyama Y, Nakamura Y, Nakayama M, Mato N, Yamasawa H, Bando M. Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Respir Med. 2015;109(2):272-8. doi: 10.1016/j.rmed.2014.12.012
11. Holmes J, Lazarus A. Sarcoidosis: extrathoracic manifestations. Dis Mon. 2009;55:675-92. doi: 10.1016/j.disamonth.2009.05.002
12. Baughman R, Baughman RP, Teirstein AS, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885-9. doi: 10.1164/ajrccm.164.10.2104046
13. Scadding J. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br Med J. 1961;2(5261):1165-72.
14. Terpigorev SA, El'zein BA, Vereshchagina VM, et al. Sarcoidosis and its classification problems. Vestnik Rossiiskoi Meditsinskoi Akademii Nauk. 2012;(5):30-7 (In Russ.).
15. Maddrey WC, Johns CJ, Boitnott JK, Iber FL. Sarcoidosis and chronic hepatic disease: a clinical and pathologic study of 20 patients. Medicine (Baltimore). 1970;49(5):375-95. doi: 10.1097/00005792-197009000-00002
16. Culver D. Sarcoidosis. Immunol Allergy Clin North Am. 2012;32(4):487-511. doi: 10.1016/j.iac.2012.08.005
17. Zissel G, Prasse A, Müller-Quernheim J. Immunologic response of sarcoidosis. Semin Respir Crit Care Med. 2010;31(4):390-403. doi: 10.1055/s-0030-1262208
18. Lazarus A. Sarcoidosis: epidemiology, etiology, pathogenesis, and genetics. Dis Mon. 2009;55(11):649-60. doi: 10.1016/j.disamonth.2009.04.008
19. Chen E, Moller D. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365-77. doi: 10.1007/s12016-015-8481-z
20. Suzuki Y, Uchida K, Takemura T. Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. PLoS One. 2018;13(2). Accessed Nov 5, 2018. doi: 10.1371/journal.pone.0192408
21. Vihlborg P, Bryngelsson IL, Andersson L, Graff P. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. BMJ Open. 2017;7:1-7. doi: 10.1136/bmjopen-2017-016839
22. Lopatkina TN, Ponomarev AB, Popova EN, et al. Interferon-induced (drug) sarcoidosis. Klinicheskaya farmakologiya i terapiya. 2008;(5):45-8 (In Russ.).
23. Alazemi S. Interferon-induced sarcoidosis. Int J ClinPract. 2006;60(2):201-11. doi: 10.1111/j.1742-1241.2005.00651.x
24. Fiel MI, Shukla D, Saraf N. Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation. Transpl Infect Dis. 2008;10:184-9. doi: 10.1111/j.1399-3062.2007.00258.x
25. Lamps L. Hepatic granulomas. A review with emphasis on infectious cause. Arch Pathol Lab Med. 2015;139:867-75. doi: 10.5858/arpa.2014-0123-RA
26. Costabel U, Hunninghake G. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders. Eur Respir J. 1999;14(4):735-7.
27. Kennedy P, Zakaria N, Modawi SB, Papadopoulou AM, Murray-Lyon I, du Bois RM, Jervoise N, Andreyev H, Devlin J. Natural history of hepatic sarcoidosis and its response to treatment. Eur J Gastroenterol Hepatol. 2006;18(7):721-6. doi: 10.1097/01.meg.0000223911.85739.38
28. Modaresi E, Culver D, Plesec T, John B. Clinical presentation and protocol for management of hepatic sarcoidosis. Expert Rev Gastroenterol Hepatol. 2015;9(3):349-58. doi: 10.1586/17474124.2015.958468
29. Drebber U, Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. Hepatic granulomas: histological and molecular pathological approach to differential diagnosis – a study of 442 cases. Liver Int. 2008;28(6):828-34. doi: 10.1111/j.1478-3231.2008.01695.x
30. Dourakis SP, Saramadou R, Alexopoulou A. Hepatic granulomas: a 6-year experience in a single center in Greece. Eur J Gastroenterol Hepatol. 2007;19(2):101-4. doi: 10.1097/01.meg.0000243882.09820.d2
31. Lewis J. Histopathology of granulomatous liver disease. Clin Liv Dis. 2018;11(3):77-80. doi: 10.1002/cld.695
32. Yee AM. Sarcoidosis: rheumatology perspective. Best Pract Res Clin Rheumatol. 2016;30(2):334-56. doi: 10.1016/j.berh.2016.07.001
33. Tadros M, Forouhar F, Wu G. Hepatic sarcoidosis. J Clin Transl Hepatol. 2013;2:87-93. doi: 10.14218/JCTH.2013.00016
34. Karagiannidis A, Karavalaki M, Koulaouzidis A. Hepatic sarcoidosis. Ann Hepatol. 2006;5(4):251-6.
35. Lebedeva MV, Popova EN, Ponomarev AB, et al. Extrapulmonary manifestations of sarcoidosis. Vrach. 2011;(3):43-5 (In Russ.).
36. Dulai PS, Rothstein RI. Disseminated Sarcoidosis Presenting as Granulomatous Gastritis. A Clinical Review of the Gastrointestinal and Hepatic Manifestations of Sarcoidosis. J Clin Gastroenterol. 2012;46(5):367-74. doi: 10.1097/MCG.0b013e318247106b
37. Mueller S. Extrapulmonary sarcoidosis primarily diagnosed in the liver. Scand J Gastroenterol. 2000;35:1003-8. doi: 10.3748/wjg.v13.i17.2504
38. Greenwood R. Atypical Presentation of Hepatic Sarcoidosis. Hawaii J Med Public Health. 2013;72(9):55.
39. Farooq PD, Potosky DR. The Klatskin Tumor That Wasn’t: An Unusual Presentation of Sarcoidosis. ACG Case Rep J. 2016;3(4):1-4. doi: 10.14309/crj.2016.114
40. Gaduputieti V. Extrahepatic Biliary Obstruction: An Unusual Presentation of Hepatic Sarcoidosis. Clin Med Insights Gastroenterol. 2015;8:19-22. doi: 10.4137/CGast.S22809
41. Rezeig MA, Fashir BM. Biliary tract obstruction due to sarcoidosis: a case report. Am J Gastroenterol. 1997;92(3):527-8.
42. Suzuki I, Zenichi M, Shinpei F, Yoshinao T, Chinatsu T, Tadashi K, Masahiro I, Atsushi S. Hepatic Sarcoidosis Mimicking Hilar Cholangiocarcinoma: Case Report and Review of the Literature. Case Rep Gastroenterol. 2011;5(1):152-8. doi: 10.1159/000323546
43. Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN. Mimics of Cholangiocarcinoma: Spectrum of Disease. RadioGraphics. 2008;28(4):1115-29. doi: 10.1148/rg.284075148
44. Philips CA, Kalal CR, Kumar A. Sarcoidosis Presenting as Acute on Chronic Liver Failure – Report of the First Case. Med Sci. 2016;5(2):655-65. doi: 10.5455/medscience.2015.04.8325
45. Judson M, Baughman RP, Costabel U, Flavin S, Lo KH, Kavuru MS, Drent M. Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J. 2008;31(6):1189-96. doi: 10.1183/09031936.00051907
46. Ayyala U, Padilla M. Diagnosis and treatment of hepatic sarcoidosis. Curr Treat Options Gastroenterol. 2006;9(6):475-83.
47. Cremers J, Drent M, Baughman RP, Wijnen PA, Koek GH. Therapeutic approach of hepatic sarcoidosis. Curr Opin Pulm Med. 2012;18(5):472-87. doi: 10.1097/MCP.0b013e3283541626
48. Syed U, Alkhawam H, Bakhit M, Ching Companioni R, Walfish A. Hepatic sarcoidosis: pathogenesis, clinical context, and treatment options. Scand J Gastroenterol. 2016;51(9):1025-30. doi: 10.1080/00365521.2016.1177856
49. Baughman R. Sarcoidosis usual and unusual manifestations. Chest. 1988;94:165-70.
50. Sharma OP. Vitamin D, calcium, and sarcoidosis. Chest. 1996;109:535-9.
51. Inui N, Murayama A. Correlation between 25-hydroxyvitamin D3 1-alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med. 2001;110:687-93.
52. Ackermann D. Hypercalcemia in sarcoidosis-case report, prevalence, pathophysiology and therapeutic options. Ther Umsch. 2007;64:281-6. doi: 10.1024/0040-5930.64.5.281
53. Yanardag H, Pehlivan M, Bilir M, Tetikkurt C. Clinical Features and Prognostic Significance of Liver Involvement in Sarcoidosis. Eur Respir Pulmon Dis. 2016;2(1):26-9. doi: 10.4081/monaldi.2017.893
54. Kessler A, Mitchell D, Israel H, Goldberg B. Hepatic and splenic sarcoidosis: ultrasound and MR imaging. Abdom Imaging. 1993;18(2):159-63.
55. Ebert E, Kierson M, Hagspiel K. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol. 2008;103(12):3184-92. doi: 10.1111/j.1572-0241.2008.02202.x
56. Gezer N, Başara I, Altay C, Harman M, Rocher L, Karabulut N, Seçil M. Abdominal sarcoidosis: cross-sectional imaging findings. Diagn Interv Radiol. 2015;21(2):111-7. doi: 10.5152/dir.2014.14210
57. Karaosmanoğlu A, Onur MR, Saini S, Taberi A, Karcaaltincaba M. Imaging of hepatobiliary involvement in sarcoidosis. Abdom Imaging. 2015;40(8):3330-7. doi: 10.1007/s00261-015-0533-6
58. Tana C, Dietrich C, Schiavone C. Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice [WEB resousce]. Biomed Res Int. 2014:926203. Accessed November 5, 2018. https://www.hindawi.com/journals/bmri/2014/926203/. doi: 10.1155/2014/926203
59. Grzelak P. Diagnostic potential of contrast-enhanced ultrasound (CEUS) in the assessment of spleen and liver granulomas in the course of sarcoidosis. Pneumonol Alergol Pol. 2013;81(5):424-8.
60. Naschitz J, Enat R, Yeshurun D, Eisenberg D, Baruch Y, Bassan L, Misselevitch I, Boss JH. Massive subcapsular fibrosis of the liver: ultrasonic and computed tomographic characteristics. J Clin Gastroenterol. 1991;13(2):470-4.
61. Ferreira A, Ramalho M, de Campos RO, Heredia V, Roque A, Vaidean G, Semelka RC. Hepatic sarcoidosis: MR appearances in patients with chronic liver disease. Magn Reson Imaging. 2013;31(3):432-8. doi: 10.1016/j.mri.2012.08.005
62. Jung G, Brill N, Poll LW, Koch JA, Wettstein M. MRI of hepatic sarcoidosis: large confluent lesions mimicking malignancy. AJR Am J Roentgenol. 2004;183(1):171-3. doi: 10.2214/ajr.183.1.1830171
63. Warshauer D, Dumbleton SA, Molina PL, Yankaskas BC, Parker LA, Woosley JT. Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology. 1994;192(1):93-8. doi: 10.1148/radiology.192.1.8208972
64. Saito H, Ohmori M, Iwamuro M, Tanaka T, Wada N, Yasunaka T, Takaki A. Hepatic and gastric involvement in a case of systemic sarcoidosis presenting with rupture of esophageal varices. Intern Med. 2017;56(19):2583-8. doi: 10.2169/internalmedicine.8768-16
65. Heinle R, Chang C. Diagnostic criteria for sarcoidosis. Autoimmun Rev. 2014;13(5):383-7. doi: 10.1016/j.autrev.2014.01.035
66. Stanca CM, Fiel MI, Allina J, Caracta CF, Odin JA. Liver failure in an antimitochondrial antibody-positive patient with sarcoidosis: primary biliary cirrhosis or hepatic sarcoidosis? Semin Liver Dis. 2005;25:364-70. doi: 10.1055/s-2005-916327
67. Gur C, Lalazar G, Doviner V, Lalazar G, Doviner V, Fridlender ZG, Molcho V, Abu-Much S, Shalit M, Elinav E. Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis. J Clin Gastroenterol. 2007;41:329-32. doi: 10.1097/01.mcg.0000212653.51397.f6
68. Kishor Turner ML, Borg BB, Kleiner DE, Cowen EW. Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases? J Am Acad Dermatol. 2007;38(2):326-35. doi: 10.1016/j.jaad.2007.07.031
69. Koulentaki M, Ioannidou D, Stefanidou M, Maraki S, Drigiannakis I, Dimoulios P. Dermatological manifestations in primary biliary cirrhosis patients: a case control study. Am J Gastroenterol. 2006;101:541-6. doi: 10.1111/j.1572-0241.2006.00423.x
70. Sherman S, Nieland N, van Thiel D. Sarcoidosis and primary biliary cirrhosis: coexistence in a single patient. Dig Dis Sci. 1988;33:368-74.
71. Leff JA, Ready JB, Repetto C, Goff JS, Schwarz M. Coexistence of primary biliary cirrhosis and sarcoidosis. West J Med. 1990;153:439-41.
72. Asvesti C, Hadziyannis SJ, Papadopoulos S, Giakoumoglou T, Hadziolou E, Trichia E. Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. Dermatology. 1994;189:198-202.
73. Keefe EB. Sarcoidosis and primary biliary cirrhosis: literature review and illustrative case. Am J Med. 1987;83:977-80.
74. Harrington AC, Fitzpatrick JE. Cutaneous sarcoidal granulomas in a patient with primary biliary cirrhosis. Cutis. 1992;49:271-4.
75. Jardine DL, Chambers ST, Hart DJ, Chapman BA. Primary biliary cirrhosis presenting with granulomatous skin lesions. Gut. 1994;35:564-6.
76. Hughes P, McGavin CR. Sarcoidosis and primary biliary cirrhosis with coexisting myositis. Thorax. 1997;52:201-2.
77. Popova EN, Nekrasova TP, Tanashchuk EL, et al. A variant form of autoimmune hepatitis / primary biliary cirrhosis in combination with generalized sarcoidosis. Dokazatel'naya gastroenterologiya. 2017;(3):51-9 (In Russ.).
78. Al-Kofahi K, Korsten P, Ascoli C, Virupannavar S, Mirsaeidi M, Chang I, Qaqish N, Saketkoo LA, Baughman RP, Sweiss NJ. Management of extrapulmonary sarcoidosis: challenges and solutions. Ther Clin Risk Manag. 2016;12:1623-34. doi: 10.2147/TCRM.S74476
79. Bakker G, Haan Y, Maillette de Buy Wenniger L, Beuers U. Sarcoidosis of the liver: to treat or not to treat? Neth J Med. 2012;70(8):349-56.
80. Cremers J, Drent M, Driessen A, Nieman F, Wijnen P, Baughman R, Koek G. Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 2012;24(1):17-24. doi: 10.1097/MEG.0b013e32834c7b71
81. Alenezi B, Lamoureux E, Alpert L, Szilagyi A. Effect of ursodeoxycholic acid on granulomatous liver disease due to sarcoidosis. Dig Dis Sci. 2005;50(1):196-200.
82. Baratta L, Cascino A, Delfino M, Giorgino F, Vitolo D, Laganà B, Urani C, Rossi Fanelli F. Ursodeoxycholic acid treatment in abdominal sarcoidosis. Dig Dis Sci. 2000;45(8):1559-62.
83. Baughman R, Lynch J. Difficult treatment issues in sarcoidosis. J Intern Med. 2003;253(1):41-5.
84. Bécheur H, Dall'osto H, Chatellier G, Charton-Bain MC, Aubertin JM, Attar A, Bloch F, Petite JP. Effect of ursodeoxycholic acid on chronic intrahepatic cholestasis due to sarcoidosis. Dig Dis Sci. 1997;42(4):789-91.
85. Heuman D. Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology. 1993;104(6):1865-70.
86. Wan Y. TPMT testing before azathioprine therapy? Drug Ther Bull. 2009;47(1):9-12. doi: 10.1136/dtb.2008.12.0033
87. Ulbricht K, Stoll M, Bierwirth J, Witte T, Schmidt RE. Successful tumor necrosis factor alpha blockade treatment in therapy-resistant sarcoidosis. Arthritis Rheum. 2003;48(12):3542-3. doi: 10.1002/art.11357
88. Doty J, Mazur J, Judson M. Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064-71. doi: 10.1378/chest.127.3.1064
89. Saleh S, Ghodsian S, Yakimova V, Henderson J, Sharma OP. Effectiveness of infliximab in treating selected patients with sarcoidosis. Respir Med. 2006;100(11):2053-9. doi: 10.1016/j.rmed.2006.02.017
90. Denys B, Bogaerts Y, Coenegrachts K, De Vriese A. Steroid-resistant sarcoidosis: is antagonism of TNF-alpha the answer? Clin Sci (Lond). 2007;112(5):281-9. doi: 10.1042/CS20060094
91. Costabel U. Sarcoidosis: clinical update. Eur Respir J Suppl. 2001;32:56-68.
92. Cengiz C, Rodriguez-Davalos M, de Boccardo G, Fiel MI, Rodriguez-Laiz G, Kovacevic M, Emre S, Schiano T. Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature. Liver Transpl. 2005;11(12):1611-4. doi: 10.1002/lt.20626
93. Bilal M, Satapathy S, Ismail M, Vanatta J. Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience. J Clin Exp Hepatol. 2016;6(2):94-9. doi: 10.1016/j.jceh.2016.02.005
94. Lipson E, Fiel M, Florman S, Korenblat K. Patient and graft outcomes following liver transplantation for sarcoidosis. Clin Transplant. 2005;19(4):487-91. doi: 10.1111/j.1399-0012.2005.00372.x
95. Casavilla F, Gordon R, Wright H. Clinical course after liver transplantation in patients with sarcoidosis. Ann Intern Med. 1993;118(11):865-66.
Авторы
В.В. Фомин 1, М.Ю. Бровко 2, М.В. Калашников 3, В.И. Шоломова 2,3, Т.П. Розина 2,4, Л.А. Акулкина 2, А.Е. Першина 4, А.Ш. Янакаева 2, Т.П. Некрасова 5
1 Кафедра факультетской терапии №1 лечебного факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 Клиника им. Е.М. Тареева ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3 Кафедра внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
4 Кафедра внутренних болезней факультета фундаментальной медицины ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
5 Кафедра патологической анатомии им. А.И. Струкова ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Faculty of Medicine, Department of Internal Medicine No.1, Moscow, Russia;
2 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), E.M. Tareev Clinic of Internal Diseases, Moscow, Russia;
3 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Medical and Preventive Faculty, Department of Internal, Occupational Diseases and Rheumatology, Moscow, Russia;
4 M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal Medicine, Moscow, Russia;
5 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), A.I. Strukov Department of Pathological Anatomy, Moscow, Russia
1 Кафедра факультетской терапии №1 лечебного факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 Клиника им. Е.М. Тареева ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3 Кафедра внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
4 Кафедра внутренних болезней факультета фундаментальной медицины ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
5 Кафедра патологической анатомии им. А.И. Струкова ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
________________________________________________
1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Faculty of Medicine, Department of Internal Medicine No.1, Moscow, Russia;
2 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), E.M. Tareev Clinic of Internal Diseases, Moscow, Russia;
3 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Medical and Preventive Faculty, Department of Internal, Occupational Diseases and Rheumatology, Moscow, Russia;
4 M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal Medicine, Moscow, Russia;
5 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), A.I. Strukov Department of Pathological Anatomy, Moscow, Russia
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