Витамин D – прогностический маркер риска развития обострения у пациентов старше 60 лет с остеоартритом коленного сустава (результаты наблюдательной программы ДИАНА)
Витамин D – прогностический маркер риска развития обострения у пациентов старше 60 лет с остеоартритом коленного сустава (результаты наблюдательной программы ДИАНА)
Золотовская И.А., Давыдкин И.Л. Витамин D – прогностический маркер риска развития обострения у пациентов старше 60 лет с остеоартритом коленного сустава (результаты наблюдательной программы ДИАНА). Терапевтический архив. 2019; 91 (5): 103–110. DOI: 10.26442/00403660.2019.05.000237
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Аннотация
Цель исследования: изучение прогностической значимости витамина D как маркера риска развития обострения остеоартрита (ОА) коленного сустава у пациентов старше 60 лет.
Материалы и методы. Исследование проведено в период с сентября 2016 по сентябрь 2018 г. на базе амбулаторно-поликлинических учреждений Самары с последовательным включением пациентов, обратившихся по любой причине к врачу и имеющих в анамнезе ОА коленного сустава с временем последнего обострения не более 6 мес. Оценивали клинико-демографические параметры, сведения о принимаемых лекарственных средствах (ЛС), характер боли по опроснику DN4, уровень когнитивного дефицита по шкале MMSE, данные офисного артериального давления, фракцию выброса левого желудочка, определяли уровень гемоглобина, глюкозы, мочевой кислоты, показатели интерлейкина (ИЛ) 1β и ИЛ-6, 25(OH)-D. Длительность наблюдения составила 36 мес.
Результаты. В течение 2 лет наблюдения у 79 (38,3%) пациентов отмечено обострение, которое в течение первого года возникло в 19,4% (n=40) случаев, в течение второго года наблюдения – в 18,9% (n=39) случаев соответственно. В 35,4% случаев отмечен нейропатический компонент боли с показателем 4,37±1,05 балла. Возраст, 25-OH-витамин D, ИЛ-1β, а также наличие сахарного диабета и хронической болезни почек являются факторами, влияющими на прогноз развития обострения у пациентов с ОА коленного сустава.
Заключение. По данным 2-летнего наблюдения установлена прогностическая значимость витамина D в отношении риска развития обострения у пациентов с ОА старше 60 лет (χ2=160,9, р<0,001).
Ключевые слова: витамин D, 25(OH)-D, остеоартрит коленного сустава, маркеры воспаления, лекарственные препараты, сопутствующие заболевания.
Materials and methods. The study was conducted from 2016–2018 on the of Samara polyclinics with the inclusion of patients who have applied to a doctor for any reason and have a history of OA of the knee joint with the time of the last exacerbation of no more than 6 months. We evaluated clinical and demographic parameters, information on the drugs taken (drugs), the nature of pain by DN4, the level of cognitive deficiency by MMSE, office blood pressure data, left ventricular ejection fraction, determined the level of hemoglobin, glucose, uric acid, interleukin (IL) 1β and IL-6, 25(OH)-D. the Duration of follow-up was 36 months.
Results. During 2 years of follow-up, 79 (38.3%) patients had exacerbation, which occurred in 19.4% (n=40) of cases during the first year, and in 18.9% (n=39) of cases respectively during the second year. In 35.4% of cases, the neuropathic component of pain was noted with an index of 4.37±1.05 points. Age, 25-OH-vitamin D, IL-1β, and the presence of diabetes mellitus and chronic kidney disease are factors that affect the prognosis of exacerbation in patients with OA of the knee joint.
Conclusion. The prognostic significance of vitamin D for the risk of exacerbation in patients with OA older than 60 years (χ2=160.9, р<0.001).
Keywords: vitamin D, 25(OH)-D, osteoarthritis knee, markers of inflammation, drugs, concomitant diseases.
Материалы и методы. Исследование проведено в период с сентября 2016 по сентябрь 2018 г. на базе амбулаторно-поликлинических учреждений Самары с последовательным включением пациентов, обратившихся по любой причине к врачу и имеющих в анамнезе ОА коленного сустава с временем последнего обострения не более 6 мес. Оценивали клинико-демографические параметры, сведения о принимаемых лекарственных средствах (ЛС), характер боли по опроснику DN4, уровень когнитивного дефицита по шкале MMSE, данные офисного артериального давления, фракцию выброса левого желудочка, определяли уровень гемоглобина, глюкозы, мочевой кислоты, показатели интерлейкина (ИЛ) 1β и ИЛ-6, 25(OH)-D. Длительность наблюдения составила 36 мес.
Результаты. В течение 2 лет наблюдения у 79 (38,3%) пациентов отмечено обострение, которое в течение первого года возникло в 19,4% (n=40) случаев, в течение второго года наблюдения – в 18,9% (n=39) случаев соответственно. В 35,4% случаев отмечен нейропатический компонент боли с показателем 4,37±1,05 балла. Возраст, 25-OH-витамин D, ИЛ-1β, а также наличие сахарного диабета и хронической болезни почек являются факторами, влияющими на прогноз развития обострения у пациентов с ОА коленного сустава.
Заключение. По данным 2-летнего наблюдения установлена прогностическая значимость витамина D в отношении риска развития обострения у пациентов с ОА старше 60 лет (χ2=160,9, р<0,001).
Ключевые слова: витамин D, 25(OH)-D, остеоартрит коленного сустава, маркеры воспаления, лекарственные препараты, сопутствующие заболевания.
________________________________________________
Materials and methods. The study was conducted from 2016–2018 on the of Samara polyclinics with the inclusion of patients who have applied to a doctor for any reason and have a history of OA of the knee joint with the time of the last exacerbation of no more than 6 months. We evaluated clinical and demographic parameters, information on the drugs taken (drugs), the nature of pain by DN4, the level of cognitive deficiency by MMSE, office blood pressure data, left ventricular ejection fraction, determined the level of hemoglobin, glucose, uric acid, interleukin (IL) 1β and IL-6, 25(OH)-D. the Duration of follow-up was 36 months.
Results. During 2 years of follow-up, 79 (38.3%) patients had exacerbation, which occurred in 19.4% (n=40) of cases during the first year, and in 18.9% (n=39) of cases respectively during the second year. In 35.4% of cases, the neuropathic component of pain was noted with an index of 4.37±1.05 points. Age, 25-OH-vitamin D, IL-1β, and the presence of diabetes mellitus and chronic kidney disease are factors that affect the prognosis of exacerbation in patients with OA of the knee joint.
Conclusion. The prognostic significance of vitamin D for the risk of exacerbation in patients with OA older than 60 years (χ2=160.9, р<0.001).
Keywords: vitamin D, 25(OH)-D, osteoarthritis knee, markers of inflammation, drugs, concomitant diseases.
Список литературы
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17. Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, et al. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthritis and Cartilage. 2016;24(11):1858-66.
18. Цветкова Е.С., Денисов Л.Н., Оттева Э.Н., Дубиков А.Н., Якупова С.П., Иванова О.Н., Коршунов Н.И., Вайсберг А.Р., Абышев Р.А., Тартынов А.В., Насонов Е.Л. Открытое многоцентровое наблюдательное исследование эффективности, переносимости и безопасности нестероидного противовоспалительного препарата амтолметина гуацила у пациентов с остеоартритом коленных суставов и диспепсией. Научно-практическая ревматология. 2016;54(6):654-9 [Tsvetkova ES, Denisov LN, Otteva AN, et al. An open-label multicenter observational study of the efficacy, tolerability, and safety of the nonsteroidal anti-inflammatory drug amtolmetin guacil in patients with knee osteoarthritis and dyspepsia. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(6):654-9 (In Russ.)]. doi: http://dx.doi.org/10.14412/1995-4484-2016-654-659
19. Алексеева Л.И., Лила А.М., Шарапова Е.П., Таскина Е.А., Кашеварова Н.Г., Аникин С.Г., Мендель О.И. Многоцентровое проспективное наблюдательное исследование по применению препаратов Артра® МСМ форте и Артра® у пациентов с остеоартритом коленных и/или тазобедренных суставов и/или с болью в нижней части спины (предварительные результаты). Трудный пациент. 2018;16(6):34-41 [Alekseeva LI, Lila AM, Sharapova EP, Taskina EA, Kashevarova NG, Anikin SG, Mendel OI. Multicentre Prospective Observational Study on the Use of ARTRA® MSM FORTE and ARTRA® in Patients with Knee and/or Hip Osteoarthritis and/or Lower Back Pain (preliminary results). Difficult Patient. 2018;16(6):34-41 (In Russ.)].
20. Bergink AP, Zillikens MC, Van Leeuwen JPTM, Hofman A, Uitterlinden AG, van Meurs JBJ. 25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data. Seminars in Arthritis and Rheumatism. 2016;45(5):539-46.
21. Tosi L, Boudreau R, Kwoh K, Prasad T, Ayonayon H, Harris T, Houston D, Kritchevsky S, Patel K, Simonsick E, et al. Vitamin D status and knee pain severity in functionally intact older adults: The health ABC study. J Bone and Mineral Research. 2012;27.
22. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: A systematic review. Rheumatology (United Kingdom). 2013;52(7):1323-34.
23. George J. Vitamin D Supplementation and progression of knee osteoarthritis. JAMA. 2016;316(3):347-8.
24. Насонов Е.Л., Яхно Н.Н., Каратеев А.Е., Алексеева Л.И., Баринов А.Н., Барулин А.Е., Давыдов О.С., Данилов А.Б., Журавлева М.В., Заводовский Б.В., Копенкин С.С., Кукушкин М.Л., Парфенов В.А., Страхов М.А., Тюрин В.П., Чичасова Н.В., Чорбинская С.А. Общие принципы лечения скелетно-мышечной боли: междисциплинарный консенсус. Научно-практическая ревматология. 2016;54(3)247-65 [Nasonov EL, Yakhno NN, Karateev AE, et al. General principles of treatment for musculoskeletal pain: Interdisciplinary consensus. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(3):247-65 (In Russ.)]. doi: http://dx.doi.org/10.14412/1995-4484-2016-247-265
25. Tan LJ, Liu SL, Lei SF, et al. Molecular genetic studies of gene identification for sarcopenia. Hum Genet. 2012;131(1):1-31.
26. Gunton JE, Girgis CM, Baldock PA, et al. Bone muscle interactions and vitamin D. Bone. 2015;80:89-94.
27. Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Curr Osteoporos Rep. 2014; 12(1):74-81.
28. Scimeca M, Centofanti F, Celi M, Gasbarra E, Novelli G, Botta A, Tarantino U. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. Aging Dis. 2018;9(6):952-64. doi: 10.14336/AD.2018.0215
29. Золотовская И.А., Давыдкин И.Л. Антирезорбтивно-цитокиновая эффективность хондропротективной терапии остеоартрита и неспецифической боли в спине (результаты исследования АЛЬБАТРОС). Фарматека. 2017;19(352):44-52 [Zolotovskaya IA, Davydkin IL. Antiresorptive-cytocin efficiency of chondroprotective therapy of osteoarthritis and non-specific low back pain (results of ALBATROS study) Pharmateca. 2017;19(352):44-52 (In Russ.)].
30. Повереннова И.Е., Золотовская И.А. Острый болевой синдром в фокусе дегенеративно-дистрофического континуума заболеваний позвоночника и суставов. РМЖ (Русский медицинский журнал). 2015;24:1455 [Poverennova IE, Zolotovskaya IA Acute pain syndrome in the focus of degenerative-dystrophic continuum of diseases of the spine and joints. RMJ (Russian Medical Journal). 2015;24:1455-8 (In Russ.)].
2. Ackerman IN, Bucknill A, Page RS, Broughton NS, Roberts C, Cavka B, et al. The substantial personal burden experienced by younger people with hip or knee osteoarthritis. Osteoarthr Cartil. 2015;23(8):1276-84.
3. March L, Smith EU, Hoy DG, Cross MJ, Sanchez-Riera L, Blyth F, et al. Burden of disability due to musculoskeletal (MSK) disorders. Best Pract Res Clin Rheumatol. 2014;28(3):353-66.
4. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355-69.
5. Mabey T, Honsawek S. Role of vitamin D in osteoarthritis: Molecular, cellular, and clinical perspectives. Int J Endocrinol. 2015;14. doi:10.1155/ 2015/383918
6. Manoy P, Yuktanandana P, Tanavalee A, Anomasiri W, Ngarmukos S, Tanpowpong T, Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients. 2017;9(8)pii: E799. doi: 10.3390/nu9080799
7. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009;20:315-22.
8. Capatina C, Caragheorgheopol A, Berteanu M, Poiana C. Short-term administration of alphacalcidol is associated with more significant improvement of muscular performance in women with vitamin D deficiency compared to native vitamin D. Exp Clin Endocrinol Diabetes. 2016;124:461-5.
9. Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471(11):3556-62.
10. Wang X, Cicuttini F, Jin X, Wluka AE, Han W, Zhu Z, et al. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthr Cartil. 2017;25(8):1304-12. doi:10.1016/j.joca.2017.02.804
11. Kashevarova NG, Alekseyeva LI, Anikin SG, Demin NV, Smirnov AV, Nasonov EL. Knee joint osteoarthritis: risk factors for disease progression during 5-year prospective observation. Issues of organization and Informatization of health care. 2016;(S):144-9 (In Russ.).
12. Knutsen KV, Madar AA, Lagerlov P, Brekke M, Raastad T, Stene LC, Meyer HE. Does vitamin D improve muscle strength in adults? A randomized, double-blind, placebo-controlled trial among ethnic minorities in norway. J Clin Endocrinol Metab. 2014;99:194-202. doi: 10.1210/jc.2013-2647
13. Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard L, et al. Effect of Vitamin D supplementation on Tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: A randomized clinical trial. JAMA. 2016;315(10):1005-13.
14. Zolotovskaya IA, Davydkin IL, Grigoryeva NJU, Tribuntseva LV, Volkorezov IA. The phenotype of knee joint osteoarthritis in 60 years old and more patients (results of the multicenter ULA study). Therapy. 2018; (5):83-90 (In Russ.). doi: https: //dx.doi.org/10.18565/
15. Nasonov EL, Gordeev AV, Galuscho EA. The concept of comorbidity and multimorbidity in rheumatology. is it possible to change paradigms? Meditsina (Almaty) = Medicine (Almaty). 2018;3(189):27-31 (In Russ.).
16. Weinstein AM, Rome BN, Reichmann WM, Collins JE, Burbine SA, Thornhill TS, Wright J, Katz JN, Losina E. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am. 2013;95(5):385-92.
17. Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, et al. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthritis and Cartilage. 2016;24(11):1858-66.
18.Tsvetkova ES, Denisov LN, Otteva AN, et al. An open-label multicenter observational study of the efficacy, tolerability, and safety of the nonsteroidal anti-inflammatory drug amtolmetin guacil in patients with knee osteoarthritis and dyspepsia. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(6):654-9 (In Russ.). doi: http://dx.doi.org/10.14412/1995-4484-2016-654-659
19. Alekseeva LI, Lila AM, Sharapova EP, Taskina EA, Kashevarova NG, Anikin SG, Mendel OI. Multicentre Prospective Observational Study on the Use of ARTRA® MSM FORTE and ARTRA® in Patients with Knee and/or Hip Osteoarthritis and/or Lower Back Pain (preliminary results). Difficult Patient. 2018;16(6):34-41 (In Russ.).
20. Bergink AP, Zillikens MC, Van Leeuwen JPTM, Hofman A, Uitterlinden AG, van Meurs JBJ. 25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data. Seminars in Arthritis and Rheumatism. 2016;45(5):539-46.
21. Tosi L, Boudreau R, Kwoh K, Prasad T, Ayonayon H, Harris T, Houston D, Kritchevsky S, Patel K, Simonsick E, et al. Vitamin D status and knee pain severity in functionally intact older adults: The health ABC study. J Bone and Mineral Research. 2012;27.
22. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: A systematic review. Rheumatology (United Kingdom). 2013;52(7):1323-34.
23. George J. Vitamin D Supplementation and progression of knee osteoarthritis. JAMA. 2016;316(3):347-8.
24. Nasonov EL, Yakhno NN, Karateev AE, et al. General principles of treatment for musculoskeletal pain: Interdisciplinary consensus. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(3):247-65 (In Russ.). doi: http://dx.doi.org/10.14412/1995-4484-2016-247-265
25. Tan LJ, Liu SL, Lei SF, et al. Molecular genetic studies of gene identification for sarcopenia. Hum Genet. 2012;131(1):1-31.
26. Gunton JE, Girgis CM, Baldock PA, et al. Bone muscle interactions and vitamin D. Bone. 2015;80:89-94.
27. Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Curr Osteoporos Rep. 2014; 12(1):74-81.
28. Scimeca M, Centofanti F, Celi M, Gasbarra E, Novelli G, Botta A, Tarantino U. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. Aging Dis. 2018;9(6):952-64. doi: 10.14336/AD.2018.0215
29. Zolotovskaya IA, Davydkin IL. Antiresorptive-cytocin efficiency of chondroprotective therapy of osteoarthritis and non-specific low back pain (results of ALBATROS study) Pharmateca. 2017;19(352):44-52 (In Russ.).
30. Poverennova IE, Zolotovskaya IA Acute pain syndrome in the focus of degenerative-dystrophic continuum of diseases of the spine and joints. RMJ (Russian Medical Journal). 2015;24:1455-8 (In Russ.).
2. Ackerman IN, Bucknill A, Page RS, Broughton NS, Roberts C, Cavka B, et al. The substantial personal burden experienced by younger people with hip or knee osteoarthritis. Osteoarthr Cartil. 2015;23(8):1276-84.
3. March L, Smith EU, Hoy DG, Cross MJ, Sanchez-Riera L, Blyth F, et al. Burden of disability due to musculoskeletal (MSK) disorders. Best Pract Res Clin Rheumatol. 2014;28(3):353-66.
4. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355-69.
5. Mabey T, Honsawek S. Role of vitamin D in osteoarthritis: Molecular, cellular, and clinical perspectives. Int J Endocrinol. 2015;14. doi:10.1155/ 2015/383918
6. Manoy P, Yuktanandana P, Tanavalee A, Anomasiri W, Ngarmukos S, Tanpowpong T, Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients. 2017;9(8)pii: E799. doi: 10.3390/nu9080799
7. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009;20:315-22.
8. Capatina C, Caragheorgheopol A, Berteanu M, Poiana C. Short-term administration of alphacalcidol is associated with more significant improvement of muscular performance in women with vitamin D deficiency compared to native vitamin D. Exp Clin Endocrinol Diabetes. 2016;124:461-5.
9. Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471(11):3556-62.
10. Wang X, Cicuttini F, Jin X, Wluka AE, Han W, Zhu Z, et al. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthr Cartil. 2017;25(8):1304-12. doi:10.1016/j.joca.2017.02.804
11. Кашеварова Н.Г., Алексеева Л.И., Аникин С.Г., Дёмин Н.В., Смирнов А.В., Насонов Е.Л. Остеоартроз коленных суставов: факторы риска прогрессирования заболевания при пятилетнем проспективном наблюдении. Вопросы организации и информатизации здравоохранения. 2016;(S):144-9 [Kashevarova NG, Alekseyeva LI, Anikin SG, Demin NV, Smirnov AV, Nasonov EL. Knee joint osteoarthritis: risk factors for disease progression during 5-year prospective observation. Issues of organization and Informatization of health care. 2016;(S):144-9 (In Russ.)].
12. Knutsen KV, Madar AA, Lagerlov P, Brekke M, Raastad T, Stene LC, Meyer HE. Does vitamin D improve muscle strength in adults? A randomized, double-blind, placebo-controlled trial among ethnic minorities in norway. J Clin Endocrinol Metab. 2014;99:194-202. doi: 10.1210/jc.2013-2647
13. Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard L, et al. Effect of Vitamin D supplementation on Tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: A randomized clinical trial. JAMA. 2016;315(10):1005-13.
14. Золотовская И.А., Давыдкин И.Л., Григорьева Н.Ю., Трибунцева Л.В., Волкорезов И.А. Фенотип остеоартрита коленного сустава пациентов в возрасте старше 60-ти лет (результаты многоцентрового исследования ЮЛА). Терапия. 2018;(5):83-90 [Zolotovskaya IA, Davydkin IL, Grigoryeva NJU, Tribuntseva LV, Volkorezov IA. The phenotype of knee joint osteoarthritis in 60 years old and more patients (results of the multicenter ULA study). Therapy. 2018; (5):83-90 (In Russ.)]. doi: https: //dx.doi.org/10.18565/
15. Насонов Е.Л., Гордеев А.В., Галушко Е.А. Концепции коморбидности и мультиморбидности в ревматологии. Возможна ли смена парадигм? Медицина (Алматы). 2018;188(3):27-31 [Nasonov EL, Gordeev AV, Galuscho EA. The concept of comorbidity and multimorbidity in rheumatology. is it possible to change paradigms? Meditsina (Almaty) = Medicine (Almaty). 2018;3(189):27-31 (In Russ.)].
16. Weinstein AM, Rome BN, Reichmann WM, Collins JE, Burbine SA, Thornhill TS, Wright J, Katz JN, Losina E. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am. 2013;95(5):385-92.
17. Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, et al. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthritis and Cartilage. 2016;24(11):1858-66.
18. Цветкова Е.С., Денисов Л.Н., Оттева Э.Н., Дубиков А.Н., Якупова С.П., Иванова О.Н., Коршунов Н.И., Вайсберг А.Р., Абышев Р.А., Тартынов А.В., Насонов Е.Л. Открытое многоцентровое наблюдательное исследование эффективности, переносимости и безопасности нестероидного противовоспалительного препарата амтолметина гуацила у пациентов с остеоартритом коленных суставов и диспепсией. Научно-практическая ревматология. 2016;54(6):654-9 [Tsvetkova ES, Denisov LN, Otteva AN, et al. An open-label multicenter observational study of the efficacy, tolerability, and safety of the nonsteroidal anti-inflammatory drug amtolmetin guacil in patients with knee osteoarthritis and dyspepsia. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(6):654-9 (In Russ.)]. doi: http://dx.doi.org/10.14412/1995-4484-2016-654-659
19. Алексеева Л.И., Лила А.М., Шарапова Е.П., Таскина Е.А., Кашеварова Н.Г., Аникин С.Г., Мендель О.И. Многоцентровое проспективное наблюдательное исследование по применению препаратов Артра® МСМ форте и Артра® у пациентов с остеоартритом коленных и/или тазобедренных суставов и/или с болью в нижней части спины (предварительные результаты). Трудный пациент. 2018;16(6):34-41 [Alekseeva LI, Lila AM, Sharapova EP, Taskina EA, Kashevarova NG, Anikin SG, Mendel OI. Multicentre Prospective Observational Study on the Use of ARTRA® MSM FORTE and ARTRA® in Patients with Knee and/or Hip Osteoarthritis and/or Lower Back Pain (preliminary results). Difficult Patient. 2018;16(6):34-41 (In Russ.)].
20. Bergink AP, Zillikens MC, Van Leeuwen JPTM, Hofman A, Uitterlinden AG, van Meurs JBJ. 25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data. Seminars in Arthritis and Rheumatism. 2016;45(5):539-46.
21. Tosi L, Boudreau R, Kwoh K, Prasad T, Ayonayon H, Harris T, Houston D, Kritchevsky S, Patel K, Simonsick E, et al. Vitamin D status and knee pain severity in functionally intact older adults: The health ABC study. J Bone and Mineral Research. 2012;27.
22. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: A systematic review. Rheumatology (United Kingdom). 2013;52(7):1323-34.
23. George J. Vitamin D Supplementation and progression of knee osteoarthritis. JAMA. 2016;316(3):347-8.
24. Насонов Е.Л., Яхно Н.Н., Каратеев А.Е., Алексеева Л.И., Баринов А.Н., Барулин А.Е., Давыдов О.С., Данилов А.Б., Журавлева М.В., Заводовский Б.В., Копенкин С.С., Кукушкин М.Л., Парфенов В.А., Страхов М.А., Тюрин В.П., Чичасова Н.В., Чорбинская С.А. Общие принципы лечения скелетно-мышечной боли: междисциплинарный консенсус. Научно-практическая ревматология. 2016;54(3)247-65 [Nasonov EL, Yakhno NN, Karateev AE, et al. General principles of treatment for musculoskeletal pain: Interdisciplinary consensus. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(3):247-65 (In Russ.)]. doi: http://dx.doi.org/10.14412/1995-4484-2016-247-265
25. Tan LJ, Liu SL, Lei SF, et al. Molecular genetic studies of gene identification for sarcopenia. Hum Genet. 2012;131(1):1-31.
26. Gunton JE, Girgis CM, Baldock PA, et al. Bone muscle interactions and vitamin D. Bone. 2015;80:89-94.
27. Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Curr Osteoporos Rep. 2014; 12(1):74-81.
28. Scimeca M, Centofanti F, Celi M, Gasbarra E, Novelli G, Botta A, Tarantino U. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. Aging Dis. 2018;9(6):952-64. doi: 10.14336/AD.2018.0215
29. Золотовская И.А., Давыдкин И.Л. Антирезорбтивно-цитокиновая эффективность хондропротективной терапии остеоартрита и неспецифической боли в спине (результаты исследования АЛЬБАТРОС). Фарматека. 2017;19(352):44-52 [Zolotovskaya IA, Davydkin IL. Antiresorptive-cytocin efficiency of chondroprotective therapy of osteoarthritis and non-specific low back pain (results of ALBATROS study) Pharmateca. 2017;19(352):44-52 (In Russ.)].
30. Повереннова И.Е., Золотовская И.А. Острый болевой синдром в фокусе дегенеративно-дистрофического континуума заболеваний позвоночника и суставов. РМЖ (Русский медицинский журнал). 2015;24:1455 [Poverennova IE, Zolotovskaya IA Acute pain syndrome in the focus of degenerative-dystrophic continuum of diseases of the spine and joints. RMJ (Russian Medical Journal). 2015;24:1455-8 (In Russ.)].
________________________________________________
2. Ackerman IN, Bucknill A, Page RS, Broughton NS, Roberts C, Cavka B, et al. The substantial personal burden experienced by younger people with hip or knee osteoarthritis. Osteoarthr Cartil. 2015;23(8):1276-84.
3. March L, Smith EU, Hoy DG, Cross MJ, Sanchez-Riera L, Blyth F, et al. Burden of disability due to musculoskeletal (MSK) disorders. Best Pract Res Clin Rheumatol. 2014;28(3):353-66.
4. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355-69.
5. Mabey T, Honsawek S. Role of vitamin D in osteoarthritis: Molecular, cellular, and clinical perspectives. Int J Endocrinol. 2015;14. doi:10.1155/ 2015/383918
6. Manoy P, Yuktanandana P, Tanavalee A, Anomasiri W, Ngarmukos S, Tanpowpong T, Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients. 2017;9(8)pii: E799. doi: 10.3390/nu9080799
7. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009;20:315-22.
8. Capatina C, Caragheorgheopol A, Berteanu M, Poiana C. Short-term administration of alphacalcidol is associated with more significant improvement of muscular performance in women with vitamin D deficiency compared to native vitamin D. Exp Clin Endocrinol Diabetes. 2016;124:461-5.
9. Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471(11):3556-62.
10. Wang X, Cicuttini F, Jin X, Wluka AE, Han W, Zhu Z, et al. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthr Cartil. 2017;25(8):1304-12. doi:10.1016/j.joca.2017.02.804
11. Kashevarova NG, Alekseyeva LI, Anikin SG, Demin NV, Smirnov AV, Nasonov EL. Knee joint osteoarthritis: risk factors for disease progression during 5-year prospective observation. Issues of organization and Informatization of health care. 2016;(S):144-9 (In Russ.).
12. Knutsen KV, Madar AA, Lagerlov P, Brekke M, Raastad T, Stene LC, Meyer HE. Does vitamin D improve muscle strength in adults? A randomized, double-blind, placebo-controlled trial among ethnic minorities in norway. J Clin Endocrinol Metab. 2014;99:194-202. doi: 10.1210/jc.2013-2647
13. Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard L, et al. Effect of Vitamin D supplementation on Tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: A randomized clinical trial. JAMA. 2016;315(10):1005-13.
14. Zolotovskaya IA, Davydkin IL, Grigoryeva NJU, Tribuntseva LV, Volkorezov IA. The phenotype of knee joint osteoarthritis in 60 years old and more patients (results of the multicenter ULA study). Therapy. 2018; (5):83-90 (In Russ.). doi: https: //dx.doi.org/10.18565/
15. Nasonov EL, Gordeev AV, Galuscho EA. The concept of comorbidity and multimorbidity in rheumatology. is it possible to change paradigms? Meditsina (Almaty) = Medicine (Almaty). 2018;3(189):27-31 (In Russ.).
16. Weinstein AM, Rome BN, Reichmann WM, Collins JE, Burbine SA, Thornhill TS, Wright J, Katz JN, Losina E. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am. 2013;95(5):385-92.
17. Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, et al. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthritis and Cartilage. 2016;24(11):1858-66.
18.Tsvetkova ES, Denisov LN, Otteva AN, et al. An open-label multicenter observational study of the efficacy, tolerability, and safety of the nonsteroidal anti-inflammatory drug amtolmetin guacil in patients with knee osteoarthritis and dyspepsia. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(6):654-9 (In Russ.). doi: http://dx.doi.org/10.14412/1995-4484-2016-654-659
19. Alekseeva LI, Lila AM, Sharapova EP, Taskina EA, Kashevarova NG, Anikin SG, Mendel OI. Multicentre Prospective Observational Study on the Use of ARTRA® MSM FORTE and ARTRA® in Patients with Knee and/or Hip Osteoarthritis and/or Lower Back Pain (preliminary results). Difficult Patient. 2018;16(6):34-41 (In Russ.).
20. Bergink AP, Zillikens MC, Van Leeuwen JPTM, Hofman A, Uitterlinden AG, van Meurs JBJ. 25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data. Seminars in Arthritis and Rheumatism. 2016;45(5):539-46.
21. Tosi L, Boudreau R, Kwoh K, Prasad T, Ayonayon H, Harris T, Houston D, Kritchevsky S, Patel K, Simonsick E, et al. Vitamin D status and knee pain severity in functionally intact older adults: The health ABC study. J Bone and Mineral Research. 2012;27.
22. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: A systematic review. Rheumatology (United Kingdom). 2013;52(7):1323-34.
23. George J. Vitamin D Supplementation and progression of knee osteoarthritis. JAMA. 2016;316(3):347-8.
24. Nasonov EL, Yakhno NN, Karateev AE, et al. General principles of treatment for musculoskeletal pain: Interdisciplinary consensus. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(3):247-65 (In Russ.). doi: http://dx.doi.org/10.14412/1995-4484-2016-247-265
25. Tan LJ, Liu SL, Lei SF, et al. Molecular genetic studies of gene identification for sarcopenia. Hum Genet. 2012;131(1):1-31.
26. Gunton JE, Girgis CM, Baldock PA, et al. Bone muscle interactions and vitamin D. Bone. 2015;80:89-94.
27. Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Curr Osteoporos Rep. 2014; 12(1):74-81.
28. Scimeca M, Centofanti F, Celi M, Gasbarra E, Novelli G, Botta A, Tarantino U. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. Aging Dis. 2018;9(6):952-64. doi: 10.14336/AD.2018.0215
29. Zolotovskaya IA, Davydkin IL. Antiresorptive-cytocin efficiency of chondroprotective therapy of osteoarthritis and non-specific low back pain (results of ALBATROS study) Pharmateca. 2017;19(352):44-52 (In Russ.).
30. Poverennova IE, Zolotovskaya IA Acute pain syndrome in the focus of degenerative-dystrophic continuum of diseases of the spine and joints. RMJ (Russian Medical Journal). 2015;24:1455-8 (In Russ.).
Авторы
И.А. Золотовская, И.Л. Давыдкин
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России, Самара, Россия
Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России, Самара, Россия
________________________________________________
Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia
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