Особенности мультифокального атеросклероза у больных инфарктом миокарда в сочетании с хронической болезнью почек
Особенности мультифокального атеросклероза у больных инфарктом миокарда в сочетании с хронической болезнью почек
Каретникова В.Н., Калаева В.В., Евсеева М.В. и др. Особенности мультифокального атеросклероза у больных инфарктом миокарда в сочетании с хронической болезнью почек. Терапевтический архив. 2019; 91 (6): 73–79.
DOI: 10.26442/00403660.2019.06.000053
DOI: 10.26442/00403660.2019.06.000053
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Аннотация
Цель исследования. Оценка особенностей мультифокального атеросклероза (МФА) у больных инфарктом миокарда (ИМ) и хронической болезнью почек (ХБП).
Материалы и методы. Всего в исследование включено 954 пациента старше 18 лет с ИМ с подъемом сегмента ST (ИМпST) давностью до 24 ч. Проведено клинико-анамнестическое обследование, физикальное обследование, запись электрокардиограммы в 16 отведениях, эхокардиограммы, лабораторное обследование с определением уровня кардиоспецифических ферментов, сывороточного креатинина с расчетом скорости клубочковой фильтрации (СКФ) по формуле CKD-EPI. Из них 771 (81%) выполнены коронарография, дуплексное сканирование брахиоцефальных артерий и артерий нижних конечностей (АНК). Среди больных выделена группа пациентов (n=281; 36,5%) с ХБП 1–4-й стадии, согласно критериям Научного общества нефрологов России. По уровню СКФ определены стадии ХБП. Пациенты с 5-й стадией исключены из исследования. Под почечной дисфункцией понимается снижение СКФ менее 60 мл/мин/1,73 м2.
Результаты и обсуждение. Результаты исследования свидетельствуют о высокой распространенности МФА у больных ХБП: у каждoго второго верифицированы стенозы АНК (р<0,001), у каждого пятого – порaжение трех и более артeриальных бассейнов (р=0,018), множественное поражение коронарного русла (р<0,001), независимо от функции почек. В группах с 1-й и 2-й стадиями ХБП преобладали гемодинамически незначимые стенозы артерий (<30%; р=0,036), в группах с 3-й и 4-й стадиями степень стенoтических изменений прогрессировала (р<0,05). Порaжение трех и более артериальных бассейнов чаще регистрировалось у пациентов с 3-й и 4-й стадиями ХБП (р=0,030). По результатам лoгиcтической регреcсии в настоящем исcледовании XБП в cочетании с почечной дисфункцией (ХБП 3-й стадии и выше) явилась независимым прeдиктором MФA.
Заключение. ХБП ассоциируется с распространенным и выраженным MФА. Тяжесть MФА прямо пропорциональна степени почечной дисфункции (cтадии ХБП).
Ключевые слова: инфаркт миокарда, мультифокальный атеросклероз, хроническая болезнь почек, почечная дисфункция, скорость клубочковой фильтрации.
Materials and methods. A total of 954 patients older than 18 years old with ST-segment elevation MI (STEMI) up to 24 hours of pain onset were included in the study. Clinical and demographic data were collected for all patients, including physical examination, 16-lead electrocardiogram recording, echocardiography, laboratory assessment with the measurements of cardiospecific enzymes and serum creatinine. Glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Of them, 771 (81%) underwent coronary angiography, duplex scanning of the brachiocephalic (BCA) and lower extremity arteries (LEA). Patients with stage 1–4 CKD diagnosed according to the criteria provided by the Russian Society of Nephrologists were allocated into a separate group (n=281; 36.5%). CKD stages were determined with the level of GFR. Patients with stage 5 CKD were excluded from the study. Renal dysfunction was defined as the presence of an estimated GFR less than 60 ml/min/1.73 m2.
Results and discussion. The results of the study indicate a high prevalence of PolyVD in patients with CKD. Every second patient had LEA stenosis (p<0.001), and every fifth patient had multiple arterial bed lesions (≥3 arterial beds; p=0.018), multiple coronary artery disease (p<0.001), independently from kidney function. Patients with stage 1 and 2 CKD commonly had hemodynamically insignificant arterial stenoses (<30%; p=0.036), whereas stage 3 and 4 CKD patients had significant stenotic lesions (p<0.05). Patients with stage 3 and 4 CKD more frequently suffered from three and more arterial bed lesions (p=0.030). Logistic regression reported that renal dysfunction (stage 3 CKD and above) was considered as an independent predictor of PolyVD.
Conclusion. CKD is associated with highly prevalent and severe PolyVD. The severity of PolyVD is directly related to the stage of renal dysfunction (CKD stage).
Keywords: myocardial infarction, polyvascular disease, chronic kidney disease, renal dysfunction, glomerular filtration rate.
Материалы и методы. Всего в исследование включено 954 пациента старше 18 лет с ИМ с подъемом сегмента ST (ИМпST) давностью до 24 ч. Проведено клинико-анамнестическое обследование, физикальное обследование, запись электрокардиограммы в 16 отведениях, эхокардиограммы, лабораторное обследование с определением уровня кардиоспецифических ферментов, сывороточного креатинина с расчетом скорости клубочковой фильтрации (СКФ) по формуле CKD-EPI. Из них 771 (81%) выполнены коронарография, дуплексное сканирование брахиоцефальных артерий и артерий нижних конечностей (АНК). Среди больных выделена группа пациентов (n=281; 36,5%) с ХБП 1–4-й стадии, согласно критериям Научного общества нефрологов России. По уровню СКФ определены стадии ХБП. Пациенты с 5-й стадией исключены из исследования. Под почечной дисфункцией понимается снижение СКФ менее 60 мл/мин/1,73 м2.
Результаты и обсуждение. Результаты исследования свидетельствуют о высокой распространенности МФА у больных ХБП: у каждoго второго верифицированы стенозы АНК (р<0,001), у каждого пятого – порaжение трех и более артeриальных бассейнов (р=0,018), множественное поражение коронарного русла (р<0,001), независимо от функции почек. В группах с 1-й и 2-й стадиями ХБП преобладали гемодинамически незначимые стенозы артерий (<30%; р=0,036), в группах с 3-й и 4-й стадиями степень стенoтических изменений прогрессировала (р<0,05). Порaжение трех и более артериальных бассейнов чаще регистрировалось у пациентов с 3-й и 4-й стадиями ХБП (р=0,030). По результатам лoгиcтической регреcсии в настоящем исcледовании XБП в cочетании с почечной дисфункцией (ХБП 3-й стадии и выше) явилась независимым прeдиктором MФA.
Заключение. ХБП ассоциируется с распространенным и выраженным MФА. Тяжесть MФА прямо пропорциональна степени почечной дисфункции (cтадии ХБП).
Ключевые слова: инфаркт миокарда, мультифокальный атеросклероз, хроническая болезнь почек, почечная дисфункция, скорость клубочковой фильтрации.
________________________________________________
Materials and methods. A total of 954 patients older than 18 years old with ST-segment elevation MI (STEMI) up to 24 hours of pain onset were included in the study. Clinical and demographic data were collected for all patients, including physical examination, 16-lead electrocardiogram recording, echocardiography, laboratory assessment with the measurements of cardiospecific enzymes and serum creatinine. Glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Of them, 771 (81%) underwent coronary angiography, duplex scanning of the brachiocephalic (BCA) and lower extremity arteries (LEA). Patients with stage 1–4 CKD diagnosed according to the criteria provided by the Russian Society of Nephrologists were allocated into a separate group (n=281; 36.5%). CKD stages were determined with the level of GFR. Patients with stage 5 CKD were excluded from the study. Renal dysfunction was defined as the presence of an estimated GFR less than 60 ml/min/1.73 m2.
Results and discussion. The results of the study indicate a high prevalence of PolyVD in patients with CKD. Every second patient had LEA stenosis (p<0.001), and every fifth patient had multiple arterial bed lesions (≥3 arterial beds; p=0.018), multiple coronary artery disease (p<0.001), independently from kidney function. Patients with stage 1 and 2 CKD commonly had hemodynamically insignificant arterial stenoses (<30%; p=0.036), whereas stage 3 and 4 CKD patients had significant stenotic lesions (p<0.05). Patients with stage 3 and 4 CKD more frequently suffered from three and more arterial bed lesions (p=0.030). Logistic regression reported that renal dysfunction (stage 3 CKD and above) was considered as an independent predictor of PolyVD.
Conclusion. CKD is associated with highly prevalent and severe PolyVD. The severity of PolyVD is directly related to the stage of renal dysfunction (CKD stage).
Keywords: myocardial infarction, polyvascular disease, chronic kidney disease, renal dysfunction, glomerular filtration rate.
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2. Mel'nik AA. Cardiorenal Syndrome: Diagnosis and Treatment. Рochki. 2017;61(1):2-14 (In Russ.) doi: 10.22141/2307-1257.6.1.2017.93777
3. Osnovy kardiorenal’noy meditsiny [Annals of cardiorenal medicine]. Kobalava ZhD, Villeval'de SV, Efremovcev MA, eds. Moscow: GEOTAR-Media, 2014. 256 p. (In Russ.)
4. Collins AJ, Li S, Gilbertson DT, et al. Chronic kidney disease and cardiovascular disease in the Medicare population. Kidney Int. 2003;64(87):24-31. PMID: 14531770
5. Muhin NA, Moiseev VS, Kobalava ZhD. Cardiovascular disease and renal function. In: Shlyahto EV, ed. Kardiologiya: nacional'noe rukovodstvo [Cardiology: national guidelance]. 2nd ed. Moscow, 2015. P. 691-4 (In Russ.)
6. Kostyukevich O.I. Arterial hypertension and kidneys: are they closely connected? Is it possible to break the vicious circle?. Russian Medical Journal. 2010;22:1330-42. Available from: https://www.rmj.ru/articles/kardiologiya/Arterialynaya_gipertenziya_i_pochki_vmeste__naveki_Moghno_l... (Accessed June 26, 2018) (In Russ.)
7. Chicherina EN, Padyganova AV. Factors for the development and progression of cardiorenal complications in women. Therapeutic Archive. 2013;85(6):85-9 (In Russ.)
8. Alidzhanova HG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.) doi: 10.23934/2223-9022-2017-6-2-112-113
9. Meisinger C, Doring A, Lowel H, et al. Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population. Eur Heart J. 2006;27(10):1245-50. doi: 10.1093/eurheartj/ehi880
10. Herzog CA, Littrell K, Arko C, et al. Clinical characteristics of dialysis patients with acute myocardial infarction in the United States: a collaborative project of the United States Renal Data System and the National Registry of Myocardial Infarction. Circulation. 2007;116:1465-72. doi: 10.1161/circulationaha.107.696765
11. Fabbian F, Pala M, De Giorgi A, et al. In-hospital mortality in patients with renal dysfunction admitted for myocardial infarction: the Emilia-Romagna region of Italy database of hospital admissions. Int Urol Nephrol. 2013;45(3):769-75. doi: 10.1007/s11255-012-0250-9
12. Ferreiro JL, Bhatt DL, Ueno M, Bauer D, Angiolillo DJ. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events). J Am Coll Cardiol. 2014;63(8):769-77. doi: 10.1016/j.jacc.2013.10.043
13. Suárez C, Zeymer U, Limbourg T, Baumgartner I, Cacoub P, Poldermans D. REACH Registry Investigators. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010;15(4):259-65. doi: 10.1177/ 1358863X10373299
14. Lesley AI, Astor BC, Fox ChH, et al. KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD. Am J Kidney Dis. 2014;63(5):713-35. doi: 10.1053/j.ajkd.2014.01.416
15. Moiseev VS, Mukhin NA, Smirnov AV, et al. Сardiovascular risk and chronic kidney disease: cardio-nephroprotection strategies. Russian Journal of Cardiology. 2014;(8):7-37 (In Russ.) doi: 10.15829/1560-4071-2014-8-7-37
16. Suslina ZA, Varakin YuYa, Vereshchagin NV. Sosudistye zabolevaniya golovnogo mozga: epidemiologiya, osnovy profilaktiki [Cerebrovascular disease: epidemiology and prevention]. Moscow: MEDpress-inform, 2006. 256 p. (In Russ.)
17. Rothwell PM, Gutnikov SA, Warlow CP, et al. Reanalysis of the final results of the European Carotid Surgery Trial. Stroke. 2003;34(2):514-23. PMID: 12574569
18. Chong E, Poh KK, Liang S, et al. Risk factors and clinical outcomes for contrast – induced nephropathy after percutaneous coronary interventions in patients with normal serum creatinine. Ann Acad Med Singapore. 2010;39(5):374-80. PMID: 20535427
19. Lash JP, Go AS, Appel LJ et al. ChronicRenalInsufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Chronic Renal Insufficiency Cohort (CRIC) Study Group. Clin J Am Soc Nephrol. 2011; 6(10): 2548-53. doi: 10.2215/CJN.00070109
20. Miskulin D, Bragg-Gresham J, Gillespie BW, et al. Key comorbid conditions that are predictive of survival among hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:1818-26. doi: 10.2215/CJN.00640109
21. Brugts JJ, Knetsch AM, Mattase-Raso FU, et al. Renal function and risk of myocardial infarction in elderly population. The Rotterdam study. Arch Intern Med. 2005;165(22):2659-65. doi: 10.1001/archinte.165.22.2659
22. Garcia-Donaire JA, Ruilope LM. Сardiovascular and renal links along the cardiorenal continuum. Nefrologiya = Clinical Nephrology. 2013;17(1):11-9 (In Russ.)
23. Sabe MA, Claggett B, Burdmann EA, et al. Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Anemia: An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). J Am Heart Assoc. 2016;5(4):e002850. doi: 10.1161/jaha.115.002850
24. Kato K, Yonetsu T, Jia H, et al. Non-culprit coronary plaque characteristics of chronic kidney disease. Circ Cardiovasc Imaging. 2013;6(3):448-56. doi: 10.1161/circimaging.112.000165
25. Schlieper G, Schurgers L, Brandenburg V, et al. Vascular calcification in chronic kidney disease: an update. Nephrol Dial Transplant. 2016;31(1):31-9. doi: 10.1093/ndt/gfv111
26. Alidzhanova KG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.) doi: 10.23934/2223-9022-2017-6-2
27. Pyrochkin VM, Karpovich YuI, Zhigal'cov AM. Disfunktsiya endoteliya, remodelirovanie miokarda i sosudistoy stenki u patsientov s khronicheskim nefriticheskim sindromom, nefroticheskoy formoy [Endothelial dysfunction, myocardial and vascular remodeling in patients with chronic nephritic syndrome of nephrotic form]. Grodno, 2016. 124 p. UDK: 616.61-002.2:[616-018.74-008.6:616.127]-085 (In Russ.)
28. Sugiyama T, Kimura S, Ohtani H, et al. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease. Cardiovasc Interv Ther. 2017 Jul;32(3):216-24. doi: 10.1007/s12928-016-0408-y
29. Kim J-K, Song YR, Kim MG, et al. Clinical significance of subclinical carotid atherosclerosis and its relationship with echocardiographic parameters in non-diabetic chronic kidney disease patients [Electronic Resource]. Cardiovasc Disord. 2013;13:96. URL: http://www.biomedcentral.com/1471-2261/13/96 (ссылка активна на 26.06.2018).
2. Мельник А.А. Кардиоренальный синдром: диагностика и лечение. Почки. 2017;61(1):2-14 [Mel'nik AA. Cardiorenal Syndrome: Diagnosis and Treatment. Рochki. 2017;61(1):2-14 (In Russ.)]. doi: 10.22141/2307-1257.6.1.2017.93777
3. Основы кардиоренальной медицины. Под ред. Кобалава Ж.Д., Виллевальде С.В., Ефремовцева М.А. М.: ГЭОТАР-Медиа, 2014. 256 с. [Osnovy kardiorenal’noy meditsiny [Annals of cardiorenal medicine]. Kobalava ZhD, Villeval'de SV, Efremovcev MA, eds. Moscow: GEOTAR-Media, 2014. 256 p. (In Russ.)].
4. Collins AJ, Li S, Gilbertson DT, et al. Chronic kidney disease and cardiovascular disease in the Medicare population. Kidney Int. 2003;64(87):24-31. PMID: 14531770
5. Мухин Н.А., Моисеев В.С., Кобалава Ж.Д. Поражение сердечно-сосудистой системы при заболеваниях почек. В кн.: Кардиология: национальное руководство. Под ред. Е.В. Шляхто. 2-е изд., перераб. и доп. М., 2015. C. 691-4 [Muhin NA, Moiseev VS, Kobalava ZhD. Cardiovascular disease and renal function. In: Shlyahto EV, ed. Kardiologiya: nacional'noe rukovodstvo [Cardiology: national guidelance]. 2nd ed. Moscow, 2015. P. 691-4 (In Russ.)].
6. Костюкевич О.И. Артериальная гипертензия и почки: вместе навеки? Можно ли разорвать порочный круг? Российский медицинский журнал. 2010;22:1330-42. Доступно по ссылке: https://www.rmj.ru/articles/kardiologiya/Arterialynaya_gipertenziya_i_pochki_vmeste__naveki_Moghno_l... (Ссылка активна на 26.06.2018) [Kostyukevich O.I. Arterial hypertension and kidneys: are they closely connected? Is it possible to break the vicious circle?. Russian Medical Journal. 2010;22:1330-42. Available from: https://www.rmj.ru/articles/kardiologiya/Arterialynaya_gipertenziya_i_pochki_vmeste__naveki_Moghno_l... (Accessed June 26, 2018) (In Russ.)].
7. Чичерина Е.Н., Падыганова А.В. Факторы развития и прогрессирования кардиоренальных осложнений у женщин. Терапевтический архив. 2013;85(6):85-9 [Chicherina EN, Padyganova AV. Factors for the development and progression of cardiorenal complications in women. Therapeutic Archive. 2013;85(6):85-9 (In Russ.)].
8. Алиджанова Х.Г., Ржевская О.Н., Сагиров М.А., Газарян Г.А. Прогностическое значение хронической болезни почек у больных с острым коронарным синдромом. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2017;6(2):132-9 [Alidzhanova HG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.)]. doi: 10.23934/2223-9022-2017-6-2-112-113
9. Meisinger C, Doring A, Lowel H, et al. Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population. Eur Heart J. 2006;27(10):1245-50. doi: 10.1093/eurheartj/ehi880
10. Herzog CA, Littrell K, Arko C, et al. Clinical characteristics of dialysis patients with acute myocardial infarction in the United States: a collaborative project of the United States Renal Data System and the National Registry of Myocardial Infarction. Circulation. 2007;116:1465-72. doi: 10.1161/circulationaha.107.696765
11. Fabbian F, Pala M, De Giorgi A, et al. In-hospital mortality in patients with renal dysfunction admitted for myocardial infarction: the Emilia-Romagna region of Italy database of hospital admissions. Int Urol Nephrol. 2013;45(3):769-75. doi: 10.1007/s11255-012-0250-9
12. Ferreiro JL, Bhatt DL, Ueno M, Bauer D, Angiolillo DJ. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events). J Am Coll Cardiol. 2014;63(8):769-77. doi: 10.1016/j.jacc.2013.10.043
13. Suárez C, Zeymer U, Limbourg T, Baumgartner I, Cacoub P, Poldermans D. REACH Registry Investigators. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010;15(4):259-65. doi: 10.1177/ 1358863X10373299
14. Lesley AI, Astor BC, Fox ChH, et al. KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD. Am J Kidney Dis. 2014;63(5):713-35. doi: 10.1053/j.ajkd.2014.01.416
15. Моисеев В.С., Мухин Н.А., Смирнов А.В. и др. Сердечно-сосудистый риск и хроническая болезнь почек: стратегии кардио-нефропротекции. Российский кардиологический журнал. 2014;(8):7-37 [Moiseev VS, Mukhin NA, Smirnov AV, et al. Сardiovascular risk and chronic kidney disease: cardio-nephroprotection strategies. Russian Journal of Cardiology. 2014;(8):7-37 (In Russ.)]. doi: 10.15829/1560-4071-2014-8-7-37
16. Суслина З.А., Варакин Ю.А., Верещагин Н.В. Сосудистые заболевания головного мозга: эпидемиология, основы профилактики. М.: МЕДпресс-информ, 2006. 256 с. [Suslina ZA, Varakin YuYa, Vereshchagin NV. Sosudistye zabolevaniya golovnogo mozga: epidemiologiya, osnovy profilaktiki [Cerebrovascular disease: epidemiology and prevention]. Moscow: MEDpress-inform, 2006. 256 p. (In Russ.)].
17. Rothwell PM, Gutnikov SA, Warlow CP, et al. Reanalysis of the final results of the European Carotid Surgery Trial. Stroke. 2003;34(2):514-23. PMID: 12574569
18. Chong E, Poh KK, Liang S, et al. Risk factors and clinical outcomes for contrast – induced nephropathy after percutaneous coronary interventions in patients with normal serum creatinine. Ann Acad Med Singapore. 2010;39(5):374-80. PMID: 20535427
19. Lash JP, Go AS, Appel LJ et al. ChronicRenalInsufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Chronic Renal Insufficiency Cohort (CRIC) Study Group. Clin J Am Soc Nephrol. 2011; 6(10): 2548-53. doi: 10.2215/CJN.00070109
20. Miskulin D, Bragg-Gresham J, Gillespie BW, et al. Key comorbid conditions that are predictive of survival among hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:1818-26. doi: 10.2215/CJN.00640109
21. Brugts JJ, Knetsch AM, Mattase-Raso FU, et al. Renal function and risk of myocardial infarction in elderly population. The Rotterdam study. Arch Intern Med. 2005;165(22):2659-65. doi: 10.1001/archinte.165.22.2659
22. Гарсиа-Донаире Ж.А., Руилопе Л.М. Кардио-васкулярно-ренальные связи в кардиоренальном континууме. Нефрология. 2013;17(1):11-9 [Garcia-Donaire JA, Ruilope LM. Сardiovascular and renal links along the cardiorenal continuum. Nefrologiya = Clinical Nephrology. 2013;17(1):11-9 (In Russ.)].
23. Sabe MA, Claggett B, Burdmann EA, et al. Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Anemia: An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). J Am Heart Assoc. 2016;5(4):e002850. doi: 10.1161/jaha.115.002850
24. Kato K, Yonetsu T, Jia H, et al. Non-culprit coronary plaque characteristics of chronic kidney disease. Circ Cardiovasc Imaging. 2013;6(3):448-56. doi: 10.1161/circimaging.112.000165
25. Schlieper G, Schurgers L, Brandenburg V, et al. Vascular calcification in chronic kidney disease: an update. Nephrol Dial Transplant. 2016;31(1):31-9. doi: 10.1093/ndt/gfv111
26. Алиджанова Х.Г., Ржевская О.Н., Сагиров М.А., Газарян Г.А. Прогностическое значение хронической болезни почек у больных с острым коронарным синдромом. Журнал им. Н. В. Склифосовского «Неотложная медицинская помощь». 2017;6(2):132-9 [Alidzhanova KG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.)]. doi: 10.23934/2223-9022-2017-6-2
27. Пырочкин В.М., Карпович Ю.И., Жигальцов А.М. Дисфункция эндотелия, ремоделирование миокарда и сосудистой стенки у пациентов с хроническим нефритическим синдромом, нефротической формой: Монография. Гродно, 2016. 124 с. УДК: 616.61-002.2:[616-018.74-008.6:616.127]-085 [Pyrochkin VM, Karpovich YuI, Zhigal'cov AM. Disfunktsiya endoteliya, remodelirovanie miokarda i sosudistoy stenki u patsientov s khronicheskim nefriticheskim sindromom, nefroticheskoy formoy [Endothelial dysfunction, myocardial and vascular remodeling in patients with chronic nephritic syndrome of nephrotic form]. Grodno, 2016. 124 p. UDK: 616.61-002.2:[616-018.74-008.6:616.127]-085 (In Russ.)].
28. Sugiyama T, Kimura S, Ohtani H, et al. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease. Cardiovasc Interv Ther. 2017 Jul;32(3):216-24. doi: 10.1007/s12928-016-0408-y
29. Kim J-K, Song YR, Kim MG, et al. Clinical significance of subclinical carotid atherosclerosis and its relationship with echocardiographic parameters in non-diabetic chronic kidney disease patients [Electronic Resource]. Cardiovasc Disord. 2013;13:96. URL: http://www.biomedcentral.com/1471-2261/13/96 (ссылка активна на 26.06.2018).
________________________________________________
2. Mel'nik AA. Cardiorenal Syndrome: Diagnosis and Treatment. Рochki. 2017;61(1):2-14 (In Russ.) doi: 10.22141/2307-1257.6.1.2017.93777
3. Osnovy kardiorenal’noy meditsiny [Annals of cardiorenal medicine]. Kobalava ZhD, Villeval'de SV, Efremovcev MA, eds. Moscow: GEOTAR-Media, 2014. 256 p. (In Russ.)
4. Collins AJ, Li S, Gilbertson DT, et al. Chronic kidney disease and cardiovascular disease in the Medicare population. Kidney Int. 2003;64(87):24-31. PMID: 14531770
5. Muhin NA, Moiseev VS, Kobalava ZhD. Cardiovascular disease and renal function. In: Shlyahto EV, ed. Kardiologiya: nacional'noe rukovodstvo [Cardiology: national guidelance]. 2nd ed. Moscow, 2015. P. 691-4 (In Russ.)
6. Kostyukevich O.I. Arterial hypertension and kidneys: are they closely connected? Is it possible to break the vicious circle?. Russian Medical Journal. 2010;22:1330-42. Available from: https://www.rmj.ru/articles/kardiologiya/Arterialynaya_gipertenziya_i_pochki_vmeste__naveki_Moghno_l... (Accessed June 26, 2018) (In Russ.)
7. Chicherina EN, Padyganova AV. Factors for the development and progression of cardiorenal complications in women. Therapeutic Archive. 2013;85(6):85-9 (In Russ.)
8. Alidzhanova HG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.) doi: 10.23934/2223-9022-2017-6-2-112-113
9. Meisinger C, Doring A, Lowel H, et al. Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population. Eur Heart J. 2006;27(10):1245-50. doi: 10.1093/eurheartj/ehi880
10. Herzog CA, Littrell K, Arko C, et al. Clinical characteristics of dialysis patients with acute myocardial infarction in the United States: a collaborative project of the United States Renal Data System and the National Registry of Myocardial Infarction. Circulation. 2007;116:1465-72. doi: 10.1161/circulationaha.107.696765
11. Fabbian F, Pala M, De Giorgi A, et al. In-hospital mortality in patients with renal dysfunction admitted for myocardial infarction: the Emilia-Romagna region of Italy database of hospital admissions. Int Urol Nephrol. 2013;45(3):769-75. doi: 10.1007/s11255-012-0250-9
12. Ferreiro JL, Bhatt DL, Ueno M, Bauer D, Angiolillo DJ. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events). J Am Coll Cardiol. 2014;63(8):769-77. doi: 10.1016/j.jacc.2013.10.043
13. Suárez C, Zeymer U, Limbourg T, Baumgartner I, Cacoub P, Poldermans D. REACH Registry Investigators. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010;15(4):259-65. doi: 10.1177/ 1358863X10373299
14. Lesley AI, Astor BC, Fox ChH, et al. KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD. Am J Kidney Dis. 2014;63(5):713-35. doi: 10.1053/j.ajkd.2014.01.416
15. Moiseev VS, Mukhin NA, Smirnov AV, et al. Сardiovascular risk and chronic kidney disease: cardio-nephroprotection strategies. Russian Journal of Cardiology. 2014;(8):7-37 (In Russ.) doi: 10.15829/1560-4071-2014-8-7-37
16. Suslina ZA, Varakin YuYa, Vereshchagin NV. Sosudistye zabolevaniya golovnogo mozga: epidemiologiya, osnovy profilaktiki [Cerebrovascular disease: epidemiology and prevention]. Moscow: MEDpress-inform, 2006. 256 p. (In Russ.)
17. Rothwell PM, Gutnikov SA, Warlow CP, et al. Reanalysis of the final results of the European Carotid Surgery Trial. Stroke. 2003;34(2):514-23. PMID: 12574569
18. Chong E, Poh KK, Liang S, et al. Risk factors and clinical outcomes for contrast – induced nephropathy after percutaneous coronary interventions in patients with normal serum creatinine. Ann Acad Med Singapore. 2010;39(5):374-80. PMID: 20535427
19. Lash JP, Go AS, Appel LJ et al. ChronicRenalInsufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Chronic Renal Insufficiency Cohort (CRIC) Study Group. Clin J Am Soc Nephrol. 2011; 6(10): 2548-53. doi: 10.2215/CJN.00070109
20. Miskulin D, Bragg-Gresham J, Gillespie BW, et al. Key comorbid conditions that are predictive of survival among hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:1818-26. doi: 10.2215/CJN.00640109
21. Brugts JJ, Knetsch AM, Mattase-Raso FU, et al. Renal function and risk of myocardial infarction in elderly population. The Rotterdam study. Arch Intern Med. 2005;165(22):2659-65. doi: 10.1001/archinte.165.22.2659
22. Garcia-Donaire JA, Ruilope LM. Сardiovascular and renal links along the cardiorenal continuum. Nefrologiya = Clinical Nephrology. 2013;17(1):11-9 (In Russ.)
23. Sabe MA, Claggett B, Burdmann EA, et al. Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Anemia: An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). J Am Heart Assoc. 2016;5(4):e002850. doi: 10.1161/jaha.115.002850
24. Kato K, Yonetsu T, Jia H, et al. Non-culprit coronary plaque characteristics of chronic kidney disease. Circ Cardiovasc Imaging. 2013;6(3):448-56. doi: 10.1161/circimaging.112.000165
25. Schlieper G, Schurgers L, Brandenburg V, et al. Vascular calcification in chronic kidney disease: an update. Nephrol Dial Transplant. 2016;31(1):31-9. doi: 10.1093/ndt/gfv111
26. Alidzhanova KG, Rzhevskaya ON, Sagirov MA, Gazaryan GA. Рrognostic importance of chronic kidney disease in patients with acute coronary syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2017;6(2):132-9 (In Russ.) doi: 10.23934/2223-9022-2017-6-2
27. Pyrochkin VM, Karpovich YuI, Zhigal'cov AM. Disfunktsiya endoteliya, remodelirovanie miokarda i sosudistoy stenki u patsientov s khronicheskim nefriticheskim sindromom, nefroticheskoy formoy [Endothelial dysfunction, myocardial and vascular remodeling in patients with chronic nephritic syndrome of nephrotic form]. Grodno, 2016. 124 p. UDK: 616.61-002.2:[616-018.74-008.6:616.127]-085 (In Russ.)
28. Sugiyama T, Kimura S, Ohtani H, et al. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease. Cardiovasc Interv Ther. 2017 Jul;32(3):216-24. doi: 10.1007/s12928-016-0408-y
29. Kim J-K, Song YR, Kim MG, et al. Clinical significance of subclinical carotid atherosclerosis and its relationship with echocardiographic parameters in non-diabetic chronic kidney disease patients [Electronic Resource]. Cardiovasc Disord. 2013;13:96. URL: http://www.biomedcentral.com/1471-2261/13/96 (ссылка активна на 26.06.2018).
Авторы
В.Н. Каретникова1,2, В.В. Калаева1, М.В. Евсеева1, О.В. Груздева1,2, М.В. Зыков1, В.В. Кашталап1,2, О.Л. Барбараш1,2
1 ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Россия;
2 ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия
1 Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia;
2 Kemerovo State Medical University, Kemerovo, Russia
1 ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Россия;
2 ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия
________________________________________________
1 Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia;
2 Kemerovo State Medical University, Kemerovo, Russia
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