1. Chiche L, Jean R, Romain F, Roux F, et al. Implications cliniques de la decouverte d’une hypervitaminemie B12 en medecine interne. Rev Med Interne. 2008;29:187-94. doi: 10.1016/j.revmed.2007.07.007 
2. Arendt JFB, Nexo E. Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS ONE. 2012;9:e45979. doi: 10.1371/journal.pone.0045979 
3. Deneuville T, Mario N, Tiev KP, Toledano C, Josselin-Mahr L, Gain M, et al. Concentration plasmatique elevee de la vitamin B12: un indicateur des maladies hepatiquesou tumorales? Rev Med Interne. 2009;30(Suppl. 2):S73. doi: 10.1016/j.revmed.2012.10.006 
4. Carmel R, Vasireddy H, Aurangzeb I, George K. High serum cobalamin levels in the clinical setting – clinical associations and holo-transcobalamin changes. Clin Lab Haematol. 2001;23:365-71. doi: 10.1046/j.1365-2257.2001.00134.x 
5. Chiche L, Mancini J, Arlet JB, investigateurs. De l’etude BDOSE. Hypervitamineґmies B12 en medecine interne: resultats de l’etude BDOSE. Rev Med Interne. 2009;30(Suppl. 4):S377. doi: 10.1016/j.revmed.2009.10.142 
6. Воробьева Л.И. Пропионовокислые бактерии и образование витамина В12. М.: МГУ, 1986 [Vorobeva LI. Propionovokislye bakterii i sintez vitamina B12 [Propionic acid bacteria and the formation of vitamin B12]. Moscow, 1976. 315 p. (In Russ.)].
7. Herbert V. Recommended dietary intakes (RDI) of vitamin B12 in humans. Am J Clin Nutr. 1987;45:671-8. doi: 10.1093/ajcn/45.4.671 
8. Fenech MF, Dresoti IE, Rinaldi JR. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis. 1997;18:1329-36. doi: 10.1093/carcin/18.7.1329 
9. Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem. 2005;16:467-78. doi: 10.1016/j.jnutbio.2005.01.018 
10. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev. 2007;21:113-30. doi: 10.1016/j.blre.2006.05.001 
11. Whipple GH, Hooper CW, Robscheit FS. Blood regeneration following anemia. IV. Influence of meat, liver, and various extractives, alone or combined with standard diets. Am J Physiol. 1920;53:236-62. doi: 10.1152/ajplegacy.1920.53.2.236 
12. Minot GR, Murphy WP. Treatment of pernicious anemia by special diet. JAMA. 1926;87:470-6. doi: 10.1001/jama.1926.02680070016005 
13. Smith EL. Purification of anti-pernicious anemia factors from liver. Nature. 1948;161:638-9. doi: 10.1038/161638a0 
14. Rickes EL, Brink NG, Koniuszy FR, Wood TR, Folkers K. Crystalline vitamin B12. Science. 1948;107:396-7. doi: 10.1126/science.107.2781.396 
15. Castle WB. Observations on etiologic relationship of achylia gastrica to pernicious anemia. I. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle. Am J Med Sci. 1929;178:748-64. 
16. Castle WB, Heath CW, Strauss MB, Heinle RW. Observations on etiologic relationship of achylia gastrica to pernicious anemia.VI. Site of interaction of food (extrinsic) and gastric (intrinsic) factors: failure of in vitro incubation to produce thermostable hematopoietic principle. Am J Med Sci. 1937;294:618-25.
17. Gärsbeck R. Fractionation of human gastric juice and saliva employing starch electrophoresis. Gastroenterologia. 1955;84:99-102. doi: 10.1159/000200176 
18. Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med. 1999;5:656-61. doi: 10.1038/9504 
19. Tanner SM, Aminoff M, Wright FA, Liyanarachchi S, et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Nat Genet. 2003;33:426-9. doi: 10.1038/ng1098 
20. Fyfe FC, Madsen M, Hojrup P, Christensen EI, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood. 2004;103:1573-9. doi: 10.1182/blood-2003-08-2852 
21. Gärsbeck R. Imerslund-Gärsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis. 2006;1:17. doi: 10.1186/1750-1172-1-17 
22. André SE, Serraj K, Zhu J, Vermorken AJM. The pathophysiology of elevated vitamin B12 in clinical practice. Q J Med. 2013;106:505-15 doi: 10.1093/qjmed/hct051 
23. Ermens AA, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36:585-90. doi: 10.1016/j.clinbiochem.2003.08.004 
24. Lindemans J, Kroes ACM, van Geel J, Van Kapel J, et al. Uptake of transcobalamin II-bound cobalamin by HL-60 cells: effects of differentiation induction. J Exp Cell Res. 1989;184:449-60. doi: 10.1016/0014-4827(89)90343-1
25. Nicolas JP, Gueant JL, Fremont S. Cobalamin binding glycoproteins. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds. Advances in Thomas Addison’s Diseases. Bristol: Journal of Endocrinology Ltd., 1994. P. 253-67.
26. Gärsbeck R. Intrinsic factor and the other vitamin B12 transport proteins. Prog Hematol. 1969;6:233-60.
27. Burger RL, Mehlman CS, Allen RH. Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I, transcobalamin III and the normal granulocyte vitamin B12-binding protein. J Biol Chem. 1975;250:7700-6. 
28. Zittoun J. Cobalamins: an update of fundamental and clinical data. Hematologie. 1996;2:119-29.
29. Li N, Seetharam S, Lindemans J, Alpers DH, Arwert F, Seetharam B. Isolation and sequence analysis of variant forms of human transcobalamin II. Biochim Biophys Acta. 1993;1172:21-30. doi: 10.1016/0167-4781(93)90264-E 
30. Павлов Ч.В., Дамулин И.В., Шульпекова О.Ю., Андреев Е.А. Неврологические расстройства при дефиците витамина В12. Терапевтический архив. 2019;91(4):122-9 [Pavlov CS, Damulin IV, Shulpekova OYu, Andreev EA. Neurological disorders in vitamin B12 deficiency. Therapeutic Archive. 2019;91(4):122-9. Review (In Russ.)]. doi: 10.26442/00403660.2019.04.000116
31. Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr. 2003;78:131-6. doi: 10.1093/ajcn/78.1.131 
32. Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med. 2000;51:357-75. doi: 10.1146/annurev.med.51.1.357 
33. Solomon LR. More on failures of cobalamin assays in pernicious anemia. N Engl J Med. 2012;367:1570. doi: 10.1056/NEJMc1210169 
34. Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr. 1998; 17:235–8. doi:10.1080/07315724.1998.10718752
35. Kanazawa S, Herbert V. Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest. 1985;53:108-10.
36. Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem. 1992;38:493-5
37. Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnormalities in patients with cancer. Cancer. 1977;40:1348-53. doi: 10.1002/1097-0142(197709)40:3%3C1348::AID-CNCR2820400352% 3E3.0.CO;2-Q
38. Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med. 1975;292:282-4. doi: 10.1056/NEJM197502062920603 
39. Gimsing P. Cobalamin metabolism in chronic myelogenous leukemia. Dan Med Bull. 1998;45:459-79.
40. Fremont S, Chamigneulle B, Gerard P, Felden P, et al. Blood transcobalamin levels in malignant hepatoma. Tumor Biol. 1991;12:353-9. doi: 10.1159/000217736 
41. Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol. 1978;21:243-9. doi: 10.1111/j.1600-0609.1978.tb00359.x 
42. Carmel R, Tatsis B, Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood. 1977;49:987-1000. 
43. Bowen RA, Drake SK, Vanjani R, Huey ED, et al. Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes. Clin Chem. 2006;52:2107-14. doi: 10.1373/clinchem.2006.073882 
44. Schwartz M, Bastrup-Madsen P. A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values. Scand J Haematol. 1968;5:35-40. doi: 10.1111/j.1600-0609.1968.tb01715.x 
45. André SE, Henoun Loukili N, Noel E, Maloisel F, et al. Oral cobalamin (daily dose of 1000 mg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Res. 2005;66:13-22. doi: 10.1016/j.curtheres.2005.02.001 
46. Kane SP, Murray-Lyon IM, Paradinas FJ, Johnson PJ, et al. Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma. Gut. 1978;19:1105-9. doi: 10.1136/gut.19.12.1105 
47. Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol. 1986;14:227-9. doi: 10.1002/mpo.2950140408 
48. Salles N, Herrmann F, Sakbani K, Rapin CH, Sieber C. High vitamin B12 level: a strong predictor of mortality in elderly in patients. J Am Geriatr Soc. 2005;53:917-8. doi: 10.1111/j.1532-5415.2005.53278_7.x 
48. Gimsing P. The cobalamin forms and analogues in plasma and myeloid cells during the course of chronic myelogenous leukemia related to the clinical condition. Br J Haematol. 1995;89:812-9. doi: 10.1111/j.1365-2141.1995.tb08419.x 
49. Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R. Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Blood. 1984;63:779-83
50. Rachmilewitz D, Rachmilewitz EA, Polliack A, Herchko CA. Acute promyelocytic leukemia. A report of five cases with a comment on the diagnostic significance of serum vitamin B12 determination. Br J Haematol. 1972;22:87-92. doi: 10.1111/j.1365-2141.1972.tb08789.x 
51. Lambert D, Benhayoun S, Adjalla C, Gelot MM, et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion. 1997;58:64-71. doi: 10.1159/000201425 
52. Fragasso A. Vitamin B12 Deficiency in Alcoholics. In: Watson R., Preedy V., Zibadi S. (eds). Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ, 2013. doi: 10.1007/978-1-62703-047-2_10 
53. Fragasso A, Mannarella C, Ciancio A, Sacco A. Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med. 2010;21:97-100. doi: 10.1016/j.ejim.2009.11.012 
54. Hofer LJ, Elian KM. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. Med Clin Exp. 2004;27:10-3.
55. Reynolds EH, Bottiglieri T, Laundry M, Stern J, et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. Arch Neurol. 1993;50:739-42. doi: 10.1001/archneur.1993.00540070055015 
56. Molad Y, Rachmilewitz B, Sidi Y, Pinkhas J, Weinberger A. Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus. Am J Med. 1989;88:141-4. doi: 10.1016/0002-9343(90)90463-N 
57. Grindulis KA, Calverley M, Cox C. Rheumatoid arthritis: is serum vitamin B12 high in active disease? J Rheumatol. 1984;11:211-2. 
58. Kalyoncu U, Buyukasik Y, Akdogan A, Karadag O, et al. Increased serum vitamin B12 levels are associated with adult-onset Still’s disease with reactive macrophage activation syndrome. Joint Bone Spine. 2010;77:131-4. doi: 10.1016/j.jbspin.2009.09.010 
59. Belousov Y.B. Klinicheskaya farmakologiya i farmakoterapiya. M.: GEOTAR-Media, 2010.-S. 624-626, 855-857. 
60. Serraj K, Mecili M, Housni I, André SE. L’hypervitaminemie B12: physiopathologie et interêt en pratique clinique. Press Med. 2011;40:1120-7. doi: 10.1016/j.lpm.2011.08.010 

________________________________________________

1. Chiche L, Jean R, Romain F, Roux F, et al. Implications cliniques de la decouverte d’une hypervitaminemie B12 en medecine interne. Rev Med Interne. 2008;29:187-94. doi: 10.1016/j.revmed.2007.07.007 
2. Arendt JFB, Nexo E. Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS ONE. 2012;9:e45979. doi: 10.1371/journal.pone.0045979 
3. Deneuville T, Mario N, Tiev KP, Toledano C, Josselin-Mahr L, Gain M, et al. Concentration plasmatique elevee de la vitamin B12: un indicateur des maladies hepatiquesou tumorales? Rev Med Interne. 2009;30(Suppl. 2):S73. doi: 10.1016/j.revmed.2012.10.006 
4. Carmel R, Vasireddy H, Aurangzeb I, George K. High serum cobalamin levels in the clinical setting – clinical associations and holo-transcobalamin changes. Clin Lab Haematol. 2001;23:365-71. doi: 10.1046/j.1365-2257.2001.00134.x 
5. Chiche L, Mancini J, Arlet JB, investigateurs. De l’etude BDOSE. Hypervitamineґmies B12 en medecine interne: resultats de l’etude BDOSE. Rev Med Interne. 2009;30(Suppl. 4):S377. doi: 10.1016/j.revmed.2009.10.142 
6. [Propionic acid bacteria and the formation of vitamin B12]. Moscow, 1976. 315 p. (In Russ.)].
7. Herbert V. Recommended dietary intakes (RDI) of vitamin B12 in humans. Am J Clin Nutr. 1987;45:671-8. doi: 10.1093/ajcn/45.4.671 
8. Fenech MF, Dresoti IE, Rinaldi JR. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis. 1997;18:1329-36. doi: 10.1093/carcin/18.7.1329 
9. Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem. 2005;16:467-78. doi: 10.1016/j.jnutbio.2005.01.018 
10. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev. 2007;21:113-30. doi: 10.1016/j.blre.2006.05.001 
11. Whipple GH, Hooper CW, Robscheit FS. Blood regeneration following anemia. IV. Influence of meat, liver, and various extractives, alone or combined with standard diets. Am J Physiol. 1920;53:236-62. doi: 10.1152/ajplegacy.1920.53.2.236 
12. Minot GR, Murphy WP. Treatment of pernicious anemia by special diet. JAMA. 1926;87:470-6. doi: 10.1001/jama.1926.02680070016005 
13. Smith EL. Purification of anti-pernicious anemia factors from liver. Nature. 1948;161:638-9. doi: 10.1038/161638a0 
14. Rickes EL, Brink NG, Koniuszy FR, Wood TR, Folkers K. Crystalline vitamin B12. Science. 1948;107:396-7. doi: 10.1126/science.107.2781.396 
15. Castle WB. Observations on etiologic relationship of achylia gastrica to pernicious anemia. I. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle. Am J Med Sci. 1929;178:748-64. 
16. Castle WB, Heath CW, Strauss MB, Heinle RW. Observations on etiologic relationship of achylia gastrica to pernicious anemia.VI. Site of interaction of food (extrinsic) and gastric (intrinsic) factors: failure of in vitro incubation to produce thermostable hematopoietic principle. Am J Med Sci. 1937;294:618-25.
17. Gärsbeck R. Fractionation of human gastric juice and saliva employing starch electrophoresis. Gastroenterologia. 1955;84:99-102. doi: 10.1159/000200176 
18. Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med. 1999;5:656-61. doi: 10.1038/9504 
19. Tanner SM, Aminoff M, Wright FA, Liyanarachchi S, et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Nat Genet. 2003;33:426-9. doi: 10.1038/ng1098 
20. Fyfe FC, Madsen M, Hojrup P, Christensen EI, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood. 2004;103:1573-9. doi: 10.1182/blood-2003-08-2852 
21. Gärsbeck R. Imerslund-Gärsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis. 2006;1:17. doi: 10.1186/1750-1172-1-17 
22. André SE, Serraj K, Zhu J, Vermorken AJM. The pathophysiology of elevated vitamin B12 in clinical practice. Q J Med. 2013;106:505-15 doi: 10.1093/qjmed/hct051 
23. Ermens AA, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36:585-90. doi: 10.1016/j.clinbiochem.2003.08.004 
24. Lindemans J, Kroes ACM, van Geel J, Van Kapel J, et al. Uptake of transcobalamin II-bound cobalamin by HL-60 cells: effects of differentiation induction. J Exp Cell Res. 1989;184:449-60. doi: 10.1016/0014-4827(89)90343-1
25. Nicolas JP, Gueant JL, Fremont S. Cobalamin binding glycoproteins. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds. Advances in Thomas Addison’s Diseases. Bristol: Journal of Endocrinology Ltd., 1994. P. 253-67.
26. Gärsbeck R. Intrinsic factor and the other vitamin B12 transport proteins. Prog Hematol. 1969;6:233-60.
27. Burger RL, Mehlman CS, Allen RH. Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I, transcobalamin III and the normal granulocyte vitamin B12-binding protein. J Biol Chem. 1975;250:7700-6. 
28. Zittoun J. Cobalamins: an update of fundamental and clinical data. Hematologie. 1996;2:119-29.
29. Li N, Seetharam S, Lindemans J, Alpers DH, Arwert F, Seetharam B. Isolation and sequence analysis of variant forms of human transcobalamin II. Biochim Biophys Acta. 1993;1172:21-30. doi: 10.1016/0167-4781(93)90264-E 
30. [Pavlov CS, Damulin IV, Shulpekova OYu, Andreev EA. Neurological disorders in vitamin B12 deficiency. Therapeutic Archive. 2019;91(4):122-9. Review (In Russ.)]. doi: 10.26442/00403660.2019.04.000116
31. Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr. 2003;78:131-6. doi: 10.1093/ajcn/78.1.131 
32. Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med. 2000;51:357-75. doi: 10.1146/annurev.med.51.1.357 
33. Solomon LR. More on failures of cobalamin assays in pernicious anemia. N Engl J Med. 2012;367:1570. doi: 10.1056/NEJMc1210169 
34. Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr. 1998; 17:235–8. doi:10.1080/07315724.1998.10718752
35. Kanazawa S, Herbert V. Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest. 1985;53:108-10.
36. Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem. 1992;38:493-5
37. Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnormalities in patients with cancer. Cancer. 1977;40:1348-53. doi: 10.1002/1097-0142(197709)40:3%3C1348::AID-CNCR2820400352% 3E3.0.CO;2-Q
38. Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med. 1975;292:282-4. doi: 10.1056/NEJM197502062920603 
39. Gimsing P. Cobalamin metabolism in chronic myelogenous leukemia. Dan Med Bull. 1998;45:459-79.
40. Fremont S, Chamigneulle B, Gerard P, Felden P, et al. Blood transcobalamin levels in malignant hepatoma. Tumor Biol. 1991;12:353-9. doi: 10.1159/000217736 
41. Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol. 1978;21:243-9. doi: 10.1111/j.1600-0609.1978.tb00359.x 
42. Carmel R, Tatsis B, Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood. 1977;49:987-1000. 
43. Bowen RA, Drake SK, Vanjani R, Huey ED, et al. Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes. Clin Chem. 2006;52:2107-14. doi: 10.1373/clinchem.2006.073882 
44. Schwartz M, Bastrup-Madsen P. A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values. Scand J Haematol. 1968;5:35-40. doi: 10.1111/j.1600-0609.1968.tb01715.x 
45. André SE, Henoun Loukili N, Noel E, Maloisel F, et al. Oral cobalamin (daily dose of 1000 mg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Res. 2005;66:13-22. doi: 10.1016/j.curtheres.2005.02.001 
46. Kane SP, Murray-Lyon IM, Paradinas FJ, Johnson PJ, et al. Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma. Gut. 1978;19:1105-9. doi: 10.1136/gut.19.12.1105 
47. Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol. 1986;14:227-9. doi: 10.1002/mpo.2950140408 
48. Salles N, Herrmann F, Sakbani K, Rapin CH, Sieber C. High vitamin B12 level: a strong predictor of mortality in elderly in patients. J Am Geriatr Soc. 2005;53:917-8. doi: 10.1111/j.1532-5415.2005.53278_7.x 
48. Gimsing P. The cobalamin forms and analogues in plasma and myeloid cells during the course of chronic myelogenous leukemia related to the clinical condition. Br J Haematol. 1995;89:812-9. doi: 10.1111/j.1365-2141.1995.tb08419.x 
49. Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R. Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Blood. 1984;63:779-83
50. Rachmilewitz D, Rachmilewitz EA, Polliack A, Herchko CA. Acute promyelocytic leukemia. A report of five cases with a comment on the diagnostic significance of serum vitamin B12 determination. Br J Haematol. 1972;22:87-92. doi: 10.1111/j.1365-2141.1972.tb08789.x 
51. Lambert D, Benhayoun S, Adjalla C, Gelot MM, et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion. 1997;58:64-71. doi: 10.1159/000201425 
52. Fragasso A. Vitamin B12 Deficiency in Alcoholics. In: Watson R., Preedy V., Zibadi S. (eds). Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ, 2013. doi: 10.1007/978-1-62703-047-2_10 
53. Fragasso A, Mannarella C, Ciancio A, Sacco A. Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med. 2010;21:97-100. doi: 10.1016/j.ejim.2009.11.012 
54. Hofer LJ, Elian KM. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. Med Clin Exp. 2004;27:10-3.
55. Reynolds EH, Bottiglieri T, Laundry M, Stern J, et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. Arch Neurol. 1993;50:739-42. doi: 10.1001/archneur.1993.00540070055015 
56. Molad Y, Rachmilewitz B, Sidi Y, Pinkhas J, Weinberger A. Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus. Am J Med. 1989;88:141-4. doi: 10.1016/0002-9343(90)90463-N 
57. Grindulis KA, Calverley M, Cox C. Rheumatoid arthritis: is serum vitamin B12 high in active disease? J Rheumatol. 1984;11:211-2. 
58. Kalyoncu U, Buyukasik Y, Akdogan A, Karadag O, et al. Increased serum vitamin B12 levels are associated with adult-onset Still’s disease with reactive macrophage activation syndrome. Joint Bone Spine. 2010;77:131-4. doi: 10.1016/j.jbspin.2009.09.010 
59. Belousov Y.B. Klinicheskaya farmakologiya i farmakoterapiya. M.: GEOTAR-Media, 2010.-S. 624-626, 855-857. 
60. Serraj K, Mecili M, Housni I, André SE. L’hypervitaminemie B12: physiopathologie et interêt en pratique clinique. Press Med. 2011;40:1120-7. doi: 10.1016/j.lpm.2011.08.010 

В.И. Подзолков, Н.А. Драгомирецкая, О.Ц. Дамбаева, С.Т. Аувинен, И.Д. Медведев

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия

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V.I. Podzolkov, N.A. Dragomiretskaya, O.Ts. Dambaeva, S.T. Auvinen, I.D. Medvedev

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia