Роль интенсивной терапии в лечении больных острыми миелоидными лейкозами
Роль интенсивной терапии в лечении больных острыми миелоидными лейкозами
Баженов А.В., Галстян Г.М., Паровичникова Е.Н. и др. Роль интенсивной терапии в лечении больных острыми миелоидными лейкозами. Терапевтический архив. 2019; 91 (7): 14–24. DOI: 10.26442/00403660.2019.07.000321
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Цель. Индукция ремиссии у больных острыми миелоидными лейкозами (ОМЛ) может привести к угрожающим жизни осложнениям, требующим перевода в отделение реанимации и интенсивной терапии (ОРИТ). Цель работы – оценить влияние интенсивной терапии угрожающих жизни осложнений на краткосрочные и отдаленные результаты лечения больных ОМЛ.
Материалы и методы. В ретроспективное исследование включены больные с de novo ОМЛ старше 18 лет, которые были разделены на группы, кому потребовался перевод в ОРИТ (группа с ОРИТ) и не нуждавшихся в переводе в ОРИТ (группа без ОРИТ). Регистрировали структуру и результаты лечения критических синдромов, сравнивали между группами демографические показатели, молекулярно-цитогенетический риск, проводившуюся химиотерапию, краткосрочные и отдаленные результаты лечения ОМЛ. Использовали методы описательной статистики, вероятность дожития по методу Каплана–Майера.
Результаты. В исследование включено 76 больных ОМЛ. Перевод в ОРИТ потребовался 37% больных. Причины перевода: острая дыхательная недостаточность (50%), септический шок (14,3%), нарушение мозгового кровообращения (17,9%), экстренное родоразрешение (10,7%), острая аритмия (7,1%). Пациенты группы с ОРИТ не отличались от пациентов группы без ОРИТ по возрасту, частоте цитогенетически неблагоприятных форм ОМЛ, но в группе с ОРИТ были более выраженные анемия, лейкоцитоз, большее количество бластных клеток в крови и костном мозге. Факторами неблагоприятного исхода в ОРИТ были септический шок и искусственная вентиляция легких. В группе ОРИТ 28-дневная общая выживаемость (ОВ) составила 64,3%, 5-летняя ОВ – 43,2%, 5-летняя безрецидивная выживаемость (БРВ) – 34%, медиана БРВ – 16,4 мес; в группе без ОРИТ – соответственно 100, 53, 44% и 23,5 мес (p=0,504).
Заключение. Отдаленные результаты лечения больных ОМЛ, которым понадобилась интенсивная терапия, значимо не отличаются от результатов лечения больных без этих осложнений.
Ключевые слова: острый миелоидный лейкоз, интенсивная терапия, индукция ремиссии, отдаленные результаты лечения.
Materials and methods. Retrospective study. All de novo AML pts younger than 60 years old admitted in the National Research Center for Hematology from 2013 to 2016 years were enrolled in the study. Patients were divided into 2 groups: pts who were required ICU admission during remission induction (ICU-pts) and pts who did not require ICU admission and received chemotherapy only in hematology ward (non-ICU pts). The reasons for ICU admissions and results of life support were analyzed. Overall survival (OS) were assessed by the Kaplan–Meier method, long rank value p<0.05 consider as significant. Univariate analysis was performed with χ2 tests or Fisher's exact tests for categorical variables to find an independent ICU mortality predictor.
Results. In total 76 pts were included. 37% of pts required admission to ICU. Reasons for the ICU admissions were: acute respiratory failure (50%), septic shock (14.3%), cerebrovascular accident (17.9%), emergency caesarian section (10.7%), cardiac arrhythmia (7.1%). There were no difference in demography, group of risk (ELN) in ICU and non-ICU pts, but in ICU pts anemia, leukocytosis were more severe. Need for vasopressors and mechanical ventilations were mortality predictors. ICU survival rate was 63.4%. A landmark analysis for overall survival (OS) was performed for patients who survived after life threatening complication in ICU group: 5-year OS – 43.2%, 5-year disease free survival (DFS) – 34%. In non-ICU group 5-yeas OS – 53%, 5-year DSF – 44% (p=0.504).
Conclusion. After discharging from ICU the long-term prognosis of ICU-pts is not worse, than non-ICU pts.
Keywords: acute myeloid leukemia, ICU, remission induction, long-term survival.
Материалы и методы. В ретроспективное исследование включены больные с de novo ОМЛ старше 18 лет, которые были разделены на группы, кому потребовался перевод в ОРИТ (группа с ОРИТ) и не нуждавшихся в переводе в ОРИТ (группа без ОРИТ). Регистрировали структуру и результаты лечения критических синдромов, сравнивали между группами демографические показатели, молекулярно-цитогенетический риск, проводившуюся химиотерапию, краткосрочные и отдаленные результаты лечения ОМЛ. Использовали методы описательной статистики, вероятность дожития по методу Каплана–Майера.
Результаты. В исследование включено 76 больных ОМЛ. Перевод в ОРИТ потребовался 37% больных. Причины перевода: острая дыхательная недостаточность (50%), септический шок (14,3%), нарушение мозгового кровообращения (17,9%), экстренное родоразрешение (10,7%), острая аритмия (7,1%). Пациенты группы с ОРИТ не отличались от пациентов группы без ОРИТ по возрасту, частоте цитогенетически неблагоприятных форм ОМЛ, но в группе с ОРИТ были более выраженные анемия, лейкоцитоз, большее количество бластных клеток в крови и костном мозге. Факторами неблагоприятного исхода в ОРИТ были септический шок и искусственная вентиляция легких. В группе ОРИТ 28-дневная общая выживаемость (ОВ) составила 64,3%, 5-летняя ОВ – 43,2%, 5-летняя безрецидивная выживаемость (БРВ) – 34%, медиана БРВ – 16,4 мес; в группе без ОРИТ – соответственно 100, 53, 44% и 23,5 мес (p=0,504).
Заключение. Отдаленные результаты лечения больных ОМЛ, которым понадобилась интенсивная терапия, значимо не отличаются от результатов лечения больных без этих осложнений.
Ключевые слова: острый миелоидный лейкоз, интенсивная терапия, индукция ремиссии, отдаленные результаты лечения.
________________________________________________
Materials and methods. Retrospective study. All de novo AML pts younger than 60 years old admitted in the National Research Center for Hematology from 2013 to 2016 years were enrolled in the study. Patients were divided into 2 groups: pts who were required ICU admission during remission induction (ICU-pts) and pts who did not require ICU admission and received chemotherapy only in hematology ward (non-ICU pts). The reasons for ICU admissions and results of life support were analyzed. Overall survival (OS) were assessed by the Kaplan–Meier method, long rank value p<0.05 consider as significant. Univariate analysis was performed with χ2 tests or Fisher's exact tests for categorical variables to find an independent ICU mortality predictor.
Results. In total 76 pts were included. 37% of pts required admission to ICU. Reasons for the ICU admissions were: acute respiratory failure (50%), septic shock (14.3%), cerebrovascular accident (17.9%), emergency caesarian section (10.7%), cardiac arrhythmia (7.1%). There were no difference in demography, group of risk (ELN) in ICU and non-ICU pts, but in ICU pts anemia, leukocytosis were more severe. Need for vasopressors and mechanical ventilations were mortality predictors. ICU survival rate was 63.4%. A landmark analysis for overall survival (OS) was performed for patients who survived after life threatening complication in ICU group: 5-year OS – 43.2%, 5-year disease free survival (DFS) – 34%. In non-ICU group 5-yeas OS – 53%, 5-year DSF – 44% (p=0.504).
Conclusion. After discharging from ICU the long-term prognosis of ICU-pts is not worse, than non-ICU pts.
Keywords: acute myeloid leukemia, ICU, remission induction, long-term survival.
Список литературы
1. McGuire S. World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr An Int Rev J. 2016;7(2):418-9. doi: 10.3945/an.116.012211
2. Dizon D, Krilov L, Cohen E. Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. J Clin Oncol. 2016;34(9):987-1011. doi: 10.1200/JCO.2015.65.8427
3. Garcia-Manero G, Othus M, Pagel J. SWOG S1203: A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML). Blood. 2016;128(22). http://www.bloodjournal.org/content/128/22/901?sso-checked=true. Accessed March 6, 2018.
4. Burnett A, Russell N, Hills R. A randomized comparison of daunorubicin 90 mg/m 2 vs 60 mg/m 2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood. 2015;125(25):3878-85. doi: 10.1182/blood-2015-01-623447
5. Döhner H, Estey E, Grimwade D. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-47. doi: 10.1182/blood-2016-08-733196
6. Denardo S, Oye R, Bellamy P. Efficacy of intensive care for bone marrow transplant patients with respiratory failure. Crit Care Med. 1989;17(1):4-6. http://www.ncbi.nlm.nih. gov/pubmed/2642401. Accessed July 13, 2017.
7. Schuster D. Everything that Should Be Done—Not Everything that Can Be Done. Am Rev Respir Dis. 1992;145(3):508-9. doi: 10.1164/ajrccm/145.3.508
8. Turnbull A, Carlon G, Baron R, Sichel W, Young C, Howland W. The inverse relationship between cost and survival in the critically ill cancer patient. Crit Care Med. 1979;7(1):20-3. http://www.ncbi.nlm.nih.gov/pubmed/104824. Accessed July 11, 2017.
9. Crawford S, Petersen F. Long-term Survival from Respiratory Failure after Marrow Transplantation for Malignancy. Am Rev Respir Dis. 1992;145(3):510-4. doi: 10.1164/ajrccm/ 145.3.510
10. Lloyd-Thomas A, Wright I, Lister A, Hinds C. Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J (Clin Res Ed). 1988;296(6628):1025-9. http://www.ncbi.nlm.nih.gov/pubmed/3130123. Accessed July 5, 2017.
11. Tack C, Santman F. Results of intensive care treatment in patients with hematologic malignancies; relation to infections. Ned Tijdschr Geneeskd. 1992;136(1):25-9. http://www.ncbi. nlm.nih.gov/pubmed/1728759. Accessed July 18, 2017.
12. Lloyd-Thomas A, Dhaliwal H, Lister T, Hinds C. Intensive therapy for life-threatening medical complications of haematological malignancy. Intensive Care Med. 1986;12(4):317-24. http://www.ncbi.nlm.nih.gov/pubmed/3463606. Accessed July 13, 2017.
13. Brunet F, Lanore J, Dhainaut J. Is intensive care justified for patients with haematological malignancies? Intensive Care Med. 1990;16(5):291-7. http://www.ncbi.nlm.nih.gov/pubmed/ 2212252. Accessed July 5, 2017.
14. Yau E, Rohatiner A, Lister T, Hinds C. Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy. Br J Cancer. 1991;64(5):938-42. http://www.ncbi.nlm.nih.gov/pubmed/1931620. Accessed July 15, 2017.
15. Van Vliet M, Verburg I, Van Den Boogaard M. Trends in admission prevalence, illness severity and survival of haematological patients treated in Dutch intensive care units. Intensive Care Med. 2014;40(9):1275-84. doi: 10.1007/s00134-014-3373-x
16. Abdul-Jabbar S, Bates I, Davies G, Shulman R. An analysis of medicine costs of adult patients on a critical care unit. J Crit Care. 2014;29(3):472.e7-e472.e12. doi: 10.1016/j.jcrc. 2013.12.014
17. Schuster D, Marion J. Precedents for meaningful recovery during treatment in a medical intensive care unit. Outcome in patients with hematologic malignancy. Am J Med. 1983;75(3):402-8. http://www.ncbi.nlm.nih.gov/pubmed/6577789. Accessed July 13, 2017.
18. Benoit D, Vandewoude K, Decruyenaere J, Hoste E, Colardyn F. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med. 2003;31(1):104-12. doi: 10.1097/01. CCM.0000038213.27741.30
19. Moors I, Pène F, Lengline É, Benoit D. Urgent chemotherapy in hematological patients in the ICU. Curr Opin Crit Care. November 2015:1. doi: 10.1097/MCC.0000000000000254
20. Azoulay E, Pène F, Darmon M, Lengliné E, Benoit D,Soares M. Managing critically Ill hematology patients: Time to think differently. Blood Rev. 2015;29(6):359-67. doi: 10.1016/j.bl re.2015.04.002
21. Ñamendys-Silva S, González-Herrera M, García-Guillén F, Texcocano-Becerra J, Herrera-Gómez A. Outcome of critically ill patients with hematological malignancies. Ann Hematol. 2013;92(5):699-705. doi: 10.1007/s00277-013-1675-7
22. Jackson K, Mollee P, Morris K, Butler J, Jackson D, Kruger P, Klein K, Kennedy G. Outcomes and prognostic factors for patients with acute myeloid leukemia admitted to the intensive care unit. Leuk Lymphoma. 2013;55(April):1-8. doi: 10.3109/10428194.2013.796045
23. Bird G, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth. 2012;108(3):452-9. doi: 10.1093/bja/aer449
24. Hinds C, Martin R, Quinton P. Intensive care for patients with medical complications of haematological malignancy: is it worth it? Schweiz Med Wochenschr. 1998;128(39):1467-73. http://www.ncbi.nlm.nih.gov/pubmed/9793166. Accessed October 10, 2017.
25. Massion P, Dive A, Doyen C. Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med. 2002;30(10):2260-70. doi: 10.1097/01.CCM.000 0030456.11264.EF
26. Ahmed T, Koch A, Isom S. Outcomes and changes in code status of patients with acute myeloid leukemia undergoing induction chemotherapy who were transferred to the intensive care unit. Leuk Res. 2017;62:51-5. doi: 10.1016/j.leukres.2017.09.017
27. Roze des Ordons L, Chan K, Mirza I, Townsend D, Bagshaw S. Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study. BMC Cancer. 2010;10:516. doi: 10.1186/1471-2407-10-516
28. Schellongowski P, Staudinger T, Kundi M. Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience. Haematologica. 2011;96(2). http://www. haematologica.org/content/96/2/231. Accessed July 19, 2017.
29. Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. Национальные клинические рекомендации по диагностике и лечению острых миелоидных лейкозов взрослых. Гематология и трансфузиология. 2014;59(2):3-28 [Savchenko VG, Parovichnikova EN, Afanasev BV, et al. National guidelines for diagnosis and treatment of acute myeloid leukemia in adults. Gematologia i transfusiologia. 2014;59(2):3-28 (In Russ.)].
30. Singer M, Deutschman C, Seymour C. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287
31. Fan E, Brodie D, Slutsky AS. Acute Respiratory Distress Syndrome. JAMA. 2018;319(7): 698. doi: 10.1001/jama.2017.21907
32. Morelli A, Ertmer C, Rehberg S, et al. Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): A randomized, controlled pilot study. Crit Care. 2009;13(4):1-14. doi: 10.1186/cc7990
33. Савченко В.Г., Паровичникова Е.Н., Троицкая В.В., Махиня С.А., Галстян Г.М., Латышкевич О.А. Протокол лечения острых лейкозов на фоне беременности. In: Алгоритмы диагностики и протоколы лечения заболеваний системы крови. М., 2018:753-792 [Savchenko VG. ed. Algorithm for diagnosis and guidelines for treatment of hematology disease. Moscow: Praktika press, 2018:753-792 (In Russ.)].
34. Hartsock B, Lim M, Roth C, Raptis N, Weber D, Sehgal A, Boyiadzis M, Raptis A, Hou J,Im A, Dorritie K, Marks S, Agha M, Lim S. ICU intervention during induction chemotherapy for adult patients with newly diagnosed acute myeloid leukemia. Leuk Res. 2016;48:16-9. doi: 10.1016/j.leukres.2016.07.001
35. Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2016;95(1):28-37. doi: 10.1111/aogs.12798
36. Sippel C, Kim Y, Wallau A, Brossart P, Schmidt-Wolf I, Walger P. AML versus ICU: outcome of septic AML patients in an intensive care setting. J Cancer Res Clin Oncol. 2015;141(9):1645-51. doi: 10.1007/s00432-015-1955-9
37. Azoulay E, Mokart D, Pène F, Lambert J, Kouatchet A, Mayaux J, Vincent F, Nyunga M, Bruneel F, Laisne L, Rabbat A, Lebert C, Perez P, Chaize M, Renault A, Meert A, Benoit D, Hamidfar R, Jourdain M, Darmon M, Schlemmer B, Chevret S, Lemiale V. Outcomes of Critically Ill Patients With Hematologic Malignancies: Prospective Multicenter Data From France and Belgium—A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. J Clin Oncol. 2013;31(22):2810-8. doi: 10.1200/JCO.2012.47.2365
38. Othus M, Kantarjian H, Petersdorf S, Ravandi F, Godwin J, Cortes J, Pierce S, Erba H, Faderl S, Appelbaum F, Estey E. Declining rates of treatment-related mortality in patients with newly diagnosed AML given “intense” induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014;28(2):289-92. doi: 10.1038/leu.2013.176
39. Estey E, Smith TL, Keating MJ, McCredie KB, Gehan EA, Freireich EJ. Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia. Leukemia. 1989;3(4):257-63. https://www.scopus.com/record/display.uri?eid=2-s2.0-0024510651& origin=inward&txGid=d755ba4b8a78e0cd3abff771339a1447. Accessed November 30, 2017.
40. Walter RB, Othus M, Borthakur G, Ravandi F, Cortes J, Pierce S, Appelbaum F, Kantarjian H, Estey E. Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment Assignment. J Clin Oncol. 2011;29(33):4417-24. doi: 10.1200/JCO.2011.35.7525
41. Yeo C, Kim J, Kim S, Kim Y, Kim K, Kim H, Lee F, Rhee C. Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit. J Crit Care. 2012;27(6):739.e1-e739.e6. doi: 10.1016/j.jcrc.2012.07.014
42. Price KJ, Cardenas-Turanzas M, Lin H, Roden L, Nigam R, Nates JL. Prognostic indicators of mortality of mechanically ventilated patients with acute leukemia in a comprehensive cancer center. Minerva Anestesiol. 2012;79(2):147-55.
43. Evison JM, Rickenbacher P, Ritz R, Gratwohl A, Haberthür C, Elsasser S, Passweg J. Intensive care unit admission in patients with haematological disease: Incidence, outcome and prognostic factors. Swiss Med Wkly. 2001;131:681-6.
44. Azoulay E, Recher C, Alberti C, Soufir L, Leleu G, Le R, Fermand P, Schlemmer B. Changing use of intensive care for hematological patients: The example of multiple myeloma. Intensive Care Med. 1999;25(12):1395-401. doi: 10.1007/s001340051087
45. Depuydt P, Benoit D, Vandewoude K, Decruyenaere J, Colardyn F. Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure. Chest. 2004;126(4):1299-306. doi: 10.1378/chest.126.4.1299
46. Rabbat A, Chaoui D, Montani D, Legrand O, Lefebvre A, Rio B, Roche N, Lorut C, Marie J, Huchon G. Prognosis of patients with acute myeloid leukaemia admitted to intensive care. Br J Haematol. 2005;129(3):350-7. doi: 10.1111/j.1365-2141.2005.05459.x
47. Pohlen M, Thoennissen N, Braess J, Thudium J, Schmid C, Kochanek M, Kreuzer K, Lebiedz P, Görlich P, Gerth H, Rohde C, Kessler C, Müller-Tidow C, Stelljes M, Büchner T, Schlimok G, Hallek M, Waltenberger J, Hiddemann W, Berdel W, Heilmeier B, Krug U. Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. PLoS One. 2016;11(8):e0160871. doi: 10.1371/journal.pone.0160871
48. Larché J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le G, Schlemmer B. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med. 2003;29(10):1688-95. doi: 10.1007/s00134-003-1957-y
49. Silfvast T, Pettila V, Ihalainen A, Elonen E. Multiple organ failure and outcome of critically ill patients with haematological malignancy. Acta Anaesthesiol Scand. 2003;47:301-6. https://doi.org/10.1034/j.1399-6576.2003.00058.x
50. Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med. 2002;28(9):1294-300. doi: 10.1007/s00134-002-1420-5
51. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: A secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2009;13(4):R137. doi: 10.1186/cc8016
52. Lamia B, Hellot MF, Girault C, Lamia, B. Hellot M, Girault C, Tamion F, Dachraoui F, Lenain P, Bonmarchand G. Changes in severity and organ failure scores as prognostic factors in onco-hematological malignancy patients admitted to the ICU. Intensive Care Med. 2006;32(10):1560-8. doi: 10.1007/s00134-006-0286-3
53. Guven GS, Uzun O, Cakir B, Akova M, Unal S. Infectious complications in patients with hematological malignancies consulted by the Infectious Diseases team: A retrospective cohort study (1997-2001). Support Care Cancer. 2006;14(1):52-5. doi: 10.1007/s00520-005-0836-1
54. Сёмочкин С.В., Толстых Т.Н., Архипова Н.В., Иванова В.Л., Клюева О.В., Лунин В.В., Мисюрина Е.Н., Туманова М.В., Хуажева Н.К. Клинико-эпидемиологическая характеристика острых миелоидных лейкозов у взрослых по данным муниципальных отделений гематологии Москвы. Терапевтический архив. 2015;87(7):26-32 [Semochkin SV, Tolstykh TN, Arkhipova NV, Ivanova VL, Klyueva OV, Lunin VV, Misyurina EN, Tumanova MV, Huazheva NK. Desiase type and demograph charcterisitis of acute myeloid leukemia in adults in departmetns of hematology of Moscow city. Therapeutic Archive. 2015;87(7):26-32 (In Russ.)]. doi: 10.17116/terarkh201587726-32
55. Воробьев А.И., Горелов В.Г., Городецкий В.М., Шулутко Е.М. Критические состояния при гемобластозах (типичные формы и выживаемость в условиях отделения реанимации). Терапевтический архив. 1993;65(7):3-6 [Vorobev AI, Gorelov VG, Gorodetskiy VM, Shulutko EM. Life-threating complication in patients with hemoblastosis (types and ICU survival rate). Therapeutic Archive. 1993;65(7):3-6 (In Russ.)].
56. Галстян Г.М., Городецкий В.М. Опыт работы отделения реанимации и интенсивной терапии ФГБУ ГНЦ МЗиСР РФ. Клиническая онкогематология. 2011;4(1):75-8 [Galstyan GM, Gorodetskiy VM. Experince of ICU National Research Center for Hematology. Klinicheskaya Onkoematologiya. 2011;4(1):75-8 (In Russ.)].
57. Grgić Medić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit - Outcomes and prognostic factors. Hematology. 2014;(5):247-53. doi: 10.1179/1607845414Y.0000000206
2. Dizon D, Krilov L, Cohen E. Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. J Clin Oncol. 2016;34(9):987-1011. doi: 10.1200/JCO.2015.65.8427
3. Garcia-Manero G, Othus M, Pagel J. SWOG S1203: A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML). Blood. 2016;128(22). http://www.bloodjournal.org/content/128/22/901?sso-checked=true. Accessed March 6, 2018.
4. Burnett A, Russell N, Hills R. A randomized comparison of daunorubicin 90 mg/m 2 vs 60 mg/m 2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood. 2015;125(25):3878-85. doi: 10.1182/blood-2015-01-623447
5. Döhner H, Estey E, Grimwade D. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-47. doi: 10.1182/blood-2016-08-733196
6. Denardo S, Oye R, Bellamy P. Efficacy of intensive care for bone marrow transplant patients with respiratory failure. Crit Care Med. 1989;17(1):4-6. http://www.ncbi.nlm.nih. gov/pubmed/2642401. Accessed July 13, 2017.
7. Schuster D. Everything that Should Be Done—Not Everything that Can Be Done. Am Rev Respir Dis. 1992;145(3):508-9. doi: 10.1164/ajrccm/145.3.508
8. Turnbull A, Carlon G, Baron R, Sichel W, Young C, Howland W. The inverse relationship between cost and survival in the critically ill cancer patient. Crit Care Med. 1979;7(1):20-3. http://www.ncbi.nlm.nih.gov/pubmed/104824. Accessed July 11, 2017.
9. Crawford S, Petersen F. Long-term Survival from Respiratory Failure after Marrow Transplantation for Malignancy. Am Rev Respir Dis. 1992;145(3):510-4. doi: 10.1164/ajrccm/ 145.3.510
10. Lloyd-Thomas A, Wright I, Lister A, Hinds C. Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J (Clin Res Ed). 1988;296(6628):1025-9. http://www.ncbi.nlm.nih.gov/pubmed/3130123. Accessed July 5, 2017.
11. Tack C, Santman F. Results of intensive care treatment in patients with hematologic malignancies; relation to infections. Ned Tijdschr Geneeskd. 1992;136(1):25-9. http://www.ncbi. nlm.nih.gov/pubmed/1728759. Accessed July 18, 2017.
12. Lloyd-Thomas A, Dhaliwal H, Lister T, Hinds C. Intensive therapy for life-threatening medical complications of haematological malignancy. Intensive Care Med. 1986;12(4):317-24. http://www.ncbi.nlm.nih.gov/pubmed/3463606. Accessed July 13, 2017.
13. Brunet F, Lanore J, Dhainaut J. Is intensive care justified for patients with haematological malignancies? Intensive Care Med. 1990;16(5):291-7. http://www.ncbi.nlm.nih.gov/pubmed/ 2212252. Accessed July 5, 2017.
14. Yau E, Rohatiner A, Lister T, Hinds C. Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy. Br J Cancer. 1991;64(5):938-42. http://www.ncbi.nlm.nih.gov/pubmed/1931620. Accessed July 15, 2017.
15. Van Vliet M, Verburg I, Van Den Boogaard M. Trends in admission prevalence, illness severity and survival of haematological patients treated in Dutch intensive care units. Intensive Care Med. 2014;40(9):1275-84. doi: 10.1007/s00134-014-3373-x
16. Abdul-Jabbar S, Bates I, Davies G, Shulman R. An analysis of medicine costs of adult patients on a critical care unit. J Crit Care. 2014;29(3):472.e7-e472.e12. doi: 10.1016/j.jcrc. 2013.12.014
17. Schuster D, Marion J. Precedents for meaningful recovery during treatment in a medical intensive care unit. Outcome in patients with hematologic malignancy. Am J Med. 1983;75(3):402-8. http://www.ncbi.nlm.nih.gov/pubmed/6577789. Accessed July 13, 2017.
18. Benoit D, Vandewoude K, Decruyenaere J, Hoste E, Colardyn F. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med. 2003;31(1):104-12. doi: 10.1097/01. CCM.0000038213.27741.30
19. Moors I, Pène F, Lengline É, Benoit D. Urgent chemotherapy in hematological patients in the ICU. Curr Opin Crit Care. November 2015:1. doi: 10.1097/MCC.0000000000000254
20. Azoulay E, Pène F, Darmon M, Lengliné E, Benoit D,Soares M. Managing critically Ill hematology patients: Time to think differently. Blood Rev. 2015;29(6):359-67. doi: 10.1016/j.bl re.2015.04.002
21. Ñamendys-Silva S, González-Herrera M, García-Guillén F, Texcocano-Becerra J, Herrera-Gómez A. Outcome of critically ill patients with hematological malignancies. Ann Hematol. 2013;92(5):699-705. doi: 10.1007/s00277-013-1675-7
22. Jackson K, Mollee P, Morris K, Butler J, Jackson D, Kruger P, Klein K, Kennedy G. Outcomes and prognostic factors for patients with acute myeloid leukemia admitted to the intensive care unit. Leuk Lymphoma. 2013;55(April):1-8. doi: 10.3109/10428194.2013.796045
23. Bird G, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth. 2012;108(3):452-9. doi: 10.1093/bja/aer449
24. Hinds C, Martin R, Quinton P. Intensive care for patients with medical complications of haematological malignancy: is it worth it? Schweiz Med Wochenschr. 1998;128(39):1467-73. http://www.ncbi.nlm.nih.gov/pubmed/9793166. Accessed October 10, 2017.
25. Massion P, Dive A, Doyen C. Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med. 2002;30(10):2260-70. doi: 10.1097/01.CCM.000 0030456.11264.EF
26. Ahmed T, Koch A, Isom S. Outcomes and changes in code status of patients with acute myeloid leukemia undergoing induction chemotherapy who were transferred to the intensive care unit. Leuk Res. 2017;62:51-5. doi: 10.1016/j.leukres.2017.09.017
27. Roze des Ordons L, Chan K, Mirza I, Townsend D, Bagshaw S. Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study. BMC Cancer. 2010;10:516. doi: 10.1186/1471-2407-10-516
28. Schellongowski P, Staudinger T, Kundi M. Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience. Haematologica. 2011;96(2). http://www. haematologica.org/content/96/2/231. Accessed July 19, 2017.
29. [Savchenko VG, Parovichnikova EN, Afanasev BV, et al. National guidelines for diagnosis and treatment of acute myeloid leukemia in adults. Gematologia i transfusiologia. 2014;59(2):3-28 (In Russ.)].
30. Singer M, Deutschman C, Seymour C. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287
31. Fan E, Brodie D, Slutsky AS. Acute Respiratory Distress Syndrome. JAMA. 2018;319(7): 698. doi: 10.1001/jama.2017.21907
32. Morelli A, Ertmer C, Rehberg S, et al. Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): A randomized, controlled pilot study. Crit Care. 2009;13(4):1-14. doi: 10.1186/cc7990
33. [Savchenko VG. ed. Algorithm for diagnosis and guidelines for treatment of hematology disease. Moscow: Praktika press, 2018:753-792 (In Russ.)].
34. Hartsock B, Lim M, Roth C, Raptis N, Weber D, Sehgal A, Boyiadzis M, Raptis A, Hou J,Im A, Dorritie K, Marks S, Agha M, Lim S. ICU intervention during induction chemotherapy for adult patients with newly diagnosed acute myeloid leukemia. Leuk Res. 2016;48:16-9. doi: 10.1016/j.leukres.2016.07.001
35. Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2016;95(1):28-37. doi: 10.1111/aogs.12798
36. Sippel C, Kim Y, Wallau A, Brossart P, Schmidt-Wolf I, Walger P. AML versus ICU: outcome of septic AML patients in an intensive care setting. J Cancer Res Clin Oncol. 2015;141(9):1645-51. doi: 10.1007/s00432-015-1955-9
37. Azoulay E, Mokart D, Pène F, Lambert J, Kouatchet A, Mayaux J, Vincent F, Nyunga M, Bruneel F, Laisne L, Rabbat A, Lebert C, Perez P, Chaize M, Renault A, Meert A, Benoit D, Hamidfar R, Jourdain M, Darmon M, Schlemmer B, Chevret S, Lemiale V. Outcomes of Critically Ill Patients With Hematologic Malignancies: Prospective Multicenter Data From France and Belgium—A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. J Clin Oncol. 2013;31(22):2810-8. doi: 10.1200/JCO.2012.47.2365
38. Othus M, Kantarjian H, Petersdorf S, Ravandi F, Godwin J, Cortes J, Pierce S, Erba H, Faderl S, Appelbaum F, Estey E. Declining rates of treatment-related mortality in patients with newly diagnosed AML given “intense” induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014;28(2):289-92. doi: 10.1038/leu.2013.176
39. Estey E, Smith TL, Keating MJ, McCredie KB, Gehan EA, Freireich EJ. Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia. Leukemia. 1989;3(4):257-63. https://www.scopus.com/record/display.uri?eid=2-s2.0-0024510651& origin=inward&txGid=d755ba4b8a78e0cd3abff771339a1447. Accessed November 30, 2017.
40. Walter RB, Othus M, Borthakur G, Ravandi F, Cortes J, Pierce S, Appelbaum F, Kantarjian H, Estey E. Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment Assignment. J Clin Oncol. 2011;29(33):4417-24. doi: 10.1200/JCO.2011.35.7525
41. Yeo C, Kim J, Kim S, Kim Y, Kim K, Kim H, Lee F, Rhee C. Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit. J Crit Care. 2012;27(6):739.e1-e739.e6. doi: 10.1016/j.jcrc.2012.07.014
42. Price KJ, Cardenas-Turanzas M, Lin H, Roden L, Nigam R, Nates JL. Prognostic indicators of mortality of mechanically ventilated patients with acute leukemia in a comprehensive cancer center. Minerva Anestesiol. 2012;79(2):147-55.
43. Evison JM, Rickenbacher P, Ritz R, Gratwohl A, Haberthür C, Elsasser S, Passweg J. Intensive care unit admission in patients with haematological disease: Incidence, outcome and prognostic factors. Swiss Med Wkly. 2001;131:681-6.
44. Azoulay E, Recher C, Alberti C, Soufir L, Leleu G, Le R, Fermand P, Schlemmer B. Changing use of intensive care for hematological patients: The example of multiple myeloma. Intensive Care Med. 1999;25(12):1395-401. doi: 10.1007/s001340051087
45. Depuydt P, Benoit D, Vandewoude K, Decruyenaere J, Colardyn F. Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure. Chest. 2004;126(4):1299-306. doi: 10.1378/chest.126.4.1299
46. Rabbat A, Chaoui D, Montani D, Legrand O, Lefebvre A, Rio B, Roche N, Lorut C, Marie J, Huchon G. Prognosis of patients with acute myeloid leukaemia admitted to intensive care. Br J Haematol. 2005;129(3):350-7. doi: 10.1111/j.1365-2141.2005.05459.x
47. Pohlen M, Thoennissen N, Braess J, Thudium J, Schmid C, Kochanek M, Kreuzer K, Lebiedz P, Görlich P, Gerth H, Rohde C, Kessler C, Müller-Tidow C, Stelljes M, Büchner T, Schlimok G, Hallek M, Waltenberger J, Hiddemann W, Berdel W, Heilmeier B, Krug U. Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. PLoS One. 2016;11(8):e0160871. doi: 10.1371/journal.pone.0160871
48. Larché J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le G, Schlemmer B. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med. 2003;29(10):1688-95. doi: 10.1007/s00134-003-1957-y
49. Silfvast T, Pettila V, Ihalainen A, Elonen E. Multiple organ failure and outcome of critically ill patients with haematological malignancy. Acta Anaesthesiol Scand. 2003;47:301-6. https://doi.org/10.1034/j.1399-6576.2003.00058.x
50. Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med. 2002;28(9):1294-300. doi: 10.1007/s00134-002-1420-5
51. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: A secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2009;13(4):R137. doi: 10.1186/cc8016
52. Lamia B, Hellot MF, Girault C, Lamia, B. Hellot M, Girault C, Tamion F, Dachraoui F, Lenain P, Bonmarchand G. Changes in severity and organ failure scores as prognostic factors in onco-hematological malignancy patients admitted to the ICU. Intensive Care Med. 2006;32(10):1560-8. doi: 10.1007/s00134-006-0286-3
53. Guven GS, Uzun O, Cakir B, Akova M, Unal S. Infectious complications in patients with hematological malignancies consulted by the Infectious Diseases team: A retrospective cohort study (1997-2001). Support Care Cancer. 2006;14(1):52-5. doi: 10.1007/s00520-005-0836-1
54. [Semochkin SV, Tolstykh TN, Arkhipova NV, Ivanova VL, Klyueva OV, Lunin VV, Misyurina EN, Tumanova MV, Huazheva NK. Desiase type and demograph charcterisitis of acute myeloid leukemia in adults in departmetns of hematology of Moscow city. Therapeutic Archive. 2015;87(7):26-32 (In Russ.)]. doi: 10.17116/terarkh201587726-32
55. [Vorobev AI, Gorelov VG, Gorodetskiy VM, Shulutko EM. Life-threating complication in patients with hemoblastosis (types and ICU survival rate). Therapeutic Archive. 1993;65(7):3-6 (In Russ.)].
56. Galstyan GM, Gorodetskiy VM. Experince of ICU National Research Center for Hematology. Klinicheskaya Onkoematologiya. 2011;4(1):75-8 (In Russ.)].
57. Grgić Medić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit - Outcomes and prognostic factors. Hematology. 2014;(5):247-53. doi: 10.1179/1607845414Y.0000000206
2. Dizon D, Krilov L, Cohen E. Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. J Clin Oncol. 2016;34(9):987-1011. doi: 10.1200/JCO.2015.65.8427
3. Garcia-Manero G, Othus M, Pagel J. SWOG S1203: A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML). Blood. 2016;128(22). http://www.bloodjournal.org/content/128/22/901?sso-checked=true. Accessed March 6, 2018.
4. Burnett A, Russell N, Hills R. A randomized comparison of daunorubicin 90 mg/m 2 vs 60 mg/m 2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood. 2015;125(25):3878-85. doi: 10.1182/blood-2015-01-623447
5. Döhner H, Estey E, Grimwade D. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-47. doi: 10.1182/blood-2016-08-733196
6. Denardo S, Oye R, Bellamy P. Efficacy of intensive care for bone marrow transplant patients with respiratory failure. Crit Care Med. 1989;17(1):4-6. http://www.ncbi.nlm.nih. gov/pubmed/2642401. Accessed July 13, 2017.
7. Schuster D. Everything that Should Be Done—Not Everything that Can Be Done. Am Rev Respir Dis. 1992;145(3):508-9. doi: 10.1164/ajrccm/145.3.508
8. Turnbull A, Carlon G, Baron R, Sichel W, Young C, Howland W. The inverse relationship between cost and survival in the critically ill cancer patient. Crit Care Med. 1979;7(1):20-3. http://www.ncbi.nlm.nih.gov/pubmed/104824. Accessed July 11, 2017.
9. Crawford S, Petersen F. Long-term Survival from Respiratory Failure after Marrow Transplantation for Malignancy. Am Rev Respir Dis. 1992;145(3):510-4. doi: 10.1164/ajrccm/ 145.3.510
10. Lloyd-Thomas A, Wright I, Lister A, Hinds C. Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J (Clin Res Ed). 1988;296(6628):1025-9. http://www.ncbi.nlm.nih.gov/pubmed/3130123. Accessed July 5, 2017.
11. Tack C, Santman F. Results of intensive care treatment in patients with hematologic malignancies; relation to infections. Ned Tijdschr Geneeskd. 1992;136(1):25-9. http://www.ncbi. nlm.nih.gov/pubmed/1728759. Accessed July 18, 2017.
12. Lloyd-Thomas A, Dhaliwal H, Lister T, Hinds C. Intensive therapy for life-threatening medical complications of haematological malignancy. Intensive Care Med. 1986;12(4):317-24. http://www.ncbi.nlm.nih.gov/pubmed/3463606. Accessed July 13, 2017.
13. Brunet F, Lanore J, Dhainaut J. Is intensive care justified for patients with haematological malignancies? Intensive Care Med. 1990;16(5):291-7. http://www.ncbi.nlm.nih.gov/pubmed/ 2212252. Accessed July 5, 2017.
14. Yau E, Rohatiner A, Lister T, Hinds C. Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy. Br J Cancer. 1991;64(5):938-42. http://www.ncbi.nlm.nih.gov/pubmed/1931620. Accessed July 15, 2017.
15. Van Vliet M, Verburg I, Van Den Boogaard M. Trends in admission prevalence, illness severity and survival of haematological patients treated in Dutch intensive care units. Intensive Care Med. 2014;40(9):1275-84. doi: 10.1007/s00134-014-3373-x
16. Abdul-Jabbar S, Bates I, Davies G, Shulman R. An analysis of medicine costs of adult patients on a critical care unit. J Crit Care. 2014;29(3):472.e7-e472.e12. doi: 10.1016/j.jcrc. 2013.12.014
17. Schuster D, Marion J. Precedents for meaningful recovery during treatment in a medical intensive care unit. Outcome in patients with hematologic malignancy. Am J Med. 1983;75(3):402-8. http://www.ncbi.nlm.nih.gov/pubmed/6577789. Accessed July 13, 2017.
18. Benoit D, Vandewoude K, Decruyenaere J, Hoste E, Colardyn F. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med. 2003;31(1):104-12. doi: 10.1097/01. CCM.0000038213.27741.30
19. Moors I, Pène F, Lengline É, Benoit D. Urgent chemotherapy in hematological patients in the ICU. Curr Opin Crit Care. November 2015:1. doi: 10.1097/MCC.0000000000000254
20. Azoulay E, Pène F, Darmon M, Lengliné E, Benoit D,Soares M. Managing critically Ill hematology patients: Time to think differently. Blood Rev. 2015;29(6):359-67. doi: 10.1016/j.bl re.2015.04.002
21. Ñamendys-Silva S, González-Herrera M, García-Guillén F, Texcocano-Becerra J, Herrera-Gómez A. Outcome of critically ill patients with hematological malignancies. Ann Hematol. 2013;92(5):699-705. doi: 10.1007/s00277-013-1675-7
22. Jackson K, Mollee P, Morris K, Butler J, Jackson D, Kruger P, Klein K, Kennedy G. Outcomes and prognostic factors for patients with acute myeloid leukemia admitted to the intensive care unit. Leuk Lymphoma. 2013;55(April):1-8. doi: 10.3109/10428194.2013.796045
23. Bird G, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth. 2012;108(3):452-9. doi: 10.1093/bja/aer449
24. Hinds C, Martin R, Quinton P. Intensive care for patients with medical complications of haematological malignancy: is it worth it? Schweiz Med Wochenschr. 1998;128(39):1467-73. http://www.ncbi.nlm.nih.gov/pubmed/9793166. Accessed October 10, 2017.
25. Massion P, Dive A, Doyen C. Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med. 2002;30(10):2260-70. doi: 10.1097/01.CCM.000 0030456.11264.EF
26. Ahmed T, Koch A, Isom S. Outcomes and changes in code status of patients with acute myeloid leukemia undergoing induction chemotherapy who were transferred to the intensive care unit. Leuk Res. 2017;62:51-5. doi: 10.1016/j.leukres.2017.09.017
27. Roze des Ordons L, Chan K, Mirza I, Townsend D, Bagshaw S. Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study. BMC Cancer. 2010;10:516. doi: 10.1186/1471-2407-10-516
28. Schellongowski P, Staudinger T, Kundi M. Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience. Haematologica. 2011;96(2). http://www. haematologica.org/content/96/2/231. Accessed July 19, 2017.
29. Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. Национальные клинические рекомендации по диагностике и лечению острых миелоидных лейкозов взрослых. Гематология и трансфузиология. 2014;59(2):3-28 [Savchenko VG, Parovichnikova EN, Afanasev BV, et al. National guidelines for diagnosis and treatment of acute myeloid leukemia in adults. Gematologia i transfusiologia. 2014;59(2):3-28 (In Russ.)].
30. Singer M, Deutschman C, Seymour C. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287
31. Fan E, Brodie D, Slutsky AS. Acute Respiratory Distress Syndrome. JAMA. 2018;319(7): 698. doi: 10.1001/jama.2017.21907
32. Morelli A, Ertmer C, Rehberg S, et al. Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): A randomized, controlled pilot study. Crit Care. 2009;13(4):1-14. doi: 10.1186/cc7990
33. Савченко В.Г., Паровичникова Е.Н., Троицкая В.В., Махиня С.А., Галстян Г.М., Латышкевич О.А. Протокол лечения острых лейкозов на фоне беременности. In: Алгоритмы диагностики и протоколы лечения заболеваний системы крови. М., 2018:753-792 [Savchenko VG. ed. Algorithm for diagnosis and guidelines for treatment of hematology disease. Moscow: Praktika press, 2018:753-792 (In Russ.)].
34. Hartsock B, Lim M, Roth C, Raptis N, Weber D, Sehgal A, Boyiadzis M, Raptis A, Hou J,Im A, Dorritie K, Marks S, Agha M, Lim S. ICU intervention during induction chemotherapy for adult patients with newly diagnosed acute myeloid leukemia. Leuk Res. 2016;48:16-9. doi: 10.1016/j.leukres.2016.07.001
35. Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2016;95(1):28-37. doi: 10.1111/aogs.12798
36. Sippel C, Kim Y, Wallau A, Brossart P, Schmidt-Wolf I, Walger P. AML versus ICU: outcome of septic AML patients in an intensive care setting. J Cancer Res Clin Oncol. 2015;141(9):1645-51. doi: 10.1007/s00432-015-1955-9
37. Azoulay E, Mokart D, Pène F, Lambert J, Kouatchet A, Mayaux J, Vincent F, Nyunga M, Bruneel F, Laisne L, Rabbat A, Lebert C, Perez P, Chaize M, Renault A, Meert A, Benoit D, Hamidfar R, Jourdain M, Darmon M, Schlemmer B, Chevret S, Lemiale V. Outcomes of Critically Ill Patients With Hematologic Malignancies: Prospective Multicenter Data From France and Belgium—A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. J Clin Oncol. 2013;31(22):2810-8. doi: 10.1200/JCO.2012.47.2365
38. Othus M, Kantarjian H, Petersdorf S, Ravandi F, Godwin J, Cortes J, Pierce S, Erba H, Faderl S, Appelbaum F, Estey E. Declining rates of treatment-related mortality in patients with newly diagnosed AML given “intense” induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014;28(2):289-92. doi: 10.1038/leu.2013.176
39. Estey E, Smith TL, Keating MJ, McCredie KB, Gehan EA, Freireich EJ. Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia. Leukemia. 1989;3(4):257-63. https://www.scopus.com/record/display.uri?eid=2-s2.0-0024510651& origin=inward&txGid=d755ba4b8a78e0cd3abff771339a1447. Accessed November 30, 2017.
40. Walter RB, Othus M, Borthakur G, Ravandi F, Cortes J, Pierce S, Appelbaum F, Kantarjian H, Estey E. Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment Assignment. J Clin Oncol. 2011;29(33):4417-24. doi: 10.1200/JCO.2011.35.7525
41. Yeo C, Kim J, Kim S, Kim Y, Kim K, Kim H, Lee F, Rhee C. Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit. J Crit Care. 2012;27(6):739.e1-e739.e6. doi: 10.1016/j.jcrc.2012.07.014
42. Price KJ, Cardenas-Turanzas M, Lin H, Roden L, Nigam R, Nates JL. Prognostic indicators of mortality of mechanically ventilated patients with acute leukemia in a comprehensive cancer center. Minerva Anestesiol. 2012;79(2):147-55.
43. Evison JM, Rickenbacher P, Ritz R, Gratwohl A, Haberthür C, Elsasser S, Passweg J. Intensive care unit admission in patients with haematological disease: Incidence, outcome and prognostic factors. Swiss Med Wkly. 2001;131:681-6.
44. Azoulay E, Recher C, Alberti C, Soufir L, Leleu G, Le R, Fermand P, Schlemmer B. Changing use of intensive care for hematological patients: The example of multiple myeloma. Intensive Care Med. 1999;25(12):1395-401. doi: 10.1007/s001340051087
45. Depuydt P, Benoit D, Vandewoude K, Decruyenaere J, Colardyn F. Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure. Chest. 2004;126(4):1299-306. doi: 10.1378/chest.126.4.1299
46. Rabbat A, Chaoui D, Montani D, Legrand O, Lefebvre A, Rio B, Roche N, Lorut C, Marie J, Huchon G. Prognosis of patients with acute myeloid leukaemia admitted to intensive care. Br J Haematol. 2005;129(3):350-7. doi: 10.1111/j.1365-2141.2005.05459.x
47. Pohlen M, Thoennissen N, Braess J, Thudium J, Schmid C, Kochanek M, Kreuzer K, Lebiedz P, Görlich P, Gerth H, Rohde C, Kessler C, Müller-Tidow C, Stelljes M, Büchner T, Schlimok G, Hallek M, Waltenberger J, Hiddemann W, Berdel W, Heilmeier B, Krug U. Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. PLoS One. 2016;11(8):e0160871. doi: 10.1371/journal.pone.0160871
48. Larché J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le G, Schlemmer B. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med. 2003;29(10):1688-95. doi: 10.1007/s00134-003-1957-y
49. Silfvast T, Pettila V, Ihalainen A, Elonen E. Multiple organ failure and outcome of critically ill patients with haematological malignancy. Acta Anaesthesiol Scand. 2003;47:301-6. https://doi.org/10.1034/j.1399-6576.2003.00058.x
50. Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med. 2002;28(9):1294-300. doi: 10.1007/s00134-002-1420-5
51. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: A secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2009;13(4):R137. doi: 10.1186/cc8016
52. Lamia B, Hellot MF, Girault C, Lamia, B. Hellot M, Girault C, Tamion F, Dachraoui F, Lenain P, Bonmarchand G. Changes in severity and organ failure scores as prognostic factors in onco-hematological malignancy patients admitted to the ICU. Intensive Care Med. 2006;32(10):1560-8. doi: 10.1007/s00134-006-0286-3
53. Guven GS, Uzun O, Cakir B, Akova M, Unal S. Infectious complications in patients with hematological malignancies consulted by the Infectious Diseases team: A retrospective cohort study (1997-2001). Support Care Cancer. 2006;14(1):52-5. doi: 10.1007/s00520-005-0836-1
54. Сёмочкин С.В., Толстых Т.Н., Архипова Н.В., Иванова В.Л., Клюева О.В., Лунин В.В., Мисюрина Е.Н., Туманова М.В., Хуажева Н.К. Клинико-эпидемиологическая характеристика острых миелоидных лейкозов у взрослых по данным муниципальных отделений гематологии Москвы. Терапевтический архив. 2015;87(7):26-32 [Semochkin SV, Tolstykh TN, Arkhipova NV, Ivanova VL, Klyueva OV, Lunin VV, Misyurina EN, Tumanova MV, Huazheva NK. Desiase type and demograph charcterisitis of acute myeloid leukemia in adults in departmetns of hematology of Moscow city. Therapeutic Archive. 2015;87(7):26-32 (In Russ.)]. doi: 10.17116/terarkh201587726-32
55. Воробьев А.И., Горелов В.Г., Городецкий В.М., Шулутко Е.М. Критические состояния при гемобластозах (типичные формы и выживаемость в условиях отделения реанимации). Терапевтический архив. 1993;65(7):3-6 [Vorobev AI, Gorelov VG, Gorodetskiy VM, Shulutko EM. Life-threating complication in patients with hemoblastosis (types and ICU survival rate). Therapeutic Archive. 1993;65(7):3-6 (In Russ.)].
56. Галстян Г.М., Городецкий В.М. Опыт работы отделения реанимации и интенсивной терапии ФГБУ ГНЦ МЗиСР РФ. Клиническая онкогематология. 2011;4(1):75-8 [Galstyan GM, Gorodetskiy VM. Experince of ICU National Research Center for Hematology. Klinicheskaya Onkoematologiya. 2011;4(1):75-8 (In Russ.)].
57. Grgić Medić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit - Outcomes and prognostic factors. Hematology. 2014;(5):247-53. doi: 10.1179/1607845414Y.0000000206
________________________________________________
2. Dizon D, Krilov L, Cohen E. Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. J Clin Oncol. 2016;34(9):987-1011. doi: 10.1200/JCO.2015.65.8427
3. Garcia-Manero G, Othus M, Pagel J. SWOG S1203: A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML). Blood. 2016;128(22). http://www.bloodjournal.org/content/128/22/901?sso-checked=true. Accessed March 6, 2018.
4. Burnett A, Russell N, Hills R. A randomized comparison of daunorubicin 90 mg/m 2 vs 60 mg/m 2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood. 2015;125(25):3878-85. doi: 10.1182/blood-2015-01-623447
5. Döhner H, Estey E, Grimwade D. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-47. doi: 10.1182/blood-2016-08-733196
6. Denardo S, Oye R, Bellamy P. Efficacy of intensive care for bone marrow transplant patients with respiratory failure. Crit Care Med. 1989;17(1):4-6. http://www.ncbi.nlm.nih. gov/pubmed/2642401. Accessed July 13, 2017.
7. Schuster D. Everything that Should Be Done—Not Everything that Can Be Done. Am Rev Respir Dis. 1992;145(3):508-9. doi: 10.1164/ajrccm/145.3.508
8. Turnbull A, Carlon G, Baron R, Sichel W, Young C, Howland W. The inverse relationship between cost and survival in the critically ill cancer patient. Crit Care Med. 1979;7(1):20-3. http://www.ncbi.nlm.nih.gov/pubmed/104824. Accessed July 11, 2017.
9. Crawford S, Petersen F. Long-term Survival from Respiratory Failure after Marrow Transplantation for Malignancy. Am Rev Respir Dis. 1992;145(3):510-4. doi: 10.1164/ajrccm/ 145.3.510
10. Lloyd-Thomas A, Wright I, Lister A, Hinds C. Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J (Clin Res Ed). 1988;296(6628):1025-9. http://www.ncbi.nlm.nih.gov/pubmed/3130123. Accessed July 5, 2017.
11. Tack C, Santman F. Results of intensive care treatment in patients with hematologic malignancies; relation to infections. Ned Tijdschr Geneeskd. 1992;136(1):25-9. http://www.ncbi. nlm.nih.gov/pubmed/1728759. Accessed July 18, 2017.
12. Lloyd-Thomas A, Dhaliwal H, Lister T, Hinds C. Intensive therapy for life-threatening medical complications of haematological malignancy. Intensive Care Med. 1986;12(4):317-24. http://www.ncbi.nlm.nih.gov/pubmed/3463606. Accessed July 13, 2017.
13. Brunet F, Lanore J, Dhainaut J. Is intensive care justified for patients with haematological malignancies? Intensive Care Med. 1990;16(5):291-7. http://www.ncbi.nlm.nih.gov/pubmed/ 2212252. Accessed July 5, 2017.
14. Yau E, Rohatiner A, Lister T, Hinds C. Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy. Br J Cancer. 1991;64(5):938-42. http://www.ncbi.nlm.nih.gov/pubmed/1931620. Accessed July 15, 2017.
15. Van Vliet M, Verburg I, Van Den Boogaard M. Trends in admission prevalence, illness severity and survival of haematological patients treated in Dutch intensive care units. Intensive Care Med. 2014;40(9):1275-84. doi: 10.1007/s00134-014-3373-x
16. Abdul-Jabbar S, Bates I, Davies G, Shulman R. An analysis of medicine costs of adult patients on a critical care unit. J Crit Care. 2014;29(3):472.e7-e472.e12. doi: 10.1016/j.jcrc. 2013.12.014
17. Schuster D, Marion J. Precedents for meaningful recovery during treatment in a medical intensive care unit. Outcome in patients with hematologic malignancy. Am J Med. 1983;75(3):402-8. http://www.ncbi.nlm.nih.gov/pubmed/6577789. Accessed July 13, 2017.
18. Benoit D, Vandewoude K, Decruyenaere J, Hoste E, Colardyn F. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med. 2003;31(1):104-12. doi: 10.1097/01. CCM.0000038213.27741.30
19. Moors I, Pène F, Lengline É, Benoit D. Urgent chemotherapy in hematological patients in the ICU. Curr Opin Crit Care. November 2015:1. doi: 10.1097/MCC.0000000000000254
20. Azoulay E, Pène F, Darmon M, Lengliné E, Benoit D,Soares M. Managing critically Ill hematology patients: Time to think differently. Blood Rev. 2015;29(6):359-67. doi: 10.1016/j.bl re.2015.04.002
21. Ñamendys-Silva S, González-Herrera M, García-Guillén F, Texcocano-Becerra J, Herrera-Gómez A. Outcome of critically ill patients with hematological malignancies. Ann Hematol. 2013;92(5):699-705. doi: 10.1007/s00277-013-1675-7
22. Jackson K, Mollee P, Morris K, Butler J, Jackson D, Kruger P, Klein K, Kennedy G. Outcomes and prognostic factors for patients with acute myeloid leukemia admitted to the intensive care unit. Leuk Lymphoma. 2013;55(April):1-8. doi: 10.3109/10428194.2013.796045
23. Bird G, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth. 2012;108(3):452-9. doi: 10.1093/bja/aer449
24. Hinds C, Martin R, Quinton P. Intensive care for patients with medical complications of haematological malignancy: is it worth it? Schweiz Med Wochenschr. 1998;128(39):1467-73. http://www.ncbi.nlm.nih.gov/pubmed/9793166. Accessed October 10, 2017.
25. Massion P, Dive A, Doyen C. Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med. 2002;30(10):2260-70. doi: 10.1097/01.CCM.000 0030456.11264.EF
26. Ahmed T, Koch A, Isom S. Outcomes and changes in code status of patients with acute myeloid leukemia undergoing induction chemotherapy who were transferred to the intensive care unit. Leuk Res. 2017;62:51-5. doi: 10.1016/j.leukres.2017.09.017
27. Roze des Ordons L, Chan K, Mirza I, Townsend D, Bagshaw S. Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study. BMC Cancer. 2010;10:516. doi: 10.1186/1471-2407-10-516
28. Schellongowski P, Staudinger T, Kundi M. Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience. Haematologica. 2011;96(2). http://www. haematologica.org/content/96/2/231. Accessed July 19, 2017.
29. [Savchenko VG, Parovichnikova EN, Afanasev BV, et al. National guidelines for diagnosis and treatment of acute myeloid leukemia in adults. Gematologia i transfusiologia. 2014;59(2):3-28 (In Russ.)].
30. Singer M, Deutschman C, Seymour C. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287
31. Fan E, Brodie D, Slutsky AS. Acute Respiratory Distress Syndrome. JAMA. 2018;319(7): 698. doi: 10.1001/jama.2017.21907
32. Morelli A, Ertmer C, Rehberg S, et al. Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): A randomized, controlled pilot study. Crit Care. 2009;13(4):1-14. doi: 10.1186/cc7990
33. [Savchenko VG. ed. Algorithm for diagnosis and guidelines for treatment of hematology disease. Moscow: Praktika press, 2018:753-792 (In Russ.)].
34. Hartsock B, Lim M, Roth C, Raptis N, Weber D, Sehgal A, Boyiadzis M, Raptis A, Hou J,Im A, Dorritie K, Marks S, Agha M, Lim S. ICU intervention during induction chemotherapy for adult patients with newly diagnosed acute myeloid leukemia. Leuk Res. 2016;48:16-9. doi: 10.1016/j.leukres.2016.07.001
35. Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: A systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2016;95(1):28-37. doi: 10.1111/aogs.12798
36. Sippel C, Kim Y, Wallau A, Brossart P, Schmidt-Wolf I, Walger P. AML versus ICU: outcome of septic AML patients in an intensive care setting. J Cancer Res Clin Oncol. 2015;141(9):1645-51. doi: 10.1007/s00432-015-1955-9
37. Azoulay E, Mokart D, Pène F, Lambert J, Kouatchet A, Mayaux J, Vincent F, Nyunga M, Bruneel F, Laisne L, Rabbat A, Lebert C, Perez P, Chaize M, Renault A, Meert A, Benoit D, Hamidfar R, Jourdain M, Darmon M, Schlemmer B, Chevret S, Lemiale V. Outcomes of Critically Ill Patients With Hematologic Malignancies: Prospective Multicenter Data From France and Belgium—A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study. J Clin Oncol. 2013;31(22):2810-8. doi: 10.1200/JCO.2012.47.2365
38. Othus M, Kantarjian H, Petersdorf S, Ravandi F, Godwin J, Cortes J, Pierce S, Erba H, Faderl S, Appelbaum F, Estey E. Declining rates of treatment-related mortality in patients with newly diagnosed AML given “intense” induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014;28(2):289-92. doi: 10.1038/leu.2013.176
39. Estey E, Smith TL, Keating MJ, McCredie KB, Gehan EA, Freireich EJ. Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia. Leukemia. 1989;3(4):257-63. https://www.scopus.com/record/display.uri?eid=2-s2.0-0024510651& origin=inward&txGid=d755ba4b8a78e0cd3abff771339a1447. Accessed November 30, 2017.
40. Walter RB, Othus M, Borthakur G, Ravandi F, Cortes J, Pierce S, Appelbaum F, Kantarjian H, Estey E. Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment Assignment. J Clin Oncol. 2011;29(33):4417-24. doi: 10.1200/JCO.2011.35.7525
41. Yeo C, Kim J, Kim S, Kim Y, Kim K, Kim H, Lee F, Rhee C. Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit. J Crit Care. 2012;27(6):739.e1-e739.e6. doi: 10.1016/j.jcrc.2012.07.014
42. Price KJ, Cardenas-Turanzas M, Lin H, Roden L, Nigam R, Nates JL. Prognostic indicators of mortality of mechanically ventilated patients with acute leukemia in a comprehensive cancer center. Minerva Anestesiol. 2012;79(2):147-55.
43. Evison JM, Rickenbacher P, Ritz R, Gratwohl A, Haberthür C, Elsasser S, Passweg J. Intensive care unit admission in patients with haematological disease: Incidence, outcome and prognostic factors. Swiss Med Wkly. 2001;131:681-6.
44. Azoulay E, Recher C, Alberti C, Soufir L, Leleu G, Le R, Fermand P, Schlemmer B. Changing use of intensive care for hematological patients: The example of multiple myeloma. Intensive Care Med. 1999;25(12):1395-401. doi: 10.1007/s001340051087
45. Depuydt P, Benoit D, Vandewoude K, Decruyenaere J, Colardyn F. Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure. Chest. 2004;126(4):1299-306. doi: 10.1378/chest.126.4.1299
46. Rabbat A, Chaoui D, Montani D, Legrand O, Lefebvre A, Rio B, Roche N, Lorut C, Marie J, Huchon G. Prognosis of patients with acute myeloid leukaemia admitted to intensive care. Br J Haematol. 2005;129(3):350-7. doi: 10.1111/j.1365-2141.2005.05459.x
47. Pohlen M, Thoennissen N, Braess J, Thudium J, Schmid C, Kochanek M, Kreuzer K, Lebiedz P, Görlich P, Gerth H, Rohde C, Kessler C, Müller-Tidow C, Stelljes M, Büchner T, Schlimok G, Hallek M, Waltenberger J, Hiddemann W, Berdel W, Heilmeier B, Krug U. Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. PLoS One. 2016;11(8):e0160871. doi: 10.1371/journal.pone.0160871
48. Larché J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le G, Schlemmer B. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med. 2003;29(10):1688-95. doi: 10.1007/s00134-003-1957-y
49. Silfvast T, Pettila V, Ihalainen A, Elonen E. Multiple organ failure and outcome of critically ill patients with haematological malignancy. Acta Anaesthesiol Scand. 2003;47:301-6. https://doi.org/10.1034/j.1399-6576.2003.00058.x
50. Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med. 2002;28(9):1294-300. doi: 10.1007/s00134-002-1420-5
51. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: A secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2009;13(4):R137. doi: 10.1186/cc8016
52. Lamia B, Hellot MF, Girault C, Lamia, B. Hellot M, Girault C, Tamion F, Dachraoui F, Lenain P, Bonmarchand G. Changes in severity and organ failure scores as prognostic factors in onco-hematological malignancy patients admitted to the ICU. Intensive Care Med. 2006;32(10):1560-8. doi: 10.1007/s00134-006-0286-3
53. Guven GS, Uzun O, Cakir B, Akova M, Unal S. Infectious complications in patients with hematological malignancies consulted by the Infectious Diseases team: A retrospective cohort study (1997-2001). Support Care Cancer. 2006;14(1):52-5. doi: 10.1007/s00520-005-0836-1
54. [Semochkin SV, Tolstykh TN, Arkhipova NV, Ivanova VL, Klyueva OV, Lunin VV, Misyurina EN, Tumanova MV, Huazheva NK. Desiase type and demograph charcterisitis of acute myeloid leukemia in adults in departmetns of hematology of Moscow city. Therapeutic Archive. 2015;87(7):26-32 (In Russ.)]. doi: 10.17116/terarkh201587726-32
55. [Vorobev AI, Gorelov VG, Gorodetskiy VM, Shulutko EM. Life-threating complication in patients with hemoblastosis (types and ICU survival rate). Therapeutic Archive. 1993;65(7):3-6 (In Russ.)].
56. Galstyan GM, Gorodetskiy VM. Experince of ICU National Research Center for Hematology. Klinicheskaya Onkoematologiya. 2011;4(1):75-8 (In Russ.)].
57. Grgić Medić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit - Outcomes and prognostic factors. Hematology. 2014;(5):247-53. doi: 10.1179/1607845414Y.0000000206
Авторы
А.В. Баженов 1, Г.М. Галстян 1, Е.Н. Паровичникова 1, В.В. Троицкая 1, Л.А. Кузьмина 1, Е.О. Грибанова 1, З.Т. Фидарова 1, С.А. Махиня 1, О.А. Латышкевич 2, Ю.А. Чабаева 1, С.М. Куликов 1, В.Г. Савченко 1
1 ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России, Москва, Россия;
2 ГБУЗ «Центр планирования семьи и репродукции» Департамента здравоохранения города Москвы, Москва, Россия
1 National Research Center for Hematology, Moscow, Russia;
2 Center of Family Planning and Reproduction, Moscow, Russia
1 ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России, Москва, Россия;
2 ГБУЗ «Центр планирования семьи и репродукции» Департамента здравоохранения города Москвы, Москва, Россия
________________________________________________
1 National Research Center for Hematology, Moscow, Russia;
2 Center of Family Planning and Reproduction, Moscow, Russia
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.